{"id":24257,"date":"2022-08-18T11:30:36","date_gmt":"2022-08-18T11:30:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24257"},"modified":"2023-02-01T02:14:31","modified_gmt":"2023-02-01T02:14:31","slug":"takipril","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/takipril\/","title":{"rendered":"Takipril &#8211; Prilocaine Hydrochloride Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Takipril  20 mg\/ml&nbsp;Prilocaine Hydrochloride Solution&nbsp;for Injection<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Takipril Is And What Takipril Used For<\/h2>\n\n\n\n<p>Takipril 20 mg\/ml is a type of medicine called a\u00a0local anaesthetic, belonging to the\u00a0amide\u00a0group and is a\u00a0solution for injection.\u00a0Takipril is used in adults to numb specific body parts and prevent <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> during surgery.<\/p>\n\n\n\n<p>Takipril is injected into the lower part of the spine.&nbsp;This quickly stops pain from the waist down for a limited time (short-term surgical procedures).<\/p>\n\n\n\n<p>Prilocaine hydrochloride contained in Takipril may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before You Receive Takipril<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Takipril Must Not Be Given To You<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to prilocaine hydrochloride, other amide-type local anaesthetics, or any of the other ingredients of this medicine (listed in section 6),<\/li><li>If you have serious conduction problems in the heart,<\/li><li>If you suffer from severe\u00a0anaemia,<\/li><li>If you have untreated\u00a0heart failure,<\/li><li>If you are in\u00a0shock\u00a0because the heart&#8217;s pumping ability fails and the amount of blood in the body is too little,<\/li><li>If you suffer from congenital or acquired methemoglobinemia,<\/li><li>If there are general or specific conditions or factors that make the technique used in spinal anaesthesia inappropriate.<\/li><\/ul>\n\n\n\n<p>Takipril must not be injected into a blood vessel. Takipril must not be used in children younger than 6 months.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Precautions<\/h2>\n\n\n\n<p>Talk to your doctor&nbsp;<strong>before<\/strong>&nbsp;receiving Takipril:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have had a severe reaction to an anaesthetic in the past<\/li><li>If you have a skin infection at or near the proposed injection site<\/li><li>If you suffer from any of the following:<ul><li>Diseases of the\u00a0central nervous system\u00a0such as\u00a0meningitis, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/polio\/\">polio<\/a>, and problems with your spinal cord due to lack of\u00a0blood<\/li><li>Severe headache<\/li><li>Tumours\u00a0in the brain,\u00a0spine, or other\u00a0tumours<\/li><li>Tuberculosis\u00a0of the spine<\/li><li>Recently had an injury to the spine<\/li><li>Very low\u00a0blood pressure\u00a0or low blood volume in the body<\/li><li>Problems with the blood&#8217;s ability to clot<\/li><li>Acute\u00a0porphyria<\/li><li>Fluid in the lungs<\/li><li>Blood poisoning<\/li><\/ul><\/li><li>If you have problems with the heart e.g. <ul><li>Total or partial heart block<\/li><li>Heart failure<\/li><li>Rhythm disturbances<\/li><\/ul><\/li><li>If you have liver or kidney problems<\/li><li>If you suffer from a neurological disease, such as\u00a0<ul><li>Multiple sclerosis<\/li><li>Unilateral paralysis<\/li><li>Bilateral paralysis<\/li><li>Neuromuscular diseases<\/li><\/ul><\/li><li>If you have a reduced general condition.<\/li><\/ul>\n\n\n\n<p>Doctors with sufficient knowledge and experience may only give takipril spinal anaesthesia.\u00a0The attending physician is responsible for taking the necessary measures to avoid\u00a0injection\u00a0into a blood vessel and to be able to recognize and treat\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p>Takipril is not recommended for children and adolescents.&nbsp;Takipril&#8217;s safety and efficacy in children and adolescents have not been established.&nbsp;No data is available.<\/p>\n\n\n\n<p>Takipril must not be given to children younger than 6 months due to the increased risk of developing methemoglobinemia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Takipril<\/h2>\n\n\n\n<p>Tell your doctor if you have recently taken or might be taking any other medicines, even those without a prescription.\u00a0This is especially true if you take medicines for irregular heart rhythm (class III\u00a0antiarrhythmics\u00a0) and pain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before receiving this medicine.