{"id":24033,"date":"2022-08-15T09:45:45","date_gmt":"2022-08-15T09:45:45","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24033"},"modified":"2022-08-16T07:15:09","modified_gmt":"2022-08-16T07:15:09","slug":"suprefact-depot","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/suprefact-depot\/","title":{"rendered":"Suprefact Depot &#8211; Buserelin uses, dose and side effects"},"content":{"rendered":"\n<p>6.3 mg&nbsp;Implant<br>buserelin<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Suprefact Depot is and what it is used for<\/h2>\n\n\n\n<p>Suprefact Depot contains a medicine called buserelin.\u00a0Buserelin is similar to a naturally occurring\u00a0hormone\u00a0released by the brain.\u00a0It belongs to a group of medicines called &#8220;luteinizing hormone-releasing hormone analogs&#8221; (LHRH\u00a0analogs).<\/p>\n\n\n\n<p>Suprefact Depot is used in the treatment of advanced prostate cancer or premature puberty.<\/p>\n\n\n\n<p>In prostate cancer, Suprefact Depot works by\u00a0inhibiting\u00a0the production of\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tostrex\/\">testosterone<\/a>, a male sex hormone.\u00a0In addition to its normal hormonal effects,\u00a0testosterone\u00a0can have a stimulating effect on the growth of certain\u00a0tumors.\u00a0After 3 \u2013 4 weeks of treatment with Suprefact Depot, the concentration of\u00a0testosterone\u00a0has dropped to a very low level.<\/p>\n\n\n\n<p>In premature puberty, Suprefact Depot works by\u00a0inhibiting\u00a0sex hormones.\u00a0In girls, breast development stops or regresses.\u00a0After initial\u00a0bleeding, any menstrual bleeding stops in parallel with the decline of the sex hormones in the body.\u00a0In boys, the growth of the testicles and other signs of puberty stop.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Suprefact Depot<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Suprefact Depot<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to buserelin or any of the other LHRH\u00a0analogs\u00a0(e.g. leuprolide, goserelin, triptorelin) or any other ingredient in this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before starting treatment with Suprefact Depot:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have had your testicles removed.<\/li><li>If your cancer has spread (\u00a0metastasized\u00a0).<\/li><li>If you have an increased risk of cardiovascular disease (e.g. heart attack).<\/li><li>If you have any cardiovascular disease including heart rhythm disorders (\u00a0arrhythmia\u00a0) or are being treated with drugs for this.\u00a0The risk of suffering from heart rhythm disorders may be increased when using Suprefact\u00a0Depot.<\/li><li>If you have\u00a0diabetes.\u00a0Check your blood sugar levels regularly.\u00a0This is because Suprefact Depot can affect your\u00a0metabolism\u00a0and thus your blood sugar levels.<\/li><li>If you have high\u00a0blood pressure.\u00a0Your doctor or nurse should regularly check your\u00a0blood pressure\u00a0as\u00a0blood pressure\u00a0can be affected by Suprefact Depot.<\/li><li>If you have ever had depression.\u00a0You should be vigilant about your mental health because there is a risk that your depression may return or worsen.<\/li><\/ul>\n\n\n\n<p>Suprefact Depot can cause a decrease in bone density,\u00a0osteoporosis\u00a0(weakening of the bones), and an increased risk of bone fractures, especially if you have risk factors for osteoporosis such as alcohol abuse, are smokers, have a family history of osteoporosis, or if you have been treated for a long time with anti-\u00a0epilepsy\u00a0or with\u00a0cortisone.\u00a0Your doctor should measure your bone density regularly to be able to\u00a0prescribe\u00a0preventive measures against osteoporosis if necessary.<\/p>\n\n\n\n<p>At the beginning of prostate cancer treatment,\u00a0tumor\u00a0activation can occur (see section 4. Possible\u00a0side effects\u00a0), therefore the addition of an antiandrogenic drug is recommended approximately 5 days before treatment begins and during the first 3-4 weeks of treatment with Suprefact Depot.\u00a0After this period, testosterone levels have usually decreased to the desired level as a result of the buserelin treatment.