{"id":24178,"date":"2022-08-17T10:03:29","date_gmt":"2022-08-17T10:03:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24178"},"modified":"2022-08-18T11:07:09","modified_gmt":"2022-08-18T11:07:09","slug":"synflorix","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/synflorix\/","title":{"rendered":"Synflorix &#8211; Polysaccharide vaccine uses, dose and side effects"},"content":{"rendered":"\n<p>solution for injection,\u00a0suspension<br>Polysaccharide vaccine against pneumococcal infections, conjugated,\u00a0adsorbed<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Synflorix is \u200b\u200band what it is used for<\/h2>\n\n\n\n<p>Synflorix is \u200b\u200ba vaccine against pneumococcal infections.&nbsp;A doctor or nurse will inject your child with this vaccine.<\/p>\n\n\n\n<p><strong>It is used from 6 weeks up to 5 years of age to protect your child against:<\/strong><\/p>\n\n\n\n<p>a\u00a0bacterium\u00a0called &#8221;\u00a0<em>Streptococcus pneumoniae<\/em>\u00a0&#8220;.\u00a0This\u00a0bacterium\u00a0can cause serious illnesses, including\u00a0meningitis, blood poisoning, and\u00a0bacteremia\u00a0(bacteria in the bloodstream) as well as ear infection or\u00a0pneumonia.<\/p>\n\n\n\n<p><strong>How Synflorix works<\/strong><\/p>\n\n\n\n<p>Synflorix helps the body produce its antibodies.\u00a0Antibodies\u00a0are part of the immune system that will protect your child against these diseases.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before your child receives Synflorix<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Synflorix should not be given if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>your child is allergic to the active substances or to any of the other ingredients in this vaccine (the ingredients are listed in section 6).\u00a0Signs of an\u00a0allergic reaction\u00a0may include an itchy rash, shortness of breath, and swelling of the face or tongue.<\/li><li>your child has a serious\u00a0infection\u00a0with a high fever (above 38\u00b0C).\u00a0If this is the case, the vaccination can be postponed until your child is better.\u00a0A mild\u00a0infection\u00a0such as a cold should not be a problem.\u00a0However, talk to your doctor first.<\/li><\/ul>\n\n\n\n<p>Synflorix should not be given if any of the above applies to your child.&nbsp;If you are not sure, talk to your doctor or pharmacist before your child receives Synflorix.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and Precautions:<\/h2>\n\n\n\n<p>Check with your doctor or pharmacist before giving this vaccine if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your child has problems with bleeding or bruises easily.<\/li><\/ul>\n\n\n\n<p>In children from the age of 2, fainting may occur after, or even before, any needle injection.\u00a0Therefore, tell the doctor or nurse if your child has fainted during a previous\u00a0injection.<\/p>\n\n\n\n<p>As with all vaccines, full protection may not be achieved in all children vaccinated with Synflorix.<\/p>\n\n\n\n<p>Synflorix only protects against&nbsp;infection&nbsp;caused by the bacteria for which the vaccine has been developed.<\/p>\n\n\n\n<p>Children with a weakened immune system (e.g. due to&nbsp;infection&nbsp;with the human immunodeficiency virus (&nbsp;HIV&nbsp;) or immunosuppressive treatment) may not get the full benefit of Synflorix.<\/p>\n\n\n\n<p>If you are not sure, talk to your doctor or pharmacist before your child receives Synflorix.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children over 5 years<\/h2>\n\n\n\n<p>The safety and efficacy of the vaccine have not been established for children older than 5 years and therefore vaccination of these children is not recommended.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Synflorix<\/h2>\n\n\n\n<p>Tell the doctor or pharmacist if your child is taking, has recently taken, or maybe taking other medicines, or if the child has recently received any other vaccine.\u00a0Synflorix may not work as well if the child is taking medicines that affect the immune system&#8217;s ability to fight\u00a0infection.