{"id":24505,"date":"2022-08-24T11:09:07","date_gmt":"2022-08-24T11:09:07","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24505"},"modified":"2022-08-25T08:12:51","modified_gmt":"2022-08-25T08:12:51","slug":"tecfidera","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tecfidera\/","title":{"rendered":"Tecfidera &#8211; Dimethyl fumarate uses, dose and side effects"},"content":{"rendered":"\n<p>120 mg and 240 mg&nbsp;enteric capsules, hard<br>dimethyl fumarate<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tecfidera is and what it is used for<\/h2>\n\n\n\n<p><strong>What Tecfidera is<\/strong><\/p>\n\n\n\n<p>Tecfidera is a medicine that contains the active substance\u00a0<strong>dimethyl fumarate<\/strong>.<\/p>\n\n\n\n<p><strong>What Tecfidera is used for<\/strong><\/p>\n\n\n\n<p><strong>Tecfidera is used to treat relapsing-remitting\u00a0multiple sclerosis\u00a0(MS)\u00a0<\/strong><strong>in patients aged 13 and over<\/strong>.\u00a0<\/p>\n\n\n\n<p>MS is a long-term disease that affects the\u00a0central nervous system\u00a0(\u00a0CNS\u00a0), including the brain and spinal cord.\u00a0Relapsing-remitting MS is characterized by repeated attacks (\u00a0relapses\u00a0) of symptoms from the nervous system.\u00a0Symptoms vary between patients but usually include walking problems, a feeling of poor balance, and vision problems (eg, blurred vision or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/distinction-and-double-vision-in-adults\/\">double vision<\/a>).\u00a0These symptoms may disappear completely when the\u00a0relapse\u00a0is over, but some problems may remain.<\/p>\n\n\n\n<p><strong>How Tecfidera works<\/strong><\/p>\n\n\n\n<p>It appears that Tecfidera works by preventing the body&#8217;s immune system from damaging the brain and spinal cord.\u00a0This may also help delay the future worsening of your MS.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Tecfidera<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Tecfidera<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic&nbsp;<\/strong><strong>to dimethyl fumarate<\/strong>&nbsp;or any of the other ingredients of this medicine (listed in section 6).<\/li><li><strong>if you are suspected of suffering from a rare brain infection called&nbsp;progressive&nbsp;multifocal&nbsp;leukoencephalopathy (PML) or if you have confirmed PML.<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Tecfidera can affect the number of\u00a0<strong>white blood cells<\/strong>, the kidneys,\u00a0and\u00a0the liver.\u00a0Before you start taking Tecfidera, your doctor will test your blood to count the number of\u00a0white blood cells\u00a0and check that your kidneys and liver are working properly.\u00a0The doctor tests this regularly during the treatment.\u00a0If your\u00a0white blood cell count\u00a0drops during treatment, your doctor may consider taking additional tests or stopping your treatment.<\/p>\n\n\n\n<p><strong>Talk to your doctor<\/strong>&nbsp;before taking Tecfidera if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a severe&nbsp;<strong>kidney disease<\/strong><\/li><li>a severe&nbsp;<strong>liver disease<\/strong><\/li><li>a disease of the&nbsp;<strong>stomach<\/strong>&nbsp;or&nbsp;<strong>intestine<\/strong><\/li><li>a serious&nbsp;<strong>infection<\/strong>&nbsp;(eg&nbsp;pneumonia&nbsp;)<\/li><\/ul>\n\n\n\n<p>Herpes\u00a0zoster (\u00a0shingles\u00a0) can occur during treatment with Tecfidera.\u00a0In some cases, serious complications have occurred.\u00a0<strong>You should inform the doctor immediately<\/strong>\u00a0if you suspect that you have symptoms of\u00a0shingles.<\/p>\n\n\n\n<p>Talk to your doctor straight away if you think your MS is getting worse (eg weakness or vision changes) or if you notice new symptoms.&nbsp;These may be symptoms of a rare brain infection called&nbsp;progressive&nbsp;multifocal&nbsp;leukoencephalopathy (PML).&nbsp;PML is a serious condition that can lead to severe disability or be life-threatening.<\/p>\n\n\n\n<p>A rare but serious kidney disease (Fanconi syndrome) has been reported for a medicine containing dimethyl fumarate in combination with other fumaric acid esters and used to treat\u00a0psoriasis\u00a0(a skin disease).