{"id":24296,"date":"2022-08-20T09:43:24","date_gmt":"2022-08-20T09:43:24","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24296"},"modified":"2022-08-22T10:51:53","modified_gmt":"2022-08-22T10:51:53","slug":"taltz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/taltz\/","title":{"rendered":"Taltz &#8211; Ixekizumab uses, dose and side effects"},"content":{"rendered":"\n<p>80 mg&nbsp;solution for injection&nbsp;in pre-filled&nbsp;pen&nbsp;ixekizumab<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Taltz is and what it is used for<\/h2>\n\n\n\n<p>Taltz contains the active substance ixekizumab.<\/p>\n\n\n\n<p>Taltz is intended for the treatment of inflammatory diseases described below:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Plaque psoriasis in adults<\/li><li>Plaque psoriasis in children from the age of 6 and adolescents, with a body weight of at least 25 kg<\/li><li>Psoriatic arthritis in adults<\/li><li>Radiographic&nbsp;axial&nbsp;spondylitis in adults<\/li><li>Non-radiographic&nbsp;axial&nbsp;spondylitis in adults.<\/li><\/ul>\n\n\n\n<p>Ixekizumab belongs to a group of medicines called&nbsp;interleukin&nbsp;inhibitors (IL inhibitors).&nbsp;This medicine works by blocking the activity of a&nbsp;protein&nbsp;called IL-17A, which favors the development of&nbsp;psoriasis&nbsp;and inflammatory diseases of the joints and spine.<\/p>\n\n\n\n<p>Plaque psoriasis<\/p>\n\n\n\n<p>Taltz is used to treat &#8216;plaque psoriasis in adults and children from the age of 6 and adolescents, weighing at least 25 kg with moderate to severe disease.\u00a0Taltz can reduce the signs and symptoms of the disease.<\/p>\n\n\n\n<p>If you use Taltz, skin healing is improved and symptoms such as scaling,\u00a0itching,\u00a0and pain are reduced.<\/p>\n\n\n\n<p>Psoriatic arthritis<\/p>\n\n\n\n<p>Taltz is used to treat &#8220;psoriatic arthritis&#8221; in adults, an\u00a0inflammatory\u00a0disease of the joints, which often occurs together with\u00a0psoriasis.\u00a0If you have psoriatic arthritis, you will first be given other medicines.\u00a0If you do not respond well enough to these medicines or if you cannot tolerate them, you will be given Taltz to reduce the signs and symptoms of the disease.\u00a0Taltz can be used alone or with another medicine (called methotrexate).<\/p>\n\n\n\n<p>By using Taltz, you will have fewer signs and symptoms of disease, improved physical function (ability to do normal daily activities), and reduced joint damage.<\/p>\n\n\n\n<p>Axial&nbsp;spondylitis<\/p>\n\n\n\n<p>Taltz is used to treat adults with an\u00a0inflammatory\u00a0disease mainly affecting the spine that causes\u00a0inflammation\u00a0of the facet joints (spinal joints), called\u00a0axial\u00a0spondylitis.\u00a0If the condition is visible on radiographs, it is called &#8220;radiographic\u00a0axial\u00a0spondyloarthritis&#8221;;\u00a0if it occurs in patients with no visible signs on radiographs, it is called &#8220;non-radiographic\u00a0axial\u00a0spondyloarthritis&#8221;.\u00a0If you have\u00a0axial\u00a0spondylitis, you will first receive other medicines.\u00a0If you do not respond well enough to these medicines, you will be given Taltz to reduce the signs and symptoms of the disease and reduce\u00a0inflammation,\u00a0and improve your physical function.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Taltz<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Taltz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to ixekizumab or any of the other ingredients of this medicine (listed in section 6).&nbsp;If you think you are allergic, consult your doctor before using Taltz.<\/li><li>if you have an&nbsp;infection&nbsp;that the doctor considers to be significant (for example, active&nbsp;tuberculosis&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Taltz:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have an ongoing\u00a0infection\u00a0or if you have had prolonged or\u00a0repeated\u00a0infections<\/li><li>if you have a\u00a0chronic\u00a0inflammatory disease of the gastrointestinal tract called\u00a0Crohn&#8217;s disease<\/li><li>if you have a\u00a0chronic\u00a0inflammatory disease of the colon called\u00a0ulcerative colitis<\/li><li>if you are receiving any other treatment for\u00a0psoriasis\u00a0(eg immunosuppressive agents or treatment with ultraviolet light) or psoriatic arthritis.