{"id":24292,"date":"2022-08-20T09:34:21","date_gmt":"2022-08-20T09:34:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24292"},"modified":"2022-08-22T10:52:07","modified_gmt":"2022-08-22T10:52:07","slug":"talmanco","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/talmanco\/","title":{"rendered":"Talmanco &#8211; Tadalafil uses, dose and side effects"},"content":{"rendered":"\n<p>20 mg&nbsp;film-coated tablets<br>tadalafil<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Talmanco is and what it is used for<\/h2>\n\n\n\n<p>Talmanco contains the active substance tadalafil.<\/p>\n\n\n\n<p>Talmanco is a treatment for&nbsp;pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;in adults.<\/p>\n\n\n\n<p>Talmanco belongs to a group of medicines called&nbsp;phosphodiesterase&nbsp;type 5 (PDE5) inhibitors, which improve blood flow to the lungs by causing the blood vessels around the lungs to relax.&nbsp;The result is improved capacity during physical exertion.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Talmanco<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Talmanco<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to tadalafil or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are taking medicines containing nitrates such as amyl nitrite, which are used to treat chest pain.\u00a0Talmanco has been shown to increase the effect of these drugs.\u00a0If you take any form of nitrate or are unsure, talk to your doctor.<\/li><li>if you have ever lost your sight &#8211; a condition called &#8216;stroke in the eye (non-arteritic anterior ischemic optic neuropathy &#8211; NAION).<\/li><li>if you have had a heart attack in the last 3 months.<\/li><li>if you have low\u00a0blood pressure.<\/li><li>if you take riociguat.\u00a0This medicine is used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0(ie high\u00a0blood pressure\u00a0in the lungs) and\u00a0chronic\u00a0thromboembolic\u00a0pulmonary\u00a0hypertension\u00a0(ie high\u00a0blood pressure\u00a0in the lungs due to blood clots).\u00a0PDE5 inhibitors, such as Talmanco, have been shown to increase the blood pressure-lowering effect of this drug.\u00a0If you are taking riociguat or if you are not sure, talk to your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking this medicine if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart problems other than your high\u00a0blood pressure\u00a0in the lungs<\/li><li>problems with your\u00a0blood pressure<\/li><li>any hereditary eye disease<\/li><li>abnormal\u00a0red blood cells\u00a0(sickle cell anemia)<\/li><li>bone marrow\u00a0cancer\u00a0(multiple\u00a0myeloma\u00a0)<\/li><li>blood cell cancer (\u00a0leukemia\u00a0)<\/li><li>a deformed penis, or unwanted or persistent\u00a0erection\u00a0lasting more than 4 hours<\/li><li>severe liver disease<\/li><li>severe kidney disease.<\/li><\/ul>\n\n\n\n<p>If you experience a sudden decrease or loss of vision, contact your doctor immediately.<\/p>\n\n\n\n<p>Impaired hearing or sudden hearing loss has been noted in some patients taking tadalafil.&nbsp;Although it is not known whether the events are related to tadalafil, you should contact your doctor immediately if you develop hearing impairment or sudden hearing loss.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be given to children or adolescents under 18 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Talmanco<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0Do NOT take this medicine if you are already taking nitrates.<\/p>\n\n\n\n<p>Some medicines can be affected by Talmanco or they can affect Talmanco&#8217;s effect.&nbsp;Tell your doctor or pharmacist if you are already taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">bosentan<\/a>\u00a0(another drug used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0)<\/li><li>nitrates (for chest pain)<\/li><li>alpha-blockers are used to treat high\u00a0blood pressure\u00a0or prostate problems.<\/li><li>riociguat<\/li><li>rifampicin (to treat bacterial infections)<\/li><li>ketoconazole tablets (to treat fungal infections)<\/li><li>ritonavir (for\u00a0HIV\u00a0treatment)<\/li><li>tablets for\u00a0erectile dysfunction\u00a0(PDE5 inhibitors).