{"id":24432,"date":"2022-08-23T13:01:58","date_gmt":"2022-08-23T13:01:58","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24432"},"modified":"2022-08-24T10:52:39","modified_gmt":"2022-08-24T10:52:39","slug":"tasigna","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tasigna\/","title":{"rendered":"Tasigna &#8211; Nilotinib uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg, 150 mg and 200 mg&nbsp;hard capsules<br>nilotinib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tasigna is and what it is used for<\/h2>\n\n\n\n<p><strong>What Tasigna is<\/strong><\/p>\n\n\n\n<p>Tasigna is a medicine that contains the active substance nilotinib.<\/p>\n\n\n\n<p><strong>What Tasigna is used for<\/strong><\/p>\n\n\n\n<p>Tasigna is used to treat a type of\u00a0leukemia\u00a0called Philadelphia chromosome-positive\u00a0chronic myeloid leukemia\u00a0(\u00a0Ph-positive CML).\u00a0CML is a cancer of the blood, which causes the body to produce too many abnormal\u00a0white blood cells.<\/p>\n\n\n\n<p>Tasigna is used in adult and&nbsp;pediatric patients&nbsp;with newly diagnosed CML or in patients with CML who no longer benefit from previous treatment that included imatinib.&nbsp;Tasigna is also used in adult and&nbsp;pediatric patients&nbsp;who have experienced serious&nbsp;side effects&nbsp;from previous treatment and therefore cannot continue with that medicine.<\/p>\n\n\n\n<p><strong>How Tasigna works<\/strong><\/p>\n\n\n\n<p>In patients with CML, a change occurs in the\u00a0DNA\u00a0(the genetic material), which triggers a signal to the body to produce abnormal\u00a0white blood cells.\u00a0Tasigna blocks this signal and thus stops the production of these cells.<\/p>\n\n\n\n<p><strong>Monitoring during treatment with Tasigna<\/strong><\/p>\n\n\n\n<p>Regular samples, including blood tests, will be taken during treatment.&nbsp;These samples check for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the number of\u00a0blood cells\u00a0(\u00a0white blood cells,\u00a0red blood cells,\u00a0and\u00a0platelets\u00a0) in the body to see how Tasigna works.<\/li><li>pancreas\u00a0&#8211; and liver function in the body to see how Tasigna works.<\/li><li>the electrolytes\u00a0in the body (\u00a0potassium,\u00a0magnesium\u00a0).\u00a0These are important for the function of the heart.<\/li><li>the level of sugar and fats in the blood.<\/li><\/ul>\n\n\n\n<p>The heart rate will also be checked using a machine that measures the electrical activity of the heart (a test called an \u201cECG\u201d).<\/p>\n\n\n\n<p>Your doctor will evaluate your treatment regularly and decide whether you should continue taking Tasigna.&nbsp;If you are told to stop taking this medicine, your doctor will continue to monitor your CML and may tell you to resume treatment with Tasigna if your condition indicates it is necessary.<\/p>\n\n\n\n<p>Contact your doctor if you have any questions about how Tasigna works or why it has been prescribed for you or your child.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Tasigna<\/h2>\n\n\n\n<p>Follow your doctor&#8217;s instructions carefully.&nbsp;They may differ from the general information contained in this leaflet.<\/p>\n\n\n\n<p><strong>Do not take Tasigna:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to nilotinib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If you think you may be allergic, ask your doctor for advice\u00a0<strong>before taking Tasigna<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Tasigna:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you previously had cardiovascular problems such as heart attack, angina, problems with the blood supply to your brain (\u00a0stroke\u00a0) or problems with the blood supply to your legs (claudication), or if you have risk factors for cardiovascular disease such as high\u00a0blood pressure\u00a0(\u00a0hypertension\u00a0),\u00a0diabetes\u00a0or problems with the level of fats in your blood (dyslipidemia).<\/li><li>if you have a\u00a0disturbance in heart function, such as an abnormal electrical signal, so-called &#8220;extended\u00a0QT\u00a0interval&#8221;.<\/li><li>if you\u00a0are being treated with medicines\u00a0that lower your blood cholesterol levels (statins) or affect the heartbeat (medicines against rhythm disorders) or the liver (see under \u201c\u00a0Other medicines and Tasigna\u00a0\u201d).<\/li><li>if you have a\u00a0potassium\u00a0or magnesium deficiency.<\/li><li>if you have any disorder of liver function or pancreas.<\/li><li>if you have symptoms such as easy bruising, feeling tired or short of breath, or have experienced recurrent\u00a0infections.<\/li><li>if you have undergone a surgical procedure in which the entire stomach has been removed (total gastrectomy).<\/li><li>if you have ever had or may now have a\u00a0hepatitis\u00a0B\u00a0infection.