{"id":24502,"date":"2022-08-24T11:07:29","date_gmt":"2022-08-24T11:07:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24502"},"modified":"2022-08-25T08:12:58","modified_gmt":"2022-08-25T08:12:58","slug":"tecentriq","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tecentriq\/","title":{"rendered":"Tecentriq &#8211; Atezolizumab uses, dose and side effects"},"content":{"rendered":"\n<p>840 mg and 1200 mg&nbsp;concentrate for&nbsp;infusion&nbsp;solution<br>atezolizumab<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tecentriq is and what it is used for<\/h2>\n\n\n\n<p><strong>What Tecentriq is<\/strong><\/p>\n\n\n\n<p>Tecentriq is an anti-cancer medicine that contains the active substance atezolizumab.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Atezolizumab belongs to a group of medicines called monoclonal\u00a0antibodies.<\/li><li>A monoclonal\u00a0antibody\u00a0is a type of\u00a0protein\u00a0designed to recognize and bind to specific targets in the body.<\/li><li>This\u00a0antibody\u00a0can help your immune system fight your cancer.<\/li><\/ul>\n\n\n\n<p><strong>What Tecentriq is used for<\/strong><\/p>\n\n\n\n<p>Tecentriq is used to treat adults with:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A type of cancer in the bladder called urothelial carcinoma<\/li><li>A type of lung cancer, so-called non-small cell lung cancer<\/li><li>A type of lung cancer, so-called\u00a0small cell lung cancer<\/li><li>A type of breast cancer, so-called triple-negative breast cancer<\/li><li>A type of liver cancer called\u00a0hepatocellular carcinoma<\/li><\/ul>\n\n\n\n<p>Patients can receive Tecentriq when cancer has spread to other parts of the body or has come back after previous treatment.<\/p>\n\n\n\n<p>Patients can receive Tecentriq when the lung cancer has not spread to other parts of the body and treatment is then given after&nbsp;surgery&nbsp;and chemotherapy.&nbsp;Treatment after&nbsp;surgery&nbsp;is called&nbsp;adjuvant&nbsp;treatment.<\/p>\n\n\n\n<p>Tecentriq can be given in combination with other cancer medicines.&nbsp;It is important that you also read the package leaflet for the other cancer medicines that you may receive.&nbsp;If you have any questions about these medicines, ask your doctor.<\/p>\n\n\n\n<p><strong>How Tecentriq works<\/strong><\/p>\n\n\n\n<p>Tecentriq works by binding to a specific\u00a0protein\u00a0in your body called programmed-death ligand 1 (PD-L1).\u00a0This\u00a0protein\u00a0suppresses the body&#8217;s immune system, thereby protecting cancer cells from being attacked by immune cells.\u00a0By binding to\u00a0protein, Tecentriq helps your immune system fight your cancer.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Tecentriq<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You cannot receive Tecentriq:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to mepolizumab or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If you are not sure, talk to your doctor or nurse before you are given Tecentriq.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before receiving Tecentriq if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have an\u00a0autoimmune\u00a0disease (a condition where the body attacks its cells)<\/li><li>have been told that cancer has spread to your brain<\/li><li>previously had\u00a0pneumonia\u00a0(\u00a0pneumonitis\u00a0)<\/li><li>have or have had\u00a0a chronic\u00a0viral infection of the liver, including\u00a0hepatitis\u00a0B (HBV) or\u00a0hepatitis\u00a0C (\u00a0HCV\u00a0)<\/li><li>have human immunodeficiency virus infection (\u00a0HIV\u00a0) or have acquired immunodeficiency syndrome (\u00a0AIDS\u00a0)<\/li><li>have a\u00a0cardiovascular\u00a0(heart) disease or blood disorder or damage to organs due to insufficient blood flow<\/li><li>have had serious\u00a0side effects\u00a0from other treatments with\u00a0antibodies\u00a0that help your immune system fight cancer<\/li><li>have received medicines to stimulate your immune system<\/li><li>have received medicines to\u00a0suppress\u00a0your immune system<\/li><li>have received a live attenuated vaccine<\/li><li>have been given medicine to treat your\u00a0infection\u00a0(\u00a0antibiotics\u00a0) for the past two weeks<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor or nurse before you are given Tecentriq.