{"id":24583,"date":"2022-08-25T09:43:27","date_gmt":"2022-08-25T09:43:27","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24583"},"modified":"2022-08-26T10:38:21","modified_gmt":"2022-08-26T10:38:21","slug":"telzir","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/telzir\/","title":{"rendered":"Telzir &#8211; Fosamprenavir uses, dose and side effects"},"content":{"rendered":"\n<p>700 mg film-coated tablets<br>fosamprenavir<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Telzir is and what it is used for<\/h2>\n\n\n\n<p><strong>Telzir is used to treat&nbsp;infection&nbsp;with&nbsp;HIV&nbsp;(human immunodeficiency virus).<\/strong><\/p>\n\n\n\n<p>Telzir is a so-called antiretroviral drug.\u00a0It is taken together with low\u00a0doses\u00a0of another medicine, ritonavir, which increases the level of Telzir in the blood.\u00a0Telzir belongs to a group of antiretroviral medicines called\u00a0<em>protease inhibitors<\/em>.\u00a0Protease\u00a0is an\u00a0enzyme\u00a0produced by\u00a0HIV\u00a0that enables the\u00a0virus\u00a0to multiply in\u00a0white blood cells\u00a0<em>(CD4 cells<\/em>\u00a0) in your blood.\u00a0By preventing the protease enzyme from working, Telzir prevents\u00a0HIV\u00a0from multiplying and infecting more CD4 cells.<\/p>\n\n\n\n<p>Telzir is used together with low\u00a0doses\u00a0of ritonavir in combination with other antiretroviral medicines (&#8220;combination therapy&#8221;) to treat adults, adolescents, and children over 6 years of age who are infected with\u00a0HIV.<\/p>\n\n\n\n<p>HIV\u00a0can become\u00a0resistant\u00a0to anti &#8211;\u00a0HIV\u00a0drugs.\u00a0To prevent this and to prevent your illness from getting worse, you must regularly take all your medications exactly as prescribed.<\/p>\n\n\n\n<p>Telzir does not prevent you from passing on\u00a0HIV.\u00a0HIV\u00a0&#8211;\u00a0infection\u00a0is spread through sexual contact with someone who has the\u00a0infection\u00a0or through the transfer of infected blood (for example, when sharing needles).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Telzir<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Telzir should be taken in combination with low doses of ritonavir and other antiretroviral medicines.<\/h2>\n\n\n\n<p>It is therefore important that you read the package insert found in the packaging for these medicines carefully.&nbsp;If you have further questions about ritonavir or the other prescribed medicines, ask your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Do not take Telzir:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>\u00a0to fosamprenavir, amprenavir, or any of the other ingredients of this medicine (listed in section 6) or to ritonavir.<\/li><li><strong>if you are taking any of these medicines:<\/strong><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>alfuzosin (used to treat\u00a0<strong>problems with the prostate<\/strong>\u00a0)<\/li><li>astemizole or terfenadine (commonly used to treat\u00a0<strong><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/insect-allergy\/\">allergy<\/a><\/strong>\u00a0symptoms \u2013 these medicines can sometimes be bought without a prescription)<\/li><li>pimozide (used to treat\u00a0<strong>schizophrenia<\/strong>\u00a0)<\/li><li>quetiapine (used to treat\u00a0<strong>schizophrenia<\/strong>,\u00a0bipolar disorder,\u00a0and\u00a0<strong>major depression<\/strong>\u00a0)<\/li><li>lurasidone (used to treat\u00a0<strong>schizophrenia<\/strong>\u00a0and\u00a0<strong>bipolar disorder\u00a0)<\/strong><\/li><li>cisapride (used to relieve\u00a0<strong>indigestion<\/strong>\u00a0)<\/li><li>ergotamine derivatives (used to treat\u00a0<strong>headaches<\/strong>\u00a0)<\/li><li>rifampicin (used to treat\u00a0<strong>tuberculosis<\/strong>\u00a0)<\/li><li>amiodarone\u00a0,\u00a0quinidine\u00a0,\u00a0flecainide\u00a0, and\u00a0propafenone\u00a0(\u00a0<strong>heart medications<\/strong>\u00a0)<\/li><li>bepridil (used to treat\u00a0<strong>high\u00a0blood