<\/a><\/p>\n\n\n\nIf you have taken too much Tacni<\/h2>\n\n\n\n
If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.
<\/p>\n\n\n\n
If you forget to take Tacni<\/h2>\n\n\n\n
Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.
If you forget to take your capsules, wait until it is time for your next\u00a0dose\u00a0and then continue as usual.
<\/p>\n\n\n\n
If you stop taking Tacni<\/h2>\n\n\n\n
Stopping treatment may increase the risk of rejection of your transplanted organ.\u00a0Do not stop your treatment until your doctor tells you to.
If you have further questions about this medicine, contact your doctor or pharmacist.<\/strong>
<\/p>\n\n\n\nPossible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n
Tacni reduces your body’s own defense mechanisms to prevent you from rejecting the transplanted organ.\u00a0As a result, your body will not be as good as usual at fighting\u00a0infection.\u00a0If you take Tacni, you may therefore get more\u00a0infections\u00a0than usual, such as\u00a0infections\u00a0in the skin, mouth, gastrointestinal tract, lungs, liver, urinary tract, and nervous system.<\/p>\n\n\n\n
Serious\u00a0side effects, including those listed below, may occur.\u00a0Contact your doctor immediately if you have or suspect you may have any of the following serious side effects:<\/p>\n\n\n\n
- Infections\u00a0(caused by bacteria, fungi,\u00a0viruses,\u00a0and\u00a0protozoa\u00a0): prolonged diarrhea, fever, and sore throat<\/li>
- Benign and malignant\u00a0tumors\u00a0(\u00a0lymphoma\u00a0) have been reported after treatment, as a result of immunosuppression.<\/li>
- Thrombotic thrombocytopenic purpura (or TTP): a condition characterized by fever and bruising under the skin that may look like red pin-sized dots, with or without unexplained extreme fatigue, confusion, yellowing of the skin or eyes (jaundice), with symptoms of\u00a0acute\u00a0kidney failure\u00a0(low or no urine production).<\/li>
- Cases of pure erythrocyte aplasia (a very severe decrease in the number of\u00a0red blood cells\u00a0) and\u00a0hemolytic anemia\u00a0(decreased number of\u00a0red blood cells\u00a0due to increased breakdown, accompanied by fatigue) and febrile\u00a0neutropenia\u00a0(a decrease in the white blood cells that fight\u00a0infection, accompanied by fever) has been reported.\u00a0It is not known exactly how often these\u00a0side effects\u00a0occur.\u00a0You may be asymptomatic or experience symptoms such as fatigue,\u00a0apathy, abnormal pallor, shortness of breath, dizziness, headache, chest pain, and cold hands and feet, depending on the severity of the condition.<\/li>
- Cases of\u00a0agranulocytosis\u00a0(severe reduction in the number of\u00a0white blood cells\u00a0along with mouth sores, fever, and\u00a0infection\u00a0(s)).\u00a0You may be symptom-free or experience symptoms such as sudden fever, stiffness, and sore throat.<\/li>
- Allergic and anaphylactic reactions with the following symptoms: sudden itchy rash (\u00a0hives\u00a0), swelling of the hands, feet, ankles, face, lips, mouth, or throat (which may cause difficulty in swallowing or breathing) and you may feel that you are about to faint.<\/li>
- Posterior\u00a0Reversible\u00a0Encephalopathy\u00a0Syndrome (PRES): headache, altered mental status, epileptic seizures, and visual disturbances.<\/li>
- Torsades de Pointes:\u00a0change in heart rate that may, but may not, be accompanied by symptoms such as chest pain (angina), weakness, dizziness or nausea, palpitations, and difficulty breathing.<\/li>
- Gastrointestinal\u00a0perforation: severe abdominal pain possibly accompanied by other symptoms, such as chills, fever, nausea, or vomiting.<\/li>
- Stevens-Johnson syndrome: unexplained widespread skin pain, facial swelling, severe illness with blistering of the skin, mouth, eyes, and genitals,\u00a0hives, swollen tongue, the red or purple rash that spreads, flaky skin.<\/li>
- Toxic\u00a0epidermal\u00a0necrolysis: lesions and blisters on the skin or mucous membranes, red swollen skin that can detach from large parts of the body.<\/li>
- The hemolytic uremic syndrome is a condition with the following symptoms: low or no urine production (\u00a0acute\u00a0kidney failure\u00a0), extreme fatigue, yellowing of the skin or eyes (jaundice), and abnormal bruising or bleeding and signs of\u00a0infection.<\/li>
- Inadequate function of the transplanted organ<\/li><\/ul>\n\n\n\n
The side effects listed below may also occur after you receive Tacni:<\/p>\n\n\n\n
Very common (may affect more than 1 in 10 users):<\/strong><\/p>\n\n\n\n- increased blood sugar,\u00a0diabetes mellitus, increased level of\u00a0potassium\u00a0in the blood<\/li>
- sleep difficulties<\/li>
- tremors, headache<\/li>
- increased\u00a0blood pressure<\/li>
- diarrhea, nausea<\/li>
- kidney problems<\/li><\/ul>\n\n\n\n