<\/p>\n\n\n\n<p>Synflorix can be given simultaneously with other childhood vaccines such as vaccine against\u00a0diphtheria, tetanus, whooping cough (pertussis),\u00a0<em>Haemophilus influenzae<\/em>\u00a0type b, polio (oral or inactivated),\u00a0hepatitis\u00a0B, measles-mumps-rubella, chicken pox, rotavirus (oral) and also\u00a0meningococcal\u00a0serogroup C and serogroup A, C, W\u2011135, Y (conjugated).\u00a0Different sites are used for\u00a0injecting\u00a0the different vaccines.<\/p>\n\n\n\n<p>The doctor may ask you to give the child an antipyretic medicine (such as\u00a0paracetamol\u00a0) before or immediately after Synflorix is \u200b\u200bgiven, especially if the child is vaccinated with the whole-cell pertussis vaccine at the same time as Synflorix.\u00a0Antipyretic drugs are also recommended for children who have convulsive disorders or who have previously had febrile convulsions.<\/p>\n\n\n\n<p>If your child has received&nbsp;paracetamol&nbsp;before or immediately after Synflorix has been given, the level of&nbsp;antibody&nbsp;obtained may decrease slightly.&nbsp;It is not known whether the reduced antibody level affects protection against pneumococcal disease.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Synflorix contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Synflorix is \u200b\u200bgiven&nbsp;<\/h2>\n\n\n\n<p><strong>How the vaccine is given<\/strong><\/p>\n\n\n\n<p>Synflorix is \u200b\u200balways injected into a muscle.&nbsp;This is usually done in the thigh or upper arm.<\/p>\n\n\n\n<p><strong>How much is given<\/strong><\/p>\n\n\n\n<p>Usually, your child (from 6 weeks to 6 months of age) receives a vaccination series consisting of 4\u00a0injections\u00a0according to official recommendations or another dosage\u00a0according to official recommendations followed by the healthcare professional.\u00a0It is important to follow the doctor&#8217;s or nurse&#8217;s instructions to complete the vaccination schedule.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Each&nbsp;injection&nbsp;is given at least one month apart, except for the last&nbsp;injection&nbsp;one (booster) which is given at least 6 months after the third&nbsp;injection&nbsp;one.<\/li><li>The first&nbsp;injection&nbsp;can be given from 6 weeks of age and up.&nbsp;The last&nbsp;injection&nbsp;(booster) can be given from 9 months of age and up.<\/li><li>You will be told when your child should return for the next vaccination.<\/li><\/ul>\n\n\n\n<p><br>Premature babies (born after 27 weeks and before 37 weeks of pregnancy):<\/p>\n\n\n\n<p>Your child (from 2 months to 6 months of age) will receive 3\u00a0injections\u00a0with an interval of at least one month between each\u00a0dose.\u00a0At least six months after the last\u00a0injection, your child will receive an additional\u00a0dose\u00a0(booster dose).<\/p>\n\n\n\n<p>Infants aged 7 to 11 months will receive 2\u00a0injections.\u00a0Each\u00a0injection\u00a0will be given at least one month apart.\u00a0A third\u00a0injection\u00a0(booster) will be given during the second year of life at least two months apart.<\/p>\n\n\n\n<p>Children from 12 months to 5 years of age will receive 2\u00a0injections.\u00a0Each\u00a0injection\u00a0is given at least two months apart.<\/p>\n\n\n\n<p><em>Special patient groups<\/em><\/p>\n\n\n\n<p>Children from 6 weeks to 5 years of age who are considered to be at higher risk of pneumococcal infections (such as children with\u00a0HIV\u00a0infection,\u00a0sickle cell anemia,\u00a0or\u00a0impaired or abnormal spleen function) can receive Synflorix.\u00a0Ask the doctor how many\u00a0injections\u00a0your child should receive and when they should be given.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If your child misses an injection<\/h2>\n\n\n\n<p>If your child misses an\u00a0injection, you must get a new appointment.\u00a0This is so that you and your doctor can talk about what should be done next to protect your child.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0may occur with this medicine:<\/p>\n\n\n\n<p>Serious allergic reactions may occur in very rare cases (up to 1 in 10,000 vaccine doses).&nbsp;Such reactions are recognized by:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>raised and itchy rash (&nbsp;hives&nbsp;)<\/li><li>swelling, sometimes of the face and mouth (&nbsp;angioedema&nbsp;), causing difficulty in breathing<\/li><li>collapse.<\/li><\/ul>\n\n\n\n<p>These reactions normally occur before leaving the doctor&#8217;s office.