{"id":24030,"date":"2022-08-15T09:45:34","date_gmt":"2022-08-15T09:45:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24030"},"modified":"2022-08-16T07:15:19","modified_gmt":"2022-08-16T07:15:19","slug":"suprefact","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/suprefact\/","title":{"rendered":"Suprefact &#8211; Buserelin uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg\/ml&nbsp;solution,&nbsp;solution for injection<br>buserelin<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Suprefact is and what it is used for<\/h2>\n\n\n\n<p>Suprefact contains a medicine called buserelin.\u00a0Buserelin is similar to a naturally occurring\u00a0hormone\u00a0released by the brain.\u00a0It belongs to a group of medicines called &#8220;luteinizing hormone-releasing hormone analogs&#8221; (LHRH\u00a0analogs).<\/p>\n\n\n\n<p>Suprefact is used in hormone-dependent prostate cancer.\u00a0In prostate cancer, Suprefact works by\u00a0inhibiting\u00a0the production of\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tostrex\/\">testosterone<\/a>, a male sex hormone.\u00a0In addition to its normal hormonal effects,\u00a0testosterone\u00a0can have a stimulating effect on the growth of certain\u00a0tumors.<\/p>\n\n\n\n<p>The buserelin contained in Suprefact may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Suprefact<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Suprefact<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to buserelin or any other LHRH\u00a0analog\u00a0(eg leuprorelin, goserelin, triptorelin) or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Suprefact:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your cancer has spread (\u00a0metastasized\u00a0).<\/li><li>If you have an increased risk of cardiovascular disease (e.g. heart attack).<\/li><li>If you have\u00a0diabetes.\u00a0Check your blood sugar levels regularly.\u00a0This is because Suprefact can affect your\u00a0metabolism\u00a0and thus your blood sugar levels.<\/li><li>If you have high\u00a0blood pressure.\u00a0Your doctor or nurse should regularly check your\u00a0blood pressure\u00a0as\u00a0blood pressure\u00a0can be affected by Suprefact.<\/li><li>If you have ever had depression.\u00a0You should be vigilant about your mental health because there is a risk that your depression may return or worsen.<\/li><li>If you have any cardiovascular disease including heart rhythm disorders (\u00a0arrhythmia\u00a0), or if you are being treated with medicines for this.\u00a0The risk of suffering from heart rhythm disorders may be increased when using Suprefact.<\/li><li>If you have risk factors for osteoporosis such as alcohol abuse, are a smoker, have osteoporosis in the family, or if you have been treated for a long time with anti-epileptic drugs\u00a0or with\u00a0cortisone.<\/li><\/ul>\n\n\n\n<p>Suprefact can cause a decrease in bone density,\u00a0osteoporosis\u00a0(weakening of the bones), and an increased risk of bone fractures, especially if you have risk factors for osteoporosis according to the last point above.\u00a0Your doctor should measure your bone density regularly to be able to\u00a0prescribe\u00a0preventive measures against osteoporosis if necessary.<\/p>\n\n\n\n<p>At the beginning of prostate cancer treatment,\u00a0tumor\u00a0activation may occur due to increased testosterone levels and you may experience a temporary worsening of symptoms (see section 4. Possible\u00a0side effects\u00a0).\u00a0To counteract this, the addition of a so-called anti-androgenic drug is recommended approximately 5 days before treatment begins and during the first 3-4 weeks of treatment with Suprefact.\u00a0After this period, testosterone levels have usually decreased to the desired level as a result of the buserelin treatment.<\/p>\n\n\n\n<p>Inform your doctor if you feel down\/depressed while taking Suprefact.&nbsp;Depression, which can be severe, has been reported in patients taking Suprefact.<\/p>\n\n\n\n<p>Suprefact can increase the risk of\u00a0anemia\u00a0( lack of\u00a0blood\u00a0).\u00a0Tell the doctor if you experience symptoms such as tiredness, shortness of breath, and palpitations.