{"id":24299,"date":"2022-08-20T09:45:34","date_gmt":"2022-08-20T09:45:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24299"},"modified":"2022-08-22T10:51:45","modified_gmt":"2022-08-22T10:51:45","slug":"talzenna","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/talzenna\/","title":{"rendered":"Talzenna &#8211; Talazoparib uses, dose and side effects"},"content":{"rendered":"\n<p>0.25 mg or 1 mg&nbsp;hard capsules<br>talazoparib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Talzenna is and what it is used for<\/h2>\n\n\n\n<p><strong>What Talzenna is and how it works<\/strong><\/p>\n\n\n\n<p>Talzenna contains the active substance talazoparib.&nbsp;It is a type of cancer medicine called a &#8220;PARP inhibitor&#8221; (poly-adenosine diphosphate ribose polymerase inhibitor).<\/p>\n\n\n\n<p>Patients with certain changes (&nbsp;mutations&nbsp;) in genes called BRCA are at risk of developing certain types of cancer.&nbsp;Talzenna works by blocking PARP, which is an&nbsp;enzyme&nbsp;that repairs damaged&nbsp;DNA&nbsp;in some cancer cells.&nbsp;As a result, the cancer cells cannot repair themselves and they die.<\/p>\n\n\n\n<p><strong>What Talzenna is used for<\/strong><\/p>\n\n\n\n<p>Talzenna is used to treat adults with a type of breast cancer called&nbsp;HER2&nbsp;-negative breast cancer that has an abnormal inherited BRCA gene.<\/p>\n\n\n\n<p>Talzenna is used if cancer has spread beyond the first\u00a0tumor\u00a0or further to other parts of the body.<\/p>\n\n\n\n<p>Your doctor will do a test to see if Talzenna is a suitable treatment for you.<\/p>\n\n\n\n<p>If you have any questions about how Talzenna works or why you have been prescribed this medicine, you can ask your doctor.<br><br> What you need to know before you use Talzenna<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Talzenna<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to talazoparib or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Talzenna and during your treatment if you get any of the signs and symptoms described in this section.<\/p>\n\n\n\n<p>Low&nbsp;blood cell&nbsp;counts<\/p>\n\n\n\n<p>Talzenna reduces the number of\u00a0blood cells, e.g.\u00a0red blood cells\u00a0(\u00a0anemia\u00a0),\u00a0white blood cells\u00a0(\u00a0neutropenia\u00a0), or\u00a0platelets\u00a0(\u00a0thrombocytopenia\u00a0).\u00a0Signs and symptoms you need to look out for are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Anemia:<\/strong>\u00a0You become short of breath, feeling very tired, have pale skin, or have a fast\u00a0heart rate\u00a0\u2013 these may be signs of a low\u00a0red blood cell count.<\/li><li>Neutropenia:\u00a0Infection, you get chills or shakes, or get a fever \u2013 these can be signs of low\u00a0white blood cell counts.<\/li><li>Thrombocytopenia:\u00a0You bruise or bleed longer than normal when you injure yourself \u2013 this may be a sign of low\u00a0platelet counts.<\/li><\/ul>\n\n\n\n<p>Blood samples are taken regularly during treatment with Talzenna to check your&nbsp;blood cells&nbsp;(white and&nbsp;red blood cells&nbsp;and&nbsp;platelets&nbsp;).<\/p>\n\n\n\n<p>Serious impact on&nbsp;bone marrow&nbsp;a<\/p>\n\n\n\n<p>In rare cases, a low\u00a0blood cell count\u00a0can be a sign of a more serious effect on the\u00a0bone marrow\u00a0such as\u00a0myelodysplastic syndrome\u00a0(MDS) or\u00a0acute myeloid leukemia\u00a0(AML).\u00a0The doctor may take samples of the\u00a0bone marrow\u00a0to check this.<\/p>\n\n\n\n<p>Contraceptives for men and women<\/p>\n\n\n\n<p>Women who may become pregnant and men with partners who are or may become pregnant should use effective contraception.<\/p>\n\n\n\n<p>See the section &#8220;Contraceptives for men and women&#8221; below.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Talzenna should not be used in children or adolescents (under 18 years of age).<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Talzenna<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0This also applies to over-the-counter medicines, (traditional) herbal medicines, and herbal medicines.\u00a0Talzenna can affect how other medicines work.\u00a0In addition, some medicines can affect how Talzenna works.