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Talmanco with alcohol<\/h2>\n\n\n\n<p>Alcohol intake can temporarily lower your\u00a0blood pressure.\u00a0Avoid consuming large amounts of alcohol (over 5 alcohol units) when you have taken or plan to take Talmanco as this may increase the risk of dizziness when standing up.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.\u00a0Do not use this medicine during pregnancy, unless it is necessary and you have discussed it with your doctor.<\/p>\n\n\n\n<p>Do not breastfeed while taking these tablets, as it is not known whether the drug passes into human breast milk.\u00a0Ask your doctor or pharmacist for advice before taking any medicine during pregnancy or breastfeeding.<\/p>\n\n\n\n<p>Treated dogs had\u00a0reduced\u00a0sperm development in the testes.\u00a0A reduced sperm concentration has been demonstrated in some men.\u00a0Its effects are unlikely to impair\u00a0male fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Dizziness has been reported.&nbsp;Feel how you react to the medicine before driving or using machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Talmanco contains lactose and sodium<\/h2>\n\n\n\n<p>If you have an intolerance to some sugars, you should consult your doctor before taking this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Talmanco<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Talmanco is supplied as a 20 mg tablet.\u00a0The\u00a0<strong>usual\u00a0dose<\/strong>\u00a0is two 20 mg tablets once daily<strong>.\u00a0<\/strong>You should take both tablets at the same time, one after the other.\u00a0Your doctor may have prescribed just one 20 mg tablet daily if you have mild to moderate liver or kidney problems.<\/p>\n\n\n\n<p>Swallow the tablets with a little water.&nbsp;You can take the tablets regardless of a meal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Talmanco<\/h2>\n\n\n\n<p>If you or someone else takes more tablets than they should, contact your doctor or go to the hospital immediately, and take the medicine pack with you.\u00a0You may experience some of the\u00a0side effects\u00a0described in section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Talmanco<\/h2>\n\n\n\n<p>Take\u00a0dose\u00a0one as soon as you remember if it is within 8 hours of when you should have taken your\u00a0dose.\u00a0Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Talmanco<\/h2>\n\n\n\n<p>Do not stop taking your tablets unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Side effects\u00a0are usually mild or moderate.<\/p>\n\n\n\n<p><strong>If you experience any of the following\u00a0side effects, stop using the medicine and see a doctor immediately:<\/strong><\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions with rash<\/li><li>chest pain &#8211; do not use nitrates but see a doctor immediately<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>priapism, prolonged and possibly painful&nbsp;erection&nbsp;after taking this medicine.&nbsp;If you get&nbsp;an erection&nbsp;that lasts continuously for more than 4 hours, consult a doctor immediately.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sudden loss of vision<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;have been reported:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>redness, nasal congestion, and blocked sinuses<\/li><li>nausea, indigestion (including stomach pain)<\/li><li>muscle pain, back pain, and pain or discomfort in the arms and legs<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blurred vision<\/li><li>low&nbsp;blood pressure<\/li><li>nosebleed<\/li><li>vomiting<\/li><li>increased or abnormal vaginal bleeding, facial swelling<\/li><li>acid reflux<\/li><li>migraine<\/li><li>irregular heartbeats<\/li><li>fainting<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>convulsions<\/li><li>temporary memory loss<\/li><li>hives<\/li><li>profuse sweating<\/li><li>bleeding from the penis<\/li><li>presence of blood in semen and\/or urine<\/li><li>Hypertension<\/li><li>palpitation<\/li><li>sudden cardiac death<\/li><li>tinnitus&nbsp;(sound in the ears without an external sound source)<\/li><\/ul>\n\n\n\n<p><strong>PDE5 inhibitors<\/strong>&nbsp;are also used to treat&nbsp;erectile dysfunction&nbsp;in men.