{"id":24179,"date":"2022-08-17T10:09:20","date_gmt":"2022-08-17T10:09:20","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24179"},"modified":"2022-08-18T11:07:04","modified_gmt":"2022-08-18T11:07:04","slug":"synjardy","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/synjardy\/","title":{"rendered":"Synjardy &#8211; Empagliflozin\/metformin hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg\/850 mg, 5 mg\/1000 mg, 12.5 mg\/850 mg, 12.5 mg\/1000 mg&nbsp;film-coated tablets<br>empagliflozin\/metformin hydrochloride<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Synjardy is and what it is used for<\/h2>\n\n\n\n<p><strong>What Synjardy is<\/strong><\/p>\n\n\n\n<p>Synjardy contains two active substances, empagliflozin, and\u00a0metformin.\u00a0Both belong to a group of medicines called &#8220;oral diabetes medicines&#8221;.\u00a0These are medicines taken by mouth to treat type 2\u00a0diabetes.<\/p>\n\n\n\n<p><strong>What is type 2\u00a0diabetes?<\/strong><\/p>\n\n\n\n<p>Type 2\u2011\u00a0diabetes\u00a0is a disease caused by both genes and lifestyle.\u00a0If you have type 2\u00a0diabetes, your\u00a0pancreas\u00a0does not produce enough\u00a0insulin\u00a0to control blood glucose levels, and the body is unable to use its insulin\u00a0effectively.\u00a0This produces high levels of glucose in the blood that can lead to medical problems such as heart disease, kidney disease, blindness, and poor circulation in the arms and legs.<\/p>\n\n\n\n<p><strong>How Synjardy works<\/strong><\/p>\n\n\n\n<p>Empagliflozin belongs to a group of medicines called\u00a0sodium-glucose\u00a0cotransporter 2 inhibitors (SGLT2 inhibitors).\u00a0It works by blocking the\u00a0protein\u00a0SGLT2 in the kidneys.\u00a0This causes blood sugar (\u00a0glucose\u00a0) to be removed via the urine.\u00a0Metformin\u00a0works in a different way to lower blood sugar levels, mainly by blocking the formation of\u00a0glucose\u00a0in the liver.<\/p>\n\n\n\n<p>In this way, Synjardy reduces the amount of sugar in the blood.&nbsp;This drug may also help prevent heart disease.<\/p>\n\n\n\n<p><strong>What Synjardy is used for<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Synjardy is used as an adjunct to diet and exercise to treat type 2\u00a0diabetes\u00a0in adult patients (18 years or older) if\u00a0diabetes\u00a0cannot be controlled by adding\u00a0metformin\u00a0alone or\u00a0metformin\u00a0together with other\u00a0diabetes\u00a0medicines.<\/li><li>Synjardy can also be combined with other medicines for the treatment of\u00a0diabetes.\u00a0It can be medicines that are taken orally or that are given as an\u00a0injection, such as\u00a0insulin.<\/li><li>In addition, Synjardy can be used as an alternative to taking both empagliflozin and\u00a0metformin\u00a0as separate tablets.\u00a0To avoid overdose, you mustn&#8217;t continue to take separate tablets of empagliflozin and\u00a0metformin\u00a0while taking this medicine.<\/li><\/ul>\n\n\n\n<p>You must continue with the diet and exercise programs recommended by your doctor, pharmacist, or nurse.<br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Synjardy<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Synjardy:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to empagliflozin,\u00a0metformin,\u00a0or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have uncontrolled\u00a0diabetes\u00a0with, for example, severe\u00a0hyperglycemia\u00a0(high blood sugar), nausea, vomiting, diarrhea, rapid weight loss,\u00a0lactic acidosis\u00a0(see &#8220;Risk of lactic acidosis&#8221; below), or\u00a0ketoacidosis.\u00a0Ketoacidosis\u00a0is a condition where substances called\u00a0ketone bodies\u00a0to accumulate in the blood, which can lead to diabetic precoma.\u00a0Symptoms include stomach ache, fast and deep breathing, sleepiness, or your breath having a different, fruity smell.<\/li><li>if you have ever had a diabetic coma (\u00a0ketoacidosis\u00a0).