<\/p>\n\n\n\n<p>Tecentriq can cause some\u00a0side effects\u00a0that you must tell your doctor about immediately.\u00a0They may appear weeks or months after your last\u00a0dose.\u00a0Tell your doctor immediately if you experience any of the symptoms below:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pneumonia\u00a0(\u00a0pneumonitis\u00a0): symptoms may include a new or worsening cough, shortness of breath, and chest pain<\/li><li>inflammation of the liver (\u00a0hepatitis\u00a0): symptoms may include yellowing of the skin or eyes, nausea, vomiting, bleeding or bruising easily, dark-colored urine, and stomach pain<\/li><li>inflammation\u00a0of the intestines (\u00a0colitis\u00a0): symptoms may include diarrhea (watery, loose or soft stools), blood in the stools, and stomach pain<\/li><li>inflammation\u00a0of the thyroid gland (\u00a0thyroid\u00a0), adrenal glands, or\u00a0pituitary gland\u00a0(\u00a0hypothyroidism,\u00a0hyperthyroidism\u00a0, adrenal insufficiency, or hypophysitis): symptoms may include fatigue, weight loss, weight gain, mood swings, hair loss, constipation, dizziness, headache, increased thirst, need to urinate more often and impaired vision<\/li><li>type 1\u00a0diabetes, including a serious, sometimes life-threatening problem due to acidic blood caused by\u00a0diabetes\u00a0(diabetic ketoacidosis): symptoms may include feeling hungrier and thirstier than usual, needing to urinate more often, weight loss and tiredness, tiredness or difficulty thinking, breath that smells sweet or fruity, a sweet or metallic taste in the mouth or a different smell from urine or sweat, nausea or vomiting, stomach pain, and deep or rapid breathing<\/li><li>inflammation\u00a0of the brain (\u00a0encephalitis\u00a0) or\u00a0inflammation\u00a0of the\u00a0membranes\u00a0around the spine and brain (\u00a0meningitis\u00a0): symptoms may include neck stiffness, headache, fever, chills, vomiting, eye sensitivity to light, confusion, and sleepiness<\/li><li>inflammation\u00a0of or problems with the nerves (\u00a0neuropathy\u00a0): symptoms may include muscle weakness and numbness, tingling in the hands and feet<\/li><li>inflammation\u00a0of the pancreas (\u00a0pancreatitis\u00a0): symptoms may include stomach pain, nausea, and vomiting<\/li><li>inflammation\u00a0of the heart muscle (\u00a0myocarditis\u00a0): symptoms may include shortness of breath, reduced energy on exertion, fatigue, chest pain, swelling of the ankles or legs, irregular heartbeat, and fainting<\/li><li>inflammation\u00a0of the kidneys (nephritis): symptoms may include changes in urine output and urine color, pelvic pain, and body swelling and may lead to\u00a0kidney failure<\/li><li>inflammation\u00a0of muscles (myositis): symptoms may include muscle weakness, tiredness after walking or standing, tripping or falling, and difficulty swallowing or breathing<\/li><li>severe reactions linked to\u00a0infusion\u00a0one (events that occur during\u00a0infusion\u00a0one or within a day of\u00a0infusion\u00a0one) may include fever, chills, shortness of breath, and facial flushing.<\/li><li>severe skin reactions (SCARs): which may include rash,\u00a0itching, blistering of the skin, peeling or sores, and\/or sores in the mouth, or the mucous membranes of the nose, throat, or genitals<\/li><\/ul>\n\n\n\n<p>If you experience any of the above symptoms, tell your doctor immediately.<\/p>\n\n\n\n<p>Do not try to treat yourself with other medicines.&nbsp;Your doctor may:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>give you other medicines to prevent complications and reduce symptoms<\/li><li>delay the time until the next&nbsp;dose&nbsp;of Tecentriq<\/li><li>stop your treatment with Tecentriq.<\/li><\/ul>\n\n\n\n<p><strong>Sampling and controls<\/strong><\/p>\n\n\n\n<p>Before the treatment, your doctor will check your general state of health.&nbsp;You will also be allowed to give a blood sample during the treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be given to children or adolescents under 18 years of age.\u00a0This is because the safety and efficacy of Tecentriq have not been established in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tecentriq<\/h2>\n\n\n\n<p>Tell the doctor or nurse if you are taking, have recently taken, or might take other medicines.