&nbsp;Some&nbsp;side effects&nbsp;that are reported&nbsp;<strong>rarely<\/strong>&nbsp;(may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Partial, temporary, or permanent visual impairment or loss of vision in one or both eyes and severe\u00a0allergic reaction\u00a0causing swelling of the face and throat.\u00a0Sudden deterioration or loss of hearing has also been reported.<\/li><\/ul>\n\n\n\n<p>Some\u00a0side effects\u00a0have been reported by men taking tadalafil for the treatment of\u00a0erectile dysfunction.\u00a0These\u00a0side effects\u00a0have not occurred in\u00a0clinical trials\u00a0of\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0and therefore the frequency is not known (cannot be estimated from the available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swollen eyelids, eye pain, red eyes, heart attack, and\u00a0stroke<\/li><\/ul>\n\n\n\n<p>Most, but not all, of the men who reported palpitations, irregular heartbeats, heart attack,\u00a0stroke, and sudden cardiac death had known heart problems before taking the drug.\u00a0It is not possible to determine whether these reactions were directly related to tadalafil.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Talmanco<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton or blister card after the Expiration date.\u00a0or EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tadalafil.\u00a0One tablet contains 20 mg of tadalafil.<\/li><li>Other ingredients in the tablet core are povidone, sodium lauryl sulfate, poloxamer 188, and anhydrous\u00a0lactose\u00a0(see section 2 &#8220;Talmanco contains\u00a0lactose\u00a0and sodium&#8221;), microcrystalline cellulose (\u00a0PH\u00a0101), croscarmellose sodium,\u00a0colloidal\u00a0anhydrous silicon dioxide, and magnesium stearate.\u00a0The film coating contains\u00a0lactose monohydrate\u00a0(see section 2 &#8220;Talmanco contains\u00a0lactose\u00a0and sodium&#8221;), hypromellose (E464), titanium dioxide (E171), and triacetin.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>This medicine is a white, film-coated, round, biconvex tablet with a beveled edge, marked with &#8220;M&#8221; on one side and &#8220;TA20&#8221; on the other.&nbsp;The medicine is supplied in blister packs containing 28 or 56 tablets and in perforated single-dose blister packs containing 28 x 1 or 56 x 1 tablets.&nbsp;Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder:<\/h2>\n\n\n\n<p>Viatris Limited<\/p>\n\n\n\n<p>Damastown Industrial Park,<\/p>\n\n\n\n<p>Mulhuddart, Dublin 15,<\/p>\n\n\n\n<p>DUBLIN<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>McDermott Laboratories Limited t\/a Gerard Laboratories t\/a Mylan Dublin<\/p>\n\n\n\n<p>35\/36 Baldoyle Industrial Estate<\/p>\n\n\n\n<p>Grange Road, Dublin 13<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Mylan Hungary Kft<\/p>\n\n\n\n<p>Mylan utca 1<\/p>\n\n\n\n<p>Kom\u00e1rom, 2900<\/p>\n\n\n\n<p>Hungary<\/p>\n\n\n\n<p>Mylan Germany GmbH<\/p>\n\n\n\n<p>Zweigniederlassung Bad Homburg vd Hoehe, Benzstrasse 1<\/p>\n\n\n\n<p>Bad Homburg CEO Hoehe<\/p>\n\n\n\n<p>Hesse, 61352,<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Talmanco belongs to a group of medicines called\u00a0phosphodiesterase\u00a0type 5 (PDE5) inhibitors, which improve blood flow to the lungs by causing the blood vessels around the lungs to relax.\u00a0The result is improved capacity during physical exertion.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[7298,7300,7301,25278,25280,25281,7299,25279,11676,25282],"class_list":["post-24292","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-tadalafil","tag-tadalafil-side-effects","tag-tadalafil-tablet","tag-talmanco","tag-talmanco-side-effects","tag-talmanco-tablet","tag-what-is-tadalafil","tag-what-is-talmanco","tag-what-tadalafil-is-used-for","tag-what-talmanco-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24292"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24292\/revisions"}],"predecessor-version":[{"id":24356,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24292\/revisions\/24356"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}