{"id":24184,"date":"2022-08-17T10:13:43","date_gmt":"2022-08-17T10:13:43","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24184"},"modified":"2022-08-18T11:06:58","modified_gmt":"2022-08-18T11:06:58","slug":"tacforius","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/tacforius\/","title":{"rendered":"Tacforius &#8211; Tacrolimus uses, dose and side effects"},"content":{"rendered":"\n<p>0.5 mg, 1 mg, 3 mg, 5 mg&nbsp;hard prolonged<br>-release capsules tacrolimus<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Tacforius is and what it is used for<\/h2>\n\n\n\n<p>Tacforius contains the active substance tacrolimus.\u00a0It is an immunosuppressive drug.\u00a0After an organ transplant (liver, kidney), the body&#8217;s immune system tries to reject the new organ.\u00a0Tacforius is used to control your body&#8217;s immune system so that it accepts the transplanted organ.<\/p>\n\n\n\n<p>You may also be given Tacforius for an ongoing rejection reaction against your transplanted liver, kidney, heart, or another organ when other treatment you received failed to control the immune system after your transplant.<\/p>\n\n\n\n<p>Tacforius is used for adults.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Tacforius<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Tacforius<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to tacrolimus or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to sirolimus or any macrolide antibiotic (eg erythromycin, clarithromycin, josamycin).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Tacrolimus immediate-release\u00a0capsules (eg Tacni) and Tacforius prolonged-release capsules both contain the active substance tacrolimus.\u00a0However, Tacforius prolonged-release capsules are taken once daily, while tacrolimus immediate-release\u00a0capsules are taken twice daily.\u00a0This is because Tacforius prolonged-release capsules have a delayed\u00a0release\u00a0(slower\u00a0release\u00a0over a longer period) of tacrolimus.\u00a0Tacforius prolonged-release capsules and tacrolimus immediate-release\u00a0capsules are not interchangeable.<\/p>\n\n\n\n<p>Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are taking any medicines mentioned below under the heading &#8220;Other medicines and Tacforius&#8221;.<\/li><li>if you have or have had liver problems<\/li><li>if you have diarrhea that lasts more than a day<\/li><li>if you experience severe abdominal pain, possibly accompanied by other symptoms, such as chills, fever, nausea, or vomiting<\/li><li>if you have a change in the heart rhythm, so-called &#8220;QT prolongation&#8221;.<\/li><\/ul>\n\n\n\n<p>Avoid taking herbal medicines, e.g.&nbsp;St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;) or other herbal products as this may affect the effectiveness of Tacforius and the&nbsp;dose&nbsp;you need to take.&nbsp;If in doubt, consult your doctor before taking any herbal medicines or products.<br><\/p>\n\n\n\n<p>Your doctor may need to adjust the&nbsp;dose&nbsp;of Tacforius.<\/p>\n\n\n\n<p>You should have regular contact with your doctor, who may occasionally need to perform blood, urine, heart function, and eye tests to determine the correct\u00a0dose\u00a0of Tacforius.<\/p>\n\n\n\n<p>You should limit exposure to sunlight and UV light (ultraviolet light) while taking Tacforius.&nbsp;This is because immunosuppressive drugs can increase the risk of getting skin cancer.&nbsp;Use suitable protective clothing and sunscreen with a high sun protection factor.<br><\/p>\n\n\n\n<p>Handling Precautions:<\/p>\n\n\n\n<p>Direct contact with any part of the body, for example, skin or eyes, or inhalation of the powder in the capsules should be avoided.\u00a0In case of such contact, skin and eyes must be rinsed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Tacforius is not recommended for children and adolescents under the age of 18.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Tacforius<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Concomitant treatment with Tacforius and ciclosporin (another medicine used to prevent rejection of transplanted organs) is not recommended.