\u00a0The reason for this is that Tasigna can cause your\u00a0hepatitis\u00a0B to become active again, which in some cases can be fatal.\u00a0Patients will be closely monitored by their doctor for signs of this\u00a0infection\u00a0before starting treatment.<\/li><\/ul>\n\n\n\n<p>If any of these apply to you or your child, talk to a doctor.<\/p>\n\n\n\n<p>During treatment with Tasigna<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you faint (lose consciousness) or have an irregular heartbeat while taking this medicine,\u00a0<strong>talk to your doctor immediately<\/strong>\u00a0as this could be a sign of a serious heart condition.\u00a0Prolongation of the\u00a0QT interval\u00a0et or an irregular heart rhythm can lead to sudden death.\u00a0Sudden death has been uncommonly reported in patients taking Tasigna.<\/li><li>if you experience sudden palpitations, severe muscle weakness or paralysis, convulsions, or sudden changes in your thoughts or level of alertness,\u00a0talk to your doctor immediately\u00a0as these may be signs of a rapid breakdown of cancer cells called tumor lysis syndrome.\u00a0Rare cases of tumor lysis syndrome have been reported in patients treated with Tasigna.<\/li><li>if you experience chest pain or discomfort, numbness or weakness, problems walking or speaking, pain, discoloration, or coldness in an arm or leg,\u00a0talk to your doctor immediately\u00a0as this may be a sign of an effect on the heart and\u00a0blood vessels.\u00a0Serious effects on the heart and blood\u00a0vessels, including problems with blood flow to the bones (\u00a0peripheral\u00a0arterial\u00a0occlusive disease), ischemic heart disease, and problems with blood supply to the brain (ischemic\u00a0cerebrovascular\u00a0disease) have been reported in patients taking Tasigna.\u00a0Your doctor should assess the level of fats (\u00a0lipids\u00a0) and sugar in the blood before starting treatment with Tasigna and during treatment.- talk to your doctor if you get swollen feet or hands, general swelling, or rapid weight gain, as this may be a sign of severe\u00a0fluid retention.\u00a0Severe\u00a0fluid retention\u00a0has been uncommonly reported in patients treated with Tasigna.<\/li><\/ul>\n\n\n\n<p>If you are the parent of a child being treated with Tasigna, contact your doctor if any of the above applies to your child.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Tasigna is a treatment for children and adolescents with CML.&nbsp;There is no experience with the use of this medicine in children under 2 years of age.&nbsp;There is no experience with the use of Tasigna in newly diagnosed children under 10 years of age and limited experience in patients under 6 years of age who no longer benefit from previous treatment against CML.<\/p>\n\n\n\n<p>Some children and adolescents taking Tasigna may grow more slowly than normal.&nbsp;The doctor will regularly check the growth.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tasigna<\/h2>\n\n\n\n<p>Tasigna can affect or be affected by certain other medicines.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This applies in particular to the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>antiarrhythmic drugs \u2013 used to treat irregular heartbeats<\/li><li>chloroquine, halofantrine, clarithromycin,\u00a0haloperidol,\u00a0methadone, and moxifloxacin \u2013 drugs that may have an unwanted effect on the heart&#8217;s electrical activity<\/li><li>ketoconazole, itraconazole, voriconazole, clarithromycin, telithromycin\u00a0\u2013 used to treat\u00a0infection<\/li><li>ritonavir &#8211; medicine from the &#8216;protease inhibitor&#8217; class, used to treat\u00a0HIV<\/li><li>carbamazepine, phenobarbital,\u00a0phenytoin\u00a0\u2013 used to treat\u00a0epilepsy<\/li><li>rifampicin \u2013 used to treat\u00a0tuberculosis<\/li><li>St. John&#8217;s wort\u00a0\u2013 a natural remedy used to treat mild depression and mild anxiety (also known as\u00a0Hypericum perforatum)<\/li><li>midazolam \u2013 used to relieve anxiety before surgery<\/li><li>alfentanil and\u00a0fentanyl\u00a0&#8211; used to treat pain and as a sedative before or during\u00a0surgery\u00a0or medical procedures;<\/li><li>cyclosporine, sirolimus, and tacrolimus &#8211; medicines that inhibit the body&#8217;s ability to &#8216;self-defense&#8217; and fight\u00a0infection\u00a0and are commonly used to prevent rejection of transplanted organs such as the liver, heart, and kidneys;<\/li><li>dihydroergotamine and\u00a0ergotamine\u00a0\u2013 used to treat dementia;<\/li><li>lovastatin,\u00a0simvastatin\u00a0&#8211; used to treat high levels of blood fats;<\/li><li>warfarin\u00a0\u2013 is used to treat disorders of the blood&#8217;s ability to clot (e.g. blood clots or\u00a0thrombosis\u00a0)<\/li><li>astemizole, terfenadine, cisapride, pimozide,\u00a0quinidine\u00a0, bepridil or ergot alkaloids (\u00a0ergotamine\u00a0, dihydroergotamine)<\/li><\/ul>\n\n\n\n<p>These drugs should be avoided while being treated with Tasigna.