{"id":24252,"date":"2022-08-18T11:28:18","date_gmt":"2022-08-18T11:28:18","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24252"},"modified":"2022-08-20T08:12:10","modified_gmt":"2022-08-20T08:12:10","slug":"takhzyro","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/takhzyro\/","title":{"rendered":"TAKHZYRO &#8211; Lanadelumab uses, dose and side effects"},"content":{"rendered":"\n<p>300 mg\u00a0solution for injection, solution in\u00a0the vial<br>lanadelumab<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What TAKHZYRO is and what it is used for<\/h2>\n\n\n\n<p>TAKHZYRO contains the active substance lanadelumab.<\/p>\n\n\n\n<p><strong>What TAKHZYRO is used for<\/strong><\/p>\n\n\n\n<p>TAKHZYRO is a medicine used in adults and adolescents over 12 years of age to prevent angioedema attacks, in patients with HAE.<\/p>\n\n\n\n<p><strong>What hereditary&nbsp;angioedema&nbsp;(HAE) is<\/strong><\/p>\n\n\n\n<p>HAE is a hereditary disease.&nbsp;In this disease, there is not enough of a&nbsp;protein&nbsp;called &#8220;C1 inhibitor&#8221; in the blood, or the C1 inhibitor does not work properly.&nbsp;This leads to too much plasma kallikrein, which in turn produces higher levels of bradykinin in the blood.&nbsp;Too much bradykinin leads to symptoms of HAE such as swelling and pain in<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hands and feet<\/li><li>eyes, eyelids, lips, or tongue<\/li><li>the larynx,\u00a0which can make breathing difficult<\/li><li>the genitals.<\/li><\/ul>\n\n\n\n<p><strong>How TAKHZYRO works<\/strong><\/p>\n\n\n\n<p>TAKHZYRO is a type of&nbsp;protein&nbsp;that blocks the activity of plasma kallikrein.&nbsp;This helps to reduce the amount of bradykinin in the blood and prevents the symptoms of HAE.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use TAKHZYRO<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use TAKHZYRO<\/h2>\n\n\n\n<p>If you are allergic to lanadelumab or any of the other ingredients of this medicine (listed in section 6).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor, pharmacist, or nurse before using TAKHZYRO.<\/li><li>If you have a serious\u00a0allergic reaction\u00a0to TAKHZYRO with symptoms such as rash, chest tightness, wheezing, or fast heartbeat,\u00a0talk to your doctor, pharmacist or nurse\u00a0<strong>immediately<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Note<\/strong><\/p>\n\n\n\n<p>It is strongly recommended that you write down the name of the medicine and the batch number each time you take a&nbsp;dose&nbsp;of TAKHZYRO.&nbsp;In this way, you can keep track of which production batches were used.<\/p>\n\n\n\n<p><strong>Laboratory tests<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you are using TAKHZYRO before having laboratory tests to measure how well your blood clots.&nbsp;This is because TAKHZYRO in the blood can interfere with certain laboratory tests, leading to incorrect results.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>TAKHZYRO is not recommended for children under 12 years of age.&nbsp;This is because the drug has not been studied in this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and TAKHZYRO<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>TAKHZYRO does not affect other medicines and is not affected by other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before you start using TAKHZYRO.\u00a0There is limited information on the safety of TAKHZYRO when used during pregnancy and breastfeeding.\u00a0For safety reasons, it is recommended to avoid the use of lanadelumab during pregnancy and breastfeeding.\u00a0Your doctor will discuss with you the risks and benefits of taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>This medicine has a negligible effect on the ability to drive and use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TAKHZYRO contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per ml of solution, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use TAKHZYRO<\/h2>\n\n\n\n<p>TAKHZYRO is supplied in single-use vials as a ready-to-use solution.&nbsp;Your treatment will be started and managed under the supervision of a doctor experienced in treating patients with HAE.<\/p>\n\n\n\n<p>Always use this medicine exactly as described in this leaflet or as directed by your doctor, pharmacist, or nurse.\u00a0Consult a doctor, pharmacist, or nurse if you are unsure or if you have further questions about the use of this medicine.<\/p>\n\n\n\n<p><strong>How much TAKHZYRO you should use<\/strong><\/p>\n\n\n\n<p>The recommended starting dose is 300 mg every two weeks.\u00a0If you have not had a seizure for a long period, your doctor may change the\u00a0dose\u00a0by one to 300 mg every 4 weeks, especially if you have low body weight.<\/p>\n\n\n\n<p><strong>How TAKHZYRO is injected<\/strong><\/p>\n\n\n\n<p><strong>If you inject TAKHZYRO yourself or if your healthcare provider injects the medicine, you or your healthcare provider must carefully read and follow the instructions in Section 7, \u201cInstructions for Use\u201d.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>TAKHZYRO is intended for\u00a0injection\u00a0under the skin (&#8220;subcutaneous injection&#8221;).<\/li><li>Injection\u00a0one can either be given by yourself or your healthcare provider.