<\/li><li>if you have severe kidney problems.\u00a0Your doctor may limit your daily\u00a0dose\u00a0or ask you to take another medicine (see also section 3, \u201cHow to take Synjardy\u201d).<\/li><li>if you have a severe\u00a0infection\u00a0such as an\u00a0infection\u00a0in the lung or\u00a0bronchi\u00a0or kidney.\u00a0Severe\u00a0infections\u00a0can cause kidney problems, which can put you at risk of lactic acidosis (see &#8220;Warnings and precautions&#8221;).<\/li><li>if you have lost a lot of water (dehydration), e.g.\u00a0due to prolonged or severe diarrhea, or if you have vomited several times in a row.\u00a0Dehydration can cause kidney problems, which can put you at risk of lactic acidosis (see &#8220;Warnings and precautions&#8221;).<\/li><li>if you are being treated for\u00a0acute\u00a0heart failure\u00a0or have recently had a heart attack, have serious problems with blood circulation, (such as\u00a0shock\u00a0), or have difficulty breathing.\u00a0This can lead to a lack of oxygen supply to the\u00a0tissues, and it can increase the risk of lactic acidosis (see section &#8220;Warnings and precautions&#8221;).<\/li><li>if you have liver problems.<\/li><li>if you drink large amounts of alcohol, either every day or only periodically (see the section &#8220;Synjardy with alcohol&#8221;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><strong>Risk of&nbsp;lactic acidosis<\/strong><\/p>\n\n\n\n<p>Synjardy can cause the very rare, but very serious\u00a0side effect\u00a0of lactic\u00a0acidosis, especially if your kidneys are not working properly.\u00a0The risk of developing\u00a0lactic acidosis\u00a0is also increased in uncontrolled\u00a0diabetes, severe\u00a0infection, prolonged fasting or alcohol intake, dehydration (see more information below), liver problems, and conditions were a part of the body has reduced oxygen supply (including\u00a0acute\u00a0severe heart disease).<\/p>\n\n\n\n<p>If any of the above apply to you, talk to your doctor for more detailed instructions.<\/p>\n\n\n\n<p><strong>Stop taking Synjardy for a short time if you have a condition that may be associated with dehydration<\/strong>\u00a0(extensive loss of body fluids) such as severe vomiting, diarrhea, fever, exposure to heat, or if you drink less fluid than normal.\u00a0Talk to your doctor for more detailed instructions.<\/p>\n\n\n\n<p><strong>Stop taking Synjardy and contact your doctor or nearest hospital immediately if you experience any of the symptoms of\u00a0lactic acidosis<\/strong>\u00a0as the condition can lead to\u00a0coma.<\/p>\n\n\n\n<p>The symptoms of&nbsp;lactic acidosis&nbsp;include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>vomiting<\/li><li>abdominal pain (stomach)<\/li><li>muscle cramps<\/li><li>a general feeling of not feeling well and pronounced fatigue<\/li><li>hard to breathe<\/li><li>lowered body temperature and\u00a0pulse.<\/li><\/ul>\n\n\n\n<p>Lactatacy\u00a0dose\u00a0is an\u00a0emergency\u00a0medical condition that must be treated in a hospital.<\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking this medicine and during treatment:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you experience rapid weight loss, nausea or vomiting, stomach pain, severe thirst, rapid and deep breathing, confusion, unusual sleepiness or tiredness, a sweet breath, sweet or metallic taste in the mouth, or a different smell of urine or sweat, contact your doctor or nearest hospital immediately.\u00a0These symptoms may be a sign of &#8220;diabetic ketoacidosis&#8221; &#8211; a rare but serious, sometimes life-threatening, problem you can get with\u00a0diabetes, due to elevated levels of &#8220;ketone bodies&#8221; in the urine or blood.\u00a0This shows in tests.\u00a0The risk of developing diabetic ketoacidosis may increase with prolonged fasting, high alcohol consumption, dehydration, a sudden reduction in the insulin dose, or a greater need for\u00a0insulin\u00a0due to major surgery or a serious illness.