pressure<\/strong>\u00a0)<\/li><li>oral (by mouth) midazolam or triazolam (used to treat\u00a0<strong>anxiety<\/strong>\u00a0and\u00a0<strong>worry<\/strong>\u00a0)<\/li><li>products containing\u00a0St. John&#8217;s wort\u00a0(\u00a0<em>Hypericum perforatum<\/em>\u00a0)<\/li><li>lovastatin,\u00a0simvastatin\u00a0(used to lower\u00a0<strong>cholesterol<\/strong>\u00a0)<\/li><li>sildenafil when used to treat\u00a0<strong>pulmonary\u00a0<\/strong><strong>arterial\u00a0<\/strong><strong><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/hypertension\/\">hypertension<\/a><\/strong>\u00a0(a disease that affects the blood vessels in your lungs)<\/li><li>paritaprevir (used to treat\u00a0hepatitis\u00a0C virus infection).<\/li><li><strong>Tell your doctor if any of these apply to you.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Be especially careful with Telzir<\/h2>\n\n\n\n<p><strong>Talk to your doctor or pharmacist before you start using Telzir:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you have a known\u00a0allergy\u00a0to medicines containing sulfonamides.\u00a0<\/strong>Then you may also be allergic to Telzir.<\/li><li><strong>If you have any liver disease.\u00a0<\/strong>Your doctor may lower the\u00a0dose\u00a0of Telzir and ritonavir depending on the degree of your liver damage.\u00a0You will be monitored while you are taking Telzir.\u00a0If your liver disease worsens, you may need to stop taking Telzir for a period or forever.\u00a0Patients with\u00a0hepatitis\u00a0B or C who are treated with combination therapy are at increased risk of serious liver problems.<\/li><li><strong>If you have\u00a0hemophilia<\/strong>\u00a0(\u00a0bleeding disease\u00a0).\u00a0The risk of bleeding may increase when using\u00a0protease inhibitors\u00a0(such as Telzir).\u00a0The cause is not known.\u00a0You may need additional\u00a0factor VIII\u00a0preparations to control any bleeding.<\/li><li><strong>If you have\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">diabetes<\/a>\u00a0, in<\/strong>some of the patients taking antiretroviral drugs, including\u00a0protease inhibitors, increased <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar levels<\/a> and worsening of\u00a0diabetes\u00a0have been reported.\u00a0In addition, some patients have developed\u00a0diabetes\u00a0while taking these drugs.<\/li><li>If you are taking other medicines.\u00a0See section &#8220;Other medicines and Telzir&#8221;.<\/li><li><strong>Tell your doctor if any of these apply to you.\u00a0<\/strong>Extra checks, including blood tests, may be needed while you are taking the medicine.<\/li><\/ul>\n\n\n\n<p>Your doctor will check your blood glucose levels before and during treatment with Telzir.<\/p>\n\n\n\n<p><strong>Pay attention to important symptoms<\/strong><\/p>\n\n\n\n<p>Some patients taking medicines for&nbsp;HIV infection&nbsp;develop&nbsp;other&nbsp;symptoms that can be serious.&nbsp;These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a flare-up of old\u00a0infection\u00a0er<\/li><li>altered body shape<\/li><li>problems with the skeleton.<\/li><\/ul>\n\n\n\n<p>It is important that you know and pays attention to important signs and symptoms while taking Telzir.\u00a0<strong>Read the information on &#8220;Other\u00a0side effects\u00a0of combination anti-HIV therapy&#8221; in section 4 of this patient information.\u00a0<\/strong>If you have any questions about this information or the advice given there:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>You may get a rash<\/strong><\/p>\n\n\n\n<p>You can still take Telzir.\u00a0The rash can be treated with\u00a0antihistamines.\u00a0In rare cases, the rash can become severe severe (\u00a0<em>Stevens-Johnson syndrome<\/em>\u00a0).\u00a0If this happens, treatment with Telzir must be stopped immediately and you must never take Telzir again.<\/p>\n\n\n\n<p><strong>Protect other people<\/strong><\/p>\n\n\n\n<p>HIV&nbsp;&#8211;&nbsp;infection&nbsp;is spread through sexual contact with someone who has the&nbsp;infection&nbsp;or through infected blood (eg by sharing injection needles).