\u00a0If you notice that you urinate more, are thirstier, and drink more than usual, if your muscles seem weak, if you break a bone or just have aches and pains, talk to your doctor as soon as possible so that this can be investigated further.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>The warnings and precautions listed above also apply to children.&nbsp;Tecfidera can be used in children and adolescents from the age of 13.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tecfidera<\/h2>\n\n\n\n<p><strong>Tell your doctor or pharmacist<\/strong>\u00a0if you are taking, have recently taken, or might take any other medicines, in particular:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines containing\u00a0<strong>fumaric acid<\/strong>\u00a0esters (fumarates) used to treat\u00a0psoriasis<\/li><li><strong>medicines that affect the body&#8217;s immune system<\/strong>\u00a0including\u00a0<strong>other medicines used to treat MS<\/strong>, such as fingolimod, natalizumab, teriflunomide, alemtuzumab, ocrelizumab or cladribine, or some common\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a> treatments\u00a0(rituximab or mitoxantrone)<\/li><li>medicines that affect the kidneys\u00a0including\u00a0certain\u00a0antibiotics\u00a0(used to treat\u00a0infections\u00a0), &#8221;\u00a0water tablets\u00a0&#8221; (\u00a0diuretics\u00a0),\u00a0certain types of\u00a0painkillers\u00a0(such as\u00a0ibuprofen\u00a0and other similar anti-inflammatory and over-the-counter medicines), and medicines containing\u00a0<strong>lithium<\/strong><\/li><li>If you take Tecfidera with certain types of vaccines (\u00a0<em>live vaccines<\/em>\u00a0), you may get an\u00a0infection\u00a0and you should therefore avoid such vaccines.\u00a0The doctor will decide whether other types of vaccines (\u00a0<em>non-live vaccines<\/em>\u00a0) should be given.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tecfidera with alcohol<\/h2>\n\n\n\n<p>Consumption of more than a small amount (more than 50 ml) of strong alcoholic drinks (more than 30% alcohol by volume, eg spirits) should be avoided within one hour before and after taking Tecfidera, as alcohol can affect this drug.\u00a0It can cause\u00a0inflammation\u00a0of the stomach (\u00a0gastritis\u00a0), especially in people who are already prone to\u00a0gastritis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding&nbsp;<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>Do not use Tecfidera if you are pregnant unless you have first discussed it with your doctor.<\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>It is unknown whether the active substance in Tecfidera is excreted in breast milk.\u00a0Tecfidera should not be used during breastfeeding.\u00a0Your doctor will help you decide whether to stop breastfeeding or to stop using Tecfidera.\u00a0This means that the benefit of breastfeeding for the baby is compared to the benefit of treatment for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>The effect of Tecfidera on the ability to drive and use machines is not known.&nbsp;Tecfidera is not expected to affect the ability to drive or use machines.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tecfidera<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p><strong>Starting dose<\/strong><\/p>\n\n\n\n<p><strong>120 mg twice daily.<\/strong><\/p>\n\n\n\n<p>Take the starting dose for the first 7 days and then take the regular\u00a0dose.<\/p>\n\n\n\n<p><strong>Usual&nbsp;dose<\/strong><\/p>\n\n\n\n<p><strong>240 mg twice daily.<\/strong><\/p>\n\n\n\n<p>Tecfidera should be swallowed.<\/p>\n\n\n\n<p><strong>Swallow the capsules whole<\/strong>\u00a0with a little water.\u00a0You must not split, crush, dissolve, suck on or chew the capsule as this may increase certain\u00a0side effects.<\/p>\n\n\n\n<p><strong>Take Tecfidera with food<\/strong>&nbsp;&#8211; it may help to reduce some of the very common&nbsp;side effects&nbsp;(listed in section 4).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tecfidera<\/h2>\n\n\n\n<p>If you have taken too many capsules<strong>, talk to your doctor straight away.