{"id":24249,"date":"2022-08-18T11:24:20","date_gmt":"2022-08-18T11:24:20","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24249"},"modified":"2022-08-20T08:12:23","modified_gmt":"2022-08-20T08:12:23","slug":"tagrisso","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tagrisso\/","title":{"rendered":"TAGRISSO &#8211; Osimertinib uses, dose and side effects"},"content":{"rendered":"\n<p>40 mg, 80 mg&nbsp;film-coated tablets<br>osimertinib<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What TAGRISSO is and what it is used for<\/h2>\n\n\n\n<p>TAGRISSO contains the active substance osimertinib, which belongs to a group of medicines called protein kinase inhibitors and is used to treat cancer.\u00a0TAGRISSO is used to treat adults with a type of lung cancer called non-small cell lung cancer.\u00a0If a test has shown that your cancer has certain changes (\u00a0mutations\u00a0) in the gene &#8220;EGFR&#8221; (\u00a0epidermal\u00a0growth factor receptor), your cancer will likely respond to treatment with TAGRISSO.\u00a0TAGRISSO can be prescribed:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>after complete removal of your cancer, as a treatment after\u00a0surgery\u00a0(\u00a0adjuvant\u00a0treatment)<br>or<\/li><li>as the first drug cancer treatment, you receive for your cancer that has spread to other parts of the body<\/li><li>in some cases, if you have previously been treated with other protein kinase inhibitors for your cancer.<\/li><\/ul>\n\n\n\n<p><strong>How TAGRISSO works<\/strong><\/p>\n\n\n\n<p>TAGRISSO works by blocking EGFR and can help slow or stop the growth of your lung cancer.&nbsp;It can also help to shrink the size of the tumor and prevent the&nbsp;tumor&nbsp;from coming back after surgical removal.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you receive TAGRISSO after complete removal of your cancer, it means that your cancer contained\u00a0a defect\u00a0(\u00a0mutation\u00a0) in the EGFR gene, &#8220;exon 19 deletion&#8221; or &#8220;exon 21 substitution mutation&#8221;.<\/li><li>If TAGRISSO is the first protein kinase inhibitor you receive, it means that your cancer has a\u00a0defect\u00a0(\u00a0mutation\u00a0) in the EGFR gene, so-called &#8220;exon 19 deletions&#8221; or &#8220;exon 21 substitution&#8221;.<\/li><li>If your cancer worsened while you were taking other protein kinase inhibitors, it means that your cancer has a gene defect (\u00a0mutation\u00a0) called \u201cT790M\u201d.\u00a0This\u00a0defect\u00a0can render other protein kinase inhibitors no longer effective.<\/li><\/ul>\n\n\n\n<p>If you have any questions about how this medicine works or why you have been prescribed this medicine, ask your doctor.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take TAGRISSO<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take TAGRISSO:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to osimertinib or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you take&nbsp;St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p>If you are not sure, talk to your doctor, pharmacist, or nurse before taking TAGRISSO.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking TAGRISSO:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have had&nbsp;inflammation&nbsp;of the lungs (a condition called interstitial lung disease).<\/li><li>if you&#8217;ve ever had heart problems \u2013 your doctor may want to monitor you.<\/li><li>if you have had eye problems.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor, pharmacist or nurse before taking this medicine.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately while you are taking this medicine if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you suddenly have difficulty breathing along with a cough or fever.<\/li><li>you have widespread scaling of the skin.<\/li><li>you experience fast or irregular heartbeats, dizziness, lightheadedness, chest discomfort, shortness of breath, and fainting.<\/li><li>you have watery eyes, sensitivity to light, eye pain, red eyes, or vision changes.<br>See \u201cSerious side effects\u201d in section 4 for more information.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>TAGRISSO has not been studied in children or adolescents.&nbsp;Do not give this medicine to children or adolescents under 18 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and TAGRISSO<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This includes (traditional) herbal and herbal medicines and medicines bought without a prescription.\u00a0The reason for this is that TAGRISSO can affect the function of certain other medicines.\u00a0Some other medicines can also affect how TAGRISSO works.<\/p>\n\n\n\n<p><strong>Tell your doctor if you are taking any of the following medicines before taking TAGRISSO:<\/strong><\/p>\n\n\n\n<p>The following medicines may reduce how well TAGRISSO works:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>phenytoin, carbamazepine, or phenobarbital \u2013 used for epileptic seizures.