&nbsp;You can still transmit&nbsp;HIV&nbsp;when taking this medicine, although the risk is reduced with effective&nbsp;antiviral&nbsp;treatment.<\/p>\n\n\n\n<p>Discuss with your doctor the necessary measures to avoid infecting others.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Telzir<\/h2>\n\n\n\n<p><strong>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.\u00a0<\/strong>This also applies to herbal preparations and other over-the-counter medicines.\u00a0Your doctor will decide if these medicines are appropriate to take with Telzir and ritonavir.\u00a0This is\u00a0<strong>very important<\/strong>\u00a0because Telzir or ritonavir can enhance or weaken the effect of other drugs, which in some cases can cause serious medical conditions.<\/p>\n\n\n\n<p><strong>Some medicines must not be taken with Telzir.\u00a0<\/strong>You must check against the medicines listed under \u201cDo not take Telzir\u201d at the beginning of section 2 of this patient information.<\/p>\n\n\n\n<p><strong>These medicines are not recommended with Telzir\/ritonavir:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ketoconazole\u00a0and itraconazole in\u00a0doses\u00a0greater than 200 mg per day (used to treat\u00a0<strong>fungal infections<\/strong>\u00a0)<\/li><li>rifabutin in a\u00a0dose\u00a0greater than 150 mg every other day (an\u00a0<strong>antibiotic<\/strong>\u00a0)<\/li><li>lidocaine\u00a0in injection form<\/li><li>halofantrine (used to treat\u00a0<strong>malaria<\/strong>\u00a0)<\/li><li>sildenafil, vardenafil, or tadalafil (used to treat\u00a0erectile dysfunction\u00a0)<\/li><li>atorvastatin in\u00a0doses\u00a0greater than 20 mg per day (used to lower\u00a0cholesterol levels\u00a0)<\/li><li>fluticasone propionate and similar medicines are used to treat\u00a0asthma, unless these are necessary.\u00a0In such cases, careful monitoring is required<\/li><li>lopinavir and ritonavir in combination (used to\u00a0treat\u00a0HIV\u00a0infection\u00a0)<\/li><li>raltegravir (used to treat\u00a0HIV\u00a0infection\u00a0).<\/li><li>simeprevir and daclatasvir (used to treat\u00a0hepatitis\u00a0C virus infection\u00a0)<\/li><li>maraviroc (used to treat\u00a0HIV\u00a0infection\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>You will be closely monitored if you take the following medicines together with Telzir\/ritonavir<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>atorvastatin in\u00a0doses\u00a0up to 20 mg per day (used to lower\u00a0<strong>cholesterol levels<\/strong>\u00a0)<\/li><li>carbamazepine, phenobarbital,\u00a0phenytoin\u00a0(used to treat\u00a0<strong>epilepsy<\/strong>\u00a0)<\/li><li>cyclosporine, rapamycin, tacrolimus (used to\u00a0suppress the\u00a0<strong>immune system<\/strong>\u00a0)<\/li><li>dolutegravir (used to\u00a0<strong>treat\u00a0<\/strong><strong>HIV\u00a0infection<\/strong>\u00a0)<\/li><li>desipramine, nortriptyline,\u00a0paroxetine,\u00a0and similar medicines (used to treat\u00a0depression\u00a0)<\/li><li>warfarin\u00a0and other medicines that\u00a0prevent blood clots<\/li><li>injectable midazolam (used to treat\u00a0anxiety and worry\u00a0)<\/li><li>clarithromycin, erythromycin (an\u00a0antibiotic\u00a0)<\/li><li>methadone\u00a0(a drug that replaces\u00a0heroin\u00a0)<\/li><li>dasatinib, nilotinib, ibrutinib, vinblastine, and everolimus (used to treat\u00a0<strong>various types of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a><\/strong>\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Your&nbsp;dosage&nbsp;of Telzir may need to be changed if you are taking<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>etravirine (used to treat\u00a0<strong>HIV\u00a0<\/strong><strong>infection\u00a0)<\/strong>.<\/li><\/ul>\n\n\n\n<p><strong>Hormonal contraceptive methods<\/strong><\/p>\n\n\n\n<p>If you take&nbsp;oral contraceptives&nbsp;at the same time as Telzir and ritonavir, your liver may be damaged and the effectiveness of&nbsp;oral contraceptives&nbsp;may be reduced.