<\/li><li>if you have type 1\u00a0diabetes\u00a0\u2013 this type usually starts in youth and causes the body not to produce any\u00a0insulin.\u00a0Synjardy should not be used for the treatment of patients with type 1\u00a0diabetes.<\/li><li>if you may be at risk of dehydration, for example:<ul><li>if you are vomiting, have diarrhea or fever, or if you cannot eat or drink<\/li><li>if you take medicines that increase urine production [diuretics] or lower\u00a0blood pressure,\u00a0etc<\/li><li>if you are over 75 years old. Possible signs are listed in section 4 under \u201cdehydration\u201d.\u00a0Your doctor may instruct you to stop taking Synjardy until you have recovered to prevent you from losing too much body fluid.\u00a0Ask what you can do to avoid dehydration.<\/li><\/ul><\/li><li>if you are 85 years of age or older, you should not start taking Synjardy due to limited experience with treatment.<\/li><li>if you have a serious\u00a0infection\u00a0of the kidneys or urinary tract along with a fever.\u00a0Your doctor may ask you to stop taking Synjardy until you have recovered.<\/li><li>If you have to undergo an examination with an iodinated contrast medium (eg X-ray examination or diagnostic imaging).\u00a0More information can be found below under &#8220;Other medicines and Synjardy&#8221;.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor straight away if you experience a combination of symptoms such as pain, tenderness,\u00a0redness,\u00a0or swelling of the genitals or the area between the genitals and the rectum along with a fever or feeling generally unwell.\u00a0These symptoms may be a sign of a rare but serious or even life-threatening\u00a0infection\u00a0called\u00a0necrotizing\u00a0fasciitis of the perineum or Fournier&#8217;s gangrene which destroys\u00a0the tissue\u00a0under the skin.\u00a0Fournier&#8217;s gangrene must be treated immediately.<\/p>\n\n\n\n<p><strong>Surgery<\/strong><\/p>\n\n\n\n<p>If you are going to have a major operation, you must stop taking Synjardy during the operation and for a certain time after it.&nbsp;Your doctor will decide when you must stop taking Synjardy and when you should start taking it again.<\/p>\n\n\n\n<p><strong>Kidney function<\/strong><\/p>\n\n\n\n<p>During treatment with Synjardy, your doctor will check your kidney function at least once a year, or more often if you are older and\/or if your kidney function is deteriorating.<\/p>\n\n\n\n<p><strong>Chiropody<\/strong><\/p>\n\n\n\n<p>For all patients with\u00a0diabetes, it is important to check their feet regularly and follow any other foot care advice given by healthcare professionals.<\/p>\n\n\n\n<p><strong>Urine glucose<\/strong><\/p>\n\n\n\n<p>Urine tests will test positive for sugar while you are taking this medicine, because of how this medicine works.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>The drug is not recommended for use in children and adolescents under 18 years of age, as it has not been studied in these patients.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Synjardy<\/h2>\n\n\n\n<p>If you need to receive an\u00a0injection\u00a0into the blood with a contrast agent containing iodine, for example in connection with an X-ray or\u00a0CT\u00a0scan, you must stop taking Synjardy before or at the time of the\u00a0injection.\u00a0Your doctor will decide when you must stop taking Synjardy and when you should start taking it again.<\/p>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>You may need to have more blood sugar and kidney function tests, or your doctor may need to adjust the\u00a0dose\u00a0of Synjardy.\u00a0You must mention the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines that increase urine production (\u00a0diuretics\u00a0), such as Synjardy can increase the risk of losing too much fluid.