<\/li><\/ul>\n\n\n\n<p>Inflammatory&nbsp;bowel disease (&nbsp;Crohn&#8217;s disease&nbsp;or&nbsp;ulcerative colitis&nbsp;)<\/p>\n\n\n\n<p>Stop using Taltz and tell your doctor or seek medical attention immediately if you notice stomach cramps and pain, diarrhea, weight loss, or blood in the stool (possible signs of bowel problems).<\/p>\n\n\n\n<p>If you are not sure if any of the above apply to you, talk to your doctor or nurse before using Taltz.<\/p>\n\n\n\n<p><strong>Be aware of\u00a0the infection\u00a0and allergic reactions<\/strong><\/p>\n\n\n\n<p>Taltz can cause serious\u00a0side effects, including\u00a0infection\u00a0and allergic reactions.\u00a0You need to be alert for signs of such reactions while using Taltz.<\/p>\n\n\n\n<p>Stop using Taltz and tell your doctor or seek medical help immediately if you develop any signs of a serious\u00a0infection\u00a0or\u00a0allergic reaction.\u00a0Such signs are listed in the \u201cSerious side effects\u201d list in section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not use this medicine to treat plaque psoriasis in children under 6 years of age because it has not been studied in this patient group.<\/p>\n\n\n\n<p>Do not use this medicine to treat psoriatic arthritis in children and adolescents under 18 years of age because it has not been studied in this patient group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Taltz<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are using, have recently used, or may be using other medicines<\/li><li>if you have recently been vaccinated or are about to be vaccinated.\u00a0You should not receive certain types of vaccines while you are using Taltz.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine. It is best to avoid using Taltz during pregnancy.\u00a0The drug&#8217;s effect on pregnant women is unknown.\u00a0If you are female and of\u00a0childbearing potential, it is recommended that you avoid becoming pregnant and you must use appropriate contraception while using Taltz and for at least 10 weeks after the last\u00a0dose\u00a0of Taltz.<\/p>\n\n\n\n<p>If you are breastfeeding or plan to breastfeed, talk to your doctor before using this medicine.\u00a0You and the doctor should decide whether you can breastfeed or use Taltz.\u00a0You should not do both.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Taltz is unlikely to affect your ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Taltz contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per 80 mg\u00a0dose, i.e.\u00a0is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Taltz<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or nurse has told you.\u00a0Consult a doctor, nurse, or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Taltz is given as an\u00a0injection\u00a0under the skin (\u00a0subcutaneous\u00a0injection\u00a0).\u00a0You and your doctor or nurse must decide whether you can\u00a0inject yourself with Taltz.<\/p>\n\n\n\n<p>For children with a body weight between 25 kg and 50 kg, a&nbsp;dose&nbsp;of 40 mg should be used.&nbsp;This must be prepared and given by qualified healthcare personnel.<\/p>\n\n\n\n<p>Use Taltz 80 mg pre-filled&nbsp;injection pen&nbsp;for children who are given an 80 mg&nbsp;dose&nbsp;and therefore do not need dose preparation.<\/p>\n\n\n\n<p>You mustn&#8217;t try to give the\u00a0injections\u00a0yourself until the doctor or nurse has shown you how to do it.\u00a0A carer can also give you Taltz\u00a0injection\u00a0after training.<\/p>\n\n\n\n<p>Use some form of reminder, write e.g.\u00a0record the\u00a0injections\u00a0in your calendar or diary, so that you do not miss a\u00a0dose\u00a0or take a double\u00a0dose.<\/p>\n\n\n\n<p>Taltz is intended for long-term treatment.&nbsp;The doctor or nurse will check you regularly to see that the treatment is having the desired effect.<\/p>\n\n\n\n<p>Each\u00a0pen\u00a0contains one\u00a0dose\u00a0of Taltz (80 mg).\u00a0Each pen delivers only one\u00a0dose.\u00a0The pen must not be shaken.<\/p>\n\n\n\n<p>Read the instructions for use of the injection pen carefully before using Taltz.<\/p>\n\n\n\n<p><strong>How much Taltz you should take and for how long<\/strong><\/p>\n\n\n\n<p>Your doctor will decide how much Taltz you need and for how long.