&nbsp;If you are taking any of these medicines, your doctor may&nbsp;prescribe&nbsp;another alternative.<\/p>\n\n\n\n<p>If you are taking a statin (a type of medicine that lowers blood cholesterol levels), talk to your doctor or pharmacist.&nbsp;If Tasigna is used together with certain statins, it may increase the risk of statin-related muscle problems which, in rare cases, can lead to severe muscle breakdown (&nbsp;rhabdomyolysis&nbsp;) and lead to kidney damage.<\/p>\n\n\n\n<p>In addition, before taking Tasigna tell your doctor or pharmacist if you are using antacids, which are heartburn medicines.&nbsp;These medications need to be taken separately from Tasigna:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>H2 blockers, reduce the production of acid in the stomach.\u00a0H2 blockers should be taken about 10 hours before and about 2 hours after you take Tasigna;<\/li><li>antacids such as those containing aluminum hydroxide,\u00a0magnesium\u00a0hydroxide, and simethicone, which neutralize high acid levels in the stomach.\u00a0These antacids should be taken about 2 hours before or about 2 hours after you take Tasigna.<\/li><\/ul>\n\n\n\n<p><strong>If you are already taking Tasigna<\/strong>, and you have now been prescribed a new medicine that you did not take before during the Tasigna treatment, you must tell the doctor about it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tasigna with food and drink<\/h2>\n\n\n\n<p><strong>Do not take Tasigna with a meal.&nbsp;<\/strong>Food can increase the&nbsp;absorption&nbsp;of Tasigna and thereby increase the amount of Tasigna in the blood, possibly so much that it can be harmful.<\/p>\n\n\n\n<p>Do not drink grapefruit juice or eat grapefruit.&nbsp;This can increase the amount of Tasigna in the blood, possibly so much that it can be harmful.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tasigna is not recommended during pregnancy<\/strong>, unless necessary.\u00a0If you are pregnant or think you may be, discuss with your doctor whether you can take this medicine during your pregnancy.<\/li><li>Women of childbearing potential\u00a0are advised to use highly effective contraception during treatment and up to two weeks after treatment.<\/li><li>Breastfeeding is not recommended\u00a0during treatment with Tasigna and for two weeks after the last\u00a0dose.\u00a0If you are breastfeeding, talk to your doctor.<\/li><\/ul>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>If you experience\u00a0side effects\u00a0(such as dizziness or blurred vision) after taking this medicine, which may affect your ability to drive or use tools or machines safely, you should refrain from these activities until the effects have worn off.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tasigna contains lactose<\/h2>\n\n\n\n<p>This medicine contains&nbsp;lactose&nbsp;(also known as milk sugar).&nbsp;If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tasigna<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much Tasigna should you take?<\/strong><\/p>\n\n\n\n<p>Use for adults<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Patients newly diagnosed with CML:<\/strong>\u00a0The recommended\u00a0dose\u00a0is 600 mg per day.\u00a0This\u00a0dose\u00a0is achieved by taking two hard capsules of 150 mg twice daily. <strong>Patients who no longer benefit from previous treatment against CML:<\/strong>\u00a0The recommended\u00a0dose\u00a0is 800 mg per day.\u00a0This\u00a0dose\u00a0is achieved by taking two hard capsules of 200 mg twice daily.<\/li><\/ul>\n\n\n\n<p>Use for children and adolescents<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The dose&nbsp;given to your child depends on your child&#8217;s body weight and height.&nbsp;The doctor will calculate the correct&nbsp;dose&nbsp;and tell you which and how many capsules of Tasigna to give your child.&nbsp;The total daily&nbsp;dose&nbsp;you give to your child must not exceed 800 mg.<\/li><\/ul>\n\n\n\n<p>Your doctor may&nbsp;prescribe&nbsp;a lower&nbsp;dose&nbsp;depending on the effect you get from the treatment.<\/p>\n\n\n\n<p><strong>Elderly people (65 years or older)<\/strong><\/p>\n\n\n\n<p>The same&nbsp;dose&nbsp;of Tasigna can be given to the elderly, 65 years of age or older, as to other adults.<\/p>\n\n\n\n<p><strong>When should Tasigna be taken?<\/strong><\/p>\n\n\n\n<p>Take the hard capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>twice daily (about every 12 hours)<\/li><li>at least 2 hours after a meal of any kind<\/li><li>then wait 1 hour before eating again<\/li><\/ul>\n\n\n\n<p>If you have any questions about when to take this medicine, talk to your doctor or pharmacist.