{"id":24426,"date":"2022-08-23T12:58:21","date_gmt":"2022-08-23T12:58:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24426"},"modified":"2022-08-24T10:53:08","modified_gmt":"2022-08-24T10:53:08","slug":"targiniq","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/targiniq\/","title":{"rendered":"Targiniq – Oxycodone hydrochloride\/Naloxone hydrochloride uses, dose and side effects"},"content":{"rendered":"\n

Targiniq 5 mg\/2.5 mg, 10 mg\/5 mg, 20 mg\/10 mg, 40 mg\/20 mg prolonged-release tablet er
oxycodone hydrochloride\/naloxone hydrochloride<\/a><\/p>\n\n\n\n

What Targiniq is and what it is used for<\/h2>\n\n\n\n

Targiniq is a\u00a0prolonged-release tablet, which means that its active substances are released over a longer period.\u00a0Its effect lasts for 12 hours.<\/p>\n\n\n\n

These tablets are intended for adults only.<\/p>\n\n\n\n

Pain relief:<\/p>\n\n\n\n

You have been prescribed Targiniq for the treatment of severe pain that can only be relieved by strong painkillers ( opioids ). Naloxone hydrochloride is added to prevent constipation.<\/p>\n\n\n\n

How these tablets work for pain relief:<\/p>\n\n\n\n

These tablets contain oxycodone hydrochloride and naloxone hydrochloride as active substances. Oxycodone hydrochloride is responsible for the analgesic effect of Targiniq and is a potent analgesic (“pain reliever”) in the opioid group. The other active ingredient in Targiniq, naloxone hydrochloride, is intended to provide relief from and prevent constipation. Bowel disturbances (eg, constipation) are a typical side effect of treatment with opioid analgesics.<\/p>\n\n\n\n

Restless legs syndrome:<\/p>\n\n\n\n

You have been prescribed Targiniq as a second-line treatment for symptoms of severe to very severe restless legs syndrome in people who cannot be treated with dopamine medication. People with restless legs syndrome have an unpleasant feeling in their legs. This can occur as soon as they sit or lie down and can only be relieved by moving the legs, but sometimes also the arms and other parts of the body. It makes it very difficult to sit still and sleep. Naloxone hydrochloride is added to prevent constipation.<\/p>\n\n\n\n

How these tablets work for restless legs syndrome:<\/p>\n\n\n\n

These tablets help relieve unpleasant feelings and reduce the urge to move arms and legs.<\/p>\n\n\n\n

The other active ingredient in Targiniq, naloxone hydrochloride, is intended to provide relief from and prevent constipation. Intestinal disturbances (e.g. constipation) are a typical side effect of treatment with strong painkillers ( opioids ).<\/p>\n\n\n\n

The oxycodone hydrochloride\/naloxone hydrochloride contained in Targiniq may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.
<\/p>\n\n\n\n

What you need to know before you take Targiniq<\/h2>\n\n\n\n

Do not take Targiniq:<\/h2>\n\n\n\n

\u2022 if you are allergic to oxycodone hydrochloride, naloxone hydrochloride, or any of the other ingredients of this medicine (listed in section 6)<\/p>\n\n\n\n

\u2022 if your breathing cannot supply enough oxygen to the blood and remove the carbon dioxide produced in the body ( respiratory depression )<\/p>\n\n\n\n

\u2022 if you suffer from severe lung disease associated with narrowing of the airways ( chronic obstructive pulmonary disease or COPD)<\/p>\n\n\n\n

\u2022 if you suffer from a disease known as cor pulmonale;\u00a0in this disease, the right side of the heart becomes enlarged due to increased pressure inside the blood vessels in the lungs, etc. (eg as a result of COPD – see above)<\/p>\n\n\n\n

\u2022 if you suffer from severe bronchial asthma<\/p>\n\n\n\n

\u2022 if you have paralytic ileus (a type of bowel obstruction) that has not been caused by opioids<\/p>\n\n\n\n

\u2022 if you have moderately to severely impaired liver function.<\/p>\n\n\n\n

Also for restless legs syndrome:<\/p>\n\n\n\n

\u2022 if you have previously abused opioids<\/a><\/p>\n\n\n\n

Warnings and precautions<\/h2>\n\n\n\n

Talk to your doctor or pharmacist before taking Targiniq:<\/p>\n\n\n\n

\u2022 when treating elderly patients or weakened (powerless) patients<\/p>\n\n\n\n