<\/p>\n\n\n\n<p><br><strong>If you need to see a doctor other than your transplant specialist, tell the doctor you are taking tacrolimus.&nbsp;The doctor may need to consult with your transplant specialist if you are going to use another medicine that can increase or decrease the concentration of tacrolimus in the blood.<\/strong><\/p>\n\n\n\n<p>Blood concentrations of Tacforius may be affected by other medicines you are taking and blood levels of other medicines may be affected by your taking Tacforius, which means that the\u00a0dosage\u00a0of Tacforius may need to be stopped, increased, or decreased.<br><\/p>\n\n\n\n<p>In some patients, tacrolimus blood concentrations have increased when they took other medicines at the same time.\u00a0This can lead to serious\u00a0side effects, such as problems with the kidneys and nervous system and heart rhythm disturbances (see section 4).<\/p>\n\n\n\n<p>The influence on the concentrations of Tacforius in the blood can occur very quickly after another medicine has started to be used.\u00a0Therefore, continuous repeated monitoring of the concentration of Tacforius in the blood may be necessary for the first days after you start taking another medicine and at frequent intervals as long as the treatment with the other medicine is ongoing.\u00a0Some other medicines can reduce the concentration of tacrolimus in the blood, which can increase the risk of transplant rejection.<br>You should especially tell your doctor if you are taking or have recently taken medicines such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs against fungal infections and\u00a0antibiotics, especially so-called macrolide antibiotics that are used to treat\u00a0infections, e.g.\u00a0ketoconazole,\u00a0fluconazole, itraconazole, posaconazole, voriconazole, clotrimazole, isavuconazole,\u00a0miconazole, telithromycin, erythromycin, clarithromycin, josamycin, azithromycin, rifampicin, rifabutin,\u00a0isoniazid\u00a0and flucloxacillin<\/li><li>letermovir is used to prevent diseases caused by\u00a0CMV\u00a0( human\u00a0cytomegalovirus\u00a0)<\/li><li>HIV\u00a0&#8211;\u00a0protease inhibitors\u00a0(eg ritonavir, nelfinavir, saquinavir), the booster drug cobicistat and combination tablets, or HIV non-nucleoside reverse transcriptase inhibitors\u00a0(\u00a0efavirenz, etravirine, nevirapine) used to treat\u00a0HIV\u00a0&#8211;\u00a0infection<\/li><li>HCV\u00a0protease\u00a0inhibitors\u00a0(eg, telaprevir, boceprevir, the combination ombitasvir\/paritaprevir\/ritonavir with or without dasabuvir, elbasvir\/grazoprevir and glecaprevir\/pibrentasvir), used to treat\u00a0hepatitis\u00a0C\u00a0infection<\/li><li>nilotinib and imatinib, idelalisib, ceritinib, crizotinib, apalutamide, enzalutamide or mitotane (used to treat certain cancers)<\/li><li>mycophenolic acid, which is used to suppress the immune system to prevent rejection of the transplanted organ<\/li><li>medicines for\u00a0stomach ulcers\u00a0and acid reflux (eg omeprazole, lansoprazole, or cimetidine)<\/li><li>medicines for nausea and vomiting (eg metoclopramide)<\/li><li>cisapride or\u00a0magnesium\u00a0aluminum hydroxide used to treat heartburn<\/li><li>Birth control pills\u00a0or other hormone treatments containing ethinylestradiol, hormone treatments with danazol<\/li><li>medicines for high\u00a0blood pressure\u00a0or heart problems (eg nifedipine, nicardipine,\u00a0diltiazem,\u00a0and verapamil)<\/li><li>antiarrhythmics\u00a0(\u00a0amiodarone\u00a0), medicines used to treat\u00a0arrhythmias\u00a0(irregular heartbeats)<\/li><li>medicines called &#8216;statins&#8217; used to treat high\u00a0cholesterol\u00a0and\u00a0triglycerides\u00a0(blood fats)<\/li><li>carbamazepine,\u00a0phenytoin,\u00a0and phenobarbital used to treat\u00a0epilepsy<\/li><li>cannabidiol (used, among other things, for the treatment of epileptic seizures)metamizole, which is used to treat pain and fever<\/li><li>the corticosteroids\u00a0prednisolone and\u00a0methylprednisolone, are used to treat\u00a0inflammation\u00a0and suppress the immune system (e.g. in case of rejection of the transplanted organ)<\/li><li>nefazodone used to treat depression<\/li><li>(Traditional) herbal medicines containing\u00a0St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0) or extracts of\u00a0Schisandra sphenanthera.