{"id":24495,"date":"2022-08-24T11:00:36","date_gmt":"2022-08-24T11:00:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24495"},"modified":"2022-08-25T08:13:24","modified_gmt":"2022-08-25T08:13:24","slug":"tavneos","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tavneos\/","title":{"rendered":"Tavneos &#8211; Avacopan uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg&nbsp;hard capsules<br>avacopan<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tavneos is and what it is used for<\/h2>\n\n\n\n<p><strong>What is Tavneos?<\/strong><\/p>\n\n\n\n<p>Tavneos contains the active substance avacopan which binds to a specific\u00a0protein\u00a0in the body, the so-called complement 5a\u00a0receptor.<\/p>\n\n\n\n<p><strong>What is Tavneos used for?<\/strong><\/p>\n\n\n\n<p>Tavneos is used to treat adults with a gradually worsening disease caused by&nbsp;inflammation&nbsp;of the small blood vessels called&nbsp;granulomatous&nbsp;polyangiitis (GPA) and microscopic polyangiitis MPA):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Granulomatous\u00a0polyangiitis mainly affects small blood vessels and\u00a0tissue\u00a0in the kidneys, lungs, pharynx, nose, and sinuses, but also other organs.\u00a0Patients develop small nodules (granulomas) in and around the blood vessels, which are formed by tissue damage caused by\u00a0inflammation\u00a0a.<\/li><li>Microscopic polyangiitis affects the smaller blood vessels, often in the kidneys but can also affect other organs.<\/li><\/ul>\n\n\n\n<p>The complement 5a receptor has a key role in stimulating\u00a0inflammation.\u00a0This drug attaches to the receptor and prevents it from working, reducing the\u00a0inflammation\u00a0of the blood vessels seen in these diseases.<\/p>\n\n\n\n<p>Tavneos can be used together with other treatments prescribed by your doctor.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Tavneos<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Tavneos<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to avacopan or any of the other ingredients of this medicine (listed in section 6)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Tavneos and during treatment if you have had or have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver disease such as increased levels of total\u00a0bilirubin, which is the yellow waste product after the breakdown of pigments in the blood, or increased levels of liver enzymes such\u00a0as\u00a0transaminases<\/li><li>an\u00a0infection, unexpected bruising, and bleeding (these two are common signs of bone marrow failure)<\/li><li>hepatitis\u00a0B,\u00a0hepatitis\u00a0C, HIV infection, or\u00a0tuberculosis<\/li><li>heart disease such as heart attack,\u00a0heart failure,\u00a0inflammation\u00a0of the blood vessels of the heart<\/li><li>any type of cancer.<\/li><\/ul>\n\n\n\n<p>Tavneos is not recommended for patients with<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>active liver disease or<\/li><li>an active serious\u00a0infection.<\/li><\/ul>\n\n\n\n<p>The doctor will take blood samples before and if necessary during treatment to check:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any liver problems (by measuring liver enzymes and total&nbsp;bilirubin&nbsp;in the blood)<\/li><li>your risk of getting an&nbsp;infection&nbsp;(by measuring the number of&nbsp;white blood cells&nbsp;).<\/li><\/ul>\n\n\n\n<p>The doctor will decide to either temporarily pause your treatment or stop it permanently.<\/p>\n\n\n\n<p>The doctor will also monitor you to see if you develop signs and symptoms of an\u00a0infection\u00a0called\u00a0<em>Neisseria meningitides\u00a0.\u00a0<\/em>This is recommended for adult patients with GPA or MPA.<\/p>\n\n\n\n<p>It is recommended that you receive treatment to prevent the lung infection&nbsp;<em>Pneumocystis jirovecii&nbsp;<\/em>pneumonia&nbsp;(&nbsp;pneumonia&nbsp;) during treatment with Tavneos.<\/p>\n\n\n\n<p>It is recommended that vaccinations are given before starting treatment with Tavneos or when the disease is not active (&nbsp;granulomatous&nbsp;polyangiitis or microscopic polyangiitis).<\/p>\n\n\n\n<p>Severe and usually painful swelling under the skin, mainly in the face, has been reported during treatment with Tavneos.&nbsp;If this affects the pharynx, it can be difficult to breathe.&nbsp;Stop treatment and seek&nbsp;emergency&nbsp;medical attention if you develop swelling of the face, lips, tongue, or throat, or if you experience difficulty breathing.