\u00a0This also applies to medicines that you can buy without a prescription, including herbal medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and contraception<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/li><li>You will not be treated with Tecentriq if you are pregnant unless your doctor considers it necessary.\u00a0This is because the effects of Tecentriq in pregnant women are not known \u2013 it is possible that it could harm your unborn baby.<\/li><li>If it is possible for you to become pregnant, you must use effective contraception;<ul><li>while being treated with Tecentriq and<\/li><li>for 5 months after the last\u00a0dose\u00a0a.<\/li><\/ul><\/li><li>If you become pregnant while being treated with Tecentriq, tell your doctor.<\/li><\/ul>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>It is not known whether Tecentriq passes into breast milk.\u00a0Ask your doctor if you should stop breastfeeding or if you should stop taking Tecentriq.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Tecentriq has a slight influence on your ability to drive or use machines.&nbsp;If you feel tired, do not drive or use machines until you feel better.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Tecentriq is given<\/h2>\n\n\n\n<p>You will be given Tecentriq by a doctor who is experienced in cancer treatment in a hospital or clinic.<\/p>\n\n\n\n<p><strong>How much Tecentriq will be given<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is either:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>840 milligrams (mg) every two weeks or<\/li><li>1200 milligrams (mg) every three weeks or<\/li><li>1680 milligrams (mg) every four weeks.<\/li><\/ul>\n\n\n\n<p><strong>How Tecentriq is given<\/strong><\/p>\n\n\n\n<p>Tecentriq is given as a drip into a vein (an&nbsp;intravenous&nbsp;infusion&nbsp;).<\/p>\n\n\n\n<p>Your first&nbsp;infusion&nbsp;will be given over 60 minutes.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will monitor you closely during the first\u00a0infusion.<\/li><li>If you do not have an infusion reaction during the first\u00a0infusion, the next\u00a0infusion\u00a0will be given over 30 minutes.<\/li><\/ul>\n\n\n\n<p><strong>How long does the treatment lasts<\/strong><\/p>\n\n\n\n<p>Your doctor will continue to give you Tecentriq until you no longer benefit from it.&nbsp;However, the treatment can be interrupted if the&nbsp;side effects&nbsp;become too severe.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you miss a dose of Tecentriq<\/h2>\n\n\n\n<p>If you miss a scheduled treatment, book a new one immediately.\u00a0For the treatment to have a full effect, you must continue to receive the\u00a0infusions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop receiving Tecentriq<\/h2>\n\n\n\n<p>Do not stop treatment with Tecentriq without discussing this with your doctor.&nbsp;If you stop treatment, the effect of the drug may cease.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or nurse.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if<\/strong>\u00a0you experience any of the\u00a0side effects\u00a0below or if they get worse.\u00a0They may appear weeks or months after your last\u00a0dose.\u00a0Do not try to treat yourself with other medicines.<\/p>\n\n\n\n<p><strong>Tecentriq used alone<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported in&nbsp;clinical studies&nbsp;with Tecentriq when used alone:<\/p>\n\n\n\n<p><strong>Very common<\/strong><strong>:<\/strong>\u00a0\u00a0may affect more than 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever<\/li><li>nausea<\/li><li>vomiting<\/li><li>feeling extremely tired or having no energy<\/li><li>lack of energy<\/li><li>itchy skin<\/li><li>diarrhea<\/li><li>joint pain<\/li><li>rash<\/li><li>loss of appetite<\/li><li>respiratory distress<\/li><li>urinary tract infection<\/li><li>back pain<\/li><li>cough<\/li><li>headache<\/li><\/ul>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pneumonia\u00a0(\u00a0pneumonitis\u00a0)<\/li><li>low oxygen levels, which can cause shortness of breath as a consequence of\u00a0pneumonia\u00a0(\u00a0hypoxia\u00a0)<\/li><li>stomach