{"id":24491,"date":"2022-08-24T10:57:44","date_gmt":"2022-08-24T10:57:44","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24491"},"modified":"2022-08-25T08:13:31","modified_gmt":"2022-08-25T08:13:31","slug":"tavlesse","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tavlesse\/","title":{"rendered":"TAVLESSE &#8211; Fostamatinib disodium hexahydrate uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg and 150 mg&nbsp;film-coated tablets<br>fostamatinib disodium hexahydrate<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What TAVLESSE is and what it is used for<\/h2>\n\n\n\n<p><strong>What TAVLESSE is<\/strong><\/p>\n\n\n\n<p>TAVLESSE contains the active substance fostamatinib.\u00a0It specifically targets an\u00a0enzyme\u00a0called splenic\u00a0tyrosine kinase, which plays an important role in the breakdown of\u00a0thrombocytes\u00a0(\u00a0blood platelets\u00a0).<\/p>\n\n\n\n<p>TAVLESSE thus limits the immune system&#8217;s breakdown of&nbsp;platelets&nbsp;and increases the number of&nbsp;platelets&nbsp;in the body.&nbsp;This helps reduce the risk of severe bleeding.<\/p>\n\n\n\n<p><strong>What TAVLESSE is used for<\/strong><\/p>\n\n\n\n<p>TAVLESSE is used to treat adults with low\u00a0platelet counts\u00a0due to\u00a0chronic\u00a0immune\u00a0thrombocytopenia\u00a0(ITP) when previous treatment for ITP has not worked well enough.\u00a0ITP is an\u00a0autoimmune\u00a0disease, where the body&#8217;s immune system attacks and breaks down\u00a0platelets\u00a0in the blood.\u00a0Platelets\u00a0are needed for the blood to clot and thus stop bleeding.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using TAVLESSE<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take TAVLESSE<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to fostamatinib or any of the other ingredients of this medicine (listed in section 6),<\/li><li>if you are pregnant.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Before taking TAVLESSE, talk to your doctor or pharmacist about all your medical conditions, especially if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have high\u00a0blood pressure,<\/li><li>have liver problems,<\/li><li>are pregnant or planning to become pregnant,<\/li><li>breastfeeding or planning to breastfeed.<\/li><\/ul>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse immediately if you get any of the following symptoms while taking this medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0).\u00a0New or worsening high\u00a0blood pressure\u00a0is common in people treated with TAVLESSE and can be serious.\u00a0Your doctor will regularly check your\u00a0blood pressure\u00a0while you are being treated with this medicine.\u00a0If necessary, the doctor can start giving you a blood pressure-lowering medicine or change your current medicine for the treatment of\u00a0blood pressure,\u00a0etc.\u00a0Tell your doctor or pharmacist if you experience headache, confusion, dizziness, chest pain, or shortness of breath,<\/li><li>if your skin or eyes appear yellow (jaundice) or if you develop abdominal pain and swollen abdomen, swollen legs and ankles, itchy skin, abnormally dark urine, pale stools or bloody or tar-colored stools,\u00a0chronic\u00a0fatigue, feeling sick or vomiting, and loss of appetite.\u00a0Changes in blood tests for liver function are common with this drug.\u00a0These may be symptoms of liver problems.\u00a0Liver problems can occur and can be serious.\u00a0The doctor will take regular blood tests to check how well your liver is working while you are being treated with this medicine.<\/li><li>if you get diarrhea.\u00a0This is common in those receiving this medicine and can be serious.\u00a0Tell your doctor or pharmacist if you get diarrhea during treatment with this medicine.\u00a0The doctor may recommend that you change your diet, drink more water, or give you an anti-diarrhea medicine to limit the symptoms.<\/li><li>if you develop a high fever (a sign of serious\u00a0infection\u00a0), chills, feel sick or feel generally unwell.\u00a0The doctor will take regular blood tests to check the number of\u00a0white blood cells, and you may be told that the number of\u00a0white blood cells\u00a0has dropped (\u00a0neutropenia\u00a0).\u00a0Decreases in the number of\u00a0white blood cells\u00a0are common with this drug and can be serious.\u00a0This can increase your risk of\u00a0infection, even severe\u00a0infection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>TAVLESSE must not be used in patients under the age of 18.&nbsp;The drug has not been studied in this age group.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and TAVLESSE<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Taking TAVLESSE with certain other medicines can affect how the other medicines work, and other medicines can affect how TAVLESSE works.<\/p>\n\n\n\n<p>In particular, tell your doctor if you take anything from this list:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ketoconazole, this medicine is normally used to treat fungal infections.