&nbsp;If your child develops any of these symptoms, contact a doctor immediately.<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(these may occur with more than 1 in 10 vaccine doses)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain,\u00a0redness,\u00a0or swelling where the\u00a0injection\u00a0has been given<\/li><li>fever, 38 \u00b0C or higher<\/li><li>feeling sleepy<\/li><li>feeling of irritation<\/li><li>loss of appetite.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(these may occur with up to 1 in 10 vaccine doses)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>induration at the injection site.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(these may occur in up to 1 in 100 vaccine doses)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>itching, bruising, bleeding, or a small lump where the injection\u00a0has been given<\/li><li>nausea, diarrhea, or vomiting<\/li><li>persistent crying<\/li><li>a temporary pause in breathing (\u00a0apnea\u00a0) if your baby is born prematurely (before or in the 28th week of pregnancy)<\/li><li>headache<\/li><li>rash<\/li><li>diffuse swelling of the injected body part, which sometimes also includes nearby joints<\/li><li>hives.<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(these may occur with up to 1 in 1,000 vaccine doses)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>convulsions without fever or due to high fever<\/li><li>allergic reactions e.g.\u00a0skin allergies<\/li><li>collapse (sudden onset of muscle weakness), periods of unconsciousness or reduced consciousness, and paleness or bluish discoloration of the skin.<\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>&nbsp;(these may occur in up to 1 in 10,000 vaccine doses)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kawasaki disease (the main signs of the disease are, for example, fever, skin rash, swollen\u00a0lymph nodes,\u00a0inflammation,\u00a0and rash on the mucous membranes of the mouth and throat).<\/li><\/ul>\n\n\n\n<p>Booster doses of Synflorix can increase the risk of\u00a0side effects.<\/p>\n\n\n\n<p>For children &gt;12 months of age, the risk of pain at the injection site may increase with increasing age.<\/p>\n\n\n\n<p>In very premature babies (born at 28 weeks of pregnancy or earlier), there may be long pauses between breaths than normal for 2-3 days after vaccination.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Synflorix<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Use before the expiry date stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2 \u00b0C-8 \u00b0C).<\/li><li>Store in the original packaging.&nbsp;Light sensitive.<\/li><li>Do not freeze.<\/li><\/ul>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>The active substances are:<br>A\u00a0dose\u00a0of 0.5 ml contains: Pneumococcal polysaccharide serotype 1\u00a0<sup>1,2<\/sup>Pneumococcal polysaccharide serotype 4\u00a0<sup>1,2<\/sup>Pneumococcal polysaccharide serotype 5\u00a0<sup>1,2<\/sup>Pneumococcal polysaccharide serotype 6B\u00a0<sup>1,2<\/sup>Pneumococcal polysaccharide serotype 7F\u00a0<sup>1,2<\/sup>Pneumococcal polysaccharide serotype 9V\u00a0<sup>1.2<\/sup>Pneumococcal polysaccharide serotype 14\u00a0<sup>1,2<\/sup>Pneumococcal polysaccharide serotype 18C\u00a0<sup>1,3<\/sup>Pneumococcal polysaccharide serotype 19F\u00a0<sup>1.4<\/sup>Pneumococcal polysaccharide serotype 23F\u00a0<sup>1,2<\/sup><br><sup>1\u00a0<\/sup>adsorbed\u00a0on aluminum phosphate<sup>2<\/sup>\u00a0conjugated to\u00a0protein\u00a0D (derived from non-typeable\u00a0<em>Haemophilus influenzae<\/em>\u00a0)\u00a0carrier protein<sup>3<\/sup>\u00a0conjugated to tetanus toxoid\u00a0carrier protein<sup>4<\/sup>\u00a0conjugated to diphtheria toxoid\u00a0carrier protein<\/td><td><br><br>1 microgram<br>3 micrograms<br>1 microgram<br>1 microgram<br>1 microgram<br>1 microgram<br>1 microgram<br>3 micrograms<br>3 micrograms<br>1 microgram<br><br><br>a total of 0.5 milligrams of Al&nbsp;<sup>3+<\/sup><br>9\u201316 micrograms<br><br><br>5\u201310 micrograms<br>3\u20136 micrograms<\/td><\/tr><tr><td>The other ingredients are: sodium chloride (see section 2 for more information) and water for injections<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Solution for injection,\u00a0suspension.