&nbsp;Take Tasigna at the same time each day, so it&#8217;s easier to remember to take the hard capsules.<\/p>\n\n\n\n<p><strong>How to take Tasigna<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the hard capsules whole with a glass of water.<\/li><li>Do not eat food in any form while taking the hard capsules.<\/li><li>Do not open the hard capsules unless you can swallow them.&nbsp;In this case, you can mix the contents of each hard capsule with&nbsp;<strong>1<\/strong>&nbsp;teaspoon of mashed apple and take it immediately.&nbsp;Do not take more than 1 teaspoon of pureed apple for each hard capsule and do not mix with anything other than pureed apple.<\/li><\/ul>\n\n\n\n<p><strong>How long should Tasigna be taken?<\/strong><\/p>\n\n\n\n<p>Continue taking Tasigna every day for as long as your doctor tells you.&nbsp;This is a long-term treatment.&nbsp;The doctor will check you regularly, to see that the treatment is having the desired effect.<\/p>\n\n\n\n<p>Your doctor may consider stopping your treatment with Tasigna based on specific criteria.<\/p>\n\n\n\n<p>If you have any questions about how long to take Tasigna, talk to your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tasigna<\/h2>\n\n\n\n<p>If you have taken more Tasigna than you should, or if someone else has accidentally taken your hard capsules, contact your doctor or hospital immediately for advice.&nbsp;Show them the package with the hard capsules and this leaflet.&nbsp;Medical treatment may be necessary.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tasigna<\/h2>\n\n\n\n<p>If you miss a\u00a0dose, take the next\u00a0dose\u00a0as planned.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten hard capsule.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Tasigna<\/h2>\n\n\n\n<p>Do not stop taking this medicine unless your doctor tells you to.&nbsp;Stopping Tasigna without your doctor&#8217;s recommendation can lead to a worsening of your disease, which can have life-threatening consequences.&nbsp;Discuss with your doctor, nurse, and\/or pharmacist if you are considering stopping Tasigna.<\/p>\n\n\n\n<p><strong>If your doctor recommends that you stop taking Tasigna<\/strong><\/p>\n\n\n\n<p>Your doctor will evaluate your treatment regularly with a specific diagnostic test and decide whether you should continue taking this medicine.\u00a0If you are told to stop taking Tasigna, your doctor will continue to closely monitor your CML before, during, and after you stop treatment.\u00a0Your doctor may tell you to resume treatment with Tasigna if your condition indicates this is necessary.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Most\u00a0side effects\u00a0are mild to moderate and generally disappear after a few days to weeks.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs of musculoskeletal pain: pain in joints and muscles<\/li><li>signs of heart failure: chest pain or discomfort, high or low\u00a0blood pressure, irregular heartbeat (fast or slow), palpitations (feeling of fast heartbeats), fainting, blue discoloration of lips, tongue, or skin<\/li><li>signs of blocked artery: pain, discomfort, weakness, or cramps in the leg muscles that may be due to reduced blood flow, sores on the legs or arms that heal slowly or not at all, and noticeable changes in skin color (blueness or paleness) or body temperature (feeling cold) in the affected leg, arm, toes or fingers<\/li><li>signs of an underactive thyroid: weight gain, fatigue, hair loss, muscle weakness, feeling cold<\/li><li>signs of overactive thyroid: palpitations, protruding eyes, weight loss, swelling in the front of the neck<\/li><li>signs of kidney or urinary tract dysfunction: thirst, dry skin, irritability, dark urine, decreased urine output, difficulty and pain when urinating, strong urge to urinate, blood in the urine, abnormal urine color<\/li><li>signs of high blood sugar: severe thirst, large urine output, increased appetite with weight loss, fatigue<\/li><li>signs of vertigo: dizziness or spinning sensation<\/li><li>signs of pancreatitis: severe pain in the upper (middle or left) part of the abdomen<\/li><li>signs of skin disease: painful red bumps, pain in the skin,\u00a0redness, scaling, or blisters<\/li><li>signs of fluid retention: rapid weight gain, swelling of the hands, ankles, feet, or face<\/li><li>signs of migraine: severe headache, often accompanied by nausea, vomiting, and sensitivity to light<\/li><li>signs of blood disease: fever, easy bruising or bleeding of unknown cause, severe or frequent\u00a0infections, weakness of the unknown cause<\/li><li>signs of a blood clot in a vein: swelling and pain in any part of the body<\/li><li>signs of a nervous system disorder: weakness or paralysis of the arms, legs, or face, difficulty speaking, severe headache, seeing, feeling, or hearing things that are not there, vision changes, loss of consciousness, confusion, disorientation, tremors, tingling sensations, pain or numbness in fingers and toes.