\u00a0Your doctor may ask you to stop taking Synjardy.\u00a0Possible signs of losing too much fluid are listed in section 4.<\/li><li>other medicines that lower the amount of sugar in the blood, for example,\u00a0insulin\u00a0or a &#8216;sulphonylurea&#8217; medicine.\u00a0Your doctor may want to lower the\u00a0dose\u00a0of one of these other medicines, to prevent your blood sugar levels from getting too low (hypoglycemia).<\/li><li>medicines that can change the amount of\u00a0metformin\u00a0in the blood, especially if you have impaired kidney function (eg verapamil, rifampicin, cimetidine, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tivicay\/\">dolutegravir<\/a>, ranolazine, trimethoprim, vandetanib, isavuconazole, crizotinib, olaparib).<\/li><li>bronchodilators\u00a0(beta-2\u00a0agonists\u00a0) are used in the treatment of\u00a0asthma.<\/li><li>corticosteroids\u00a0are used to treat\u00a0inflammation\u00a0in diseases such as\u00a0asthma\u00a0and\u00a0arthritis.\u00a0They can be taken by mouth, as an\u00a0injection,\u00a0or with an\u00a0inhaler.<\/li><li>medicines used to treat pain and\u00a0inflammation\u00a0(\u00a0NSAIDs\u00a0and COX 2 inhibitors, such as\u00a0ibuprofen\u00a0and celecoxib)<\/li><li>certain medicines for the treatment of high\u00a0blood pressure\u00a0(\u00a0ACE inhibitors\u00a0and\u00a0angiotensin\u00a0II receptor antagonists)<\/li><li>medicines that contain alcohol (see the section &#8220;Synjardy with alcohol&#8221;).<\/li><li>iodinated contrast agents (medicines used in X-ray examinations; see section &#8220;Warnings and precautions&#8221;).<\/li><li>if you are taking lithium because Synjardy can reduce the amount of lithium in your blood.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Synjardy with alcohol<\/h2>\n\n\n\n<p>Avoid heavy alcohol intake while taking Synjardy as alcohol may increase the risk of&nbsp;lactic acidosis&nbsp;(see section &#8220;Warnings and precautions&#8221;).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>Do not use Synjardy if you are pregnant.&nbsp;It is unknown whether the drug is harmful to the unborn child.<\/p>\n\n\n\n<p>Metformin\u00a0is excreted in breast milk in small amounts.\u00a0It is unknown whether empagliflozin is excreted in human milk.\u00a0Do not use Synjardy if you are breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Synjardy has little effect on the ability to drive and use machines.<\/p>\n\n\n\n<p>Taking this medicine in combination with medicines called sulphonylureas or together with\u00a0insulin\u00a0can cause too much drop in blood sugar (hypoglycemia), it can cause symptoms such as tremors, sweating, and vision changes, and can affect your ability to drive and use machines.\u00a0Do not drive vehicles or use tools or machines if you feel dizzy while taking Synjardy.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Synjardy<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p>The dose of Synjardy&nbsp;varies depending on your health and the&nbsp;dose&nbsp;of the diabetes medicines you are currently taking.&nbsp;Your doctor adjusts the&nbsp;dose&nbsp;if necessary and tells you exactly what strength of the medicine you should take.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is one tablet twice a day.&nbsp;Your doctor will usually start Synjardy treatment by prescribing the tablet strength that gives you the same&nbsp;dose&nbsp;of&nbsp;metformin&nbsp;you are already taking (850 mg or 1000 mg twice daily), and the lowest&nbsp;dose&nbsp;of empagliflozin (5 mg twice daily ).&nbsp;If you are already taking both medicines separately, your doctor will start you on a course of Synjardy tablets that will give you the same amount of both medicines.<\/p>\n\n\n\n<p>If you have impaired kidney function, the doctor may prescribe a lower&nbsp;dose&nbsp;or decide to use another medicine.