Common (may affect up to 1 in 10 users):<\/strong><\/p>\n\n\n\n- changes in the number of certain\u00a0blood cells\u00a0(e.g. red or\u00a0white blood cells,\u00a0platelets\u00a0),<\/li>
- decrease in\u00a0magnesium,\u00a0phosphate,\u00a0potassium,\u00a0calcium,\u00a0or\u00a0sodium\u00a0in the blood, increased water content in the body, increased amount of\u00a0uric acid\u00a0or fats in the blood, decreased appetite, increased acid content in the blood, and other changes in blood salts (seen by blood tests).<\/li>
- anxiety, confusion, disorientation, depression, mood changes, nightmares, hallucinations, mental illness<\/li>
- convulsions, disturbances of consciousness, tingling and numbness (sometimes painful) in the hands and feet, dizziness, impaired writing ability, nervous disorders<\/li>
- blurred vision, increased sensitivity to light, eye diseases<\/li>
- earrings<\/li>
- reduced blood flow in the\u00a0vessels\u00a0of the heart, faster heartbeat<\/li>
- bleeding, partial or complete blockage of blood vessels decreased\u00a0blood pressure.<\/li>
- shortness of breath, changes in lung tissue, fluid accumulation around the lung,\u00a0inflammation\u00a0of the pharynx, cough,\u00a0flu-like symptoms<\/li>
- inflammation\u00a0or ulcers causing abdominal pain or diarrhea, bleeding in the stomach,\u00a0inflammation\u00a0or ulcers in the mouth, fluid retention in the abdomen, vomiting, abdominal pain, indigestion, constipation, flatulence, flatulence, loose stools, stomach problems<\/li>
- changes in liver enzyme values \u200b\u200band function, yellowing of the skin due to liver problems, damage to liver tissue, and inflammation of the liver<\/li>
- itching, rash, hair loss,\u00a0acne, increased sweating<\/li>
- pain in the joints, legs or arms, back and feet, muscle cramps<\/li>
- insufficient kidney function decreased urine production, impaired or painful urination<\/li>
- general weakness, fever, fluid accumulation in the body, pain, and discomfort, increase in\u00a0enzymes\u00a0and alkaline phosphatases in the blood, weight gain, the sensation of disturbed temperature perception<\/li><\/ul>\n\n\n\n
Uncommon (may affect up to 1 in 100 users):<\/strong><\/p>\n\n\n\n- changes in the clotting ability of the blood, reduction in the number of all types of\u00a0blood\u00a0cells<\/li>
- dehydration, decrease in\u00a0protein\u00a0or sugar in the blood, increase in\u00a0phosphate\u00a0in the blood<\/li>
- coma, cerebral hemorrhage,\u00a0stroke, paralysis, brain disease, speech and language difficulties, memory problems<\/li>
- cloudiness in the lens of the eye<\/li>
- impaired hearing<\/li>
- irregular heartbeats, cardiac arrest, decreased force of the heart, heart muscle disease, enlargement of the heart muscle, stronger heartbeat, abnormal\u00a0EKG, abnormal\u00a0pulse\u00a0and heart rate<\/li>
- insufficient blood flow to\u00a0tissues\u00a0(resulting in cell death), blood clot in a vein in a leg or arm,\u00a0shock<\/li>
- breathing difficulties, respiratory disease,\u00a0asthma<\/li>
- obstruction of the intestinal passage, increased blood level of the\u00a0enzyme\u00a0amylase, acid reflux, delayed emptying of the stomach<\/li>
- skin inflammation, burning sensation in the sun<\/li>
- joint diseases<\/li>
- inability to urinate, painful periods, and abnormal menstrual bleeding<\/li>
- failure of certain organs,\u00a0flu-like symptoms, increased sensitivity to heat and cold, pressure on the chest, nervousness or abnormal feeling, increase in the\u00a0enzyme\u00a0lactate\u00a0dehydrogenase\u00a0in the blood, weight loss<\/li><\/ul>\n\n\n\n
Rare (may affect up to 1 in 1,000 users):<\/strong><\/p>\n\n\n\n- small bleeding in the skin due to blood clots<\/li>
- increased muscle stiffness<\/li>
- blindness<\/li>
- deafness<\/li>
- accumulation of fluid around the heart<\/li>
- acute breathing difficulties<\/li>
- cyst formation in the pancreas<\/li>
- problems with blood flow in the liver<\/li>
- increased hair growth<\/li>
- thirst falls, feeling of pressure on the chest, reduced mobility, ulcers<\/li><\/ul>\n\n\n\n
Very rare (may affect up to 1 in 10,000 users):<\/strong><\/p>\n\n\n\n- muscle weakness<\/li>
- abnormal echocardiogram<\/li>
- liver failure, narrowing of the bile duct<\/li>
- painful urination with blood in the urine<\/li>
- the increased amount of adipose tissue<\/li><\/ul>\n\n\n\n
Frequency not known (cannot be estimated from available data):<\/strong><\/p>\n\n\n\n- optic nerve involvement ( optic neuropathy )<\/li><\/ul>\n\n\n\n
How to store Tacni<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Use before the expiry date stated after Exp. date\/EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n
Store at a maximum of 30 \u00b0C.<\/p>\n\n\n\n
Store in the original packaging (in the aluminum bag). Light sensitive. Moisture sensitive.<\/p>\n\n\n\n
From the time the aluminum bag is opened, the product must be used within 1 year.<\/p>\n\n\n\n
Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.