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are receiving treatment for&nbsp;hepatitis&nbsp;C. Drug treatment for&nbsp;hepatitis&nbsp;C can affect liver function and thus the tacrolimus concentration in the blood.&nbsp;The concentration of tacrolimus in the blood may decrease or increase depending on the medicines prescribed for&nbsp;hepatitis&nbsp;C. The doctor may need to monitor tacrolimus concentrations in the blood closely and adjust the Tacforius&nbsp;dose&nbsp;once you start treatment for&nbsp;hepatitis&nbsp;C.<\/p>\n\n\n\n<p>Tell your doctor if you are taking or need to take\u00a0ibuprofen\u00a0(medicine for fever,\u00a0inflammation,\u00a0and pain),\u00a0antibiotics\u00a0(trimethoprim\/sulfamethoxazole co-trimoxazole, vancomycin, or aminoglycoside antibiotics such as gentamicin), amphotericin B (medicine for fungal infections) or medicines for viral infections (e.g. . aciclovir, ganciclovir, cidofovir, foscarnet).\u00a0These may worsen kidney or nervous system problems when taken with Tacforius.<\/p>\n\n\n\n<p>Your doctor also needs to know if you are taking potassium supplements or certain\u00a0diuretics, used in\u00a0heart failure, high\u00a0blood pressure,\u00a0and kidney disease (eg amiloride, triamterene, or\u00a0spironolactone\u00a0), or trimethoprim or trimethoprim\/sulfamethoxazole\u00a0antibiotics\u00a0which can increase potassium levels in your blood, certain medicines used for fever,\u00a0inflammation,\u00a0and pain (so-called\u00a0NSAIDs, eg\u00a0ibuprofen\u00a0), blood thinners or\u00a0oral\u00a0medication to treat\u00a0diabetes\u00a0while you are taking Tacforius.<\/p>\n\n\n\n<p>If you need to be vaccinated, you must tell your doctor about this in advance.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tacforius with food and drink<\/h2>\n\n\n\n<p>Avoid grapefruit (even as grapefruit juice) when being treated with Tacforius, as it may affect blood levels of the drug.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<p>Tacrolimus is excreted in breast milk.\u00a0Therefore, you should not breastfeed while taking Tacforius.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Do not drive or use tools or machines if you feel dizzy or sleepy, or have trouble seeing clearly after taking Tacforius.&nbsp;These effects are more common if you also drink alcohol.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tacforius contains<\/h2>\n\n\n\n<p><strong>Tacforius contains&nbsp;lactose<\/strong><\/p>\n\n\n\n<p>If you have an intolerance to some sugars, you should consult your doctor before taking this medicine.<\/p>\n\n\n\n<p><strong>Tacforius 5 mg capsules contain nycoccine<\/strong><\/p>\n\n\n\n<p>This can cause allergic reactions.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Tacforius<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>This medicine should only be prescribed to you by doctors experienced in the treatment of transplant patients.<\/p>\n\n\n\n<p>Make sure you get the same tacrolimus medicine each time you pick up your prescription unless your transplant doctor has decided that you should switch to a different tacrolimus medicine.\u00a0This medicine should be taken once daily.\u00a0If the appearance of the medicine is not the same as usual, or if the dosage instructions have changed, talk to your doctor or pharmacist as soon as possible to make sure you have received the correct medicine.<\/p>\n\n\n\n<p>The starting dose to prevent rejection of your transplanted organ is determined by your doctor and calculated according to your body weight.&nbsp;The starting doses immediately after the transplant are normally within the range<\/p>\n\n\n\n<p>0.10-0.30 mg per kg of body weight per day<\/p>\n\n\n\n<p>depending on which organ was transplanted.&nbsp;In the treatment of rejection, the same&nbsp;dosage&nbsp;can be used.