<\/p>\n\n\n\n<p>The following medicines may in particular increase the risk of&nbsp;side effects&nbsp;from Talzenna:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Amiodarone\u00a0, carvedilol, dronedarone,\u00a0propafenone\u00a0,\u00a0quinidine\u00a0, ranolazine and verapamil \u2013 often used for heart problems.<\/li><li>Clarithromycin and erythromycin \u2013 are\u00a0antibiotics\u00a0used to treat bacterial infections.<\/li><li>Itraconazole and\u00a0ketoconazole\u00a0\u2013 are used against fungal infections.<\/li><li>Cobicistat, darunavir, indinavir, lopinavir, ritonavir, saquinavir, telaprevir and tipranavir \u2013 used for\u00a0HIV\u00a0infection\/AIDS.<\/li><li>Cyclosporine \u2013 is used to prevent transplant rejection.<\/li><li>Lapatinib \u2013 is used to treat certain types of breast cancer.<\/li><li>Curcumin \u2013 (e.g. found in turmeric) in some medicines (see also section Talzenna with food and drink below).<\/li><\/ul>\n\n\n\n<p>The following medicines may reduce the effect of Talzenna:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Carbamazepine and\u00a0phenytoin\u00a0\u2013 anti-epileptic drugs\u00a0to reduce seizures and convulsions.<\/li><li>St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0) \u2013 is a herbal remedy used for mild depression and mild anxiety.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Talzenna with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not use dietary supplements that contain curcumin while taking Talzenna as it may increase the&nbsp;side effects&nbsp;of Talzenna.&nbsp;Curcumin is found in turmeric and you should not use large amounts of turmeric.&nbsp;However, its use as a seasoning in food is not likely to cause problems.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Talzenna can cause birth defects.\u00a0If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.\u00a0Your doctor will do a pregnancy test before you start Talzenna.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You should not use Talzenna if you are pregnant.<\/li><li>You should not become pregnant while taking Talzenna.<\/li><li>Discuss contraception with your doctor if you or your partner are at risk of becoming pregnant.<\/li><\/ul>\n\n\n\n<p><strong>Contraceptives for men and women<\/strong><\/p>\n\n\n\n<p><strong>Women<\/strong>&nbsp;of childbearing potential should use effective contraception during treatment with Talzenna and for at least 7 months after the last&nbsp;dose&nbsp;of Talzenna.&nbsp;Since the use of a hormonal contraceptive is not recommended if you have breast cancer, you should use two non-hormonal contraceptives.&nbsp;Discuss with the doctor\/midwife which contraceptives are suitable for you.<\/p>\n\n\n\n<p><strong>Men<\/strong>\u00a0who have a female partner who is pregnant or may become pregnant should use effective contraception (even after vasectomy) during treatment with Talzenna and for at least 4 months after the last\u00a0dose.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>You should not breastfeed while taking Talzenna and for at least 1 month after the last\u00a0dose.\u00a0It is not known whether Talzenna passes into breast milk.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Talazoparib may reduce&nbsp;fertility&nbsp;in men.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Talzenna may have a minor effect on the ability to drive and use machines.\u00a0If you feel dizzy, weak, or tired (these are very common\u00a0side effects\u00a0of Talzenna), you should avoid driving or using machines.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Talzenna<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is one capsule of 1 mg taken orally once a day.<\/p>\n\n\n\n<p>If you experience certain&nbsp;side effects&nbsp;while taking Talzenna (see section 4), your doctor may lower your&nbsp;dose&nbsp;or stop treatment, temporarily or completely.&nbsp;The dose&nbsp;can be reduced to 0.75 mg (three capsules of 0.25 mg) once daily or 0.5 mg (two capsules of 0.25 mg) once daily or 0.25 mg (one capsule of 0.25 mg) once daily.<\/p>\n\n\n\n<p>Swallow the capsule whole with a glass of water.&nbsp;The capsules must not be chewed or crushed.