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Therefore, use another non-hormonal contraceptive method such as a condom.<\/strong><\/li><\/ul>\n\n\n\n<p>There have been no studies on how Telzir\/ritonavir affects other hormonal treatments, such as hormone replacement therapy\u00a0(\u00a0HRT\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Consult a doctor\u00a0<\/strong><strong>or\u00a0<\/strong><strong>pharmacist before using this medicine<\/strong>.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Breast-feeding<\/h2>\n\n\n\n<p><strong>Women who are\u00a0HIV\u00a0-positive must not breastfeed<\/strong>\u00a0because\u00a0HIV\u00a0infection\u00a0can be transferred to\u00a0the child through breast milk.\u00a0It is not known whether the ingredients in Telzir can also pass into breast milk.\u00a0If you are breastfeeding or thinking about starting to breastfeed:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor immediately<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Telzir can make you feel dizzy and cause other&nbsp;side effects&nbsp;that make you less alert.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Avoid driving or using machinery<\/strong>&nbsp;if you are unwell.<\/li><\/ul>\n\n\n\n<p><strong>Have regular contact with your doctor<\/strong><\/p>\n\n\n\n<p>Telzir\u00a0helps you keep your disease under control, but is not a cure for\u00a0HIV\u00a0infection.\u00a0You must take the medicine every day to prevent your disease from getting worse.\u00a0You can still develop other\u00a0infections\u00a0and diseases related\u00a0to\u00a0HIV\u00a0infection.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Keep in touch with your doctor and do not stop taking Telzir<\/strong>&nbsp;without first talking to your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Telzir contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Telzir<\/h2>\n\n\n\n<p><strong>Always take this medicine exactly as your doctor or pharmacist has told you.\u00a0You must take<\/strong>\u00a0the full\u00a0daily\u00a0dose\u00a0of Telzir and ritonavir as prescribed by your doctor.\u00a0Do not take more\u00a0than the recommended\u00a0dose.\u00a0Consult your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Swallow the tablets whole with a little water or other drink.\u00a0<\/strong>Telzir tablets can be taken with or without food.\u00a0Telzir is also available in liquid form (\u00a0oral\u00a0suspension\u00a0) for patients who cannot swallow tablets.\u00a0(Read the package insert for Telzir\u00a0oral\u00a0suspension\u00a0for guidance on whether to take the medicine with or without food.)<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is&nbsp;<strong>one 700 mg Telzir tablet&nbsp;<\/strong><strong>twice<\/strong>&nbsp;daily together with 100 mg ritonavir twice daily.<\/p>\n\n\n\n<p><strong>Children from 6 years of age who weigh at least 39 kg<\/strong><\/p>\n\n\n\n<p>Children can take the adult tablet dose of&nbsp;<strong>one 700 mg Telzir tablet twice<\/strong>&nbsp;daily with ritonavir 100 mg twice daily if they can swallow the tablets whole.<\/p>\n\n\n\n<p><strong>Children from 6 years who weigh less than 39 kg<\/strong><\/p>\n\n\n\n<p>Use Telzir\u00a0oral\u00a0suspension.<\/p>\n\n\n\n<p><strong>Adults with liver disease<\/strong><\/p>\n\n\n\n<p>If you have mild liver disease, the\u00a0dose\u00a0is one\u00a0<strong>tablet of Telzir (700 mg) twice<\/strong>\u00a0daily together with 100 mg ritonavir\u00a0<strong>only once daily<\/strong>.\u00a0If you have moderate or severe liver disease, the\u00a0dosage\u00a0of Telzir must be reduced.\u00a0This dose change cannot be made with Telzir tablets.\u00a0You must take Telzir\u00a0oral\u00a0suspension.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Telzir<\/h2>\n\n\n\n<p>If you have taken more than the prescribed&nbsp;dose&nbsp;of Telzir:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Contact your doctor or pharmacist immediately for advice.