\u2022 if you have paralytic ileus (a type of bowel obstruction) that has been caused by opioids<\/p>\n\n\n\n

\u2022 if you have reduced kidney function<\/p>\n\n\n\n

\u2022 if you have mildly impaired liver function<\/p>\n\n\n\n

\u2022 if you have severely reduced lung function (i.e. reduced ability to breathe)<\/p>\n\n\n\n

\u2022 if you suffer from a condition characterized by frequent pauses in breathing during the night which can make you feel very sleepy during the day ( sleep apnea )<\/p>\n\n\n\n

\u2022 if you have\u00a0myxedema\u00a0(a thyroid disorder with dry, cold, and swollen skin affecting the face and legs)<\/p>\n\n\n\n

\u2022 if your thyroid does not produce enough hormones (underactive thyroid or hypothyroidism )<\/p>\n\n\n\n

\u2022 if your adrenal glands do not produce enough hormones (adrenocortical insufficiency or Addison’s disease )<\/p>\n\n\n\n

\u2022 if you have a mental illness accompanied by a ( partial ) loss of perception of reality ( psychosis ), due to alcohol or intoxication with other substances (substance-induced psychosis )<\/p>\n\n\n\n

\u2022 if you suffer from gallstone problems<\/p>\n\n\n\n

\u2022 if your prostate gland is abnormally enlarged ( prostatic hypertrophy )<\/p>\n\n\n\n

\u2022 if you suffer from alcoholism or delirium tremens<\/p>\n\n\n\n

\u2022 if your pancreas is inflamed ( pancreatitis )<\/p>\n\n\n\n

\u2022 if you have low blood pressure ( hypotension )<\/p>\n\n\n\n

\u2022 if you have high blood pressure ( hypertension )<\/p>\n\n\n\n

\u2022 if you have a pre-existing cardiovascular disease ( cardiovascular disease)<\/p>\n\n\n\n

\u2022 if you have a head injury (due to the risk of increased pressure in the brain)<\/p>\n\n\n\n

\u2022 if you suffer from epilepsy or are prone to convulsions<\/p>\n\n\n\n

\u2022 if you also take\u00a0MAO inhibitors\u00a0(used to treat depression or\u00a0Parkinson’s disease\u00a0) or if you have taken this type of medicine in the last two weeks, e.g.\u00a0medicines containing tranylcypromine<\/a>, phenelzine, isocarboxazid, moclobemide, and linezolid.<\/p>\n\n\n\n

\u2022 if sleepiness or episodes of sudden falling asleep occur.<\/p>\n\n\n\n

This medicine may cause breathing problems when you sleep.\u00a0These problems may include breathing pauses during sleep, awakenings due to shortness of breath, difficulty maintaining sleep, or excessive daytime sleepiness.\u00a0If you or someone else observes these symptoms, see a doctor.\u00a0The doctor may lower the\u00a0dose.<\/p>\n\n\n\n

You should tell your doctor if you have previously suffered from any of the above.\u00a0Also, tell your doctor if any of the above diseases occur while you are taking these tablets.<\/p>\n\n\n\n

The most serious risk of opioid overdose is respiratory depression (slow and shallow breathing). This can also cause the oxygen levels in the blood to drop, which in turn can lead to fainting, etc.<\/p>\n\n\n\n

You must swallow the\u00a0prolonged-release tablets\u00a0whole in order not to affect the slow\u00a0release\u00a0of oxycodone hydrochloride from the\u00a0prolonged-release tablet.\u00a0You must not split, chew or crush the tablets.\u00a0If the tablets are split, chewed, or crushed, this can lead to the absorption of a potentially fatal\u00a0dose of\u00a0oxycodone hydrochloride (see section 3 \u201cIf you take too much Targiniq\u201d).<\/p>\n\n\n\n

If you suffer from severe diarrhea at the beginning of treatment, this may be due to the effect of naloxone hydrochloride.\u00a0It may be a sign that bowel function is returning to normal.\u00a0Such diarrhea may occur during the first 3\u20135 days of treatment.\u00a0Contact your doctor if diarrhea continues after 3-5 days, or is of concern.<\/p>\n\n\n\n

If you have been using another\u00a0opioid, withdrawal symptoms may appear at first when you switch to treatment with Targiniq, e.g.\u00a0restlessness, sweating, and muscle pain.\u00a0If you experience such symptoms, you may need special monitoring by your doctor.<\/p>\n\n\n\n