<\/li><li>rifabutin or rifampicin \u2013 used for\u00a0tuberculosis\u00a0(TB).<\/li><li>St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0) \u2013 is a (traditional) herbal medicine used to treat mild depression and mild anxiety.<\/li><\/ul>\n\n\n\n<p>TAGRISSO can affect how well the following medicines work and\/or increase the&nbsp;side effects&nbsp;of these medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rosuvastatin \u2013 used to lower\u00a0cholesterol<\/li><li>Birth control pills\u00a0\u2013 used to prevent pregnancy<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">Bosentan<\/a>\u00a0\u2013 used for high\u00a0blood pressure\u00a0in the lungs<\/li><li>Efavirenz and etravirine \u2013 used to treat\u00a0HIV\u00a0infections\/AIDS<\/li><li>Modafinil \u2013 used for sleep disorders.<\/li><li>Dabigatran \u2013 is used to prevent blood clots.<\/li><li>Digoxin\u00a0\u2013 used for irregular heartbeats or other heart problems.<\/li><li>Aliskiren \u2013 used for high\u00a0blood pressure.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor if you are taking any of the medicines listed above before taking&nbsp;<\/strong><strong>TAGRISSO.&nbsp;<\/strong>&nbsp;Your doctor will discuss appropriate treatment options with you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy information for women<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant, think you may be pregnant, or are planning to have a baby, consult your doctor before taking this medicine.\u00a0If you become pregnant during treatment, tell the doctor immediately.\u00a0Your doctor will decide whether you should continue taking TAGRISSO or not.<\/li><li>You should not become pregnant while taking this medicine.\u00a0If you are\u00a0fertile, you must use effective contraception.\u00a0See &#8220;Contraceptives &#8211; information for women and men&#8221; below.<\/li><li>Ask your doctor for advice if you plan to become pregnant after you have taken the last\u00a0dose\u00a0of this medicine.\u00a0This is because a certain amount of medicine may remain in your body (see advice on contraception below).<\/li><\/ul>\n\n\n\n<p><strong>Pregnancy information for men<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your partner becomes pregnant while you are taking this medicine, tell your doctor immediately.<\/li><\/ul>\n\n\n\n<p><strong>Contraceptives &#8211; information for women and men<\/strong><\/p>\n\n\n\n<p>You must use effective contraception during treatment.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>TAGRISSO can interfere with the function of\u00a0birth control pills.\u00a0Discuss the most appropriate birth control methods with your doctor.<\/li><li>TAGRISSO can be transferred to semen.\u00a0Therefore, it is important that men also use an effective contraceptive.<\/li><\/ul>\n\n\n\n<p>You must also do this after finishing treatment with TAGRISSO:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Women<\/strong>\u00a0\u2013 continue to use contraception for 2 months afterward.<\/li><li>Men\u00a0&#8211; continue to use contraception for 4 months afterward.<\/li><\/ul>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Do not breastfeed while taking this medicine.\u00a0This is because it has not been determined whether there is a risk to your child.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>TAGRISSO has no or no apparent effect on the ability to drive and use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TAGRISSO contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per tablet, i.e.&nbsp;is almost &#8220;sodium-free&#8221;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take TAGRISSO<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much should you take?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;is one 80 mg tablet a day.<\/li><li>If necessary, your doctor can reduce your&nbsp;dose&nbsp;to one 40 mg tablet a day.<\/li><\/ul>\n\n\n\n<p><br><strong>How to take TAGRISSO<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>TAGRISSO is taken orally.\u00a0Swallow the tablet whole with water.\u00a0The tablet should not be crushed, split, or chewed.<\/li><li>Take TAGRISSO every day at the same time.<\/li><li>You can take this medicine with or without food.<\/li><\/ul>\n\n\n\n<p>If you have trouble swallowing the tablet, you can mix it with water:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Place the tablet in a glass.<\/li><li>Add 50ml (about two-thirds of a drinking glass) of still water.\u00a0Do not use any other liquids.<\/li><li>Stir the water until the tablet crumbles into very small pieces.\u00a0The tablet will not dissolve completely.<\/li><li>Drink the liquid immediately.<\/li><li>To make sure you have taken all the medicine, rinse the glass thoroughly with another 50 ml of water and drink it.