\u00a0Your doctor will decide if you can receive an\u00a0injection\u00a0of Takipril.\u00a0Prilocaine should not be given for local or regional anaesthesia during labour.<\/p>\n\n\n\n<p>It is not known whether prilocaine passes into breast milk.\u00a0Breastfeeding can be resumed approximately 24 hours after treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving Ability And Use Of Machinery<\/h2>\n\n\n\n<p>Do not drive or work with tools or machines, as Takipril may temporarily affect your ability to react and muscle coordination.<\/p>\n\n\n\n<p>You are responsible for assessing whether you can drive a motor vehicle or perform work requiring increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effects.<\/p>\n\n\n\n<p>A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Taquipril Contains Sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) of\u00a0sodium\u00a0per\u00a0dose\u00a0(maximum\u00a0dose\u00a0of 4 ml Takipril\u00a0solution for injection\u00a0), i.e. it is almost &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Takipril Is Used<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will give you this medicine and decide which\u00a0dose\u00a0is correct.<\/li><li>The usual\u00a0dose\u00a0for adults is 40-60 mg prilocaine hydrochloride (2-3 ml Takipril).\u00a0The maximum\u00a0dose\u00a0is 80 mg prilocaine hydrochloride (4 ml Takipril).<\/li><li>The doctor will give you Takipril in the lower part of your spine while sitting or lying down.<\/li><li>Takipril is not recommended for children and adolescents.\u00a0Takipril&#8217;s safety and efficacy in children and adolescents have not been established.<\/li><li>Takipril must not be given to children younger than 6 months due to the increased risk of developing methemoglobinemia.<\/li><li>In patients with poor general conditions and with diagnosed concomitant diseases (e.g. blockage of blood vessels, arteriosclerosis, disease of peripheral nerves caused by\u00a0diabetes\u00a0(diabetic\u00a0polyneuropathy ), a\u00a0dose\u00a0reduction is\u00a0necessary.<\/li><li>A lower dose level is recommended in case of reduced liver or kidney function.<\/li><li>Takipril is injected into the spinal fluid.<\/li><li>Equipment, drugs and personnel capable of dealing with an emergency must be in the immediate vicinity.\u00a0Rare cases of serious reactions have been reported following local anaesthetics, even in patients who have not previously suffered from hypersensitivity.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If You Have Received Too Much Takipril<\/h2>\n\n\n\n<p>The doctor who gives you Takipril is experienced in giving\u00a0local anaesthetic\u00a0to the spinal cord, so it is unlikely that you will get overdose.\u00a0If a dose is accidentally injected directly into the bloodstream, you may experience <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Short-term vision or hearing problems<\/li><li>Muscle twitching<\/li><li>Tremors<\/li><li>Convulsions (seizures)<\/li><li>Loss of consciousness<\/li><\/ul>\n\n\n\n<p>When you receive Takipril, equipment will be available to treat you if an overdose occurs. If you have any further questions about this medicine, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Takipril Side Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them.<\/p>\n\n\n\n<p>As with all local anaesthetics, arterial pressure may drop, and\u00a0heart rate\u00a0may slow. You may feel nauseous, have low\u00a0blood pressure\u00a0or have a slower heartbeat.\u00a0Other possible\u00a0side effects\u00a0are headaches after surgery, vomiting and difficulty urinating.<\/p>\n\n\n\n<p>Possible&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<p><strong>Very common: may&nbsp;<\/strong><strong>affect more than 1 in 10 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lowered\u00a0blood pressure<\/li><li>Nausea<\/li><\/ul>\n\n\n\n<p><strong>Common: may affect up to 1 in 10 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Numbness<\/li><li>Dizziness<\/li><li>Vomiting<\/li><\/ul>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cramps<\/li><li>Numbness around the mouth<\/li><li>Unconsciousness<\/li><li>Tremors<\/li><li>Tongue numbness<\/li><li>Speech difficulties<\/li><li>Hearing problems<\/li><li>Tinnitus<\/li><li>Visual disturbances<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/back-hurts\/\">Back pain<\/a><\/li><li>Temporary muscle weakness<\/li><li>Slow heartbeat<\/li><li>Increased\u00a0blood pressure<\/li><\/ul>\n\n\n\n<p><strong>Rare: may affect up to 1 in 1,000 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Methemoglobinemia (a disorder in the blood&#8217;s ability to absorb oxygen and release\u00a0carbon