With long-term use, you may develop a tolerance to these tablets. This means that you may need a higher dose to achieve the desired effect. Long-term use of these tablets can also lead to physical dependence. Withdrawal symptoms may occur if treatment is stopped too quickly (restlessness, sweating, muscle pain). If you no longer need treatment, reduce the daily dose gradually, in consultation with your doctor.<\/p>\n\n\n\n

The active substance oxycodone hydrochloride has the same abuse profile as other strong\u00a0opioids\u00a0(strong painkillers).\u00a0There is a risk of developing psychological dependence.\u00a0Medicines containing oxycodone hydrochloride should be avoided in patients who have previously abused alcohol, drugs, or medicines.<\/p>\n\n\n\n

Tell your doctor if you have cancer with peritoneal metastases or incipient colon cancer in advanced stages of cancer of the gastrointestinal tract or pelvis.<\/p>\n\n\n\n

If you have to have surgery, tell your doctors that you are taking Targiniq.<\/p>\n\n\n\n

Like other\u00a0opioids, oxycodone can affect the body’s normal production of\u00a0hormones, such as\u00a0cortisol\u00a0or sex hormones, especially if you have taken high\u00a0doses\u00a0for a long time.\u00a0If you experience persistent symptoms, such as being or feeling sick or sick (including vomiting), loss of appetite, fatigue, weakness, dizziness, changes in the menstrual cycle,\u00a0impotence,\u00a0infertility,\u00a0or decreased sex drive, talk to your doctor as he\/she may want to examine your hormone levels.<\/p>\n\n\n\n

This medicine may increase your pain sensitivity, especially at high\u00a0doses.\u00a0Tell your doctor if this happens.\u00a0It may be necessary to lower your\u00a0dose\u00a0or switch to another medicine.<\/p>\n\n\n\n

You may detect residues of\u00a0prolonged-release tablets\u00a0in your stool.\u00a0Don’t worry about this.\u00a0The active substances (oxycodone hydrochloride and naloxone hydrochloride) have already been released into the stomach and intestines and absorbed into the body.<\/p>\n\n\n\n

Improper use of Targiniq<\/em><\/p>\n\n\n\n

These tablets are not suitable for the treatment of\u00a0withdrawal.<\/p>\n\n\n\n

Targiniq should never be abused.\u00a0This is especially true if you are addicted to drugs.\u00a0If you are addicted to substances such as heroin, morphine, or\u00a0methadone, you will likely suffer severe withdrawal symptoms if you abuse these tablets because they contain the ingredient naloxone hydrochloride.\u00a0Pre-existing withdrawal symptoms may worsen.<\/p>\n\n\n\n

You must never abuse these tablets by dissolving them and injecting them (eg into a blood vessel). The tablets contain talc which can lead to local tissue destruction ( necrosis ) and changes to the lung tissue (pulmonary granuloma). Such abuse can also have other serious consequences and can even be fatal.<\/a><\/p>\n\n\n\n

Other medicines and Targiniq<\/h2>\n\n\n\n

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n

The risk of\u00a0side effects\u00a0increases if you take antidepressants (for example\u00a0citalopram, duloxetine, escitalopram,\u00a0fluoxetine, fluvoxamine,\u00a0paroxetine,\u00a0sertraline,\u00a0venlafaxine\u00a0).\u00a0These medicines can affect or be affected by oxycodone, and you may have symptoms such as involuntary, rhythmic muscle contractions, including in the muscles that control eye movements, sudden movements, profuse sweating, tremors, and exaggerated reflexes movements, increased muscle tension, body temperature above 38\u00b0C.\u00a0Contact your doctor if you experience these symptoms.<\/p>\n\n\n\n

The simultaneous use of\u00a0opioids, including oxycodone hydrochloride, and sedative drugs for sleep disorders, such as\u00a0benzodiazepines\u00a0or similar drugs, increases the risk of drowsiness, breathing difficulties (\u00a0respiratory depression\u00a0),\u00a0coma,\u00a0and can be life-threatening.\u00a0Because of this, concomitant use should only be considered when other treatment options are not possible.<\/p>\n\n\n\n

If the doctor prescribes Targiniq together with sedative drugs, the dose and duration of treatment should be limited by the doctor.<\/p>\n\n\n\n

Tell your doctor if you are taking any sedative medication and follow your doctor’s dosage recommendation carefully.\u00a0It may be helpful to inform friends or relatives to be aware of the signs and symptoms listed above.\u00a0Contact a doctor when you experience such symptoms.\u00a0Examples of these sedatives or similar drugs are:<\/p>\n\n\n\n