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>In the absence of information on safety and efficacy in children, Suprefact should not be used in children.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Suprefact<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Inform the doctor if you use medicines for\u00a0diabetes.\u00a0This is because Suprefact can reduce the effect of these medicines.<\/p>\n\n\n\n<p>Suprefact may affect certain other medicines used to treat heart rhythm disorders (eg quinidine,\u00a0procainamide,\u00a0amiodarone,\u00a0and sotalol) or may increase the risk of heart rhythm disorders when used with other medicines (eg methadone (used for pain and in the treatment of drug addiction), moxifloxacin (an\u00a0antibiotic\u00a0), antipsychotics (used for serious mental illness).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Suprefact should not be used in women.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Suprefact can cause\u00a0side effects\u00a0(such as drowsiness and dizziness) that can affect your concentration and reaction speed.\u00a0You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effect\u00a0.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Suprefact contains sodium and the best alcohol<\/h2>\n\n\n\n<p><strong>Suprefact contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per ml, i.e. it is almost &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<p><strong>Suprefact contains benzyl alcohol<\/strong><\/p>\n\n\n\n<p>This medicine contains 10 mg of benzyl alcohol per ml\u00a0vial, solution.<\/p>\n\n\n\n<p>Benzyl alcohol can cause allergic reactions.<\/p>\n\n\n\n<p>If you have impaired liver function or impaired kidney function, consult a doctor or pharmacist before using this medicine.&nbsp;Large amounts of benzyl alcohol can be stored in the body and cause&nbsp;side effects&nbsp;(metabolic&nbsp;acidosis&nbsp;).<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Suprefact<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>To ensure the desired effect, you must take Suprefact at the appointed times.<\/p>\n\n\n\n<p>The recommended starting\u00a0dose\u00a0is 0.5 ml (0.5 mg) of Suprefact given as an\u00a0injection\u00a0under the skin every 8 hours for the first seven days.\u00a0This part of the treatment should, if possible, take place in a hospital.\u00a0The doctor will then take a blood sample to check levels of\u00a0testosterone.<\/p>\n\n\n\n<p>A possible worsening of symptoms during the initial phase of treatment can be avoided by taking an antiandrogen at the same time (see also section 4).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Suprefact<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has accidentally ingested the medicine, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Too much of this medicine can make you feel weak, anxious, dizzy, or sick (nausea).\u00a0You may also experience headaches, hot flashes, stomach pain, swelling (\u00a0edema\u00a0) of the ankles and lower legs, breast tenderness, or reactions at the injection site.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, contact your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong><em>Contact a doctor immediately<\/em><\/strong>\u00a0if you develop symptoms such as a rash, difficulty swallowing or breathing, swelling of the lips, face, throat, or tongue.\u00a0This could be a serious\u00a0allergic reaction.\u00a0This is a rare\u00a0side effect\u00a0(which may affect up to 1 in 1,000 users) that can lead to anaphylactic\u00a0shock.<\/p>\n\n\n\n<p>At the beginning of prostate cancer treatment, the amount of\u00a0testosterone\u00a0your body produces may increase and you may experience a temporary worsening of symptoms.\u00a0Contact a doctor if you experience symptoms such as bone pain, worsening bone pain (in patients with\u00a0metastases\u00a0), muscle weakness in the legs, or problems with urination or fluid retention.\u00a0These reactions can largely be avoided by treatment with a so-called antiandrogenic drug, see section 2.