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much TAGRISSO<\/h2>\n\n\n\n<p>If you take more than your normal\u00a0dose, contact your doctor or nearest hospital immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take TAGRISSO<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, take it as soon as you remember.\u00a0However, if it is less than 12 hours until the next\u00a0dose\u00a0is due, skip the missed\u00a0dose.\u00a0Take the next normal\u00a0dose\u00a0at the scheduled time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking TAGRISSO<\/h2>\n\n\n\n<p>Do not stop taking this medicine without talking to your doctor first.\u00a0You must take this medicine every day, for as long as your doctor prescribes it for you.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you experience any of the following serious&nbsp;side effects&nbsp;(see also section 2):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden difficulty breathing along with cough or fever.\u00a0This may be a sign of\u00a0inflammation\u00a0in the lungs (a condition called interstitial lung disease).\u00a0Most cases can be treated but some cases have been fatal.\u00a0Your doctor may stop your treatment with TAGRISSO if you experience this\u00a0side effect.\u00a0This\u00a0side effect\u00a0is common: it may affect up to 1 in 10 users.<\/li><li>Stevens-Johnson syndrome, which may appear as a red-violet target-like rash or as round spots on the trunk often with central blistering, scaling of the skin, sores in the mouth, throat, nose, genitals, and eyes, and may be preceded by fever and\u00a0flu-like symptoms.\u00a0This side effect is rare: it may affect up to 1 in 1,000 users.<\/li><li>Changes in the electrical activity of the heart (QTc prolongation) such as fast or irregular heartbeats, dizziness, lightheadedness, chest discomfort, shortness of breath, or fainting.\u00a0This side effect is less common: it may affect up to 1 in 100 users.<\/li><li>If you get watery eyes, sensitivity to light, eye pain, redness in the eye or vision changes.\u00a0This\u00a0side effect\u00a0is less common: it may affect up to 1 in 100 users.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if you experience any of the serious&nbsp;side effects&nbsp;listed above.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effect&nbsp;ar<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea \u2013 may come and go during treatment.\u00a0Tell your doctor if the diarrhea does not go away or becomes severe.<\/li><li>Skin and nail problems &#8211; signs may include pain,\u00a0itching\u00a0, dry skin, rash and\u00a0redness\u00a0around the fingernails.\u00a0This is more common in areas exposed to sunlight.\u00a0Regular use of moisturizing\u00a0cream\u00a0on skin and nails can help.\u00a0Tell your doctor if your skin and nail problems get worse.<\/li><li>Stomatitis\u00a0\u2013\u00a0inflammation\u00a0of the mouth or ulcers that form in the mouth.<\/li><li>Loss of appetite.<\/li><li>Reduction in the number of white blood cells (\u00a0leukocytes,\u00a0lymphocytes,\u00a0or\u00a0neutrophils\u00a0).<\/li><li>Reduction in the number of\u00a0platelets\u00a0in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Epistaxis (&nbsp;epistaxis&nbsp;).<\/li><li>Hair loss (&nbsp;alopecia&nbsp;).<\/li><li>Hives (&nbsp;urticaria&nbsp;) \u2013 itchy, raised patches anywhere on the skin.&nbsp;These can be pink or red and round in shape.&nbsp;Tell your doctor if you experience this side effect.<\/li><li>Hand-foot syndrome \u2013 this may include&nbsp;redness&nbsp;, swelling, stinging or burning with cracking of the skin on the palms of the hands and\/or soles of the feet.<\/li><li>Increase in a substance in the blood called&nbsp;creatinine&nbsp;(made by the body and removed by the kidneys).<\/li><li>Abnormal blood test results related to blood creatine phosphokinase (an&nbsp;enzyme&nbsp;released into the blood when muscles are damaged).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Target-like rash, which are ring-like skin reactions (suggesting erythema multiforme).<\/li><li>Inflammation&nbsp;of the blood vessels in the skin.&nbsp;It may look like bruises or&nbsp;redness&nbsp;of the skin that does not fade in color when pressed.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the muscles that can cause muscle pain or weakness<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store TAGRISSO<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the blister and carton after &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Do not use this medicine if the package is damaged or shows signs of having been opened.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is osimertinib (as mesylate).&nbsp;Each 40 mg film-coated tablet contains 40 mg osimertinib.&nbsp;Each 80 mg film-coated tablet contains 80 mg osimertinib.