<\/p>\n\n\n\n<p>The dose&nbsp;depends on your general condition and which other immunosuppressive medicine(s) you are receiving.<\/p>\n\n\n\n<p>After you have started treatment with Tacforius, your doctor will take blood samples often to arrive at the right\u00a0dose.\u00a0Then, regular blood tests are required that your doctor takes to determine the correct\u00a0dose and to adjust the\u00a0dose\u00a0from time to time.\u00a0The dose of Tacforius\u00a0is usually reduced by the doctor when your condition has stabilized.\u00a0Your doctor will tell you exactly how many capsules to take.<\/p>\n\n\n\n<p>You will need to take Tacforius every day for as long as you need immunosuppression to prevent rejection of your transplanted organ.&nbsp;You should be in regular contact with your doctor.<\/p>\n\n\n\n<p>Tacforius is taken orally once daily in the morning.&nbsp;Take Tacforius on an empty stomach or 2 to 3 hours after a meal.&nbsp;Wait at least 1 hour for the next meal.&nbsp;Take the capsules immediately after removing them from the blister.&nbsp;The capsules should be swallowed&nbsp;<strong>whole<\/strong>&nbsp;with a glass of water.&nbsp;Do not swallow the desiccant contained in the aluminum bag.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Tacforius<\/h2>\n\n\n\n<p>If you have accidentally taken too many capsules, contact your doctor or nearest emergency department immediately<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Tacforius<\/h2>\n\n\n\n<p>If you forget to take your Tacforius capsules in the morning, take them as soon as possible on the same day.&nbsp;Do not take a double&nbsp;dose&nbsp;the next morning.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Tacforius<\/h2>\n\n\n\n<p>Stopping treatment with Tacforius may increase the risk of rejection of your transplanted organ.&nbsp;Do not stop your treatment until your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<br><\/p>\n\n\n\n<p>Tacforius weakens the body&#8217;s defense mechanisms (the immune system), which makes the body&#8217;s ability to fight&nbsp;infection&nbsp;worse.&nbsp;When you take Tacforius, you may therefore get more&nbsp;infections&nbsp;than usual.<\/p>\n\n\n\n<p>Some\u00a0infections\u00a0can be serious or life-threatening and can include\u00a0infections\u00a0caused by bacteria,\u00a0viruses, fungi, parasites, or other\u00a0infections.<\/p>\n\n\n\n<p>Contact a doctor immediately if you develop signs of\u00a0infection, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever, cough, sore throat, feeling weak or generally unwell<\/li><li>Memory loss, trouble thinking, difficulty walking, or vision loss \u2013 may be due to a very rare, serious\u00a0infection\u00a0of the brain, which can be life-threatening (\u00a0progressive\u00a0multifocal\u00a0leukoencephalopathy, or PML)<\/li><\/ul>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;have been reported, including allergic and anaphylactic reactions.&nbsp;Benign and malignant&nbsp;tumors&nbsp;have been reported during treatment with Tacforius.<\/p>\n\n\n\n<p><strong>Contact your doctor immediately if you have or suspect you have any of the following serious side effects:<br><\/strong><\/p>\n\n\n\n<p><strong>Serious common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gastrointestinal\u00a0perforation: severe abdominal pain possibly accompanied by other symptoms, such as chills, fever, nausea, or vomiting.<\/li><li>Inadequate function of the transplanted organ.<\/li><li>Blurred vision.<\/li><\/ul>\n\n\n\n<p><strong>Serious uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The hemolytic uremic syndrome is a condition with the following symptoms: low or no urine production (\u00a0acute\u00a0kidney failure\u00a0), extreme fatigue, yellowing of the skin or eyes (jaundice), and abnormal bruising or bleeding and signs of\u00a0infection.