<\/li><li>Rifampicin, this medicine is normally used to treat bacterial infections.<\/li><li>Simvastatin\u00a0and rosuvastatin, these drugs are normally used to treat high\u00a0cholesterol.<\/li><li>Digoxin, this drug is normally used to treat various heart diseases such as\u00a0atrial fibrillation,\u00a0atrial flutter,\u00a0and\u00a0heart failure.<\/li><li>Midazolam, this drug is normally used for\u00a0sedation\u00a0or to treat anxiety.<\/li><li>Anticoagulants, this drug is normally used to prevent the blood from clotting.<\/li><li>Nelfinavir, this medicine is normally used to treat HIV infections.<\/li><li>Verapamil, this drug is normally used to treat various heart diseases such as high\u00a0blood pressure.<\/li><li>Ranitidine, this medicine is normally used to treat heartburn.<\/li><li>Ethinylestradiol, this drug is normally used as a contraceptive.<\/li><li>Pioglitazone, this drug is normally used to treat type 2\u00a0diabetes.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>TAVLESSE should not be used during pregnancy.&nbsp;It can harm your unborn child or cause birth defects.<\/p>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>If you are a woman of childbearing potential, you must use reliable contraception while taking TAVLESSE, and you must continue to use reliable contraception for at least 1 month after taking your last\u00a0dose.<\/p>\n\n\n\n<p>Contact your doctor immediately if you become pregnant while taking this medicine.<\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>TAVLESSE is not recommended during breastfeeding.\u00a0You should not breastfeed during treatment with TAVLESSE and for at least 1 month after your last\u00a0dose.<\/p>\n\n\n\n<p>If you are breastfeeding or plan to breastfeed, consult your doctor or pharmacist before using this medicine.<\/p>\n\n\n\n<p>Fertility<\/p>\n\n\n\n<p>TAVLESSE can affect a woman&#8217;s ability to get pregnant and have a baby.&nbsp;Talk to your doctor if you are concerned about this.&nbsp;There is no effect on men.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TAVLESSE contains sodium<\/h2>\n\n\n\n<p>TAVLESSE 100 mg film-coated tablets&nbsp;contain 23 mg&nbsp;sodium&nbsp;(the main ingredient in common\/table salt) per tablet.&nbsp;This corresponds to 1.2 percent of the maximum recommended daily intake of dietary&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<p>TAVLESSE 150 mg film-coated tablets&nbsp;contain 34 mg&nbsp;sodium&nbsp;(the main ingredient in common salt\/table salt) per tablet.&nbsp;This corresponds to 1.7 percent of the maximum recommended daily intake of dietary&nbsp;sodium&nbsp;for adults.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take TAVLESSE<\/h2>\n\n\n\n<p><strong>Recommended&nbsp;dose<\/strong><\/p>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Before you start the treatment, the doctor will measure the number of&nbsp;platelets&nbsp;in your blood.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;of TAVLESSE is 100 mg twice a day (one 100 mg tablet).<\/p>\n\n\n\n<p>However, the doctor will check the&nbsp;platelet count&nbsp;during treatment with TAVLESSE and may change the&nbsp;dose&nbsp;as needed.<\/p>\n\n\n\n<p>After you start treatment with TAVLESSE, the&nbsp;dose&nbsp;can be increased to 150 mg twice a day (one 150 mg tablet) based on the platelet count and how well you tolerate the medicine.&nbsp;A daily&nbsp;dose&nbsp;of 300 mg (two tablets of 150 mg) must not be exceeded.<\/p>\n\n\n\n<p>If you do not get any effect from the treatment with fostamatinib, the doctor will stop the treatment.<\/p>\n\n\n\n<p>If you have liver problems or high\u00a0blood pressure, your doctor may give you a lower starting dose.\u00a0If you experience serious\u00a0side effects\u00a0(such as high\u00a0blood pressure, liver problems, diarrhea, or a reduced number of\u00a0white blood cells\u00a0), the doctor may lower your\u00a0dose\u00a0or stop treatment temporarily or permanently.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take TAVLESSE<\/h2>\n\n\n\n<p>Swallow the tablets whole with water.<\/p>\n\n\n\n<p>TAVLESSE can be taken with food or between meals.<\/p>\n\n\n\n<p>In case of stomach upset, take the tablets with food.<\/p>\n\n\n\n<p><strong>If you feel sick<\/strong><\/p>\n\n\n\n<p>If you ever feel unwell after taking TAVLESSE, do not take another tablet.&nbsp;Take the next&nbsp;dose&nbsp;at the regularly scheduled time.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much TAVLESSE<\/h2>\n\n\n\n<p>If you have taken too much TAVLESSE, contact your doctor or pharmacist immediately or go to the nearest emergency department.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take TAVLESSE<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.&nbsp;Take the next&nbsp;dose&nbsp;at the regularly scheduled time<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking TAVLESSE<\/h2>\n\n\n\n<p>It is important to take TAVLESSE for as long as the doctor prescribes it.