&nbsp;You can take Talzenna with food or between meals.&nbsp;The capsules must not be opened.&nbsp;Avoid contact with the contents of the capsule.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Talzenna<\/h2>\n\n\n\n<p>If you have taken more Talzenna than your usual\u00a0dose, contact your doctor or nearest hospital immediately.\u00a0You may need emergency treatment.<\/p>\n\n\n\n<p>Take the carton and this leaflet with you so the doctor knows what you have taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Talzenna<\/h2>\n\n\n\n<p>If you miss a&nbsp;dose&nbsp;or vomit it up, take the next&nbsp;dose&nbsp;as planned.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for capsules you have forgotten or vomited up.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Talzenna<\/h2>\n\n\n\n<p>Do not stop taking Talzenna unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you experience any of the following symptoms, which may be signs of a serious blood disorder:<\/strong>&nbsp;<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You become short of breath, feeling very tired, have pale skin or have a fast\u00a0pulse\u00a0\u2013 these may be signs of a low number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0).<\/li><li>Infection, getting chills or shaking, or fever, or feeling warm \u2013 may be signs of a low\u00a0white blood cell count\u00a0(\u00a0neutropenia\u00a0).<\/li><li>You bruise or bleed longer than normal when you injure yourself &#8211; this may be a sign of a low\u00a0platelet count\u00a0(\u00a0thrombocytopenia\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor if you get any other\u00a0side effects, such as:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low levels of\u00a0white blood cells,\u00a0red blood cells,\u00a0and\u00a0platelets<\/li><li>reduced appetite<\/li><li>dizziness<\/li><li>headache<\/li><li>nausea<\/li><li>vomiting<\/li><li>diarrhea<\/li><li>stomach pains<\/li><li>hair loss<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>taste change (&nbsp;dysgeusia&nbsp;)<\/li><li>digestive problems<\/li><li>inflammation&nbsp;of the mouth.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Talzenna<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and can or blister card after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>The medicine has no special storage instructions.<\/p>\n\n\n\n<p>Do not use this medicine if the packaging is damaged or appears to have been tampered with.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is talazoparib.&nbsp;Talzenna hard capsules are available in different strengths.<\/li><li>Talzenna 0.25 mg hard capsules: each hard capsule contains talazoparibtosylate equivalent to 0.25 mg talazoparib.<\/li><li>Talzenna 1 mg hard capsules: each hard capsule contains talazoparibtosylate equivalent to 1 mg talazoparib.Other ingredients are:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Capsule content: silicon-modified microcrystalline cellulose (sMCC) (microcrystalline cellulose and silicon dioxide).<\/li><li>Capsule shell 0.25 mg capsule: hypromellose (HPMC), yellow iron oxide (E172), and titanium dioxide (E171)<\/li><li>Capsule shell 1 mg capsule: hypromellose (HPMC), iron oxide yellow (E172), titanium dioxide (E171), and iron oxide red (E172)<\/li><\/ul>\n\n\n\n<p>Printing ink: shellac (E904), propylene glycol (E1520), ammonium hydroxide (E527), black iron oxide (E172), and potassium hydroxide (E525).<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Talzenna 0.25 mg is an opaque, hard capsule, approximately 14.30 mm x 5.32 mm, with an off-white body (with \u201cPfizer\u201d printed in black) and white body (with \u201cTLZ 0.25\u201d printed in black).<\/p>\n\n\n\n<p>Talzenna 1 mg is an opaque, hard capsule, approximately 14.30 mm x 5.32 mm, with a bright red cap (with \u201cPfizer\u201d printed in black) and white body (with \u201cTLZ 1\u201d printed in black).<\/p>\n\n\n\n<p>Talzenna 0.25 mg is available in perforated single-dose blisters with 30, 60, or 90 hard capsules, as well as in plastic cans containing 30 hard capsules.<\/p>\n\n\n\n<p>Talzenna 1 mg is available in perforated single-dose blisters with 30 hard capsules, as well as in plastic cans containing 30 hard capsules.