<\/p>\n\n\n\n<p><strong>Ingestion of this medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the tablet whole with water.<\/li><li>Take the tablets with a meal to reduce the risk of stomach upset.<\/li><li>Take one tablet twice daily by mouth.<\/li><\/ul>\n\n\n\n<p>Your doctor may&nbsp;prescribe&nbsp;Synjardy together with another diabetes medicine.&nbsp;Remember to take all medications as directed by your doctor to achieve the best possible results for your health.&nbsp;Your doctor may need to adjust the&nbsp;doses&nbsp;to get your blood sugar under control.<\/p>\n\n\n\n<p>Appropriate diet and exercise help your body make better use of blood sugar.&nbsp;It is important to continue with the diet and exercise program recommended by the doctor during the time you are taking Synjardy.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Synjardy<\/h2>\n\n\n\n<p>If you have taken too many tablets of Synjardy, you may get lactic acidosis.&nbsp;The symptoms of lactic acidosis are non-specific such as severe nausea, vomiting, stomach pain with muscle cramps, general malaise with severe fatigue, and breathing difficulties.&nbsp;Additional symptoms are lowered body temperature and heart rate.<\/p>\n\n\n\n<p><strong>If you get such symptoms, you may need immediate hospital care, as lactic acidosis can lead to\u00a0coma.\u00a0Stop taking Synjardy immediately and contact a doctor immediately or go to the nearest hospital (see section 2).\u00a0Take the medicine package with you.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Synjardy<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, take it as soon as you remember.\u00a0If you do not remember until it is time for the next\u00a0dose, skip the missed\u00a0dose\u00a0and continue according to your regular schedule.\u00a0Do not take a double\u00a0dose\u00a0of this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Synjardy<\/h2>\n\n\n\n<p>Do not stop taking Synjardy without discussing this with your doctor.&nbsp;Your blood sugar levels may rise when you stop using Synjardy.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact a doctor or the nearest hospital immediately if you experience any of the following side effects:<\/strong><\/p>\n\n\n\n<p><strong>Serious allergic reactions have been reported uncommonly (may affect up to 1 in 100 users)<\/strong><\/p>\n\n\n\n<p>Possible signs of a serious&nbsp;allergic reaction&nbsp;may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, lips, mouth, tongue, or throat and may lead to difficulty breathing or swallowing.<\/li><\/ul>\n\n\n\n<p><strong>Lactic acidosis<\/strong>\u00a0is very rare (may affect up to 1 user in 10,000).\u00a0Synjardy can cause the very rare, but very serious\u00a0side effect\u00a0of lactic\u00a0acidosis\u00a0(see section 2).\u00a0If this happens to you, you must\u00a0stop taking Synjardy and immediately contact a doctor or the nearest hospital, as\u00a0lactic acidosis\u00a0can lead to\u00a0coma.<\/p>\n\n\n\n<p><strong>Diabetic ketoacidosis is rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<p>These are the signs of diabetic ketoacidosis (see section 2):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased levels of &#8220;ketone bodies&#8221; in urine or blood<\/li><li>rapid weight loss<\/li><li>nausea or vomiting<\/li><li>stomach pain<\/li><li>severe thirst<\/li><li>rapid and deep breathing<\/li><li>confusion<\/li><li>unusual sleepiness or tiredness<\/li><li>a sweet smell on the breath, a sweet or metallic taste in the mouth, or a different smell of urine or sweat<\/li><\/ul>\n\n\n\n<p>This can occur regardless of blood sugar levels.&nbsp;Your doctor may decide to temporarily or permanently stop treatment with Synjardy.<\/p>\n\n\n\n<p><strong>Contact your doctor as soon as possible if you notice any of the following side effects:<\/strong><\/p>\n\n\n\n<p><strong>Low blood sugar (hypoglycemia<\/strong>), is <strong>very common (may affect more than 1 in 10 people)<\/strong><\/p>\n\n\n\n<p>If you take Synjardy together with another medicine that can cause low blood sugar, such as sulphonylurea or\u00a0insulin, the risk of getting low blood sugar is higher.