{"id":24287,"date":"2022-08-20T09:30:51","date_gmt":"2022-08-20T09:30:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24287"},"modified":"2022-12-22T18:57:11","modified_gmt":"2022-12-22T18:57:11","slug":"tacrozem","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tacrozem\/","title":{"rendered":"Tacrozem &#8211; Tacrolimus Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Tacrozem 0.1%&nbsp;<strong>Tacrolimus<\/strong><\/strong> <strong>Ointment<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tacrozem Is And What Tacrozem Used For<\/h2>\n\n\n\n<p>The active substance in Tacrozem, tacrolimus monohydrate, is an immunomodulatory agent.<\/p>\n\n\n\n<p><strong>\u00a0Tacrozem, 0.1% ointment<\/strong>, is used to treat moderate to severe atopic\u00a0dermatitis\u00a0(\u00a0eczema\u00a0) in adults who have not had sufficient effect from or cannot tolerate conventional treatment such as\u00a0topical\u00a0corticosteroids.<\/p>\n\n\n\n<p>When moderate to severe atopic\u00a0dermatitis\u00a0is completely or almost completely healed after up to 6 weeks of treatment of an eczema flare-up, and if you tend to have eczema flare-ups frequently (4 times a year or more), it may be possible to prevent the eczema flare-ups from coming back or to extend the time you have no breakouts by using <strong>\u00a0Tacrozem, 0.1% ointment<\/strong> twice a week.<\/p>\n\n\n\n<p>In atopic\u00a0dermatitis, an overreaction in the skin&#8217;s immune system causes\u00a0inflammation\u00a0(\u00a0itching, redness, dryness).\u00a0Tacrozem alters the abnormal immune response and relieves\u00a0inflammation\u00a0and itching in the skin.<\/p>\n\n\n\n<p>The tacrolimus contained in <strong>Tacrozem<\/strong> may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before You Use Tacrozem<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use <\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic (<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/peanut-allergy-and-nut-allergy\/\">hypersensitive<\/a>) to tacrolimus or any of the other ingredients of this medicine (listed in section 6) or to macrolide antibiotics (e.g. azithromycin, clarithromycin, erythromycin).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Precautions<\/h2>\n\n\n\n<p>Talk to your doctor if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Have\u00a0liver failure.<\/li><li>Have any form of\u00a0skin <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>\u00a0(tumour) or if you have a\u00a0weakened immune system\u00a0(immunodeficiency), for whatever reason.<\/li><li>Have an\u00a0inherited skin barrier\u00a0disorder such as Netherton&#8217;s syndrome,\u00a0lamellar\u00a0ichthyosis\u00a0(skin that scales heavily due to thickening of the outermost layer of skin), or if you have\u00a0generalized\u00a0\u00a0erythroderma\u00a0(red, inflamed, scaly skin all over the body)<\/li><li>Have\u00a0cutaneous\u00a0Graft versus Host disease (an immune reaction in the skin that is a common complication in bone marrow transplant patients).<\/li><li>Have\u00a0swollen lymph nodes at the start of treatment.\u00a0If your\u00a0lymph nodes\u00a0swell during treatment with this medicine, consult your doctor.<\/li><li>Have infected\u00a0eczema.\u00a0Do not use the ointment on infected eczema.<\/li><li>Notice any\u00a0change\u00a0in the appearance of the skin, and you should contact your doctor.<\/li><li>The safety of long-term treatment with tacrolimus ointment is unknown.\u00a0A very small number of people who have used tacrolimus ointment have developed\u00a0malignancy\u00a0(for example, skin cancer or lymphoma).\u00a0However, the connection between tacrolimus ointment and cancer has not been proven.<\/li><li>Avoid\u00a0exposing\u00a0the skin to sunlight for long periods and artificial sunlight such as tanning beds.\u00a0If you spend a lot of time outdoors after using <strong>Tacrozem<\/strong>, wear sunscreen and loose clothing that protects the skin from sunlight.\u00a0Ask your doctor for other appropriate ways to protect yourself from the sun.\u00a0If you have been prescribed light therapy, you should inform your doctor that you are using Takrozem, as simultaneous treatment with Takrozem and light therapy is not recommended.<\/li><li>If your doctor prescribes treatment with <strong>Tacrozem<\/strong> twice a week to keep eczema away, your condition should be evaluated by a doctor at least once a year, even if the disease is under control.\u00a0For children, a break must be made in the maintenance treatment after 12 months to assess whether continued treatment is needed.<\/li><li>You should not bathe, shower, or swim immediately after using the ointment;\u00a0water can wash away the medicine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Tacrozem, 0.1% ointment, is\u00a0not approved for treating children under 16 years of age.