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children under 18 years of age because there is not enough evidence to know if this medicine is safe and effective in this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tavneos<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>It is especially important to tell the doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>carbamazepine, phenobarbital, phenytoin: medicines to treat&nbsp;epilepsy&nbsp;and other disorders<\/li><li>enzalutamide, mitotane: medicines to treat cancer<\/li><li>rifampicin: a medicine to treat&nbsp;tuberculosis&nbsp;or some&nbsp;other&nbsp;infections<\/li><li>St. John&#8217;s wort: a herbal medicine used for mild depression.<\/li><\/ul>\n\n\n\n<p>If short-term use of any of these medicines cannot be avoided during treatment with Tavneos, your doctor may check your condition regularly to see how well Tavneos is working.<\/p>\n\n\n\n<p>Tavneos can affect or be affected by the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>alfentanil: a pain-relieving drug used during operations with&nbsp;anesthetics<\/li><li>boceprevir, telaprevir: medicines to treat&nbsp;hepatitis&nbsp;C<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">bosentan<\/a>: a medicine to treat high&nbsp;blood pressure&nbsp;in the lungs, and ulcers on the fingers and toes called&nbsp;scleroderma<\/li><li>clarithromycin, telithromycin:&nbsp;antibiotics&nbsp;to treat bacterial infections<\/li><li>conivaptan: a medicine to treat low levels of&nbsp;sodium&nbsp;in the blood<\/li><li>ciclosporin: a medicine to suppress the immune system and prevent transplant rejection, treat severe skin diseases and severe eye or joint inflammation<\/li><li>dabigatran: a blood-thinning medicine<\/li><li>dihydroergotamine, ergotamine: medicine to treat&nbsp;migraine<\/li><li>fentanyl: a powerful pain reliever<\/li><li>indinavir, efavirenz, etravirine, lopinavir\/ritonavir, nelfinavir, ritonavir, saquinavir: medicines to treat HIV infections<\/li><li>itraconazole, posaconazole, voriconazole: medicines to treat fungal infections<\/li><li>ketoconazole: a medicine to treat symptoms caused by excessive production of&nbsp;cortisol&nbsp;in the body, so-called Cushing&#8217;s syndrome<\/li><li>mibefradil: a medicine to treat irregular heart rhythms and high&nbsp;blood pressure<\/li><li>modafinil: a drug to treat an extreme tendency to fall asleep<\/li><li>nefazodone: a medicine to treat depression<\/li><li>sirolimus, tacrolimus: drugs to suppress the immune system and prevent transplant rejection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tavneos with food and drink<\/h2>\n\n\n\n<p>Avoid grapefruit and grapefruit juice during treatment with Tavneos, as these can affect the effectiveness of the medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pregnancy<\/strong><br>This medicine is not recommended during pregnancy or for women of childbearing potential who are not using contraception.<\/li><li><strong>Breastfeeding<\/strong><br>It is not known whether avacopa passes into breast milk.&nbsp;A risk to the child cannot be ruled out.&nbsp;The doctor will help you decide whether to stop treatment with Tavneos or stop breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>It is considered unlikely that Tavneos would affect your ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tavneos contains macrogol glycerol hydroxy stearate<\/h2>\n\n\n\n<p>This can cause stomach upset and diarrhea.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tavneos<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is&nbsp;<strong>3 capsules in the morning and 3 capsules in the evening.<\/strong><\/p>\n\n\n\n<p><strong>Mode of administration<\/strong><\/p>\n\n\n\n<p>Swallow the capsules whole with a glass of water.\u00a0The capsules\u00a0<strong>must not<\/strong>\u00a0be crushed, chewed, or opened.\u00a0Take the capsules with a meal, 3 capsules in the morning and 3 capsules in the evening.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tavneos<\/h2>\n\n\n\n<p>Talk to the doctor immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tavneos<\/h2>\n\n\n\n<p>If you have\u00a0<strong>more than 3 hours<\/strong>\u00a0until your next scheduled\u00a0dose, take the missed\u00a0dose\u00a0as soon as possible and then take the next\u00a0dose\u00a0at the correct time.<\/p>\n\n\n\n<p>If it is\u00a0<strong>less than 3 hours<\/strong>\u00a0until the next scheduled\u00a0dose, do not take the missed\u00a0dose.\u00a0Just take the next\u00a0dose\u00a0at the usual time.<\/p>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Tavneos<\/h2>\n\n\n\n<p>Stop treatment and seek&nbsp;emergency&nbsp;medical attention if you develop swelling of the face, lips, tongue, or throat, or if you experience difficulty breathing.&nbsp;In all other situations, do not stop taking this medicine without talking to your doctor.