<\/li><\/ul>\n\n\n\n<p><strong>Serious rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 1,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Thrombotic thrombocytopenic purpura (or TTP): a condition characterized by fever and bruising under the skin that may look like red pin-sized dots, with or without unexplained extreme fatigue, confusion, yellowing of the skin or eyes (jaundice), with symptoms of&nbsp;acute&nbsp;kidney failure&nbsp;(low or no urine production).<\/li><li>Toxic&nbsp;epidermal&nbsp;necrolysis: lesions and blisters on the skin or mucous membranes, red swollen skin that can detach from large parts of the body.<\/li><li>Blindness.<\/li><\/ul>\n\n\n\n<p><strong>Serious very rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stevens-Johnson syndrome: unexplained widespread skin pain, facial swelling, severe illness with blistering of the skin, mouth, eyes, and genitals,\u00a0hives, swollen tongue, the red or purple rash that spreads, flaky skin.<\/li><li>Torsades de Pointes: change in heart rate that may, but may not, be accompanied by symptoms such as chest pain (angina), weakness, dizziness or nausea, palpitations, and difficulty breathing.<\/li><\/ul>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;&#8211; frequency not known<\/strong>&nbsp;(frequency cannot be estimated from available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Opportunistic\u00a0infections\u00a0(caused by bacteria, fungi,\u00a0viruses,\u00a0and\u00a0protozoa\u00a0): prolonged diarrhea, fever, and sore throat.<\/li><li>Benign and malignant\u00a0tumors\u00a0have been reported after treatment as a result of immunosuppression.<\/li><li>Cases of pure erythrocyte aplasia (a very severe decrease in the number of\u00a0red blood cells\u00a0),\u00a0hemolytic anemia\u00a0(decreased number of\u00a0red blood cells\u00a0due to increased breakdown, accompanied by fatigue) and febrile\u00a0neutropenia\u00a0(a decrease in the number of\u00a0white blood cells\u00a0that fight\u00a0infection, accompanied by fever) have been reported.\u00a0It is not known exactly how often these\u00a0side effects\u00a0occur.\u00a0You may be asymptomatic or experience symptoms such as fatigue,\u00a0apathy, abnormal pallor, shortness of breath, dizziness, headache, chest pain, and cold hands and feet, depending on the severity of the condition.<\/li><li>Cases of\u00a0agranulocytosis\u00a0(severe reduction in the number of\u00a0white blood cells\u00a0along with mouth sores, fever, and\u00a0infection\u00a0(s)).\u00a0You may be symptom-free or experience symptoms such as sudden fever, stiffness, and sore throat.<\/li><li>Allergic and anaphylactic reactions with the following symptoms: sudden itchy rash (\u00a0hives\u00a0), swelling of the hands, feet, ankles, face, lips, mouth, or throat (which may cause difficulty in swallowing or breathing) and you may feel that you are about to faint.<\/li><li>Posterior reversible encephalopathy syndrome (PRES): headache, confusion, mood swings, seizures, and visual disturbances.\u00a0This may be a sign of a condition called posterior reversible encephalopathy syndrome, which has been reported in some patients treated with tacrolimus.<\/li><li>Optic\u00a0neuropathy\u00a0(optic nerve involvement): problems with your vision such as blurred vision, changes in color vision, difficulty seeing details, or your field of\u00a0vision\u00a0becoming restricted.<\/li><\/ul>\n\n\n\n<p>The&nbsp;side effects&nbsp;listed below may also occur after receiving Tacforius and may be serious:<br><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect more than 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased blood sugar,\u00a0diabetes mellitus, increased\u00a0potassium\u00a0in the blood<\/li><li>Difficulty sleeping<\/li><li>Tremors, headache<\/li><li>Increased\u00a0blood pressure<\/li><li>Abnormal liver function tests<\/li><li>Diarrhea, nausea<\/li><li>Kidney problems<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased number of\u00a0blood cells\u00a0(\u00a0platelets, red or\u00a0white blood cells\u00a0), increased number of\u00a0white blood cells, changed the number of\u00a0red blood cells\u00a0(seen in blood samples)<\/li><li>Decreased\u00a0magnesium,\u00a0phosphate,\u00a0potassium,\u00a0calcium,\u00a0or\u00a0sodium\u00a0in the