{"id":24508,"date":"2022-08-24T11:13:58","date_gmt":"2022-08-24T11:13:58","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24508"},"modified":"2022-08-25T08:12:42","modified_gmt":"2022-08-25T08:12:42","slug":"teglutic","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/teglutic\/","title":{"rendered":"Teglutic &#8211; Riluzole uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg\/ml&nbsp;oral&nbsp;suspension<br>riluzole<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Teglutik is and what it is used for<\/h2>\n\n\n\n<p><strong>What Teglutik is<\/strong><\/p>\n\n\n\n<p>The active substance in Teglutik is riluzole, which acts on the nervous system.<\/p>\n\n\n\n<p><strong>What Teglutik is used for<\/strong><\/p>\n\n\n\n<p>Teglutik is used in patients with amyotrophic lateral sclerosis (&nbsp;ALS&nbsp;).<\/p>\n\n\n\n<p>ALS\u00a0is a type of\u00a0<strong>motor neuron disease<\/strong>\u00a0where attacks on the nerve cells responsible for sending instructions to the muscles lead to weakness, muscle atrophy, and paralysis.<\/p>\n\n\n\n<p>The breakdown of nerve cells in a motor neuron disease can be due to too much&nbsp;glutamate&nbsp;(a chemical messenger) in the brain and spinal cord.&nbsp;Teglutik stops&nbsp;the release&nbsp;of&nbsp;glutamate&nbsp;and this can help prevent nerve cells from being destroyed.<\/p>\n\n\n\n<p>Ask your doctor for additional information about&nbsp;ALS&nbsp;and why you have been prescribed this medication.<\/p>\n\n\n\n<p>Riluzole contained in Teglutik may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Teglutik<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Teglutik:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are\u00a0<strong>allergic<\/strong>\u00a0to riluzole or any of the other ingredients of this medicine (listed in section 6),<\/li><li>if you have any\u00a0<strong>liver disease<\/strong>\u00a0or elevated blood levels of certain liver enzymes (\u00a0<strong>transaminases<\/strong>\u00a0)<strong>,<\/strong><\/li><li>if you are\u00a0<strong>pregnant or breastfeeding.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Teglutik:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have\u00a0<strong>liver problems<\/strong>: skin or whites of the eyes have turned yellow (jaundice),\u00a0itching\u00a0all over the body, feeling sick, vomiting<\/li><li>if your\u00a0kidneys\u00a0are not working very well<\/li><li>if you have a\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a>: it may be due to a low number of\u00a0white blood cells, which may cause an increased risk of\u00a0infection<\/li><\/ul>\n\n\n\n<p>If any of the above applies to you or if you are unsure, contact the doctor who will then decide what to do.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>If you are younger than 18 years, the use of Teglutik is not recommended, as there is no data for this patient group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Teglutik<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>You&nbsp;<strong>should not<\/strong>&nbsp;take Teglutik if you are pregnant, think you are pregnant, or if you are breastfeeding.<\/p>\n\n\n\n<p>If you think you may be pregnant or if you intend to breastfeed, consult your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>You can drive and use tools or machines unless you feel dizzy or light-headed after taking this medicine.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effects.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Teglutik contains liquid sorbitol (E420) and sodium.<\/h2>\n\n\n\n<p>This medicine contains 4000 mg of sorbitol (E420) in 10 ml of\u00a0oral\u00a0suspension.<\/p>\n\n\n\n<p>Sorbitol is a source of fructose.\u00a0If you have an intolerance to certain sugars, or if you have been diagnosed with\u00a0hereditary\u00a0fructose intolerance, a rare, inherited disease that makes it impossible to break down fructose, consult a doctor before using this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0of sodium\u00a0per 10 ml\u00a0of oral\u00a0suspension, i.e. it is almost &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Teglutik<\/h2>\n\n\n\n<p>Suspension\u00a0one can be given orally.\u00a0Alternatively, it is also suitable for use via\u00a0an enteral tube\u00a0(feeding tube).<\/p>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended daily dose is 100 mg (50 mg every 12 hours).\u00a010 ml\u00a0of oral\u00a0suspension, containing 50 mg of riluzole, should be taken by mouth every 12 hours at the same time every day (eg morning and evening).\u00a0Suspension\u00a0is given\/taken with a graduated dosing syringe.<\/p>\n\n\n\n<p>The oral&nbsp;suspension&nbsp;should be gently shaken by hand for at least 30 seconds by continuously turning the bottle upside down until the Teglutik&nbsp;suspension&nbsp;is well mixed and you do not see any clear liquid at the top of the&nbsp;suspension&nbsp;or any particles at the bottom of the bottle.<\/p>\n\n\n\n<p><strong>User manual:<\/strong><\/p>\n\n\n\n<p>Instructions for use by mouth&nbsp;:<\/p>\n\n\n\n<p>Open the bottle: push the cap down and turn it counterclockwise (picture 1).<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20210316000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/71d6a069-ae02-42dc-b079-df6beccd350b\" alt=\"Picture 1\" title=\"Picture 1\"\/><\/a><\/figure>\n\n\n\n<p>Take the dosing syringe, remove the tip cover and place the syringe in the adapter opening (picture 2).&nbsp;Turn the bottle upside down (picture 3).<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20210316000012#\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p>Fill the syringe with a small amount of&nbsp;suspension&nbsp;by pulling down on the syringe plunger (Figure 3A), then push up on the syringe plunger to remove any bubbles (Figure 3B).&nbsp;Pull the syringe plunger down to the graduation that corresponds to the number of milliliters (ml) your doctor prescribed (Figure 3C).