<\/p>\n\n\n\n<p>Plaque psoriasis in adults<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The first\u00a0dose\u00a0is 160 mg (two pens with 80 mg in each) given as a\u00a0subcutaneous\u00a0injection.\u00a0This can be given by a doctor or nurse.<\/li><li>After the first\u00a0dose, you should take an 80 mg\u00a0dose\u00a0(one\u00a0injection pen\u00a0) at weeks 2, 4, 6, 8, 10, and 12. From week 12, you should take an 80 mg\u00a0dose\u00a0(one\u00a0injection pen\u00a0) every 4: e weeks.<\/li><\/ul>\n\n\n\n<p>Plaque psoriasis in children (from the age of 6 and above and with a body weight of at least 25 kg) and adolescents.\u00a0The recommended\u00a0dose\u00a0is given as a\u00a0subcutaneous\u00a0injection\u00a0to children and is based on the following weight categories:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>The child&#8217;s body weight<\/strong><\/td><td><strong>Recommended starting dose (week 0)<\/strong><\/td><td><strong>Recommended&nbsp;dose&nbsp;every 4 weeks (Q4W) thereafter<\/strong><\/td><\/tr><tr><td>More than 50 kg<\/td><td>160 mg (2\u00a0pens)<\/td><td>80 mg (1&nbsp;pen&nbsp;)<\/td><\/tr><tr><td>25 to 50 kg<\/td><td>80 mg (1&nbsp;pen&nbsp;)<\/td><td>40 mg (&nbsp;dose&nbsp;needs to be prepared)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Ixekizumab&nbsp;doses&nbsp;below 40 mg must be prepared and administered from the commercial Taltz 80 mg\/1 ml pre-filled&nbsp;syringe&nbsp;by qualified healthcare professionals.<\/p>\n\n\n\n<p>Taltz 80 mg pre-filled\u00a0pen\u00a0should be used for children who need a\u00a0dose\u00a0of 80 mg and do not need dose preparation.\u00a0Do not use the\u00a0Taltz 80 mg pre-filled pen to prepare\u00a0a\u00a040\u00a0mg\u00a0dose.<\/p>\n\n\n\n<p>Taltz is not recommended for children weighing less than 25 kg.<\/p>\n\n\n\n<p>Psoriatic arthritis<\/p>\n\n\n\n<p>For patients with psoriatic arthritis who also have moderate to severe plaque psoriasis:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The first\u00a0dose\u00a0is 160 mg (two pens with 80 mg in each) given as a\u00a0subcutaneous\u00a0injection.\u00a0This can be given by a doctor or nurse.<\/li><li>After the first\u00a0dose, you should take an 80 mg\u00a0dose\u00a0(one\u00a0injection pen\u00a0) at weeks 2, 4, 6, 8, 10, and 12. From week 12, you should take an 80 mg\u00a0dose\u00a0(one\u00a0injection pen\u00a0) every 4: e weeks.<\/li><\/ul>\n\n\n\n<p>For other patients with psoriatic arthritis<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The first\u00a0dose\u00a0is 160 mg (two injection pens with 80 mg in each) given as a\u00a0subcutaneous\u00a0injection.\u00a0This can be given by a doctor or nurse.<\/li><li>After the first\u00a0dose, you should take an 80 mg\u00a0dose\u00a0(one\u00a0injection pen\u00a0) every 4 weeks.<\/li><\/ul>\n\n\n\n<p>Axial&nbsp;spondylitis<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended\u00a0dose\u00a0is 160 mg (2 pens with 80 mg in each) given as a\u00a0subcutaneous\u00a0injection.<\/li><li>After the first\u00a0dose, you should take an 80 mg\u00a0dose\u00a0(one\u00a0injection pen\u00a0) every 4 weeks.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much Taltz&nbsp;<\/h2>\n\n\n\n<p>If you have received more Taltz than you should or if you have received a&nbsp;dose&nbsp;too early, tell your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Taltz<\/h2>\n\n\n\n<p>Tell your doctor if you forget to inject a&nbsp;dose&nbsp;of Taltz.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Taltz<\/h2>\n\n\n\n<p>Do not stop using Taltz without talking to your doctor first.&nbsp;If you stop treatment, your symptoms of&nbsp;psoriasis&nbsp;or psoriatic arthritis may return.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Stop using Taltz and tell your doctor or seek medical help immediately if you experience any of the following\u00a0side effects.\u00a0Your doctor will decide if and when you can start the treatment again.<\/p>\n\n\n\n<p><strong>Possible serious&nbsp;infection&nbsp;<\/strong>(may affect up to 1 in 100 people) &#8211; signs of this may be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever,\u00a0flu-like symptoms, night sweats<\/li><li>tiredness or shortness of breath, cough that does not go away<\/li><li>hot,\u00a0reddened,\u00a0and sore skin, or a painful rash with blisters.