\u00a0<\/strong>You may experience\u00a0side effects\u00a0similar to those described below in section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tecfidera<\/h2>\n\n\n\n<p><strong>Do not take a double\u00a0<\/strong>dose\u00a0to make up for a forgotten or missed\u00a0dose.<\/p>\n\n\n\n<p>You can take the missed\u00a0dose\u00a0if you leave at least 4 hours between\u00a0doses.\u00a0Otherwise, you wait until it is time for your next scheduled\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious effects<\/strong><\/p>\n\n\n\n<p>Tecfidera can lower the number of\u00a0lymphocytes\u00a0(a type of\u00a0white blood cell\u00a0).\u00a0Having a low\u00a0white blood cell count\u00a0can increase your risk of\u00a0infection, including the risk of getting an unusual brain infection called\u00a0progressive\u00a0multifocal\u00a0leukoencephalopathy (PML).\u00a0PML can lead to severe disability or be life-threatening.\u00a0PML has occurred after 1 to 5 years of treatment and the doctor should therefore continue to check the count via\u00a0blood cells\u00a0throughout treatment and you should be alert for any symptoms of PML described below.\u00a0The risk of PML may be higher if you have previously taken medication that inhibits the function of the body&#8217;s immune system.<\/p>\n\n\n\n<p>The symptoms of PML can be similar to an MS\u00a0relapse.\u00a0Symptoms may include new or worsening weakness on one side of the body;\u00a0clumsiness;\u00a0changes in vision, thinking, or memory;\u00a0confusion or personality changes, or speech and communication difficulties that last longer than a few days.\u00a0It is therefore very important that you talk to your doctor as soon as possible if you think your MS is getting worse or if you notice any new symptoms while you are being treated with Tecfidera.\u00a0Also, talk to your partner or caregiver and inform them about your treatment.\u00a0Symptoms may occur that you may not be aware of yourself.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Contact your doctor immediately if you experience any of these symptoms<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Severe allergic reactions<\/strong><\/p>\n\n\n\n<p>The frequency of severe allergic reactions cannot be estimated from the available data (no frequency known).<\/p>\n\n\n\n<p>Redness\u00a0of the face or body (\u00a0<em>flush<\/em>\u00a0) is a very common\u00a0side effect.\u00a0If, however, you\u00a0develop redness\u00a0on your face or body along with a red rash or hives\u00a0<strong>and<\/strong>\u00a0experience any of these symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, lips, mouth, or tongue\u00a0(\u00a0angioedema\u00a0)<\/li><li>wheezing, difficulty breathing, or shortness of breath\u00a0(\u00a0dyspnea<em>,\u00a0hypoxia\u00a0)<\/em><\/li><li>dizziness or fainting\u00a0<em>(\u00a0hypotension\u00a0)<\/em><\/li><\/ul>\n\n\n\n<p>could it be a severe&nbsp;allergic reaction&nbsp;<em>(&nbsp;anaphylactic reaction&nbsp;)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Stop taking Tecfidera and see a doctor immediately<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may affect&nbsp;<em>more than 1 in 10 people:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>redness\u00a0of the face or body, feeling of heat, hotness, burning or\u00a0itching\u00a0(\u00a0<em>flush<\/em>\u00a0)<\/li><li>loose stools (\u00a0<em>diarrhea<\/em>\u00a0)<\/li><li>nausea<\/li><li>stomach pain or stomach cramps<\/li><li><strong>If you take the medicine in conjunction with food<\/strong>, it can help to reduce the above-mentioned\u00a0side\u00a0effects<\/li><\/ul>\n\n\n\n<p>While taking Tecfidera, substances called ketones, which are produced naturally in the body can very often be seen in urine tests.<\/p>\n\n\n\n<p><strong>Talk to your doctor<\/strong>\u00a0about how to manage these\u00a0side effects.\u00a0The doctor may lower the\u00a0dose.\u00a0Do not lower the\u00a0dose\u00a0unless your doctor tells you to.