<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20210316000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/f6cece44-8df9-471d-a438-a5d4e11bb3bf\" alt=\"Figure 3A, 3B, 3C\" title=\"Figure 3A, 3B, 3C\"\/><\/a><\/figure>\n\n\n\n<p>Turn the bottle to an upright position (Figure 4A).&nbsp;Detach the dosing syringe from the adapter (picture 4B).<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20210316000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/0bb14f46-7198-44a8-a3ec-8e60fbab33f2\" alt=\"Figure 4A and 4B\" title=\"Figure 4A and 4B\"\/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Give\/take the entire contents of the syringe by mouth.<\/li><li>Close the bottle with the plastic screw cap.<\/li><li>Rinse the syringe with water only and replace the tip cover when the syringe is dry (picture 5).<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20210316000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/b7ce826c-b947-44aa-97dc-c6d70a6aa7d0\" alt=\"Picture 5\" title=\"Picture 5\"\/><\/a><\/figure>\n\n\n\n<p>Instructions for use via&nbsp;enteral tube&nbsp;:<\/p>\n\n\n\n<p>Ensure that there is no blockage in the enteral tube before\u00a0administration.<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Flush the enteral tube with 30 ml of water.<\/li><li>Give\/take the prescribed&nbsp;dose&nbsp;of Teglutik&nbsp;oral&nbsp;suspension&nbsp;with the graduated dosing syringe.<\/li><li>Flush the enteral tube with 30 ml of water.<\/li><\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Teglutik<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0if a child has ingested the medicine by mistake, immediately contact a doctor or hospitaview l<\/p>\n\n\n\n<p> for an assessment of the risk and advice<em>.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Teglutik<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, skip that\u00a0dose\u00a0and take the next\u00a0dose\u00a0as usual.<\/p>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Important<\/p>\n\n\n\n<p><strong>Tell your doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you develop a\u00a0<strong>fever<\/strong>\u00a0(elevated temperature) because Teglutik can reduce the number of\u00a0white blood cells.\u00a0The doctor may want to take a blood test to check the number of\u00a0white blood cells, which are important for fighting\u00a0infection.<\/li><li>if you experience any of the following symptoms: skin or whites of the eyes turn yellow (jaundice),\u00a0itching\u00a0all over the body, nausea or vomiting, as these may be signs of\u00a0liver disease\u00a0(\u00a0hepatitis\u00a0).\u00a0Doctors may need to do regular blood tests while you are taking Teglutik, to check that this does not happen.<\/li><li>if you develop a <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a> or difficulty breathing, this may be a sign of\u00a0<strong>lung disease<\/strong>\u00a0(called interstitial lung disease).<\/li><\/ul>\n\n\n\n<p>Other\u00a0side effects\u00a0are<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/fatigue-syndrome\/\">fatigue<\/a><\/li><li>nausea<\/li><li>increased blood levels of certain liver enzymes (&nbsp;transaminases&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>numbness or tingling in the mouth<\/li><li>vomiting<\/li><li>somnolence<\/li><li>increase in&nbsp;pulse&nbsp;a<\/li><li>diarrhea<\/li><li>headache<\/li><li>stomach <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pains<\/a><\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a><\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood deficiency&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>allergic reactions<\/li><li>inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;)<\/li><\/ul>\n\n\n\n<p>Since riluzole&nbsp;oral&nbsp;suspension&nbsp;is absorbed more quickly than riluzole tablets, a small increase in fatigue, dizziness, diarrhea and elevated blood levels of certain liver enzymes cannot be excluded.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Teglutik<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and bottle after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Shelf life after opening: 15 days.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is riluzole.\u00a01 ml\u00a0of oral\u00a0suspension\u00a0contains 5 mg of riluzole.<\/li><li>Other ingredients are liquid sorbitol (E420), aluminum magnesium silicate, xanthan gum (E415), saccharin sodium (E954), simethicone emulsion 30%, and sodium lauryl sulfate, macrogol cetostearyl ether, water.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>The oral\u00a0suspension\u00a0is slightly brown, opaque, and\u00a0homogeneous\u00a0after being shaken gently by hand.<\/p>\n\n\n\n<p>Teglutik is available in bottles of 250 ml and 300 ml.&nbsp;A plastic graduated dosing syringe is included in the package.<\/p>\n\n\n\n<p>Package sizes:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>carton containing one or two 250 ml bottles of riluzole 5 mg\/ml\u00a0oral\u00a0suspension<\/li><li>carton containing a 300 ml bottle of riluzole 5 mg\/ml\u00a0oral\u00a0suspension.<\/li><\/ul>\n\n\n\n<p>The syringe is graduated in milliliters up to 10 ml.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Italfarmaco SA<\/p>\n\n\n\n<p>San Rafael 3<\/p>\n\n\n\n<p>28108 Alcobendas (Madrid)<\/p>\n\n\n\n<p>Spain<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in Teglutik is riluzole, which acts on the nervous system.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[14407,25415,14402,14406,25411,25414,14403,25412,14404,25413],"class_list":["post-24508","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-riluzole","tag-benefits-of-teglutic","tag-riluzole","tag-riluzole-side-effects","tag-teglutic","tag-teglutic-side-effects","tag-what-is-riluzole","tag-what-is-teglutic","tag-what-riluzole-is-used-for","tag-what-teglutic-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24508"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24508\/revisions"}],"predecessor-version":[{"id":24552,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24508\/revisions\/24552"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}