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Pfizer Europe MA EEIG<\/p>\n\n\n\n<p>Boulevard de la Plaine 17<\/p>\n\n\n\n<p>1050 Brussels<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Excella GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>N\u00fcrnberger Strasse 12<\/p>\n\n\n\n<p>90537 Feucht<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder if you want to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong><strong>Luxembourg\/Luxembourg<\/strong>Pfizer NV\/SATel\/Tel: +32 (0)2 554 62 11<\/td><td><strong>Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel.&nbsp;+ 370 52 51 4000<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Pfizer Luxembourg \u0421\u0410\u0420\u041b, \u041a\u043b\u043e\u043d \u0411\u0443\u043b\u0433\u0430\u0440\u0438\u044fTel.: +359 2 970 4333<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Pfizer Kft.Tel.: +36-1-488-37-00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Pfizer, coil.\u00a0s iPhone: +420 283 004 111<\/td><td><strong>Malta<\/strong>Vivian Corporation LtdTel.&nbsp;+356 21344610<\/td><\/tr><tr><td><strong>Denmark<\/strong>Pfizer ApSPhone: +45 44 20 11 00<\/td><td><strong>The Netherlands<\/strong>Pfizer BVPhone: +31 (0)10 406 43 01<\/td><\/tr><tr><td><strong>Deutschland<\/strong>PFIZER PHARMA GmbHPhone: +49 (0)30 550055-51000<\/td><td><strong>Norway<\/strong>Pfizer iPhone: +47 67 52 61 00<\/td><\/tr><tr><td><strong>Estonia<\/strong>Pfizer Luxembourg SARL Eesti branch phone: +372 666 7500<\/td><td><strong>Austria<\/strong>Pfizer Corporation Austria Ges.mbHPhone: +43 (0)1 521 15-0<\/td><\/tr><tr><td><strong>Greece<\/strong>Pfizer Hellas AETel: +30 210 6785 800<\/td><td><strong>Polish<\/strong>Pfizer Polska Sp.&nbsp;z o. oTel.: +48 22 335 61 00<\/td><\/tr><tr><td><strong>Spain<\/strong>Pfizer, SLPhone: +34 91 490 99 00<\/td><td><strong>Portugal<\/strong>Laborat\u00f3rios Pfizer, Lda.Phone: +351 21 423 5500<\/td><\/tr><tr><td><strong>France<\/strong>PfizerTel: +33 (0)1 58 07 34 40<\/td><td><strong>Romania<\/strong>Pfizer Romania SRL.Phone: +40 (0) 21 207 28 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Pfizer Croatia dooPhone: +385 1 3908 777<\/td><td><strong>Slovenija<\/strong>Pfizer Luxembourg SARLPfizer, a branch of marketing, LjubljanaPhone: + 386 (0)1 52 11 400<\/td><\/tr><tr><td><strong>Ireland<\/strong>Pfizer Healthcare IrelandPhone: 1800 633 363 (toll free)+44 (0)1304 616161<\/td><td><strong>Slovenian Republic<\/strong>Pfizer Luxembourg SARL, organiza\u010dn\u00e1 zlo\u017ekaTel.: + 421 2 3355 5500<\/td><\/tr><tr><td><strong>Iceland<\/strong>Icepharma hf.Telephone: +354 540 8000<\/td><td><strong>Finland\/Finland<\/strong>Pfizer OyPhone\/Tel: +358 (0)9 43 00 40<\/td><\/tr><tr><td><strong>Italy<\/strong>Pfizer SrlPhone: +39 06 33 18 21<\/td><td><strong>Sweden<\/strong>Pfizer phone: +46 (0)8 550 520 00<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Pfizer \u0395\u03bb\u03bb\u03ac\u03c2 \u0391.\u0395.&nbsp;(Cyprus Branch)Phone: +357 22 817690<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedPhone: +44 (0) 1304 616161<\/td><\/tr><tr><td><strong>Latvia<\/strong>Pfizer Luxembourg SARL branch in LatviaPhone: + 371 670 35 775<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Talzenna contains the active substance talazoparib.\u00a0It is a type of cancer medicine called a &#8220;PARP inhibitor&#8221; (poly-adenosine diphosphate ribose polymerase inhibitor).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25249,25250,25252,25253,25256,25257,25248,25254,25251,25255],"class_list":["post-24299","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-talazoparib","tag-talazoparib-capsules","tag-talazoparib-side-effects","tag-talzenna","tag-talzenna-capsules","tag-talzenna-side-effects","tag-what-is-talazoparib","tag-what-is-talzenna","tag-what-talazoparib-is-used-for","tag-what-talzenna-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24299"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24299\/revisions"}],"predecessor-version":[{"id":24353,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24299\/revisions\/24353"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}