<\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These may affect&nbsp;<em>up to&nbsp;<\/em><em>1 in 10 people:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;of the intestines (&nbsp;<em>gastroenteritis<\/em>&nbsp;)<\/li><li>vomiting<\/li><li>indigestion (&nbsp;<em>dyspepsia<\/em>&nbsp;)<\/li><li>inflammation&nbsp;of the stomach (&nbsp;<em>gastritis<\/em>&nbsp;)<\/li><li>gastrointestinal upset<\/li><li>burning sensation<\/li><li>hot flush, feeling of warmth<\/li><li>itching&nbsp;of the skin (&nbsp;<em>pruritus<\/em>&nbsp;)<\/li><li>rash<\/li><li>pink or red spots on the skin (&nbsp;<em>erythema<\/em>&nbsp;)<\/li><li>hair loss (&nbsp;alopecia&nbsp;)<\/li><\/ul>\n\n\n\n<p>Side effects&nbsp;that can show up in blood or urine tests<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a low number of\u00a0white blood cells\u00a0(\u00a0lymphopenia,\u00a0leukopenia\u00a0) in the blood.\u00a0A reduced number of\u00a0white blood cells\u00a0can mean that the body has less ability to fight infection.\u00a0If you get a serious\u00a0infection\u00a0(e.g.\u00a0pneumonia\u00a0), you must talk to your doctor straight away<\/li><li>protein\u00a0(\u00a0albumin\u00a0) in the urine<\/li><li>elevation of liver enzymes (\u00a0ALT<em>,\u00a0AST<\/em>\u00a0) in the blood<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;These<\/strong><br>may affect&nbsp;<em>up to 1 in 100 people:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions (&nbsp;<em>hypersensitivity<\/em>&nbsp;)<\/li><li>decreased number of&nbsp;platelets<\/li><\/ul>\n\n\n\n<p><strong>Frequency not known<\/strong>&nbsp;(cannot be estimated from available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver inflammation and increased levels of liver enzymes (\u00a0<em>A\u00a0<\/em><em>LAT or\u00a0AST\u00a0in combination with\u00a0bilirubin<\/em>\u00a0)<\/li><li>herpes\u00a0zoster (\u00a0shingles\u00a0) with symptoms such as blisters, burning sensation,\u00a0itching,\u00a0or pain in the skin, typically on one side of the upper body or in the face, and other symptoms such as <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">fever<\/a> and weakness during the early stages of\u00a0infection\u00a0a followed by numbness,\u00a0itching\u00a0or red spots with severe pain<\/li><li>runny nose (\u00a0<em>rhinorrhea<\/em>\u00a0)<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children (13 years and older) and young people<\/h2>\n\n\n\n<p>The side effects&nbsp;listed above also apply to children and young people.<\/p>\n\n\n\n<p>Some\u00a0side effects\u00a0were reported more often in children and adolescents than in adults, eg headache, stomach pain or stomach cramps, nausea\u00a0<em>(vomiting)<\/em>, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a>, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a>, and painful periods.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tecfidera<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the blister pack and carton after EXP The expiry date is the last day of the month indicated.<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00b0C.&nbsp;Store the blister pack in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p><strong>The active substance is dimethyl fumarate.<\/strong><\/p>\n\n\n\n<p>Tecfidera 120 mg: One capsule contains 120 mg of dimethyl fumarate.<\/p>\n\n\n\n<p>Tecfidera 240 mg: One capsule contains 240 mg of dimethyl fumarate.<\/p>\n\n\n\n<p><strong>Other ingredients<\/strong>\u00a0are microcrystalline cellulose, croscarmellose sodium, talc, silicon dioxide (\u00a0colloidal, anhydrous), magnesium stearate, triethyl citrate, methacrylic acid-methyl methacrylate copolymer (1:1), methacrylic acid-ethyl acrylate copolymer (1:1)\u00a0dispersion\u00a030%, simethicone, sodium lauryl sulfate, polysorbate 80, gelatin, titanium dioxide (E171), brilliant blue FCF (E133), yellow iron oxide (E172), shellac, potassium hydroxide and black iron oxide (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tecfidera 120 mg gastro-resistant capsules, hard, are green and white and marked \u201cBG-12 120 mg\u201d and are available in packs of 14 capsules.<\/p>\n\n\n\n<p>Tecfidera 240 mg gastro-resistant capsules, hard, are green and marked \u201cBG-12 240 mg\u201d and are available in packs of 56 or 168 capsules.