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact your doctor immediately if you experience any of the following serious side effects:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood tests showing increased levels of<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>liver enzymes (signs of liver problems)<\/li><li>bilirubin: a yellow breakdown substance of the pigment in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pneumonia\u00a0(symptoms may be wheezing, difficulty breathing, or chest pain).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe allergic reactions that cause swelling under the skin, mainly in the face, and may cause breathing difficulties (&nbsp;angioedema&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;may occur with the following frequencies:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>upper respiratory tract&nbsp;infection<\/li><li>sore throat and&nbsp;inflammation&nbsp;of the throat and nose<\/li><li>headache<\/li><li>nausea<\/li><li>diarrhea<\/li><li>vomiting<\/li><li>decreased number of&nbsp;white blood cells&nbsp;seen in blood tests.<\/li><\/ul>\n\n\n\n<p><strong>Usual<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation\u00a0inside the nose that causes sneezing,\u00a0itching, runny and blocked nose<\/li><li>urinary tract infection<\/li><li>inflammation\u00a0of the sinuses or trachea<\/li><li>inflammation\u00a0of the stomach and intestinal mucosa<\/li><li>lower respiratory tract\u00a0infection<\/li><li>cellulitis\u00a0(\u00a0inflammation\u00a0of skin\/connective tissue)<\/li><li>shingles<\/li><li>influenza<\/li><li>infection\u00a0with the yeast\u00a0Candida\u00a0or\u00a0herpes\u00a0in the mouth<\/li><li>inflammation\u00a0of the middle ear<\/li><li>reduced number of\u00a0white blood cells\u00a0called\u00a0neutrophils\u00a0(symptoms may be\u00a0infection, fever, or pain when swallowing)<\/li><li>pain in the upper part of the abdomen<\/li><li>increased levels of the\u00a0enzyme\u00a0creatinine phosphokinase in the blood (symptoms may be chest pain, confusion, aches and pains, sudden weakness, or numbness in the body).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tavneos<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton or can after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special temperature instructions.&nbsp;Store in the original jar.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is avacopa.<br>Each hard capsule contains 10 mg of avacopan.<\/li><li>Other ingredients are:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>macrogol glycerol hydroxy stearate<\/li><li>macrogol (4000)<\/li><li>gelatine<\/li><li>polysorbate 80<\/li><li>red iron oxide (E172), yellow iron oxide (E172), black iron oxide (E172)<\/li><li>titanium dioxide (E171)<\/li><li>shellac<\/li><li>potassium hydroxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tavneo&#8217;s hard capsules consist of a yellow body and light orange body marked with &#8220;CCX168&#8221; in black ink.<\/p>\n\n\n\n<p>The capsules are 22 mm long and have a diameter of 8 mm.<\/p>\n\n\n\n<p>The capsules are packaged in plastic jars with child-resistant closures.<\/p>\n\n\n\n<p>Tavneos are available in packs of 30 or 180 capsules.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Vifor Fresenius Medical Care&nbsp;Renal&nbsp;Pharma France<\/p>\n\n\n\n<p>100\u2013101 Terrasse Boieldieu<\/p>\n\n\n\n<p>Tour Franklin La D\u00e9fense 8<\/p>\n\n\n\n<p>92042 Paris la D\u00e9fense Cedex<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>For France<\/p>\n\n\n\n<p>100\u2013101 Terrasse Boieldieu<\/p>\n\n\n\n<p>Tour Franklin La D\u00e9fense 8<\/p>\n\n\n\n<p>92042 Paris La D\u00e9fense Cedex<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>ABOUT Pharma SA<\/p>\n\n\n\n<p>R. da Ind\u00fastria, 2<\/p>\n\n\n\n<p>Quinta Grande<\/p>\n\n\n\n<p>Amadora, 2610-088<\/p>\n\n\n\n<p>Portugal<\/p>\n\n\n\n<p>Contact the marketing authorization holder if you want to know more about this medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tavneos contains the active substance avacopan which binds to a specific\u00a0protein\u00a0in the body, the so-called complement 5a\u00a0receptor\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25453,25450,25454,25459,25455,25457,25451,25452,25456,25458],"class_list":["post-24495","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-avacopan","tag-avacopan-capsule","tag-avacopan-side-effects","tag-benefits-of-tavneos","tag-tavneos","tag-tavneos-side-effects","tag-what-avacopan-is-used-for","tag-what-is-avacopan","tag-what-is-tavneos","tag-what-tavneos-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24495"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24495\/revisions"}],"predecessor-version":[{"id":24557,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24495\/revisions\/24557"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}