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Telzir<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose\u00a0of Telzir, take it as soon as possible.\u00a0Then continue the treatment as before.\u00a0<strong>Do not take a double\u00a0dose\u00a0to make up for the\u00a0missed dose.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop Telzir without first seeking advice<\/h2>\n\n\n\n<p>Take Telzir for as long as your doctor has prescribed it.&nbsp;Do not stop taking Telzir unless your doctor recommends it.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>During\u00a0HIV\u00a0treatment, weight gain and increased levels of\u00a0lipids\u00a0and\u00a0glucose\u00a0in the blood may occur.\u00a0This is partly related to restored health and lifestyle, but in the case of blood lipids, there can sometimes be a connection with HIV\u00a0drugs.\u00a0The doctor will perform tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0When treating\u00a0HIV\u00a0infection,\u00a0it is not always possible to distinguish disease symptoms from\u00a0side effects\u00a0caused by Telzir or by other medicines taken at the same time.\u00a0For this reason, you must inform<strong> your doctor of any changes in your state of health.<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>more than 1 in 10 users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><li>increase in&nbsp;<em>cholesterol<\/em>&nbsp;(a type of blood fat).<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 10 users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increases in\u00a0<em>triglycerides\u00a0(<\/em>\u00a0a type of blood fat)<\/li><li>nausea or vomiting, abdominal pain, loose stools<\/li><li>skin rash (red, raised, or itchy) \u2013 if the rash is severe, you may need to stop the medication<\/li><li>headache, dizziness<\/li><li>feeling of fatigue<\/li><li>increase in\u00a0enzymes\u00a0called\u00a0transaminases\u00a0which are\u00a0produced in the liver, and increase in an\u00a0enzyme\u00a0called\u00a0<em>lipase<\/em>\u00a0which is made in the pancreas.<\/li><li>tingling or numbness around the lips and mouth.<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 100 users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, lips, and tongue (\u00a0<em>angioedema<\/em>\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Rare\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p>These may occur in&nbsp;<strong>up to 1 in 1000 users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a serious or life-threatening skin reaction (&nbsp;<em>Stevens-Johnson syndrome<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>You may have muscle problems<\/strong><\/p>\n\n\n\n<p>There have been reports of muscle pain, tenderness, or weakness, particularly in association with\u00a0antiretroviral\u00a0therapy containing\u00a0protease inhibitors\u00a0and\u00a0nucleoside analogs.\u00a0In rare cases, these muscle problems have been severe (\u00a0<em>rhabdomyolysis<\/em>\u00a0).\u00a0If this happens to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Contact your doctor.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Hemophilia&nbsp;can suffer from more bleeding<\/strong><\/p>\n\n\n\n<p>In patients with\u00a0<strong>hemophilia\u00a0(\u00a0bleeding disease\u00a0) type A and B<\/strong>, there are reports of more bleeding during treatment with\u00a0protease inhibitors.<\/p>\n\n\n\n<p>If this happens to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Contact your doctor immediately.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>If you get a&nbsp;side effect&nbsp;ar<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor or pharmacist.&nbsp;This also applies to any&nbsp;side effects&nbsp;that<\/strong>&nbsp;are not mentioned in this information.