pains<\/li><li>pain in muscles and bones<\/li><li>liver inflammation<\/li><li>elevated liver enzymes (shown on sampling), which may be a sign of liver inflammation<\/li><li>difficulty swallowing<\/li><li>blood tests showing low levels of\u00a0potassium\u00a0(\u00a0hypokalemia\u00a0) or\u00a0sodium\u00a0(\u00a0hyponatremia\u00a0)<\/li><li>low\u00a0blood pressure\u00a0(\u00a0hypotension\u00a0)<\/li><li>underactive\u00a0thyroid\u00a0(\u00a0hypothyroidism\u00a0)<\/li><li>allergic reaction\u00a0(infusion-related reaction, hypersensitivity, or anaphylactic\u00a0shock\u00a0)<\/li><li>flu-like illness<\/li><li>pain in muscles and bones<\/li><li>overindulge<\/li><li>inflammation\u00a0of the intestines<\/li><li>low levels of\u00a0platelets\u00a0which can make you bruise or bleed more easily<\/li><li>high blood sugar<\/li><li>common cold (\u00a0nasopharyngitis\u00a0)<\/li><li>pain in the mouth and throat<\/li><li>dry skin<\/li><li>abnormal kidney test (possible damage to the kidneys)<\/li><li>overactive\u00a0thyroid gland\u00a0(\u00a0hyperthyroidism\u00a0)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the pancreas<\/li><li>numbness or paralysis, which may be signs of Guillain-Barr\u00e9 syndrome<\/li><li>inflammation\u00a0of the\u00a0membrane\u00a0around the spinal cord and brain<\/li><li>low levels of adrenal hormones<\/li><li>type 1\u00a0diabetes\u00a0(including diabetic ketoacidosis)<\/li><li>inflammation\u00a0of muscles (myositis)<\/li><li>red, dry, scaly patches of thickened skin (\u00a0psoriasis\u00a0)<\/li><li>kidney inflammation<\/li><li>itching, blistering of the skin, peeling or sores, and\/or sores in the mouth, or in the mucous membranes of the nose, throat, or genitals which may become severe (severe skin reactions)<\/li><\/ul>\n\n\n\n<p><strong>Rare:<\/strong>&nbsp;&nbsp;may affect up to 1 in 1,000 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the heart muscle<\/li><li>myasthenia gravis, a disease that can cause muscle weakness<\/li><li>inflammation\u00a0of the\u00a0pituitary gland, which is located in the lower part of the brain<\/li><li>inflammation\u00a0of the eye (\u00a0uveitis\u00a0)<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that have been reported<\/strong>&nbsp;(frequency not known: cannot be estimated from the available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0of the bladder.\u00a0Signs and symptoms may include frequent and\/or painful urination, urge to urinate, blood in the urine, and pain or pressure in the lower abdomen.<\/li><\/ul>\n\n\n\n<p><strong>Tecentriq used in combination with cancer drugs<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported in&nbsp;clinical studies&nbsp;where Tecentriq was given in combination with cancer drugs:<\/p>\n\n\n\n<p><strong>Very common<\/strong><strong>:<\/strong>\u00a0\u00a0may affect more than 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low\u00a0red blood cell count, which can cause tiredness and shortness of breath<\/li><li>the low number of\u00a0white blood cells\u00a0with or without fever, &#8211; which can increase the risk of\u00a0infection\u00a0(\u00a0neutropenia,\u00a0leukopenia\u00a0)<\/li><li>the low number of\u00a0platelets, which can make you bruise or bleed more easily (\u00a0thrombocytopenia\u00a0)<\/li><li>constipation<\/li><li>nerve damage resulting in possible numbness, pain, and\/or loss of motor function (\u00a0peripheral\u00a0neuropathy\u00a0)<\/li><li>underactive\u00a0thyroid\u00a0(\u00a0hypothyroidism\u00a0)<\/li><li>loss of appetite<\/li><li>respiratory distress<\/li><li>diarrhea<\/li><li>nausea<\/li><li>itching\u00a0of the skin<\/li><li>rash<\/li><li>joint pain<\/li><li>feeling extremely tired<\/li><li>fever<\/li><li>headache<\/li><li>cough<\/li><li>pain in muscles and bones<\/li><li>vomiting<\/li><li>back pain<\/li><li>lack of energy<\/li><li>lung infection<\/li><li>common cold (\u00a0nasopharyngitis\u00a0)<\/li><li>hair loss<\/li><li>high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0)<\/li><li>swelling of arms or legs<\/li><\/ul>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood tests showing low levels of\u00a0potassium\u00a0(\u00a0hypokalemia\u00a0) or\u00a0sodium\u00a0(\u00a0hyponatremia\u00a0)<\/li><li>inflammation\u00a0of the