<\/p>\n\n\n\n<p><strong>Reported\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Common (may affect up to 1 in 10 users)<\/strong><ul><li>Headache<\/li><li>Feeling of heat in the skin, sweating<\/li><li>Pain or other local reactions (eg\u00a0redness, swelling) at the injection site<\/li><li>Impotence, reduced testicle size<\/li><li>Decreased sex drive, mood changes, depression (with long-term use).<\/li><\/ul><\/li><li>Uncommon (may affect up to 1 in 100 users)<ul><li>Influence on liver function values<\/li><li>Weight loss or weight gain<\/li><li>Drowsiness, dizziness<\/li><li>Constipation<\/li><li>Hypersensitivity reaction\u00a0(redness, itching, hives)<\/li><li>Enlargement of the mammary gland (not painful)<\/li><li>Mood changes, depression (with short-term use)<\/li><li>Fluid accumulation (\u00a0edema\u00a0) around the ankles and calves<\/li><li>Fatigue.<\/li><\/ul><\/li><li>Rare (may affect up to 1 in 1,000 users)<ul><li>Altered blood fat values<\/li><li>Palpitation<\/li><li>Sleep disturbances, memory and concentration disorders<\/li><li>Nausea, vomiting, diarrhea<\/li><li>Increased or decreased head or body hair<\/li><li>Increased\u00a0blood pressure\u00a0in patients with already high\u00a0blood pressure<\/li><li>Emotional instability, anxiety.<\/li><li>Increase in the substance\u00a0bilirubin\u00a0in blood serum.<\/li><\/ul><\/li><li>Very rare (may affect up to 1 in 10,000 users)<ul><li>Changes in the blood picture<\/li><li>Discomfort and pain in muscles and bones<\/li><li>Visual impairment (eg, blurred vision) and feeling of pressure behind the eyes<\/li><li>Tinnitus, hearing disorders<\/li><li>Decreased bone density,\u00a0increased risk of\u00a0fracture<\/li><li>Increased thirst, change in appetite, reduced glucose tolerance (can lead to impaired control of the disease in diabetics)<\/li><li>Growth of benign\u00a0tumor\u00a0in\u00a0the pituitary\u00a0gland<\/li><li>Mild transitory tumor-related pain<\/li><li>Deterioration of general well-being.<\/li><\/ul><\/li><li>Has been reported (occurring in an unknown number of users)<ul><li>Changes (\u00a0QT\u00a0prolongation) that can be seen on\u00a0an electrocardiogram\u00a0(\u00a0ECG\u00a0)<\/li><li>Abnormal sensations such as\u00a0tingling (\u00a0paresthesia\u00a0) have been observed in connection with other buserelin preparations.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Suprefact<\/h2>\n\n\n\n<p>Store at a maximum of 25\u00b0 C.<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the bottle after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is buserelin acetate corresponding to buserelin 1 mg\/ml.<\/li><li>Other ingredients are benzyl alcohol, sodium hydroxide, sodium dihydrogen phosphate, sodium chloride, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Packaging containing 2 vials of 5.5 ml.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>CHEPLAPHARM Arzneimittel GmbH<\/p>\n\n\n\n<p>Ziegelhof 24<\/p>\n\n\n\n<p>17489 Greifswald<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Sanofi-Aventis Deutschland GmbH<\/p>\n\n\n\n<p>Industriepark H\u00f6chst<\/p>\n\n\n\n<p>Br\u00fcningstra\u00dfe 50<\/p>\n\n\n\n<p>65926 Frankfurt am Main<\/p>\n\n\n\n<p>Germa<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Suprefact contains a medicine called buserelin.\u00a0Buserelin is similar to a naturally occurring\u00a0hormone\u00a0released by the brain.\u00a0It belongs to a group of medicines called &#8220;luteinizing hormone-releasing hormone analogues&#8221; (LHRH\u00a0analogues\u00a0).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[25033,25046,25032,25037,25042,25045,25034,25036,25043,25044],"class_list":["post-24030","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-buserelin","tag-benefits-of-suprefact","tag-buserelin","tag-buserelin-side-effects","tag-suprefact","tag-suprefact-side-effects","tag-what-buserelin-is-used-for","tag-what-is-buserelin","tag-what-is-suprefact","tag-what-suprefact-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24030"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24030\/revisions"}],"predecessor-version":[{"id":24079,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24030\/revisions\/24079"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}