blood, increased amount of fluid in the body, increased amount of\u00a0uric acid\u00a0or fats in the blood, decreased appetite, increased acidity in the blood, and other changes in blood salts (seen in blood tests)<\/li><li>Anxiety, confusion, disorientation, depression, mood changes, nightmares, hallucinations, mental illness<\/li><li>Convulsions, disturbances of consciousness, tingling or numbness (sometimes painful) in the hands and feet, dizziness, reduced ability to write, nervous system disorders<\/li><li>Increased photosensitivity, eye diseases<\/li><li>Earrings<\/li><li>Reduced blood flow in the\u00a0vessels\u00a0of the heart, faster heartbeat<\/li><li>Bleeding, partial or complete blockage of blood vessels decreased\u00a0blood pressure<\/li><li>Shortness of breath, changes in the lungs, fluid accumulation around the lung,\u00a0inflammation\u00a0of the throat, cough,\u00a0flu-like symptoms<\/li><li>Inflammation\u00a0or ulcers causing abdominal pain or diarrhea, bleeding in the stomach,\u00a0inflammation\u00a0or ulcers in the mouth, fluid retention in the abdomen, vomiting, abdominal pain, indigestion, constipation, gas, bloating, loose stools, stomach problems<\/li><li>Bile duct problems, yellowing of the skin due to liver problems, damage to liver tissue, and inflammation of the liver<\/li><li>Itching, rash, hair loss,\u00a0acne, increased sweating<\/li><li>Pain in joints, limbs, back and feet, muscle twitching<\/li><li>Insufficient functioning of the kidneys reduced urine production, impaired or painful urination<\/li><li>General weakness, fever, fluid accumulation in the body, pain and discomfort, increase in alkaline phosphatases in the blood, weight gain, the sensation of disturbed temperature perception<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Changes in the clotting ability of the blood, reduced numbers of all types of\u00a0blood cells\u00a0(seen in blood samples)<\/li><li>Dehydration<\/li><li>Decreased\u00a0protein\u00a0or sugar in the blood, increased\u00a0phosphate\u00a0in the blood<\/li><li>Coma, cerebral hemorrhage,\u00a0stroke, paralysis, brain disease, speech and language difficulties, memory problems<\/li><li>Clouding in the lens of the eye<\/li><li>Impaired hearing<\/li><li>Irregular heartbeats, cardiac arrest, decreased force of the heart, disease of the heart muscle, enlargement of the heart muscle, stronger heartbeat, abnormal\u00a0EKG, abnormal heart rate and\u00a0pulse<\/li><li>Blood clot in a vein in the leg or arm,\u00a0shock<\/li><li>Difficulty breathing, respiratory disease,\u00a0asthma<\/li><li>Obstructions in the intestinal passage, increased blood level of\u00a0enzyme\u00a0et amylase, regurgitation of contents from the stomach to the throat, prolonged emptying of the stomach<\/li><li>Skin inflammation, burning sensation in the sun<\/li><li>Joint diseases<\/li><li>Inability to urinate, painful periods, and abnormal menstrual bleeding<\/li><li>Impaired function in several organs,\u00a0flu-like symptoms, increased sensitivity to heat and cold, pressure on the chest, nervousness or abnormal feeling, increase in the\u00a0enzyme\u00a0lactate\u00a0dehydrogenase\u00a0in the blood, weight loss<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Small skin bleeding due to blood clots<\/li><li>Increased muscle stiffness<\/li><li>Deafness<\/li><li>Accumulation of fluid around the heart<\/li><li>Acute breathing difficulties<\/li><li>Cyst formation in the pancreas<\/li><li>Problems with blood flow in the liver<\/li><li>Severe disease with blistering of the skin, mouth, eyes, and genitals, increased hairiness<\/li><li>Thirst falls, feeling of pressure on the chest, reduced mobility, wounds<\/li><\/ul>\n\n\n\n<p><strong>Very rare&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10,000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Muscle weakness<\/li><li>Abnormal echocardiogram (\u00a0ECG\u00a0)<\/li><li>Liver failure<\/li><li>Painful urination with blood in the urine<\/li><li>The increased amount of adipose tissue<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Tacforius<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister after &#8220;EXP&#8221;.