\u00a0Signs of low blood sugar may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>shaking, sweating, feeling very anxious or confused, fast heartbeat<\/li><li>excessive hunger, headache<\/li><\/ul>\n\n\n\n<p>Your doctor will tell you how to treat low blood sugar levels and what to do if you get any of the signs above.&nbsp;If you have symptoms of low blood sugar, eat dextrose tablets, a sugary snack, or drink fruit juice.&nbsp;If possible, measure your blood sugar and rest.<\/p>\n\n\n\n<p><strong>Urinary tract infections are common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<p>Signs of a urinary tract infection are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a burning sensation when urinating<\/li><li>cloudy urine<\/li><li>pain in the pelvis, or middle of the back (when the kidneys are infected)<\/li><\/ul>\n\n\n\n<p>Urinary urgency or the need to urinate more often may be due to the way Synjardy works, but may also be a sign of a urinary tract infection.&nbsp;If you notice an increase in these symptoms, contact your doctor.<\/p>\n\n\n\n<p><strong>Dehydration is uncommon (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<p>Signs of dehydration are not specific, but may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>unusual thirst<\/li><li>dizziness or lightheadedness when standing up<\/li><li>fainting or fainting<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;when taking Synjardy:<\/strong><\/p>\n\n\n\n<p>Very common<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea, vomiting<\/li><li>diarrhea or stomach pain<\/li><li>loss of appetite<\/li><\/ul>\n\n\n\n<p>Usual<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fungal infection around the genitals<\/li><li>a larger amount of urine than usual or having to urinate more often<\/li><li>itching<\/li><li>skin rash or redness \u2013 these may itch and include raised bumps, blisters, or be oozing<\/li><li>changes in the sense of taste<\/li><li>thirst<\/li><li>blood tests may show an increase in blood fat values \u200b\u200b(\u00a0cholesterol\u00a0)<\/li><li>constipation<\/li><\/ul>\n\n\n\n<p>Less common<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hives<\/li><li>straining or pain when emptying the bladder<\/li><li>blood tests may show a deterioration of kidney function (&nbsp;creatinine&nbsp;or&nbsp;urea&nbsp;)<\/li><li>blood tests may show increases in the number of&nbsp;red blood cells&nbsp;in the blood (&nbsp;hematocrit&nbsp;)<\/li><\/ul>\n\n\n\n<p>Rare<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>necrotizing&nbsp;fasciitis of the perineum or Fournier&#8217;s gangrene, a serious soft tissue infection of the genitals or the area between the genitals and the rectum<\/li><\/ul>\n\n\n\n<p>Very rare<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduced level of&nbsp;vitamin&nbsp;B12 in the blood<\/li><li>abnormal liver function tests,&nbsp;inflammation&nbsp;of the liver (&nbsp;hepatitis&nbsp;)<\/li><li>skin redness (&nbsp;erythema&nbsp;)<\/li><li>inflammation&nbsp;of the kidneys (tubulointerstitial nephritis)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Synjardy<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and blister card after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Do not use this medicine if the package is damaged or shows signs of having been previously opened.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substances are empagliflozin and\u00a0metformin.<\/p>\n\n\n\n<p>Each Synjardy 5 mg\/850 mg film-coated tablet (tablet) contains 5 mg empagliflozin and 850 mg metformin hydrochloride.<\/p>\n\n\n\n<p>Each Synjardy 5 mg\/1000 mg film-coated tablet (tablet) contains 5 mg of empagliflozin and 1000 mg of metformin hydrochloride.