<\/li><li>signs of lung function disorder: difficulty breathing or painful breathing, cough, wheezing with or without fever, swelling of the feet or legs<\/li><li>signs of gastrointestinal disease: abdominal pain, nausea, vomiting blood, black or bloody stools, constipation, heartburn, gastric acid reflux, swollen abdomen<\/li><li>signs of liver dysfunction: yellow skin and eyes, nausea, loss of appetite, dark-colored urine<\/li><li>signs of liver infection: recurrent (reactivation)\u00a0hepatitis\u00a0B\u00a0infection<\/li><li>signs of eye disease: visual disturbances including blurred vision, double vision, visual phenomena with flashes of light, reduced\u00a0visual acuity\u00a0or loss of vision, blood in the eye, increased sensitivity to light in the eyes, eye pain, red eyes,\u00a0itching\u00a0or irritation, dry eyes, swelling or\u00a0itching\u00a0of the eyelids<\/li><li>signs of imbalance in electrolyte levels: nausea, shortness of breath, irregular heartbeat, cloudy urine, fatigue, and\/or joint pain associated with abnormal blood levels (eg high levels of\u00a0potassium,\u00a0uric acid,\u00a0and phosphorus, and low levels of\u00a0calcium\u00a0)<\/li><\/ul>\n\n\n\n<p>Contact a doctor immediately if you notice any of the&nbsp;side effects&nbsp;above<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><li>headache<\/li><li>lack of energy<\/li><li>muscle pain<\/li><li>itching, rash<\/li><li>nausea<\/li><li>constipation<\/li><li>vomiting<\/li><li>hair loss<\/li><li>pain in the\u00a0extremities\u00a0(arms and legs), bone pain, and back pain at the end of treatment with Tasigna<\/li><li>slow growth in children and adolescents<\/li><li>upper respiratory tract infection including sore throat and runny or stuffy nose, sneezing<\/li><li>low levels of\u00a0blood cells\u00a0(\u00a0red blood cells,\u00a0platelets\u00a0) or\u00a0hemoglobin<\/li><li>high levels of\u00a0lipase\u00a0in the blood (pancreatic dysfunction)<\/li><li>high levels of\u00a0bilirubin\u00a0in the blood (liver function)<\/li><li>high levels of alanine aminotransferase (liver enzyme)<\/li><\/ul>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pneumonia<\/li><li>abdominal pain, upset stomach after you eat, gas, swollen or bloated abdomen<\/li><li>bone pain, muscle twitching<\/li><li>pain (including neck pain)<\/li><li>dry skin,\u00a0acne, reduced skin sensitivity<\/li><li>weight loss or weight gain<\/li><li>insomnia, depression, anxiety<\/li><li>night sweats, profuse sweating<\/li><li>general malaise<\/li><li>nosebleed<\/li><li>signs of gout: painful and swollen joints<\/li><li>inability to get or keep\u00a0an erection<\/li><li>flu-like symptoms<\/li><li>sore throat<\/li><li>bronchial catarrh<\/li><li>ear pain sounds in the ears (eg ringing, humming) that have no external source (also called\u00a0tinnitus\u00a0)<\/li><li>hemorrhoids<\/li><li>heavy periods<\/li><li>itching\u00a0in the hair follicles<\/li><li>oral\u00a0or\u00a0vaginal yeast\u00a0infection<\/li><li>signs of conjunctivitis: watery eyes with\u00a0itching, redness, and swelling<\/li><li>eye irritation, red eyes<\/li><li>signs of hypertension: high\u00a0blood pressure, headache, dizziness<\/li><li>redness<\/li><li>signs of\u00a0peripheral\u00a0arterial\u00a0occlusive disease: pain, discomfort, weakness, or cramps in the leg muscles that may be due to reduced blood flow, sores on the legs or arms that heal slowly or not at all, and noticeable changes in skin color (blueness or paleness) or body temperature (feeling cold) in the legs or arms (possible signs of a blocked\u00a0artery\u00a0in the affected leg, arm, toes or fingers)<\/li><li>shortness of breath (also called dyspnoea)<\/li><li>mouth ulcers with\u00a0inflammation\u00a0of the gums (also called\u00a0stomatitis\u00a0)<\/li><li>high levels of amylase in the blood (pancreatic function)<\/li><li>high levels of\u00a0creatinine\u00a0in the blood (kidney function)<\/li><li>high levels of alkaline phosphatase or creatinine phosphokinase<\/li><li>high levels of\u00a0aspartate aminotransferase\u00a0(liver enzyme)<\/li><li>high levels of gamma-glutamyl transferase (liver enzyme)<\/li><li>signs of\u00a0leukopenia\u00a0or neutropenia: low levels of\u00a0white blood cells<\/li><li>increased number of\u00a0platelets\u00a0or\u00a0white blood cells<\/li><li>low levels of\u00a0magnesium,\u00a0potassium,\u00a0sodium,\u00a0calcium,\u00a0or phosphorus in the blood<\/li><li>increased levels of\u00a0potassium,\u00a0calcium,\u00a0or phosphorus