\u00a0The ointment should, therefore, not be used in this age group.\u00a0Consult your doctor.<\/li><li>The effect of treatment with <strong>Tacrozem<\/strong> on a developing immune system in children, especially young children, have not been investigated.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines, Cosmetics, And Tacrozem<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription.<\/p>\n\n\n\n<p>You can use emollient\u00a0creams\u00a0and skin lotions during treatment with <em>Tacrozem 0.1% ointment<\/em>, and these products should not be used within two hours before and after using <strong>Tacrozem<\/strong>.<\/p>\n\n\n\n<p>The use of tacrolimus at the same time as other drugs for&nbsp;external&nbsp;use or during simultaneous treatment with oral&nbsp;corticosteroids&nbsp;(e.g.&nbsp;cortisone&nbsp;) or medications that affect the immune system has not been studied.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tacrozem With Alcohol<\/h2>\n\n\n\n<p>When using <strong>Tacrozem<\/strong>, consuming <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/alcohol-and-drugs-risk-use-harmful-use-and-addiction\/\">alcohol<\/a> may cause flushing or\u00a0redness\u00a0and a feeling of warmth in the skin or face.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>Do not use <strong>Tacrozem<\/strong> if you are pregnant or breastfeeding.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tacrozem Contains<\/h2>\n\n\n\n<p>White petroleum jelly, liquid paraffin, propylene carbonate, white wax, and solid paraffin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Use Tacrozem<\/h2>\n\n\n\n<p>Always use <strong>Tacrozem<\/strong> as directed by your doctor.\u00a0Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Apply a thin layer of <strong>Tacrozem<\/strong> to the affected skin areas.<\/li><li><strong>Tacrozem<\/strong> can be used on most body parts, including the face and neck and in the creases of the elbows and knees.<\/li><li>Avoid using the ointment on the inside of the nose or mouth or in the eyes.\u00a0If the ointment comes into contact with any of these areas, it should be wiped off thoroughly or rinsed with water.<\/li><li>Do not cover skin areas treated with the ointment with bandages or the like.<\/li><li>Wash your hands after using <strong>Tacrozem<\/strong>, unless your hands are also to be treated.<\/li><li>Before using <strong>Tacrozem<\/strong> after showering or bathing, the skin must be completely dry.<\/li><li>You should not bathe, shower, or swim immediately after using the ointment.\u00a0Water can wash away the medicine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Adults (16 years and older)<\/h2>\n\n\n\n<p>For adult patients (16 years and older), there are two strengths of tacrolimus ointment (tacrolimus 0.03% ointment and tacrolimus 0.1% ointment).\u00a0Your doctor will decide which strength is best for you.<\/p>\n\n\n\n<p>Treatment usually begins with <strong>Tacrozem<\/strong> 0.1% ointment twice daily, once in the morning and once in the evening, until the\u00a0eczema\u00a0is healed.\u00a0Depending on the effect on your\u00a0eczema, the doctor will decide if you can use the ointment less often or if the lower strength, tacrolimus 0.03% ointment, can be used.<\/p>\n\n\n\n<p>Treat each affected skin area until the&nbsp;eczema&nbsp;is gone.&nbsp;Improvement usually occurs within a week.&nbsp;If you do not notice any improvement within two weeks, consult your doctor about other possible treatments.<\/p>\n\n\n\n<p>Your doctor may\u00a0prescribe\u00a0you to use <strong>Tacrozem<\/strong> 0.1% ointment twice a week when\u00a0the eczema\u00a0is completely or almost healed.<strong>\u00a0Tacrozem, 0.1% ointment<\/strong>, should be used once a day, two days a week (e.g. Monday and Thursday) on the skin areas where you usually get\u00a0eczema.\u00a0Between each treatment session, there must be 2-3 days without treatment with Takrozem.<\/p>\n\n\n\n<p>If the symptoms of the disease return, you should use <strong>Tacrozem<\/strong> twice daily, in the same way described above, and contact your doctor to review the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Accidentally Swallow The Ointment<\/h2>\n\n\n\n<p>If you accidentally swallow the ointment, talk to your doctor or pharmacist as soon as possible.&nbsp;Do not try to induce vomiting.<\/p>\n\n\n\n<p>If you have used too much medicine or, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Tacrozem<\/h2>\n\n\n\n<p>If you forget to apply the ointment when you are supposed to, do it as soon as you remember and then continue as before.<\/p>\n\n\n\n<p>Contact your doctor or pharmacist if you have further questions about this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Tacrozem Side Effects<\/h2>\n\n\n\n<p>Like all medicines, although not everybody gets them, <strong>Tacrozem<\/strong> can cause side effects.