<\/p>\n\n\n\n<p>At the beginning of treatment for premature puberty, vaginal bleeding is common.<\/p>\n\n\n\n<p>Inform your doctor if you become moody\/depressed while taking Suprefact Depot.&nbsp;Depression, which can be severe, has been reported in patients taking Suprefact Depot.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Suprefact Depot<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Suprefact&nbsp;Depot&nbsp;can affect or be affected by certain other medicines.<\/p>\n\n\n\n<p>Talk to your doctor especially if you are using:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs against\u00a0diabetes.\u00a0This is because Suprefact Depot can reduce the effect of these medicines.<\/li><li>medicines to treat heart rhythm disorders (eg\u00a0quinidine,\u00a0procainamide,\u00a0amiodarone,\u00a0and sotalol).<\/li><li>other medicines that may increase the risk of heart rhythm disturbances when used together with Suprefact\u00a0Depot, eg\u00a0methadone\u00a0(used as a pain reliever and in the treatment of drug addiction), moxifloxacin (an\u00a0antibiotic\u00a0), antipsychotics (used in severe mental illnesses).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Suprefact Depot should not be used during pregnancy or breastfeeding.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Suprefact Deopt can cause\u00a0side effects\u00a0(such as dizziness) that can affect your concentration and reaction speed.<br>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.<br>Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Suprefact Depot<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 1 pre-filled&nbsp;syringe&nbsp;(2 implants) every two months.<\/p>\n\n\n\n<p>Suprefact Depot is given as an\u00a0injection\u00a0under the skin (\u00a0subcutaneously\u00a0) in the stomach area.\u00a0Injection\u00a0one will normally be given by a doctor or nurse.\u00a0Local anesthesia\u00a0can be given to relieve the pain when\u00a0injecting\u00a0one of the\u00a0implants\u00a0ones.<\/p>\n\n\n\n<p>Suprefact Depot is intended for long-term treatment.&nbsp;In case of premature puberty, treatment for 3-4 years may be needed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Suprefact Depot<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has accidentally ingested the medicine, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Too much of this medicine can make you feel weak, anxious, dizzy, or sick (nausea).\u00a0You may also experience headaches, hot flashes, stomach pain, swelling (\u00a0edema\u00a0) of the ankles and lower legs, breast tenderness, or reactions at the injection site.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, contact your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong><em>Contact a doctor immediately<\/em><\/strong>\u00a0if you develop symptoms such as a rash, difficulty swallowing or breathing, swelling of the lips, face, throat, or tongue.\u00a0This could be a serious\u00a0allergic reaction.\u00a0Inform that you have Suprefact\u00a0Depot\u00a0implants, as it may be necessary to remove the\u00a0implant\u00a0et.<\/p>\n\n\n\n<p>At the beginning of prostate cancer treatment, the amount of\u00a0testosterone\u00a0your body produces may increase and you may experience a temporary worsening of symptoms.\u00a0Contact a doctor if you experience symptoms such as bone pain, worsening bone pain (in patients with\u00a0metastases\u00a0), muscle weakness in the legs, problems with urination, fluid retention, or blood clots in the lungs.\u00a0These reactions can largely be avoided by treatment with a so-called antiandrogenic drug, see section 2.<\/p>\n\n\n\n<p><strong>Reported&nbsp;side effects&nbsp;are<\/strong><br>Common (may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Hot flashes<\/li><li>Pain or other local reactions at the injection site (such as\u00a0redness, swelling)<\/li><li>Impotence, testicular atrophy<\/li><li>Decreased sex drive (\u00a0libido\u00a0), mood changes, depression (long-term treatment).<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Influence on certain blood tests due to an increase in\u00a0enzymes\u00a0produced in your liver<\/li><li>Weight loss or weight gain<\/li><li>Drowsiness, dizziness, fatigue<\/li><li>Constipation<\/li><li>Fluid accumulation (\u00a0edema\u00a0) around the ankles and calves<\/li><li>Hypersensitivity reactions\u00a0such as skin rash,\u00a0redness,\u00a0and\u00a0itching\u00a0as well as hives<\/li><li>Enlargement of the mammary glands (not painful)<\/li><li>Mood changes, depression (short-term treatment).