in the blood<\/li><li>high levels of fats in the blood (including\u00a0cholesterol\u00a0)<\/li><li>high levels of\u00a0uric acid\u00a0in the blood<\/li><\/ul>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are less common<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergy\u00a0(hypersensitivity to Tasigna)<\/li><li>dry mouth<\/li><li>chest pain<\/li><li>pain or discomfort in the side of the body<\/li><li>increased appetite<\/li><li>breast augmentation in men<\/li><li>infection\u00a0with herpes virus<\/li><li>muscle and joint stiffness, swollen joints<\/li><li>the sensation of body temperature changes (including hot sensation, cold sensation)<\/li><li>altered sense of taste<\/li><li>need to urinate frequently<\/li><li>signs of\u00a0inflammation\u00a0of the stomach lining: abdominal pain, nausea, vomiting, diarrhea, swollen stomach<\/li><li>memory loss<\/li><li>skin cyst, thinning or thickening of the skin, thickening of the outermost layer of the skin, skin discoloration<\/li><li>signs of psoriasis: thickened patches of red\/silvery skin<\/li><li>increased sensitivity to light in the skin<\/li><li>hearing difficulties<\/li><li>inflammation\u00a0of the joints<\/li><li>urinary incontinence<\/li><li>inflammation\u00a0of the intestine (also called enterocolitis)<\/li><li>anal abscess<\/li><li>swollen nipples<\/li><li>symptoms of restless legs (an irresistible need to move a body part, usually the leg, accompanied by an uncomfortable feeling)<\/li><li>signs of blood poisoning: fever, chest pain, elevated\/increased\u00a0heart rate, labored breathing or rapid breathing<\/li><li>skin infection (bruising under the skin)<\/li><li>skin wart<\/li><li>increase in specific types of\u00a0white blood cells\u00a0(called\u00a0eosinophils\u00a0)<\/li><li>signs of lymphopenia: low levels of\u00a0white blood cells<\/li><li>high levels of parathyroid hormone in the blood (a\u00a0hormone\u00a0that regulates\u00a0calcium\u00a0and phosphorus levels)<\/li><li>high levels of\u00a0lactate dehydrogenase\u00a0(an\u00a0enzyme\u00a0)<\/li><li>signs of low blood sugar: nausea, sweating, weakness, dizziness, tremors, headache<\/li><li>dehydration<\/li><li>abnormal fat content in the blood<\/li><li>involuntary shaking (also called\u00a0tremor\u00a0)<\/li><li>concentration difficulties<\/li><li>discomfort and abnormal sensation to touch (also called dysaesthesia)<\/li><li>fatigue (also called fatigue)<\/li><li>numbness or tingling sensation in fingers and toes (also called\u00a0peripheral\u00a0neuropathy\u00a0)<\/li><li>paralysis of a muscle in the face<\/li><li>red spot in the white of the eye caused by burst blood vessels (also called conjunctival hemorrhage)<\/li><li>blood in the eyes (ocular hemorrhage)<\/li><li>eye irritation<\/li><li>signs of heart attack (also called\u00a0myocardial infarction\u00a0): sudden and pressing chest pain, fatigue, irregular heartbeat<\/li><li>signs of heart murmur: tiredness, chest discomfort, unsteadiness, chest pain, palpitations<\/li><li>fungal infection of the feet<\/li><li>signs of heart failure: shortness of breath, difficulty breathing when lying down, swollen feet or legs<\/li><li>pain behind the sternum (also called pericarditis)<\/li><li>signs of hypertensive crisis: severe headache, dizziness, nausea<\/li><li>painful and weak legs when walking (also called\u00a0intermittent claudication\u00a0)<\/li><li>signs of narrowing of the\u00a0arteries\u00a0in the extremities: possible high\u00a0blood pressure, painful cramps in one or both hips, thighs, or calf muscles after certain activities such as walking or climbing stairs, numbness or weakness in the legs<\/li><li>bruises (without injury)<\/li><li>fatty deposits in the arteries\u00a0that\u00a0can cause blockage (also called\u00a0arteriosclerosis\u00a0)<\/li><li>signs of low\u00a0blood pressure\u00a0(also called\u00a0hypotension\u00a0), unsteadiness, dizziness, or fainting<\/li><li>signs of pulmonary edema: shortness of breath<\/li><li>signs of pleural effusion: accumulation of fluid between the layers of\u00a0tissue\u00a0surrounding the lungs and chest cavity (which if severe can reduce the heart&#8217;s ability to pump blood), chest pain, coughing, hiccups, rapid breathing<\/li><li>signs of interstitial lung disease: cough, difficulty breathing, painful breathing<\/li><li>signs of pleural pain: chest pain<\/li><li>signs of pleurisy: cough painful breathing<\/li><li>huskiness<\/li><li>signs of\u00a0pulmonary\u00a0hypertension: high\u00a0blood pressure\u00a0in the pulmonary arteries<\/li><li>wheezing<\/li><li>sensitivity in the teeth<\/li><li>signs of inflammation: (also called\u00a0gingivitis\u00a0): bleeding gums, sore or swollen gums<\/li><li>high levels of\u00a0urea\u00a0in the blood (kidney function)<\/li><li>change in blood proteins (low