<\/p>\n\n\n\n<p>The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.&nbsp;Moisture sensitive.&nbsp;No special temperature instructions.<\/p>\n\n\n\n<p>Use all prolonged-release capsules within one year of opening the aluminum foil.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is tacrolimus<\/p>\n\n\n\n<p>One capsule of Tacforius 0.5 mg contains 0.5 mg tacrolimus (as a monohydrate).<\/p>\n\n\n\n<p>One capsule of Tacforius 1 mg contains 1 mg of tacrolimus (as a monohydrate).<\/p>\n\n\n\n<p>One capsule of Tacforius 3 mg contains 3 mg tacrolimus (as a monohydrate).<\/p>\n\n\n\n<p>One capsule of Tacforius 5 mg contains 5 mg tacrolimus (as a monohydrate).<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Capsule contents<\/em><\/p>\n\n\n\n<p>Hypromellose 2910, ethyl cellulose,\u00a0lactose, magnesium stearate.<\/p>\n\n\n\n<p><em>Capsule shell<\/em><\/p>\n\n\n\n<p>Tacforius 0.5 mg\/1 mg\/3 mg prolonged-release hard capsules:&nbsp;red iron oxide (E 172), yellow iron oxide (E 172)&nbsp;<em>,<\/em>&nbsp;titanium dioxide (E 171), gelatin<\/p>\n\n\n\n<p>Tacforius 5 mg prolonged-release hard capsules:&nbsp;red iron oxide (E 172), yellow iron oxide (E 172), titanium dioxide (E 171), black iron oxide (E 172), nycoccin (E 124), gelatin<\/p>\n\n\n\n<p><em>Ink<\/em><\/p>\n\n\n\n<p>Shellac,\u00a0propylene glycol<em>,<\/em>\u00a0black iron oxide (E 172), potassium hydroxide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p><em>Tacforius 0.5 mg hard prolonged-release capsules<\/em><\/p>\n\n\n\n<p>Hard gelatin capsules are marked with \u201cTR\u201d on the light yellow capsule cap and \u201c0.5 mg\u201d on the light orange body of the capsule.<\/p>\n\n\n\n<p><em>Tacforius 1 mg hard prolonged-release capsules<\/em><\/p>\n\n\n\n<p>Hard gelatin capsules are marked with \u201cTR\u201d on the white capsule cap and \u201c1 mg\u201d on the light orange body of the capsule.<\/p>\n\n\n\n<p><em>Tacforius 3 mg hard prolonged-release capsules<\/em><\/p>\n\n\n\n<p>Hard gelatin capsules marked with \u201cTR\u201d on the light orange capsule cap and \u201c3 mg\u201d on the light orange capsule body.<\/p>\n\n\n\n<p><em>Tacforius 5 mg hard prolonged-release capsules<\/em><\/p>\n\n\n\n<p>Hard gelatin capsules marked with \u201cTR\u201d on the gray capsule cap and \u201c5 mg\u201d on the light orange capsule body.<\/p>\n\n\n\n<p><em>Tacforius 0.5 mg\/3 mg\/5 mg prolonged-release hard capsules<\/em><\/p>\n\n\n\n<p>Supplied in blisters or perforated unit-dose blisters with 10 capsules in a protective aluminum pouch, containing desiccant.\u00a0Packs of 30, 50, and 100 prolonged-release capsules are available in blisters, and packs of 30&#215;1, 50&#215;1, and 100&#215;1 prolonged-release capsules are available in perforated single-dose blisters.<\/p>\n\n\n\n<p><em>Tacforius&nbsp;<\/em><em>1 mg hard prolonged-release capsules<\/em><\/p>\n\n\n\n<p>Supplied in blisters or perforated unit-dose blisters with 10 capsules in a protective aluminum pouch, containing desiccant.\u00a0Packs of 30, 50, 60 and 100 hard prolonged-release capsules are available in blisters, and packs of 30&#215;1, 50&#215;1, 60&#215;1, and 100&#215;1 hard prolonged-release capsules are available in perforated single-dose blisters.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Teva BV<\/p>\n\n\n\n<p>Swensveg 5<\/p>\n\n\n\n<p>2031 GA Haarlem<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Merkle GmbH<\/p>\n\n\n\n<p>Ludwig-Merckle-Stra\u00dfe 3<\/p>\n\n\n\n<p>89143 Blaubeuren<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>PLIVA Hrvatska doo<\/p>\n\n\n\n<p>Prilaz baruna Filipovi\u0107a 25<\/p>\n\n\n\n<p>10000 Zagreb<\/p>\n\n\n\n<p>Croatia<\/p>\n\n\n\n<p>Teva Czech Industries s.r.o<\/p>\n\n\n\n<p>Ostravsk\u00e1 29, cp 305<\/p>\n\n\n\n<p>Opava-Kom\u00e1rov<\/p>\n\n\n\n<p>74770<\/p>\n\n\n\n<p>Czech Republic<\/p>\n\n\n\n<p>Teva Operations Poland Sp.&nbsp;Zoo<\/p>\n\n\n\n<p>ul.