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder&nbsp;<\/h2>\n\n\n\n<p>Biogen Netherlands BV<\/p>\n\n\n\n<p>Prins Mauritslaan 13<\/p>\n\n\n\n<p>1171 LP Badhoevedorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>FUJIFILM Diosynth Biotechnologies Denmark ApS<\/p>\n\n\n\n<p>Biotek All\u00e9 1<\/p>\n\n\n\n<p>DK &#8211; 3400 Hiller\u00f8d<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Biogen Netherlands BV<\/p>\n\n\n\n<p>Prins Mauritslaan 13<\/p>\n\n\n\n<p>1171 LP Badhoevedorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Biogen Belgium NV\/SATel\/Tel: +32 2 2191218<\/td><td><strong>Lithuania<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221;Phone: +370 5 278 68 88<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>\u0422\u041f \u0415\u0412\u041e\u0424\u0410\u0420\u041c\u0410Phone: +359 2 962 12 00<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Biogen Belgium NV\/Satel\/Tel: +32 2 2191218<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Biogen (Czech Republic) s.r.oPhone: +420 255 706 200<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Biogen Hungary Kft.Phone: + 36 1 899 9883<\/td><\/tr><tr><td><strong>Denmark<\/strong>Biogen (Denmark) A\/SPhone: +45 77 41 57 57<\/td><td><strong>Malta<\/strong>Pharma.&nbsp;MT Ltd.Phone: +356 21337008<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Biogen GmbHPhone: +49 (0) 89 99 6170<\/td><td><strong>The Netherlands<\/strong>Biogen Netherlands BVPhone: +31 20 542 2000<\/td><\/tr><tr><td><strong>Estonia<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221; Eesti branch phone: +372 617 7410<\/td><td><strong>Norway<\/strong>Biogen Norway iPhone: +47 23 40 01 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Genesis Pharma Satel: +30 210 8771500<\/td><td><strong>Austria<\/strong>Biogen Austria GmbHPhone: +43 1 484 46 13<\/td><\/tr><tr><td><strong>Spain<\/strong>Biogen Spain, SLPhone: +34 91 310 7110<\/td><td><strong>Polish<\/strong>Biogen Poland Sp.\u00a0z o. iPhone: +48 22 351 51 00<\/td><\/tr><tr><td><strong>France<\/strong>Biogen France SASTel: +33 (0)1 41 37 95 95<\/td><td><strong>Portugal<\/strong>Biogen Portugal Sociedade Farmac\u00eautica, Unipessoal, Lda.Phone: +351 21 318 8450<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Medis Adria dooPhone: +385 (0) 1 230 34 46<\/td><td><strong>Romania<\/strong>Johnson &amp; Johnson Romania SRL&nbsp;Phone: +40 21 207 18 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Biogen Idec (Ireland) Ltd.Phone: +353 (0)1 463 7799<\/td><td><strong>Slovenija<\/strong>Biogen Pharma dooPhone: +386 1 511 02 90<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma of telephone: +354 540 8000<\/td><td><strong>Slovenian Republic<\/strong>Biogen Slovakia s.r.oPhone: +421 2 323 340 08<\/td><\/tr><tr><td><strong>Italy<\/strong>Biogen Italia sulfone: +39 02 5849901<\/td><td><strong>Finland\/Finland<\/strong>Biogen Finland OyTel: +358 207 401 200<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Genesis Pharma Cyprus LtdTel: +3572 2 769946<\/td><td><strong>Sweden<\/strong>Biogen Sweden ABPhone: +46 8 594 113 60<\/td><\/tr><tr><td><strong>Latvia<\/strong>UAB &#8220;JOHNSON &amp; JOHNSON&#8221; branch in LatviaPhone: +371 678 93561<\/td><td><strong>United Kingdom&nbsp;<\/strong><strong>(Northern Ireland)<\/strong>Biogen Idec (Ireland) LimitedPhone: +44 (0) 1628 50 1000<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Tecfidera is a medicine that contains the active substance\u00a0dimethyl fumarate\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25421,24339,25416,24343,25417,25419,24341,24340,25418,25420],"class_list":["post-24505","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tecfidera","tag-dimethyl-fumarate","tag-dimethyl-fumarate-benefits","tag-dimethyl-fumarate-side-effects","tag-tecfidera","tag-tecfidera-side-effects","tag-what-dimethyl-fumarate-is-used-for","tag-what-is-dimethyl-fumarate","tag-what-is-tecfidera","tag-what-tecfidera-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24505","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24505"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24505\/revisions"}],"predecessor-version":[{"id":24553,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24505\/revisions\/24553"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24505"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24505"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}