<\/li><li>Synflorix is \u200b\u200ba cloudy white\u00a0suspension.<\/li><li>Synflorix is \u200b\u200bavailable as vials for 1\u00a0dose\u00a0in packs of 1, 10, or 100.<\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>GlaxoSmithKline Biologicals said<br>Rue de l&#8217;Institut 89<\/p>\n\n\n\n<p>B-1330 Rixen species<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique\/Belgi\u00eb&nbsp;<\/strong><strong>\/&nbsp;<\/strong><strong>Belgium<\/strong>GlaxoSmithKline Pharmaceuticals sa\/nvTel\/Tel: + 32 10 85 52 00<\/td><td><strong>Lithuania<\/strong>GlaxoSmithKline Biologicals SAPhone: +370 80000334<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>GlaxoSmithKline Biologicals Satel.: + 359 80018205<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>GlaxoSmithKline Pharmaceuticals sa\/nvTel\/Tel: + 32 10 85 52 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline s.r.oPhone: + 420 2 22 00 11 11cz.info@gsk.com<\/td><td><strong>Magyarorsz\u00e1g<\/strong>GlaxoSmithKline Biologicals SATel.: + 36 80088309<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A\/SPhone: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>GlaxoSmithKline Biologicals SAPhone: + 356 80065004<\/td><\/tr><tr><td><strong>Deutschland<\/strong>GlaxoSmithKline GmbH &amp; Co.&nbsp;KGPhone: + 49 (0)89 360448701product.info@gsk.com<\/td><td><strong>The Netherlands<\/strong>GlaxoSmithKline BVPhone: + 31 (0)33 2081100<\/td><\/tr><tr><td><strong>Estonia<\/strong>GlaxoSmithKline Biologicals SAPhone: + 372 8002640<\/td><td><strong>Norway<\/strong>GlaxoSmithKline iPhone: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b7A.EBETel: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>GlaxoSmithKline Pharma GmbH.Tel: + 43 (0)1 97075 0at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>GlaxoSmithKline, SAPhone: + 34 900 202 700es-ci@gsk.com<\/td><td><strong>Polish<\/strong>GSK Services Sp.&nbsp;z o. oTel.: + 48 (22) 576 9000<\/td><\/tr><tr><td><strong>France<\/strong><br>Laboratoire GlaxoSmithKline<br>T\u00e9l: + 33 (0) 1 39 17 84 44diam@gsk.com<\/td><td><strong>Portugal<\/strong>GlaxoSmithKline &#8211; Produtos Farmac\u00eauticos, Lda.Phone: + 351 21 412 95 00FI.PT@gsk.com<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>GlaxoSmithKline Biologicals SATel.: + 385 800787089<\/td><td><strong>Romania<\/strong>GlaxoSmithKline Biologicals SAPhone: + 40 800672524<\/td><\/tr><tr><td><strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LtdPhone: + 353 (0)1 495 5000<\/td><td><strong>Slovenija<\/strong>GlaxoSmithKline Biologicals SAPhone: + 386 80688869<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Telephone: +354 535 7000<\/td><td><strong>Slovenian Republic<\/strong>GlaxoSmithKline Biologicals SAPhone: + 421 800500589<\/td><\/tr><tr><td><strong>Italy<\/strong>GlaxoSmithKline SpATel: + 39 (0)45 7741 111<\/td><td><strong>Finland\/Finland<\/strong>GlaxoSmithKline OyPhone\/Tel: + 358 10 30 30 30<\/td><\/tr><tr><td><strong>Cyprus<\/strong>GlaxoSmithKline Biologicals Satel: + 357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABPhone: + 46 (0)8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>GlaxoSmithKline Biologicals SAPhone: + 371 80205045<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>GlaxoSmithKline Biologicals SAPhone: +44 (0)800 221 441customercontactuk@gsk.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Synflorix is \u200b\u200ba vaccine against pneumococcal infections.\u00a0A doctor or nurse will inject your child with this vaccine.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[25138,25141,21462,21465,25142,21463,25139,21464,25140],"class_list":["post-24178","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-polysaccharide-vaccine-synflorix","tag-benefits-of-synflorix","tag-polysaccharide-vaccine","tag-polysaccharide-vaccine-side-effects","tag-synflorix-side-effects","tag-what-is-polysaccharide-vaccine","tag-what-is-synflorix","tag-what-polysaccharide-vaccine-is-used-for","tag-what-synflorix-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24178"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24178\/revisions"}],"predecessor-version":[{"id":24233,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24178\/revisions\/24233"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}