<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Influence on certain blood tests due to changes in blood lipids and bilirubin increase<\/li><li>Fast or uneven heartbeats (&nbsp;palpitations&nbsp;), increased&nbsp;blood pressure&nbsp;in people with already high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/li><li>Sleep difficulties, memory or concentration disorders<\/li><li>Nausea, vomiting, diarrhea<\/li><li>Increased or decreased head or body hair<\/li><li>Severe allergic reactions such as difficulty breathing<\/li><li>Anxiety, feeling anxious, emotional instability.<\/li><\/ul>\n\n\n\n<p>Very rare (may affect up to 1 in 10,000 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased number of\u00a0blood cells, which can lead to abnormal blood tests and\/or bruising<\/li><li>Visual impairment such as blurred vision and feeling of pressure behind the eyes<\/li><li>Ringing in the ears (\u00a0tinnitus\u00a0), hearing disorders<\/li><li>Discomfort and pain in muscles and bones<\/li><li>Increased thirst, changes in appetite, decreased glucose tolerance (in diabetics this may lead to impaired diabetic control)<\/li><li>Enlargement\u00a0of\u00a0benign\u00a0pituitary\u00a0tumor<\/li><li>Slight transient increase in tumor pain despite treatment with antiandrogen medication<\/li><li>Deterioration of general well-being<\/li><li>Severe allergic reactions with\u00a0shock.<\/li><\/ul>\n\n\n\n<p>Has been reported (occurring in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin sensations such as tingling have been observed for other pharmaceutical forms of buserelin.<\/li><li>Changes (\u00a0QT\u00a0prolongation) can be seen on the\u00a0electrocardiogram\u00a0(\u00a0ECG\u00a0).<\/li><\/ul>\n\n\n\n<p>This group of drugs (so-called LHRH agonists&nbsp;)&nbsp;can cause reduced bone density and lead to osteoporosis (&nbsp;osteoporosis&nbsp;) and an increased risk of bone fractures (&nbsp;fracture&nbsp;).&nbsp;The risk of bone fracture increases with the length of the treatment period.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Suprefact Depot<\/h2>\n\n\n\n<p>No special storage instructions.<br>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is buserelin.\u00a0Each pre-filled\u00a0syringe\u00a0contains two rod-shaped\u00a0implants, providing a\u00a0dose\u00a0of 6.6 mg buserelin acetate.\u00a0This is equivalent to 6.3 mg of buserelin.<\/li><li>Other ingredients are Poly (D, L-lactide-co-glycolide) with a molar ratio of lactide: glycolide of 75:25.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>One package contains 1 pre-filled\u00a0syringe.\u00a0Each\u00a0syringe\u00a0contains two cream-colored rod-shaped\u00a0implants.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>CHEPLAPHARM Arzneimittel GmbH<\/p>\n\n\n\n<p>Ziegelhof 24<\/p>\n\n\n\n<p>17489 Greifswald<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Suprefact Depot contains a medicine called buserelin.\u00a0Buserelin is similar to a naturally occurring\u00a0hormone\u00a0released by the brain.\u00a0It belongs to a group of medicines called &#8220;luteinizing hormone-releasing hormone analogues&#8221; (LHRH\u00a0analogues\u00a0).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[25033,25041,25032,25037,25035,25040,25034,25036,25038,25039],"class_list":["post-24033","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-buserelin","tag-benefits-of-suprefact-depot","tag-buserelin","tag-buserelin-side-effects","tag-suprefact-depot","tag-suprefact-depot-side-effects","tag-what-buserelin-is-used-for","tag-what-is-buserelin","tag-what-is-suprefact-depot","tag-what-suprefact-depot-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24033","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24033"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24033\/revisions"}],"predecessor-version":[{"id":24078,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24033\/revisions\/24078"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}