<\/li><li>Your doctor, pharmacist, or nurse should show you how to prepare and inject TAKHZYRO correctly before you use it for the first time.\u00a0Do not inject yourself or someone else until you have been trained to inject the medicine.<\/li><li>Insert the needle into the fatty tissue in the stomach (abdomen), thigh, or upper arm.<\/li><li>Inject the medicine in a new place each time.<\/li><li>Each\u00a0vial\u00a0of TAKHZYRO should be used only once.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much TAKHZYRO&nbsp;<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse if you have used too much TAKHZYRO.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use TAKHZYRO<\/h2>\n\n\n\n<p>If you miss a\u00a0dose\u00a0of TAKHZYRO, inject your\u00a0dose\u00a0as soon as possible, but there must be at least 10 days between\u00a0doses.\u00a0If you are not sure when to inject TAKHZYRO after a missed\u00a0dose, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using TAKHZYRO<\/h2>\n\n\n\n<p>You must continue to inject TAKHZYRO as directed by your doctor, even if you feel better.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you have a serious\u00a0allergic reaction\u00a0to TAKHZYRO with symptoms such as rash, chest tightness, wheezing or fast heartbeat,\u00a0tell your doctor, pharmacist, or nurse, immediately<strong>.<\/strong><\/p>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reactions where an\u00a0injection\u00a0is given &#8211; symptoms can be a pain, redness, bruising, discomfort, swelling, bleeding,\u00a0itching, hardening of the skin, tingling, warmth, and rash.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reactions with e.g.\u00a0itching, discomfort, and tingling in the tongue<\/li><li>Dizziness, feeling faint<\/li><li>Raised skin rash<\/li><li>Muscle pain<\/li><li>Blood tests showing changes in the liver<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store TAKHZYRO<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C \u2013 8 \u00b0C).&nbsp;Do not freeze.&nbsp;Store the vial in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Vials can be stored at a temperature below 25 \u00b0C for a single period of 14 days, but not after the expiry date.&nbsp;Do not return TAKHZYRO to the refrigerator after storage at room temperature.<\/p>\n\n\n\n<p>Do not use this medicine if you see e.g.\u00a0particles in the vial or a change in color of the solution in the vial.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lanadelumab.\u00a0Each\u00a0vial\u00a0(with 2 ml of solution) contains 300 mg of lanadelumab.<\/li><li>Other ingredients are disodium phosphate dihydrate, citric acid monohydrate, histidine, sodium chloride, polysorbate 80, and water for injections &#8211; see section 2 &#8220;TAKHZYRO contains sodium&#8221;<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>TAKHZYRO is supplied as a clear, colorless to slightly yellow\u00a0solution for injection\u00a0in a\u00a0glass\u00a0vial.<\/p>\n\n\n\n<p>TAKHZYRO is available as a single-use pack containing a 2 ml&nbsp;vial&nbsp;and as a multipack with 2 or 6 cartons, where each carton contains 1 vial.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<p>Each pack also contains the following items:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Empty 3 ml&nbsp;syringe<\/li><li>18 G needle with a blunt tip for use in the injection vial<\/li><li>27 G x 13 mm needle with sharp tip for&nbsp;administration&nbsp;(&nbsp;injection&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Takeda Pharmaceuticals International AG Ireland Branch<\/p>\n\n\n\n<p>Block 3 Miesian Plaza<\/p>\n\n\n\n<p>50-58 Baggot Street Lower<\/p>\n\n\n\n<p>Dublin 2<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Phone: +80066838470<\/p>\n\n\n\n<p>Email:&nbsp;<a href=\"http:\/\/medinfoEMEA@shire.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">medinfoEMEA@takeda.com<\/a><\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Takeda Pharmaceuticals International AG Ireland Branch<\/p>\n\n\n\n<p>Block 3 Miesian Plaza<\/p>\n\n\n\n<p>50 \u2013 58 Baggot Street Lower<\/p>\n\n\n\n<p>Dublin 2<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Shire Pharmaceuticals Ireland Limited<\/p>\n\n\n\n<p>Blocks 2 &amp; 3 Miesian Plaza<\/p>\n\n\n\n<p>50-58 Baggot Street Lower<\/p>\n\n\n\n<p>Dublin 2<\/p>\n\n\n\n<p>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TAKHZYRO is a medicine used in adults and adolescents over 12 years of age to prevent angioedema attacks, in patients with HAE.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25191,25196,25198,25190,25195,25197,25192,25193,25194,25199],"class_list":["post-24252","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-lanadelumab","tag-benefits-of-takhzyro","tag-lanadelumab","tag-lanadelumab-side-effects","tag-takhzyro","tag-takhzyro-side-effects","tag-what-is-lanadelumab","tag-what-is-takhzyro","tag-what-lanadelumab-is-used-for","tag-what-takhzyro-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24252"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24252\/revisions"}],"predecessor-version":[{"id":24279,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24252\/revisions\/24279"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}