<\/li><\/ul>\n\n\n\n<p><strong>Serious&nbsp;allergic reaction&nbsp;<\/strong>(may affect up to 1 in 1,000 people) &#8211; signs of this may be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing or swallowing<\/li><li>low\u00a0blood pressure, which can cause dizziness or lightheadedness<\/li><li>swelling of the face, lips, tongue, or throat<\/li><li>severe\u00a0itching\u00a0of the skin, with red rashes or raised nodules.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that have been reported<\/strong><\/p>\n\n\n\n<p><strong>Very&nbsp;<\/strong><strong>common<\/strong>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>upper respiratory tract infections with symptoms such as sore throat and stuffy nose<\/li><li>injection site reactions (eg skin redness, pain).<\/li><\/ul>\n\n\n\n<p><strong>Common (may&nbsp;<\/strong><strong>affect<\/strong>&nbsp;up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea<\/li><li>fungal infections, e.g.\u00a0athlete&#8217;s foot<\/li><li>pains in the posterior pharynx<\/li><li>ulcers in the mouth, skin, and mucous membranes (\u00a0herpes\u00a0simplex,\u00a0mucocutaneous\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may&nbsp;<\/strong><strong>affect<\/strong>&nbsp;up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>thrush (a fungal infection of the mouth)<\/li><li>influenza<\/li><li>runny nose<\/li><li>bacterial infection of the skin<\/li><li>hives<\/li><li>watery eyes with\u00a0itching,\u00a0redness,\u00a0and swelling (\u00a0conjunctivitis\u00a0)<\/li><li>symptoms of lack of\u00a0white blood cells\u00a0(\u00a0neutropenia\u00a0), e.g.\u00a0fever, sore throat, or mouth ulcers caused by\u00a0infection\u00a0er<\/li><li>low\u00a0platelet count\u00a0(\u00a0thrombocytopenia\u00a0)<\/li><li>eczema<\/li><li>rash<\/li><li>rapid swelling of the\u00a0tissues\u00a0in the neck, face, mouth, or throat (\u00a0angioedema\u00a0).<\/li><li>stomach cramps and pain, diarrhea, weight loss, or blood in the stool (possible signs of bowel problems).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Taltz<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the pen label and the outer carton after \u201cEXP\u201d.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C to 8 \u00b0C).&nbsp;Do not freeze.&nbsp;Should not be stored against the back of the refrigerator.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Taltz can be stored at room temperature (at a maximum of 30 \u00baC) for up to 5 days.<\/p>\n\n\n\n<p>Do not use the medicine if the injection pen is damaged or if the medicine is cloudy, distinctly brown, or contains particles.<\/p>\n\n\n\n<p>This medicine is for single use only.<\/p>\n\n\n\n<p>Medicines should not be thrown down the drain.\u00a0Ask the doctor, nurse, or pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is ixekizumab.<br>A pre-filled\u00a0pen\u00a0contains 80 mg of ixekizumab in 1 ml of solution.<\/li><li>Other ingredients are sodium citrate, anhydrous citric acid, sodium chloride, polysorbate 80, and water for\u00a0injection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Taltz is a solution in a clear glass syringe.&nbsp;The color can vary from colorless to pale yellow.<\/p>\n\n\n\n<p>The syringe is enclosed in a single-dose pen for single use.<\/p>\n\n\n\n<p>Pack sizes of 1, 2, and 3 pre-filled pens.\u00a0Not all pack sizes may be available in your country.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Eli Lilly and Company (Ireland) Limited, Dunderrow, Kinsale, Co.&nbsp;Cork, Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Eli Lilly Italia SpA, Via Gramsci 731\/733, 50019, Sesto Fiorentino (FI), Italy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Taltz is intended for the treatment of inflammatory diseases described below:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25263,25266,25259,25258,25262,25267,25260,25264,25261,25265],"class_list":["post-24296","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-ixekizumab","tag-benefits-of-taltz","tag-ixekizumab","tag-ixekizumab-side-effects","tag-taltz","tag-taltz-side-effects","tag-what-is-ixekizumab","tag-what-is-taltz","tag-what-ixekizumab-is-used-for","tag-what-taltz-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24296"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24296\/revisions"}],"predecessor-version":[{"id":24354,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24296\/revisions\/24354"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}