mouth or lips<\/li><li>hoarseness (\u00a0dysphonia\u00a0)<\/li><li>low levels of\u00a0magnesium\u00a0(\u00a0hypomagnesemia\u00a0), which can cause weakness and muscle cramps, numbness, and pain in the arms and legs<\/li><li>protein\u00a0in the urine (\u00a0proteinuria\u00a0)<\/li><li>fainting<\/li><li>increased levels of liver enzymes (seen in tests) which may be a sign of inflamed liver<\/li><li>changes in taste (taste disturbance)<\/li><li>decreased levels of\u00a0lymphocytes\u00a0(a type of\u00a0white blood cell\u00a0) which is associated with an increased risk of\u00a0infection<\/li><li>abnormal kidney function values \u200b\u200b(possible kidney damage)<\/li><li>overactive\u00a0thyroid gland\u00a0(\u00a0hyperthyroidism\u00a0)<\/li><li>dizziness<\/li><li>infusion-related reactions<\/li><li>serious\u00a0infection\u00a0in the blood (\u00a0sepsis\u00a0)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>red, dry, scaly patches of thickened skin (\u00a0psoriasis\u00a0)<\/li><li>itching, blistering of the skin, peeling or sores, and\/or sores in the mouth, or in the mucous membranes of the nose, throat, or genitals which may become severe (severe skin reactions)<\/li><\/ul>\n\n\n\n<p>If you experience any of the&nbsp;side effects&nbsp;above or if they get worse, tell your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tecentriq<\/h2>\n\n\n\n<p>Tecentriq will be stored by the healthcare staff at the hospital or clinic.&nbsp;The storage conditions are as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Use before the expiry date which is stated on the label on the carton after &#8220;Exp.&#8221;\u00a0and on the vial after \u201cEXP\u201d.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2\u00b0C &#8211; 8\u00b0C).\u00a0Do not freeze.<\/li><li>Store the vial in the outer carton.\u00a0Light sensitive.<\/li><li>The diluted solution should not be stored for more than 24 hours at 2\u00b0C &#8211; 8\u00b0C or 8 hours at room temperature (\u2264 25\u00b0C), unless dilution has been performed under controlled and validated aseptic conditions.<\/li><li>Do not use this medicine if it is cloudy, discolored, or contains particles.<\/li><\/ul>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Healthcare staff will dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is atezolizumab.\u00a0Each ml contains 60 mg of atezolizumab.\u00a0Each 14 ml\u00a0vial\u00a0contains 840 mg of atezolizumab.\u00a0Each 20 ml\u00a0vial\u00a0contains 1200 mg of atezolizumab.<\/li><li>After dilution, the final concentration of the diluted solution should be between 3.2 and 16.8 mg\/ml.<\/li><li>Other ingredients are L-histidine, concentrated acetic acid, sucrose, polysorbate 20, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tecentriq is a concentrate for\u00a0infusion solution, solution.\u00a0It is a clear, colorless to slightly yellowish liquid.<\/p>\n\n\n\n<p>Tecentriq is available in a pack size of 1 glass\u00a0vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Roche Registration GmbH<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Roche Pharma AG<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>D-79639<\/p>\n\n\n\n<p>Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Finland\/Finland<\/strong>Roche Oy&nbsp;Tel: +358 (0) 10 554 500<\/td><\/tr><tr><td><strong>Sweden<\/strong>Roche phone: +46 (0) 8 726 1200<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Tecentriq is an anti-cancer medicine that contains the active substance atezolizumab.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25422,25424,25426,25431,25425,25429,25427,25423,25428,25430],"class_list":["post-24502","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-atezolizumab","tag-atezolizumab-side-effects","tag-benefits-of-atezolizumab","tag-benefits-of-tecentriq","tag-tecentriq","tag-tecentriq-side-effects","tag-what-atezolizumab-is-used-for","tag-what-is-atezolizumab","tag-what-is-tecentriq","tag-what-tecentriq-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24502"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24502\/revisions"}],"predecessor-version":[{"id":24554,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24502\/revisions\/24554"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}