<\/li><li>Other ingredients are mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sodium stearyl fumarate, polyvinyl alcohol, titanium dioxide, macrogol 3350, talc, yellow iron oxide, red iron oxide and black iron oxide (see section 2 &#8220;TAGRISSO contains sodium&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>TAGRISSO 40 mg is supplied as beige, film-coated, round and biconvex tablets, marked with \u201cAZ\u201d and \u201c40\u201d on one side and blank on the other.<\/p>\n\n\n\n<p>TAGRISSO 80 mg is supplied as beige, film-coated, oval and biconvex tablets, marked with \u201cAZ\u201d and \u201c80\u201d on one side and blank on the other.<\/p>\n\n\n\n<p>TAGRISSO is supplied in blisters containing 30 x 1 film-coated tablets, packaged in cartons containing 3 blisters of 10 tablets each.<\/p>\n\n\n\n<p>TAGRISSO is supplied in blisters containing 28 x 1 film-coated tablets, packaged in cartons containing 4 blisters of 7 tablets each.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>AstraZeneca AB<\/p>\n\n\n\n<p>SE-151 85 S\u00f6dert\u00e4lje<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>AstraZeneca SA\/NVPhone: +32 2 370 48 11<\/td><td><strong>Lithuania<\/strong>UAB AstraZeneca LietuvaPhone: +370 5 266 0550<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>AstraZeneca Bulgaria EOODTel.: +359 244 55 000<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>AstraZeneca SA\/NVT\u00e9l\/Tel: +32 2 370 48 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>AstraZeneca Czech Republic s.r.oPhone: +420 222 807 111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>AstraZeneca Kft.Phone: +36 1 883 6500<\/td><\/tr><tr><td><strong>Denmark<\/strong>AstraZeneca A\/SPhone: +45 43 66 64 62<\/td><td><strong>Malta<\/strong>Associated Drug Co.&nbsp;LtdPhone: +356 2277 8000<\/td><\/tr><tr><td><strong>Deutschland<\/strong>AstraZeneca GmbHPhone: +49 40 80 90 34100<\/td><td><strong>The Netherlands<\/strong>AstraZeneca BVPhone: +31 79 363 2222<\/td><\/tr><tr><td><strong>Estonia<\/strong>AstraZenecaPhone: +372 6549 600<\/td><td><strong>Norway<\/strong>AstraZeneca iPhone: +47 21 00 64 00<\/td><\/tr><tr><td><strong>Greece<\/strong>AstraZeneca AETel: +30 210 687 1500<\/td><td><strong>Austria<\/strong>AstraZeneca \u00d6sterreich GmbHPhone: +43 1 711 31 0<\/td><\/tr><tr><td><strong>Spain<\/strong>AstraZeneca Farmac\u00e9utica Spain, SAPhone: +34 91 301 91 00<\/td><td><strong>Polish<\/strong>AstraZeneca Pharma Poland Sp.\u00a0z o. iPhone: +48 22 245 73 00<\/td><\/tr><tr><td><strong>France<\/strong>AstraZenecaTel: +33 1 41 29 40 00<\/td><td><strong>Portugal<\/strong>AstraZeneca Produtos Farmac\u00eauticos, Lda.Phone: +351 21 434 61 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>AstraZeneca dooPhone: +385 1 4628 000<\/td><td><strong>Romania<\/strong>AstraZeneca Pharma SRLPhone: +40 21 317 60 41<\/td><\/tr><tr><td><strong>Ireland<\/strong>AstraZeneca Pharmaceuticals (Ireland) DACPhone: +353 1609 7100<\/td><td><strong>Slovenija<\/strong>AstraZeneca UK LimitedPhone: +386 1 51 35 600<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>AstraZeneca AB, ozone: +421 2 5737 7777<\/td><\/tr><tr><td><strong>Italy<\/strong>AstraZeneca S.p.iPhone: +39 02 00704500<\/td><td><strong>Finland\/Finland<\/strong>AstraZeneca OyPhone\/Tel: +358 10 23 010<\/td><\/tr><tr><td><strong>Cyprus<\/strong>\u0391\u03bb\u03ad\u03ba\u03c4\u03c9\u03c1 \u03a6\u03b1\u03c1\u00b5\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u039b\u03c4\u03b4Phone: +357 2249 0305<\/td><td><strong>Sweden<\/strong>AstraZeneca ABPhone: +46 8 553 26 000<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA AstraZeneca LatvijaPhone: +371 67377100<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>AstraZeneca UK LtdPhone: +44 1582 836 836<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>TAGRISSO contains the active substance osimertinib, which belongs to a group of medicines called protein kinase inhibitors and is used to treat cancer.\u00a0TAGRISSO is used to treat adults with a type of lung cancer called non-\u00a0small cell lung cancer\u00a0.\u00a0If a test has shown that your cancer has certain changes (\u00a0mutations\u00a0) in the gene &#8220;EGFR&#8221; (\u00a0epidermal\u00a0growth factor receptor), your cancer will likely respond to treatment with TAGRISSO.\u00a0TAGRISSO can be prescribed:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25204,25200,25205,25201,25206,25209,25210,25203,25207,25202,25208],"class_list":["post-24249","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-osimertinib","tag-osimertinib","tag-osimertinib-side-effects","tag-osimertinib-tablet","tag-tagrisso","tag-tagrisso-side-effects","tag-tagrisso-tablet","tag-what-is-osimertinib","tag-what-is-tagrisso","tag-what-osimertinib-is-used-for","tag-what-tagrisso-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24249"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24249\/revisions"}],"predecessor-version":[{"id":24280,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24249\/revisions\/24280"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}