&nbsp;Do not stop taking TAVLESSE unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about the use of this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>TAVLESSE can cause serious\u00a0side effects.\u00a0Tell your doctor immediately if you get any of the following serious\u00a0side effects, either for the first time or if they get worse (see also section 2):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high fever.\u00a0Fever has been associated with low levels of\u00a0white blood cells\u00a0(febrile\u00a0neutropenia\u00a0) or\u00a0infection<\/li><li>diarrhea<\/li><li>infection\u00a0and\u00a0inflammation\u00a0of the lungs (\u00a0pneumonia\u00a0).\u00a0Symptoms include feeling short of breath, chest pain and production of discolored mucus<\/li><li>jaundice, abdominal pain and swollen stomach, swollen legs and ankles, itchy skin, abnormally dark urine, pale stools, or bloody or tar-colored stools,\u00a0chronic\u00a0fatigue, feeling sick or vomiting, loss of appetite.\u00a0These may be symptoms of liver problems.<\/li><li>severe increase in blood pressure that can lead to\u00a0stroke\u00a0(hypertensive crisis).\u00a0The symptoms are headache, confusion, and dizziness.<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p>In addition to the serious\u00a0side effects\u00a0mentioned above, you may also experience other\u00a0side effects.<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>problems from the stomach and intestines, such as diarrhea, nausea, vomiting, and frequent bowel movements<\/li><li>high&nbsp;blood pressure<\/li><li>abnormal blood test results that show how your liver is working<\/li><li>dizziness<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low\u00a0white blood cell count\u00a0or\u00a0neutropenia<\/li><li>stomach ache<\/li><li>chest pain<\/li><li>fatigue (exhaustion)<\/li><li>flu-like symptoms<\/li><li>infection\u00a0in your nose and throat, such as sore throat and the common cold<\/li><li>infection\u00a0of the airways, such as\u00a0bronchitis<\/li><li>taste changes<\/li><li>rash<\/li><li>headache<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How TAVLESSE should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>No special temperature instructions.&nbsp;Store in the original packaging.&nbsp;Moisture sensitive.&nbsp;Close the jar well.<\/p>\n\n\n\n<p>Use before the expiration date stated on the label after \u201cExp.\u201d&nbsp;respectively &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is fostamatinib disodium hexahydrate.<\/li><\/ul>\n\n\n\n<p>TAVLESSE 100 mg film-coated tablets<\/p>\n\n\n\n<p>TAVLESSE 150 mg film-coated tablets<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Other ingredients are:<ul><li>Mannitol, sodium bicarbonate, sodium starch glycolate (type A), povidone (K30), magnesium stearate<\/li><li>Film coating: poly(vinyl alcohol), titanium dioxide, macrogol (3350), talc, iron oxide yellow, iron oxide red<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>TAVLESSE 100 mg film-coated tablets<\/p>\n\n\n\n<p>The tablet is round, domed on both sides with a dark orange film coating.&nbsp;The tablets are marked with &#8220;R&#8221; on one side and &#8220;100&#8221; on the other.<\/p>\n\n\n\n<p>The tablets are supplied in cans of 30 and 60 film-coated tablets.&nbsp;Each jar contains 2 desiccants.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<p>TAVLESSE 150 mg film-coated tablets<\/p>\n\n\n\n<p>The tablet is oval, domed on both sides with a light orange film coating.&nbsp;The tablets are marked with &#8220;R&#8221; on one side and &#8220;150&#8221; on the other.<\/p>\n\n\n\n<p>The tablets are supplied in cans of 30 and 60 film-coated tablets.&nbsp;Each jar contains 2 desiccants.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Instituto Grifols, SA<\/p>\n\n\n\n<p>Can Guasc, 2 &#8211; Parets del Vall\u00e8s 08150 Barcelona \u2013 Spain<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<p>Grifols Nordic AB Tel: +46 8 441 89 50<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TAVLESSE contains the active substance fostamatinib.\u00a0It specifically targets an\u00a0enzyme\u00a0called splenic\u00a0tyrosine kinase\u00a0, which plays an important role in the breakdown of\u00a0thrombocytes\u00a0(\u00a0blood platelets\u00a0).f<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25463,25464,25465,25462,25466,25469,25461,25460,25468,25467],"class_list":["post-24491","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-fostamatinib-disodium-hexahydrate","tag-fostamatinib-disodium-hexahydrate-side-effects","tag-fostamatinib-disodium-hexahydrate-tablet","tag-tavlesse","tag-tavlesse-side-effects","tag-tavlesse-tablet","tag-what-fostamatinib-disodium-hexahydrate-is-used-for","tag-what-is-fostamatinib-disodium-hexahydrate","tag-what-is-tavlesse","tag-what-tavlesse-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24491"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24491\/revisions"}],"predecessor-version":[{"id":24558,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24491\/revisions\/24558"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}