<\/p>\n\n\n\n<p>Very common (may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Burning sensation and\u00a0itching<\/li><\/ul>\n\n\n\n<p>These symptoms are normally mild to moderate and usually disappear within a week of starting treatment with <strong>Tacrozem<\/strong>.<\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Redness<\/li><li>Feeling of warmth<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">Pain<\/a><\/li><li>Increased sensitivity of the skin (especially to heat and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a>)<\/li><li>Skin crawling and irritated skin<\/li><li>Rash<\/li><li>Local skin reactions of any cause;\u00a0a reaction may be inflamed or infected hair follicles, herpes virus infections e.g. <ul><li>Cold sores<\/li><li>Generalized\u00a0herpes\u00a0simplex\u00a0infections\u00a0<\/li><\/ul><\/li><li>Facial redness\u00a0or skin irritation after drinking alcohol<\/li><li>Hypersensitivity at the treatment site<\/li><\/ul>\n\n\n\n<p>Uncommon Tacrozem side effects (may affect up to 1 in 100 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acne<\/li><\/ul>\n\n\n\n<p>After treatment twice a week,\u00a0adult infection at the treatment site has been reported.<\/p>\n\n\n\n<p>Rosacea&nbsp;(&nbsp;redness&nbsp;of the face), rosacea-like skin inflammation, lentigo (flat brown spots on the skin),&nbsp;edema&nbsp;(fluid accumulation) at the treatment site, as well as herpes infection of the eye, have been reported after the product was introduced to the market.<\/p>\n\n\n\n<p>After the market introduction, a very small number of people who used tacrolimus ointment have\u00a0developed malignancies\u00a0(e.g.,\u00a0lymphoma, including skin lymphoma and other skin tumours). Still, an association with treatment with tacrolimus ointment has not been proven or disproved.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Tacrozem<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Use before the expiry date stated on the tube and the carton after &#8220;EXP&#8221;.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store at a maximum of 25 \u00b0C.<\/li><li>Throw away opened tubes 90 days after opening, even if they are not empty.\u00a0Do not save them for later use.<\/li><\/ul>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tacrolimus monohydrate.<\/li><li>1 g of <strong>Tacrozem, 0.1% ointment<\/strong> contains 1.0 mg of tacrolimus (as tacrolimus monohydrate).<\/li><li>Other ingredients are white vaseline, liquid paraffin, propylene carbonate, white wax, and solid paraffin.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance And Package Sizes Of The Medicine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tacrozem<\/strong> is a white to slightly yellowish ointment.\u00a0It is supplied in tubes containing 10, 30, or 60 grams ointment.<\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>Pierre Fabre Dermatology<\/p>\n\n\n\n<p>45, Place Abel Gance<\/p>\n\n\n\n<p>92 100 Boulogne<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Pierre Fabre Medicament Production<\/p>\n\n\n\n<p>Aquitaine Pharm International 1<\/p>\n\n\n\n<p>Avenue du B\u00e9arn<\/p>\n\n\n\n<p>64320 Idron<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>This medicine is approved in the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p><strong><strong>Tacrozem<\/strong><\/strong>: Austria, Belgium, Denmark, Finland, France, Germany, Greece, Italy, Luxembourg, Netherlands, Norway, Portugal, Spain, Sweden, and Great Britain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tacrozem, 0.1% ointment, is used to treat mild to severe atopic dermatitis in adults who are not adequately responsive to or are intolerant of conventional therapies such as topical corticosteroids.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25288,4095,25283,4097,25284,25287,4096,25285,11512,25286],"class_list":["post-24287","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tacrozem","tag-tacrolimus","tag-tacrolimus-ointment","tag-tacrolimus-side-effects","tag-tacrozem","tag-tacrozem-side-effects","tag-what-is-tacrolimus","tag-what-is-tacrozem","tag-what-tacrolimus-is-used-for","tag-what-tacrozem-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24287","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24287"}],"version-history":[{"count":59,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24287\/revisions"}],"predecessor-version":[{"id":41208,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24287\/revisions\/41208"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24287"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24287"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}