levels of\u00a0globulins\u00a0or presence of paraprotein)<\/li><li>high levels of unconjugated\u00a0bilirubin\u00a0in the blood<\/li><li>high levels of troponins in the blood<\/li><\/ul>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are rare (may affect up to 1 in 1,000 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>redness\u00a0and\/or swelling, possible peeling of the palms of the hands and soles of the feet (also called hand-foot syndrome)<\/li><li>warts in the mouth<\/li><li>the feeling of hardness or stiffness in the breasts<\/li><li>inflammation\u00a0of the thyroid gland (also called\u00a0thyroiditis\u00a0)<\/li><li>affect mood or low mood<\/li><li>signs of secondary hyperparathyroidism: bone and joint pain, heavy urination, abdominal pain, weakness, fatigue<\/li><li>signs of narrowing of the\u00a0arteries\u00a0in the brain: partial or complete loss of vision in both eyes, double vision,\u00a0vertigo\u00a0(spinning sensation), numbness or tingling, loss of coordination, dizziness or confusion<\/li><li>swelling of the brain (possibly headache and\/or change in mental status<\/li><li>signs of inflammation of the optic nerve: blurred vision, vision loss<\/li><li>signs of\u00a0heart failure\u00a0(decreased\u00a0ejection fraction\u00a0): fatigue, chest discomfort, unsteadiness, pain, palpitations<\/li><li>low or high levels of\u00a0insulin\u00a0(a\u00a0hormone\u00a0that regulates blood sugar levels)<\/li><li>low levels of\u00a0insulin\u00a0C-peptide\u00a0(a measure of pancreatic function)<\/li><li>sudden death<\/li><\/ul>\n\n\n\n<p><strong>The following other&nbsp;side effects&nbsp;have been reported (occurring in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs of\u00a0heart failure\u00a0(ventricular dysfunction): shortness of breath, feeling of exertion at rest, irregular heartbeat, chest discomfort, unsteadiness, pain, palpitations, heavy urination, swollen feet, ankles, and swollen abdomen.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tasigna<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Use before the expiry date which is stated on the carton and blister after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store at a maximum of 30\u00b0C.<\/li><li>Store in the original packaging.\u00a0Moisture sensitive.<\/li><li>Do not use this medicine if you see that the packaging is damaged or shows signs of tampering.<\/li><li>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is nilotinib.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Each 50 mg hard capsule contains 50 mg nilotinib (as hydrochloride monohydrate).<br>Other ingredients are:<br>Capsule content:\u00a0lactose monohydrate, crospovidone type A, poloxamer 188, colloidal anhydrous silica, magnesium stearate.<br>Capsule shell: gelatin, titanium dioxide (E171), red iron oxide (E172), yellow iron oxide (E172)<br>Printing ink: shellac (E904), black iron oxide (E172), propylene glycol, ammonium hydroxide<br><\/li><li>Each 150 mg hard capsule contains 150 mg nilotinib (as hydrochloride monohydrate).<br>Other ingredients are:<br>Capsule content:\u00a0lactose monohydrate, crospovidone type A, poloxamer 188, colloidal anhydrous silica, magnesium stearate.<br>Capsule shell: gelatin, titanium dioxide (E171), red iron oxide (E172), yellow iron oxide (E172)<br>Printing ink: shellac (E904), black iron oxide (E172), n-butyl alcohol, propylene glycol, anhydrous\u00a0ethanol, isopropyl alcohol, ammonium hydroxide<br><\/li><li>Each 200 mg hard capsule contains 200 mg nilotinib (as hydrochloride monohydrate).<br>Other ingredients are:<br>Capsule content:\u00a0lactose monohydrate, crospovidone type A, poloxamer 188, colloidal anhydrous silica, magnesium stearate.<br>Capsule shell: gelatin, titanium dioxide (E171), yellow iron oxide (E172)<br>Printing ink: shellac (E904), anhydrous alcohol, isopropyl alcohol, butyl alcohol, propylene glycol, strong ammonia solution, potassium hydroxide, red iron oxide (E172)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tasigna 50 mg is supplied as hard capsules.&nbsp;The hard capsules are red\/light yellow.&nbsp;Each hard capsule is embossed in black (\u201cNVR\/ABL\u201d).<\/p>\n\n\n\n<p>Tasigna 150 mg is supplied as hard capsules.&nbsp;The hard capsules are red.&nbsp;Each hard capsule is embossed in black (\u201cNVR\/BCR\u201d).<\/p>\n\n\n\n<p>Tasigna 200 mg is supplied as hard capsules.&nbsp;The hard capsules are light yellow.&nbsp;Each hard capsule is imprinted in red (\u201cNVR\/TKI\u201d).<\/p>\n\n\n\n<p>Tasigna 50 mg is supplied in packs of 120 hard capsules (3 packs of 40 hard capsules).<\/p>\n\n\n\n<p>Tasigna 150 mg is supplied in packs containing 28 or 40 hard capsules and in multipacks containing 112 hard capsules (consisting of 4 cartons, each containing 28 hard capsules), 120 hard capsules (consisting of 3 cartons, each containing 40 hard capsules), or 392 hard capsules (consisting of 14 cartons, each containing 28 hard capsules).