{"id":24082,"date":"2022-08-16T07:21:27","date_gmt":"2022-08-16T07:21:27","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24082"},"modified":"2022-08-17T08:11:47","modified_gmt":"2022-08-17T08:11:47","slug":"sylvant","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sylvant\/","title":{"rendered":"SYLVANT &#8211; Siltuximab uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;powder for concentrate for&nbsp;infusion&nbsp;solution<br>siltuximab<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What SYLVANT is and what it is used for<\/h2>\n\n\n\n<p><strong>What SYLVANT is<\/strong><\/p>\n\n\n\n<p>SYLVANT is a medicine that contains the active substance siltuximab.<\/p>\n\n\n\n<p>Siltuximab is a monoclonal&nbsp;antibody&nbsp;(a special type of&nbsp;protein&nbsp;) that specifically binds to an&nbsp;antigen&nbsp;(a target protein) in the body called&nbsp;interleukin&nbsp;-6 (IL 6).<\/p>\n\n\n\n<p><strong>What SYLVANT is used for<\/strong><\/p>\n\n\n\n<p>SYLVANT is used to treat multicentric Castleman&#8217;s disease (MCD) in adult patients who do not have human immunodeficiency virus (\u00a0HIV\u00a0) or human herpesvirus-8 (HHV-8)\u00a0infection.<\/p>\n\n\n\n<p>Multicentric Castleman&#8217;s disease causes benign\u00a0tumors\u00a0(non-cancerous growths) to develop in the body&#8217;s\u00a0lymph nodes.\u00a0Symptoms of the disease may include feeling tired, sweating at night, having a tingling sensation, and decreased appetite.<\/p>\n\n\n\n<p><strong>How SYLVANT works<\/strong><\/p>\n\n\n\n<p>Patients with MCD produce too much IL-6 and this is thought to contribute to the abnormal growth of certain cells in the lymph nodes.&nbsp;By binding to IL-6, siltuximab blocks its activity and stops abnormal cell growth.&nbsp;This helps to reduce the size of the lymph nodes which reduces the symptoms of the disease and makes it easier for you to carry out your normal daily tasks.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given SYLVANT<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not be given SYLVANT if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>You are severely allergic to siltuximab or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before you are given SYLVANT if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you currently have an\u00a0infection\u00a0\u2013 this is because SYLVANT can reduce your ability to recognize and fight\u00a0infection, and your\u00a0infection\u00a0can get worse.<\/li><li>you need to be vaccinated or may need to be vaccinated shortly \u2013 this is because some vaccines should not be given with SYLVANT<\/li><li>you have high levels of blood fats (\u00a0hypertriglyceridemia\u00a0) \u2013 this is because SYLVANT can increase these levels.\u00a0The doctor can\u00a0prescribe\u00a0medication to correct this.<\/li><li>you have a condition such as a\u00a0stomach ulcer\u00a0or intestinal pouches that may increase the risk of a tear inside the stomach or intestine (\u00a0gastrointestinal\u00a0perforation\u00a0).\u00a0Signs that such a fissure is developing include stomach pain that gets worse, nausea, changes in bowel habits, and fever &#8211; if you get any of these see a doctor straight away.<\/li><li>you have liver disease or liver changes that show up in blood tests.\u00a0The doctor will monitor you and your liver function.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor, pharmacist, or nurse before you are given SYLVANT.<\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<p>Talk to your doctor right away if you have a serious\u00a0allergic reaction\u00a0during or after the\u00a0infusion.\u00a0Signs include difficulty breathing, tightness in the chest, wheezing, severe dizziness or lightheadedness, swelling of the lips, or skin rash.<\/p>\n\n\n\n<p><strong>Infection&nbsp;you<\/strong><\/p>\n\n\n\n<p>You may get an&nbsp;infection&nbsp;more easily when you are treated with SYLVANT.<\/p>\n\n\n\n<p>These&nbsp;infections&nbsp;can be serious, e.g.&nbsp;pneumonia&nbsp;or blood poisoning (also called &#8220;sepsis&#8221;).<\/p>\n\n\n\n<p>Talk to your doctor immediately if you develop any signs of\u00a0infection\u00a0during treatment with SYLVANT.\u00a0Signs include cough,\u00a0flu-like symptoms, feeling unwell, red or warm skin, and fever.<\/p>\n\n\n\n<p>The doctor may immediately stop treatment with SYLVANT.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>It is unknown whether SYLVANT is safe and effective in this group and therefore SYLVANT should not be given to children and adolescents.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and SYLVANT<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>In particular, tell your doctor or pharmacist if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>theophylline used to treat\u00a0asthma<\/li><li>warfarin, a blood thinner<\/li><li>ciclosporin, used during and after organ transplantation<\/li><li>birth control pills\u00a0are used to prevent pregnancy.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or if you are not sure), talk to your doctor or pharmacist before you are given SYLVANT.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before you are given this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>SYLVANT is not recommended for use during pregnancy.\u00a0It is unknown whether SYLVANT can affect the baby or a pregnant or breastfeeding woman.<\/li><li>You should not become pregnant during treatment with SYLVANT and up to 3 months after the end of treatment.\u00a0You should use effective contraception during this time.