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;of combination therapy against&nbsp;HIV<\/strong><\/p>\n\n\n\n<p><strong>Old&nbsp;infections&nbsp;can flare up<\/strong><\/p>\n\n\n\n<p>People with advanced\u00a0HIV\u00a0infection\u00a0(\u00a0AIDS\u00a0) have a weak immune system and are more likely to develop serious\u00a0infections\u00a0(opportunistic\u00a0infections\u00a0).\u00a0When these people start treatment, it happens that old, hidden\u00a0infections\u00a0flare up again and give rise to symptoms of inflammation.\u00a0These symptoms are probably caused by the body&#8217;s immune system becoming stronger so that the body starts to fight these\u00a0infections.<\/p>\n\n\n\n<p>In addition to these opportunistic\u00a0infections, autoimmune diseases (a condition that occurs when the immune system attacks healthy body tissue) can also occur after you start\u00a0taking medication for your\u00a0HIV\u00a0infection.\u00a0Autoimmune diseases can develop several months after the start of treatment.\u00a0If you notice any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, a weakness that starts in the hands and feet and moves to the trunk, palpitations, tremors, or hyperactivity, contact your doctor immediately to get the necessary treatment.<\/p>\n\n\n\n<p><strong>If you develop symptoms of infection or see signs of&nbsp;inflammation&nbsp;while taking Telzir:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Contact your doctor immediately.\u00a0Do not take other anti-infective<\/strong> medicines\u00a0without first consulting your doctor<strong>.<\/strong><\/li><\/ul>\n\n\n\n<p><br><strong>You&nbsp;<\/strong><strong>may have problems with the skeleton<\/strong><\/p>\n\n\n\n<p>Some people receiving combination anti-HIV therapy develop a condition called\u00a0<em>osteonecrosis<\/em>.\u00a0This condition means that part of the bone tissue dies due to reduced blood supply to the skeleton.<\/p>\n\n\n\n<p>People are more likely to develop this condition:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if they have received combination therapy for a long time<\/li><li>if they also take anti-inflammatory medicines&nbsp;called&nbsp;corticosteroids<\/li><li>if they drink alcohol<\/li><li>if their immune system is very weak<\/li><li>if they are overweight.<\/li><\/ul>\n\n\n\n<p><strong>Signs to watch out for are:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>stiffness in the joints<\/strong><\/li><li><strong>aches and pains<\/strong>\u00a0(mainly in hips, knees, and shoulders)<\/li><li><strong>movement difficulties.<\/strong><\/li><\/ul>\n\n\n\n<p>If you notice any of these symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor about it.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Telzir<\/h2>\n\n\n\n<p>Store out of sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the can and carton.<\/p>\n\n\n\n<p>Telzir does not require special storage conditions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The active ingredient is fosamprenavir<\/strong>.\u00a0Each tablet contains 700 mg of fosamprenavir in the form of fosamprenavir calcium (equivalent to approximately 600 mg of amprenavir).<br><\/li><li>Other ingredients: microcrystalline cellulose, croscarmellose sodium, povidone K30, magnesium stearate, anhydrous\u00a0colloidal\u00a0silicon dioxide, hypromellose, titanium dioxide (E171), glycerol triacetate, red iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and packaging of the medicine<\/h2>\n\n\n\n<p>Telzir is supplied in plastic bottles containing 60 film-coated tablets.\u00a0The tablets are capsule-shaped, biconvex, pink in color, and marked with &#8220;GXLL7&#8221; on one side.<\/p>\n\n\n\n<p>Telzir is also available as an&nbsp;oral&nbsp;suspension&nbsp;for those patients who cannot swallow tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Manufacturer<\/strong><\/td><td><strong>Marketing Authorisation Holder<\/strong><\/td><\/tr><tr><td>Glaxo Wellcome SAAvenida de Extremadura 309400 Aranda de Duero BurgosSpain<\/td><td>ViiV Healthcare BVVan Asch van Wijckstraat 55H3811 LP Amersfoort&nbsp;Netherlands<\/td><\/tr><tr><td><\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Contact the representative of the marketing authorization holder if you want to know more about this medicine.