dioxide)<\/li><li>Reduced blood oxygenation with bluish skin and lips (cyanosis)<\/li><li>Anaphylactic\u00a0shock<\/li><li>Anaphylactic reactions<\/li><li>Allergic reactions<\/li><li>Itching<\/li><li>Inflammation\u00a0of the\u00a0membranes\u00a0surrounding the spine (arachnoiditis)<\/li><li>Numbness or weakness in the arms and legs (\u00a0neuropathy\u00a0)<\/li><li>Damage to peripheral nerves<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/distinction-and-double-vision-in-adults\/\">Double vision<\/a><\/li><li>Cardiac arrest<\/li><li>Irregular heartbeat<\/li><li>Impaired respiratory function<\/li><\/ul>\n\n\n\n<p>Takipril is unlikely to cause serious\u00a0side effects\u00a0unless it is accidentally given in the wrong way or used with other local anaesthetics.\u00a0If this happens, <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Numb tongue<\/li><li>Clouding<\/li><li>Dizziness<\/li><li>Tremors<\/li><\/ul>\n\n\n\n<p>Convulsions may occur.\u00a0In extremely rare cases, prilocaine has been associated with <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Heart attack<\/li><li>Difficulty breathing<\/li><li>Loss of sensation in the lower part of the body and allergic reactions may cause skin rash, swelling or very low\u00a0blood pressure.<\/li><li>A rare but serious\u00a0side effect\u00a0of takipril spinal anaesthesia is a high or complete spinal cord blockade, which leads to severely reduced cardiovascular\u00a0and\u00a0lung function.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Takipril<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Use before the expiry date stated on the\u00a0ampoules\u00a0and carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store at a maximum of 25 \u00baC.\u00a0Store protected from <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">cold<\/a>.\u00a0Do not freeze.<\/li><li>Store in the original packaging.\u00a0Light sensitive.<\/li><li>Use immediately after opening.<\/li><li>This medicine must not be used if the solution is not clear and free of particles.<\/li><li>Leftover medicine should be thrown away.\u00a0As the medicine is only given in the hospital, the hospital takes care of the destruction.\u00a0These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is prilocaine hydrochloride.<\/li><li>1 ml\u00a0solution for injection\u00a0contains 20 mg prilocaine hydrochloride (equivalent to 2%).<\/li><li>1 ampoule with 5 ml of solution contains 100 mg of prilocaine hydrochloride.<\/li><li>Other ingredients are:<ul><li>Anhydrous\u00a0glucose\u00a0or glucose monohydrate<\/li><li>Sodium hydroxide 1N (for\u00a0pH\u00a0adjustment)<\/li><li>Water for injections<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance And Package Sizes Of The Medicine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Solution for injection.\u00a0Clear colourless solution.<\/li><li>This solution is supplied in clear, colourless\u00a0glass ampoules, type I.<\/li><li>Carton of 10 ampoules, each containing 5 ml\u00a0solution for injection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>B. Braun Melsungen AG<\/p>\n\n\n\n<p>Carl-Braun-Strasse 1<\/p>\n\n\n\n<p>34212 Melsungen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><em>Mailing address:<\/em><\/p>\n\n\n\n<p>34209 Melsungen, Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Sirton Pharmaceuticals SpA<\/p>\n\n\n\n<p>Piazza XX Settembre 2<\/p>\n\n\n\n<p>22079 Villa Guardia (CO)<\/p>\n\n\n\n<p>Italy<\/p>\n\n\n\n<p>Sintetica GmbH<\/p>\n\n\n\n<p>Albersloher Weg 11<\/p>\n\n\n\n<p>48155 &#8211; M\u00fcnster<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Agent<\/strong>&nbsp;: B. Braun Medical AB, Box 110,<\/p>\n\n\n\n<p>182 12 Danderyd<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Takipril is used in adults to provide spinal anaesthesia during short-term surgical procedures.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25189,25180,25182,25183,25184,25188,25181,25186,25185,25187],"class_list":["post-24257","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-takipril","tag-prilocaine-hydrochloride","tag-prilocaine-hydrochloride-benefits","tag-prilocaine-hydrochloride-side-effects","tag-takipril","tag-takipril-side-effects","tag-what-is-prilocaine-hydrochloride","tag-what-is-takipril","tag-what-prilocaine-hydrochloride-is-used-for","tag-what-takipril-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24257"}],"version-history":[{"count":63,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24257\/revisions"}],"predecessor-version":[{"id":47632,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24257\/revisions\/47632"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}