&nbsp;Mogilska 80<\/p>\n\n\n\n<p>31-546 Cracow<\/p>\n\n\n\n<p>Poland<\/p>\n\n\n\n<p>Teva Pharma SLU<\/p>\n\n\n\n<p>C\/C, n. 4, Poligono Industrial Malpica<\/p>\n\n\n\n<p>ES-50016 Zaragoza<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Teva Pharmaceutical Works Private Limited Company&nbsp;<\/p>\n\n\n\n<p>Pallagi \u00fat 13<\/p>\n\n\n\n<p>4042 Debrecen<\/p>\n\n\n\n<p>Hungary<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Teva Pharma Belgium NV\/SA\/AGTel\/Tel: +32 38207373<\/td><td><strong>Lithuania<\/strong>UAB Teva BalticsPhone: +370 52660203<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Teva Pharma EADPhone: +359 24899585<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>ratiopharm GmbHAllemagne\/DeutschlandTel\/Tel: +49 73140202<\/td><\/tr><tr><td><br><strong>Czech Republic<\/strong>Teva Pharmaceuticals CR, sroPhone: +420 251007111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Teva Gy\u00f3gyszergy\u00e1r ZrtPhone: +36 12886400<\/td><\/tr><tr><td><br><strong>Denmark<\/strong>Teva Denmark A\/SPhone: +45 44985511<\/td><td><strong>Malta<\/strong>Teva Pharmaceuticals IrelandL- IrelandPhone: +44 2075407117<\/td><\/tr><tr><td><br><strong>Deutschland<\/strong>TEVA GmbHPhone: +49 73140208<\/td><td><strong>The Netherlands<\/strong>Teva Netherlands BVPhone: +31 8000228400<\/td><\/tr><tr><td><strong>Estonia<\/strong>UAB Teva Baltic&#8217;s Estonian branch phone: +372 6610801<\/td><td><strong>Norway<\/strong>Teva Norway iPhone: +47 66775590<\/td><\/tr><tr><td><strong>Greece<\/strong>Specify ABEEPhone: +30 2118805000<\/td><td><strong>Austria<\/strong>ratiopharm Arzneimittel Vertriebs-GmbHPhone: +43 1970070<\/td><\/tr><tr><td><strong>Spain<\/strong>Nordic Pharma, SAUPhone: + 34 916404041<\/td><td><strong>Polish<\/strong>Teva Pharmaceuticals Polska Sp.\u00a0z o. iPhone: +48 223459300<\/td><\/tr><tr><td><strong>France<\/strong>Teva HealthPhone: +33 155917800<\/td><td><strong>Portugal<\/strong>Teva Pharma &#8211; Produtos Farmac\u00eauticos, Lda.Phone: +351 214767550<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Pliva Hrvatska dooPhone: + 385 13720000<\/td><td><strong>Romania<\/strong>Teva Pharmaceuticals SRLPhone: +40 212306524<\/td><\/tr><tr><td><strong>Ireland<\/strong>Teva Pharmaceuticals IrelandPhone: +44 2075407117<\/td><td><strong>Slovenija<\/strong>Pliva Ljubljana dooPhone: +386 15890390<\/td><\/tr><tr><td><strong>Iceland<\/strong>Teva Pharma Iceland Ehf.Phone: +354 5503300<\/td><td><strong>Slovenian Republic<\/strong>Teva Pharmaceuticals Slovakia s.r.oPhone: +421 257267911<\/td><\/tr><tr><td><strong>Italy<\/strong>Teva Italia SrlPhone: +39 028917981<\/td><td><strong>Finland\/Finland<\/strong>Teva Finland OyPhone\/Tel: +358 201805900<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Specify ABEEGreecePhone: +30 2118805000<\/td><td><strong>Sweden<\/strong>Teva Sweden ABPhone: +46 42121100<\/td><\/tr><tr><td><strong>Latvia<\/strong>UAB Teva Baltic branch in LatviaPhone: +371 67323666<\/td><td><strong>United Kingdom<\/strong><strong>(Northern Ireland)<\/strong>Pharmaceuticals IrelandIrelandPhone: +44 2075407117<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Tacforius contains the active substance tacrolimus.\u00a0It is an immunosuppressive drug.\u00a0After an organ transplant (liver, kidney), the body&#8217;s immune system tries to reject the new organ.\u00a0Tacforius is used to control your body&#8217;s immune system, so that it accepts the transplanted organ.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[25131,11513,25127,25129,4095,4097,25128,4096,25130,11512],"class_list":["post-24184","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-benefits-of-tacforius","tag-benefits-of-tacrolimus","tag-tacforius","tag-tacforius-side-effects","tag-tacrolimus","tag-tacrolimus-side-effects","tag-what-is-tacforius","tag-what-is-tacrolimus","tag-what-tacforius-is-used-for","tag-what-tacrolimus-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24184"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24184\/revisions"}],"predecessor-version":[{"id":24231,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24184\/revisions\/24231"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}