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Viiv Healthcare srl\/bvTel\/Tel: + 32 (0)10 85 65 00<\/td><td><strong>Lithuania<\/strong>ViiV Healthcare BVPhone: +370 80000334<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>ViiV Healthcare BVPhone: +359 80018205<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>ViiV Healthcare srl\/bvBelgique\/BelgiumTel\/Tel: + 32 (0) 10 85 65 00<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline s.r.oPhone: + 420 222 001 111cz.info@gsk.com<\/td><td><strong>Magyarorsz\u00e1g<\/strong>ViiV Healthcare BVTel.: +36 80088309<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A\/SPhone: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>ViiV Healthcare BVPhone: +356 80065004<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Deutschland<\/strong>ViiV Healthcare GmbHTel.: + 49 (0)89 203 0038-10viiv.med.info@viivhealthcare.com<\/td><td><strong>The Netherlands<\/strong>ViiV Healthcare BVPhone: + 31 (0)33 2081199<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Estonia<\/strong>ViiV Healthcare BVPhone: +372 8002640<\/td><td><strong>Norway<\/strong>GlaxoSmithKline iPhone: + 47 22 70 20 00<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AEBETel: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>GlaxoSmithKline Pharma GmbHTel: + 43 (0)1 97075 0at.info@gsk.com<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Spain<\/strong>Laboratorios ViiV Healthcare, SLPhone: + 34 900 923 501es-ci@viivhealthcare.com<\/td><td><strong>Polish<\/strong>GSK Services Sp.&nbsp;z o. oTel.: + 48 (0)22 576 9000<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>France<\/strong>ViiV Healthcare SASTel: + 33 (0)1 39 17 6969Infomed@viivhealthcare.com<\/td><td><strong>Portugal<\/strong>VIIVHIV HEALTHCARE, UNIPESSOAL, LDA.Phone: + 351 21 094 08 01viiv.fi.pt@viivhealthcare.com<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>ViiV Healthcare BVPhone: +385 800787089<\/td><td><strong>Romania<\/strong>ViiV Healthcare BVPhone: +40 800672524<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LimitedPhone: + 353 (0)1 4955000<\/td><td><strong>Slovenija<\/strong>ViiV Healthcare BVPhone: +386 80688869<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Simi: + 354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>ViiV Healthcare BVPhone: +421 800500589<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Italy<\/strong>ViiV Healthcare SrlPhone: + 39 (0)45 7741600<\/td><td><strong>Finland\/Finland<\/strong>GlaxoSmithKline OyPhone\/Tel: + 358 (0)10 30 30 30Finland.tuoteinfo@gsk.com<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Cyprus<\/strong>ViiV Healthcare BVPhone: +357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABPhone: + 46 (0)8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Latvia<\/strong>ViiV Healthcare BVPhone: +371 80205045<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>ViiV Healthcare BVPhone: + 44 (0)800 221441customercontactuk@gsk.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Telzir is used to treat\u00a0infection\u00a0with\u00a0HIV\u00a0(human immunodeficiency virus).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25470,25474,25471,25475,25479,25478,25472,25473,25476,25477],"class_list":["post-24583","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-fosamprenavir","tag-fosamprenavir-side-effects","tag-fosamprenavir-tablet","tag-telzir","tag-telzir-side-effects","tag-telzir-tablet","tag-what-fosamprenavir-is-used-for","tag-what-is-fosamprenavir","tag-what-is-telzir","tag-what-telzir-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24583"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24583\/revisions"}],"predecessor-version":[{"id":24604,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24583\/revisions\/24604"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}