<\/li><li>In some cases, if you are pregnant and need treatment for MCD, your doctor may advise you that the benefit of taking SYLVANT to your health outweighs any potential risks to your unborn baby, including increased risk of\u00a0infection\u00a0and the use of certain vaccines in children whose mothers treated with SYLVANT during pregnancy.<\/li><li>It is unknown if SYLVANT passes into breast milk.\u00a0You and the doctor should decide whether to continue taking SYLVANT or breast-feed and stop treatment with SYLVANT.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>SYLVANT is unlikely to affect your ability to drive, cycle or use tools or machines.<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How SYLVANT is given<\/h2>\n\n\n\n<p>SYLVANT will only be given to you by a doctor or nurse in a hospital or clinic.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended\u00a0dose\u00a0is 11 milligrams per kilogram of body weight given once every 3 weeks<\/li><li>SYLVANT will be given as an &#8216;intravenous infusion&#8217; (drip into a vein, usually in the arm).<\/li><li>It will be given slowly over 1 hour.<\/li><li>During the\u00a0infusion\u00a0with SYLVANT, you will be monitored for\u00a0side effects.<\/li><li>You will receive treatment until you and the doctor agree that you no longer benefit from the treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have received too much SYLVANT<\/h2>\n\n\n\n<p>As this medicine will be given to you by a doctor or nurse, it is unlikely that you will get too much.&nbsp;If you think you have been given too much SYLVANT, talk to a doctor or nurse straight away.&nbsp;It is unknown what possible&nbsp;side effects&nbsp;may occur after receiving too much SYLVANT.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using SYLVANT<\/h2>\n\n\n\n<p>You should not stop using SYLVANT without first talking to your doctor.<\/p>\n\n\n\n<p>If you have any further questions about the use of this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0may occur with this medicine.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you notice the following\u00a0side effects, as he or she may need to stop treatment:<\/strong><\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe\u00a0allergic reaction\u00a0&#8211; signs may include difficulty breathing, chest tightness, wheezing, severe dizziness or lightheadedness, swelling of the lips, or skin rash.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;include:<\/strong><\/p>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of\u00a0white blood cells\u00a0(\u00a0neutropenia\u00a0)<\/li><li>decreased number of\u00a0blood platelets\u00a0(\u00a0thrombocytopenia\u00a0)<\/li><li>itching<\/li><li>rash, itchy\u00a0eczema<\/li><li>high levels of blood fats (\u00a0hypertriglyceridemia\u00a0)<\/li><li>high level of\u00a0uric acid\u00a0in the blood which can cause\u00a0gout<\/li><li>abnormal kidney function test<\/li><li>swollen arms, legs, neck, or face<\/li><li>high\u00a0blood pressure<\/li><li>respiratory infections such as in the nose, sinuses, or throat<\/li><li>urinary tract infection<\/li><li>cold<\/li><li>sore throat<\/li><li>stomach pain or discomfort, constipation, diarrhea, heartburn, mouth ulcers, nausea, vomiting<\/li><li>dizziness<\/li><li>headache<\/li><li>pain in joints, pain in arms or legs<\/li><li>weight gain<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high cholesterol levels in the blood<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store SYLVANT<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label and the carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2&nbsp;<sup>o<\/sup>&nbsp;C-8&nbsp;<sup>o<\/sup>&nbsp;C).&nbsp;Do not freeze.&nbsp;Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Do not use if you see cloudy or foreign particles and\/or if the solution appears to be discolored after\u00a0preparation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is siltuximab.\u00a0Each\u00a0vial\u00a0contains 100 mg of siltuximab.\u00a0After\u00a0reconstitution, the solution contains 20 mg of siltuximab per ml.<\/li><li>Other ingredients (excipients) are histidine, histidine hydrochloride monohydrate, polysorbate 80, and sucrose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>SYLVANT is supplied as glass vials containing a white powder to concentrate for solution for\u00a0infusion\u00a0(powder to concentrate).<\/li><li>SYLVANT is available in packages containing 1\u00a0injection vial.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>EUSA Pharma<\/p>\n\n\n\n<p>(Netherlands) BV<\/p>\n\n\n\n<p>54 Beechavenue,<\/p>\n\n\n\n<p>1119PW Schiphol-Rijk<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Janssen Biologics BV<\/p>\n\n\n\n<p>Einsteinweg 101<\/p>\n\n\n\n<p>NL-2333 CB Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SYLVANT is a medicine that contains the active substance siltuximab.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[25090,25095,25087,25089,25088,25094,25086,25092,25091,25093],"class_list":["post-24082","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-siltuximab","tag-benefits-of-sylvant","tag-siltuximab","tag-siltuximab-side-effects","tag-sylvant","tag-sylvant-side-effects","tag-what-is-siltuximab","tag-what-is-sylvant","tag-what-siltuximab-is-used-for","tag-what-sylvant-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24082"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24082\/revisions"}],"predecessor-version":[{"id":24159,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24082\/revisions\/24159"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}