<\/p>\n\n\n\n
Contents of the packaging and other information<\/h2>\n\n\n\nContents declaration<\/h2>\n\n\n\n
0.5 mg<\/strong>
The active substance is tacrolimus. Each capsule contains 0.5 mg tacrolimus.
Other ingredients are:<\/p>\n\n\n\n- Capsule contents: Povidone K-30, croscarmellose sodium (E 468),\u00a0lactose, magnesium stearate.<\/li>
- Capsule shell: Titanium dioxide (E 171), yellow iron oxide (E 172), gelatin.<\/li><\/ul>\n\n\n\n
1 mg<\/strong><\/p>\n\n\n\nThe active substance is tacrolimus. Each capsule contains 1 mg tacrolimus.
Other ingredients are:<\/p>\n\n\n\n
- Capsule contents: Povidone K-30, croscarmellose sodium (E 468),\u00a0lactose, magnesium stearate.<\/li>
- Capsule shell: Titanium dioxide (E 171), gelatin.<\/li><\/ul>\n\n\n\n
5 mg<\/strong><\/p>\n\n\n\nThe active substance is tacrolimus. Each capsule contains 5 mg tacrolimus.
Other ingredients are:<\/p>\n\n\n\n
- Capsule contents: Povidone K-30, croscarmellose sodium (E 468),\u00a0lactose, magnesium stearate.<\/li>
- Capsule shell: Titanium dioxide (E 171), red iron oxide (E 172), gelatin.<\/li><\/ul>\n\n\n\n
Appearance and package sizes of the medicine<\/h2>\n\n\n\n
0.5 mg<\/strong><\/p>\n\n\n\nIvory-colored cap and ivory-colored hard capsule shell with white powder.<\/p>\n\n\n\n
1 mg<\/strong><\/p>\n\n\n\nWhite cap and white hard capsule shell with white powder.<\/p>\n\n\n\n
5 mg<\/strong><\/p>\n\n\n\nRed cap and red hard capsule shell with white powder.<\/p>\n\n\n\n
The hard capsules are supplied in blister cards of 10 capsules in a protective aluminum bag with a desiccant to protect the capsules from moisture. The desiccant must not be swallowed.<\/p>\n\n\n\n
Tacni is supplied in blister packs of 20, 30, 50, 50 x 1, 60, 90, and 100 capsules containing blister cards of 10 capsules each.<\/p>\n\n\n\n
Not all pack sizes may be marketed.
<\/a><\/p>\n\n\n\nMarketing authorization holder and manufacturer<\/h2>\n\n\n\n
Marketing <\/em><\/p>\n\n\n\nManufacturer:<\/em>
Laboratorios Cinfa, SA, Olaz-Chipi, 10-Pol\u00edg Areta 31620 Huarte-Pamplona, \u200b\u200bNavarre, Spain<\/p>\n\n\n\nPharmachemie BV, Swensweg 5, 2031 GA Haarlem, The Netherlands<\/p>\n\n\n\n
Teva Pharma BV, Swensweg 5, 2031 GA Haarlem, The Netherlands<\/p>\n\n\n\n
Teva Operations Poland Sp. z o. o., Ul. Mogilska 80, 31-546 Krak\u00f3w, Poland<\/p>\n","protected":false},"excerpt":{"rendered":"
Tacni belongs to a group of medicines called immunosuppressants.\u00a0After your organ transplant (e.g. liver, kidney, heart), your body’s immune system tries to reject the new organ.\u00a0Tacni is used to control your body’s immune system to accept the transplanted organ.\u00a0Tacni is often used in combination with other drugs that also suppress the immune system.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25125,11513,25122,25126,4095,4097,25123,4096,25124,11512],"class_list":["post-24185","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tacni","tag-benefits-of-tacrolimus","tag-tacni","tag-tacni-side-effects","tag-tacrolimus","tag-tacrolimus-side-effects","tag-what-is-tacni","tag-what-is-tacrolimus","tag-what-tacni-is-used-for","tag-what-tacrolimus-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24185"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24185\/revisions"}],"predecessor-version":[{"id":24230,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24185\/revisions\/24230"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24185"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}