<\/p>\n\n\n\n<p>Tasigna 200 mg is supplied in wallet packs of 28 hard capsules and carton packs of 28 or 40 hard capsules.\u00a0Tasigna is also supplied in multipacks of 112 hard capsules (consisting of 4 wallet packs, each containing 28 hard capsules), 112 hard capsules (consisting of 4 cartons, each containing 28 capsules), 120 hard capsules (consisting of 3 cartons, each containing 40 hard capsules) or 392 hard capsules (consisting of 14 cartons, each containing 28 hard capsules).<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Europharm Limited<\/p>\n\n\n\n<p>Vista Building<\/p>\n\n\n\n<p>Elm Park, Merrion Road<\/p>\n\n\n\n<p>Dublin 4<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Novartis Farmac\u00e9utica SA<\/p>\n\n\n\n<p>Gran Via de Les Corts Catalanes, 764<\/p>\n\n\n\n<p>08013 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Novartis Pharma GmbH<\/p>\n\n\n\n<p>Roonstra\u00dfe 25<\/p>\n\n\n\n<p>D-90429 Nuremberg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Lek dd, PE PROIZVODNJA LENDAVA<\/p>\n\n\n\n<p>Trimline 2D<\/p>\n\n\n\n<p>Lendava, 9220<\/p>\n\n\n\n<p>Slovenia<\/p>\n\n\n\n<p>For further information about this medicine, contact the representative of the marketing authorization holder:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Novartis Pharma NVT\u00e9l\/Tel: +32 2 246 16 11<\/td><td><strong>Lithuania<\/strong>SIA Novartis Baltics Lietuvos filialasPhone: +370 5 269 16 50<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Novartis Bulgaria EOODTel.: +359 2 489 98 28<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Novartis Pharma NVT\u00e9l\/Tel: +32 2 246 16 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Novartis s.r.oPhone: +420 225 775 111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Novartis Hung\u00e1ria Kft.Tel.: +36 1 457 65 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Novartis Healthcare A\/SPhone: +45 39 16 84 00<\/td><td><strong>Malta<\/strong>Novartis Pharma Services Inc.Phone: +356 2122 2872<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Novartis Pharma GmbHPhone: +49 911 273 0<\/td><td><strong>The Netherlands<\/strong>Novartis Pharma BVPhone: +31 88 04 52 555<\/td><\/tr><tr><td><strong>Estonia<\/strong>SIA Novartis Baltics Eesti branchPhone: +372 66 30 810<\/td><td><strong>Norway<\/strong>Novartis Norway iPhone: +47 23 05 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Novartis (Greece) AEBEPhone: +30 210 281 17 12<\/td><td><strong>Austria<\/strong>Novartis Pharma GmbHPhone: +43 1 86 6570<\/td><\/tr><tr><td><strong>Spain<\/strong>Novartis Farmac\u00e9utica, SAPhone: +34 93 306 42 00<\/td><td><strong>Polish<\/strong>Novartis Poland Sp.\u00a0z o. iPhone: +48 22 375 4888<\/td><\/tr><tr><td><strong>France<\/strong>Novartis Pharma SASTel: +33 1 55 47 66 00<\/td><td><strong>Portugal<\/strong>Novartis Farma &#8211; Produtos Farmac\u00eauticos, SAPhone: +351 21 000 8600<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Novartis Hrvatska dooTel.&nbsp;+385 1 6274 220<\/td><td><strong>Romania<\/strong>Novartis Pharma Services Romania SRLPhone: +40 21 31299 01<\/td><\/tr><tr><td><strong>Ireland<\/strong>Novartis Ireland LimitedPhone: +353 1 260 12 55<\/td><td><b>Slovenija Novartis<\/b> Pharma Services Inc.Phone: +386 1 300 75 50<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>Novartis Slovakia s.r.oPhone: +421 2 5542 5439<\/td><\/tr><tr><td><strong>Italy<\/strong>Novartis Pharma SpAPhone: +39 02 96 54 1<\/td><td><strong>Finland\/Finland<\/strong>Novartis Finland OyTel: +358 (0)10 6133 200<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Novartis Pharma Services Inc.Phone: +357 22 690 690<\/td><td><strong>Sweden<\/strong>Novartis Sweden ABPhone: +46 8 732 32 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Novartis BalticsPhone: +371 67 887 070<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Tasigna is a medicine that contains the active substance nilotinib.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25373,25378,25369,25372,25370,25377,25374,25375,25371,25376],"class_list":["post-24432","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-nilotinib","tag-benefits-of-tasigna","tag-nilotinib","tag-nilotinib-side-effects","tag-tasigna","tag-tasigna-side-effects","tag-what-is-nilotinib","tag-what-is-tasigna","tag-what-nilotinib-is-used-for","tag-what-tasigna-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24432"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24432\/revisions"}],"predecessor-version":[{"id":24485,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24432\/revisions\/24485"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}