<\/p>\n\n\n\n<p>Each Synjardy 12.5 mg\/850 mg film-coated tablet (tablet) contains 12.5 mg empagliflozin and 850 mg metformin hydrochloride.<\/p>\n\n\n\n<p>Each Synjardy 12.5 mg\/1000 mg film-coated tablet (tablet) contains 12.5 mg empagliflozin and 1000 mg metformin hydrochloride.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Tablet core:<\/em>&nbsp;corn starch, copovidone,&nbsp;colloidal&nbsp;anhydrous silica, magnesium stearate.<\/li><li><em>Film coating<\/em>&nbsp;: hypromellose, macrogol 400, titanium dioxide (E171), talc.Synjardy 5 mg\/850 mg and Synjardy 5 mg\/1000 mg tablets also contain yellow iron oxide (E172).&nbsp;Synjardy 12.5 mg\/850 mg and Synjardy 12.5 mg\/1000 mg tablets also contain black iron oxide (E172) and red iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Synjardy 5 mg\/850 mg film-coated tablets are yellow-white, oval, and biconvex.\u00a0They have &#8220;S5&#8221; and the Boehringer Ingelheim logo on one side and &#8220;850&#8221; on the other side.\u00a0The tablet is 19.2 mm long and has a width of 9.4 mm.<\/p>\n\n\n\n<p>Synjardy 5 mg\/1000 mg film-coated tablets are brown-yellow, oval, and biconvex.\u00a0They have &#8220;S5&#8221; and the Boehringer Ingelheim logo on one side and &#8220;1000&#8221; on the other side.\u00a0The tablet is 21.1 mm long and has a width of 9.7 mm.<\/p>\n\n\n\n<p>Synjardy 12.5 mg\/850 mg film-coated tablets are pinkish white, oval, and biconvex.\u00a0They have &#8220;S12&#8221; and the Boehringer Ingelheim logo on one side and &#8220;850&#8221; on the other side.\u00a0The tablet is 19.2 mm long and has a width of 9.4 mm.<\/p>\n\n\n\n<p>Synjardy 12.5 mg\/1000 mg film-coated tablets are dark brown-purple, oval, and biconvex.\u00a0They have &#8220;S12&#8221; and the Boehringer Ingelheim logo on one side and &#8220;1000&#8221; on the other side.\u00a0The tablet is 21.1 mm long and has a width of 9.7 mm.<\/p>\n\n\n\n<p>The tablets are available in PVC\/aluminum perforated single-dose blisters.\u00a0Pack sizes are 10 x 1, 14 x 1, 30 x 1, 56 x 1, 60 x 1, 90 x 1 and 100 x 1 film-coated tablets and multipacks of 120 (2 packs of 60 x 1), 180 (2 packs of 90 x 1) and 200 (2 packs of 100 x 1) film-coated tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed in your country.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Boehringer Ingelheim International GmbH<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Boehringer Ingelheim Hellas Single Member SA<\/p>\n\n\n\n<p>5th km Paiania \u2013 Markopoulo<\/p>\n\n\n\n<p>Koropi Attiki, 19441<\/p>\n\n\n\n<p>Greece<\/p>\n\n\n\n<p>Patheon France<\/p>\n\n\n\n<p>40 boulevard de Champaret<\/p>\n\n\n\n<p>Bourgoin Jallieu, 38300<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Boehringer Ingelheim France<\/p>\n\n\n\n<p>100-104 Avenue de France<\/p>\n\n\n\n<p>75013 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>SCS Boehringer Ingelheim Comm.VT\u00e9l\/Tel: +32 2 773 33 11<\/td><td><strong>Lithuania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGLietuvos filialasTel.: +370 5 2595942<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>B\u00f6ringer Ingelheim \u0420\u0426\u0412 \u0413\u043c\u0431\u0425 \u0438 \u041a\u043e \u041a\u0413 -branch BulgariaPhone: +359 2 958 79 98<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>SCS Boehringer Ingelheim Comm.VT\u00e9l\/Tel: +32 2 773 33 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Boehringer Ingelheim coil.&nbsp;s roPhone: +420 234 655 111<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGMagyarorsz\u00e1gi Fi\u00f3ktelepeTel.: +36 1 299 89 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Boehringer Ingelheim Danmark A\/SPhone: +45 39 15 88 88<\/td><td><strong>Malta<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +353 1 295 9620<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KGPhone: +49 (0) 800 77 90 900<br>Lilly Deutschland GmbHTel.&nbsp;+49 (0) 6172 273 2222<\/td><td><strong>The Netherlands<\/strong>Boehringer Ingelheim bvPhone: +31 (0) 800 22 55 889<\/td><\/tr><tr><td><strong>Estonia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGEstonian branchPhone: +372 612 8000<\/td><td><strong>Norway<\/strong>Boehringer Ingelheim Norway KSPhone: +47 66 76 13 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Boehringer Ingelheim\u0395\u03bb\u03bb\u03ac\u03c2 \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AETel: +30 2 10 89 06 300<\/td><td><strong>Austria<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGPhone: +43 1 80 105-7870<\/td><\/tr><tr><td><strong>Spain<\/strong>Boehringer Ingelheim Espa\u00f1a SAPhone: +34 93 404 51 00<br>Lilly SAPhone: +34 91 663 50 00<\/td><td><strong>Polish<\/strong>Boehringer Ingelheim Sp.zo.o.Tel.: +48 22 699 0 699<\/td><\/tr><tr><td><strong>France<\/strong>Boehringer Ingelheim France SASTel: +33 3 26 50 45 33<br>Lilly France SASTel: +33 1 55 49 34 34<\/td><td><strong>Portugal<\/strong>Boehringer Ingelheim Portugal, Lda.Phone: +351 21 313 53 00<br>Lilly Portugal Produtos Farmac\u00eauticos, LdaPhone: +351 21 412 66 00<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Boehringer Ingelheim Zagreb dooPhone: +385 1 2444 600<\/td><td><strong>Romania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGViena &#8211; Sucursala Bucure\u015ftiPhone: +40 21 302 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +353 1 295 9620<br>Eli Lilly and Company (Ireland) LimitedPhone: +353 1 661 4377<\/td><td><strong>Slovenija<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGPodru\u017enica LjubljanaPhone: +386 1 586 40 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Telephone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGorganiza\u010dn\u00e1 zlo\u017ekaPhone: +421 2 5810 1211<\/td><\/tr><tr><td><strong>Italy<\/strong>Boehringer Ingelheim Italia SpAPhone: +39 02 5355 1<br>Eli Lilly Italia SpAPhone: +39 055 42571<\/td><td><strong>Finland\/Finland<\/strong>Boehringer Ingelheim Finland KyPhone\/Tel: +358 10 3102 800<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Boehringer Ingelheim\u0395\u03bb\u03bb\u03ac\u03c2 \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7 AETel: +30 2 10 89 06 300<\/td><td><strong>Sweden<\/strong>Boehringer Ingelheim ABPhone: +46 8 721 21 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGLatvijas filialePhone: +371 67 240 011<\/td><td><strong>United Kingdom&nbsp;<\/strong><strong>(Northern Ireland)<\/strong>Boehringer Ingelheim Ireland Ltd.Phone: +353 1 295 9620<br>Eli Lilly and Company (Ireland) LimitedPhone: +353 1 661 4377<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Synjardy contains two active substances, empagliflozin and\u00a0metformin\u00a0.\u00a0Both belong to a group of medicines called &#8220;oral diabetes medicines&#8221;.\u00a0These are medicines taken by mouth to treat type 2\u00a0diabetes\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,22500],"tags":[14131,14135,14136,3466,4837,25132,25136,25135,25137,14132,4836,25134,14316,25133],"class_list":["post-24179","post","type-post","status-publish","format-standard","hentry","category-medicines","category-t","tag-empagliflozin","tag-empagliflozin-side-effects","tag-empagliflozin-tablet","tag-metformin-hydrochloride","tag-metformin-hydrochloride-tablet","tag-synjardy","tag-synjardy-side-effects","tag-synjardy-tablet","tag-what-empagliflozin-is-usedfor","tag-what-is-empagliflozin","tag-what-is-metformin-hydrochloride","tag-what-is-synjardy","tag-what-metformin-hydrochloride-is-used-for","tag-what-synjardy-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24179"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24179\/revisions"}],"predecessor-version":[{"id":24232,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24179\/revisions\/24232"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}