{"id":24003,"date":"2022-08-13T08:37:39","date_gmt":"2022-08-13T08:37:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=24003"},"modified":"2022-08-15T09:28:19","modified_gmt":"2022-08-15T09:28:19","slug":"suprane","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/suprane\/","title":{"rendered":"Suprane &#8211; Desflurane uses, dose and side effects"},"content":{"rendered":"\n<p>100%\u00a0Inhalation vapor, liquid<br><\/p>\n\n\n\n<p>R<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Suprane is and what it is used for<\/h2>\n\n\n\n<p>Suprane contains desflurane.\u00a0Suprane is a drug for anesthesia used in surgical procedures.\u00a0It is an\u00a0inhalation anesthetic\u00a0(it is given as a vapor you inhale).\u00a0By inhaling Suprane, you sleep deeply and feel no pain.\u00a0Suprane also maintains a deep, pain-free sleep (anesthesia) so that you can undergo a surgical procedure.\u00a0In adults, Suprane is used to initiate and maintain anesthesia, and in children only to maintain anesthesia.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you receive Suprane<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Your anesthetist will not give you Suprane:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to desflurane or other\u00a0inhalation anesthetics\u00a0such as isoflurane, sevoflurane, halothane, or enflurane.<\/li><li>if you have previously had unexplained liver problems with jaundice, fever, and elevated levels of a certain type of\u00a0white blood cell\u00a0following anesthesia with desflurane or other anesthetics such as isoflurane, sevoflurane, halothane, or enflurane.<\/li><li>if you or a relative of yours suffers from a condition called\u00a0malignant\u00a0hyperthermia.\u00a0Malignant\u00a0hyperthermia\u00a0is a sudden and dangerous increase in body temperature during or shortly after a surgical procedure.\u00a0Deaths from\u00a0malignant\u00a0hyperthermia\u00a0have been reported with desflurane.<\/li><\/ul>\n\n\n\n<p>In children, the anesthesiologist will not give Suprane to induce anesthesia because coughing, respiratory arrest, respiratory arrest,\u00a0laryngospasm\u00a0(spasm of the muscles of the larynx, preventing air from passing through), and increased salivation are common.<\/p>\n\n\n\n<p>Suprane should only be given by healthcare professionals trained in general anesthesia and under the supervision of an anesthesiologist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before you receive Suprane.&nbsp;The doctor will be extra careful when treating with this medicine if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a reduced blood volume.\u00a0Your doctor may need to give you treatment to restore your blood volume before you are put to sleep.<\/li><li>if you have an injury or pathological change in the brain, e.g. a brain tumor.<\/li><li>if you develop\u00a0malignant\u00a0hyperthermia\u00a0(a sudden and dangerous increase in body temperature during or shortly after a surgical procedure), which is rare and unpredictable.\u00a0In this case, your anesthetist will stop giving Suprane.\u00a0To treat malignant hyperthermia, you will be given a medicine called dantrolene and other supportive care.<\/li><li>if you have a neuromuscular disease (such as Duchenne muscular dystrophy).\u00a0You may then be more sensitive to the rare increases in blood potassium levels that Suprane can cause.<\/li><li>if you have been given an anesthetic by\u00a0inhalation\u00a0before, especially if this was given repeatedly recently.<\/li><li>if you have low\u00a0blood pressure.<\/li><li>if you have coronary artery disease (a disease of the blood vessels that surround the heart and supply the heart muscle with oxygen).\u00a0Your doctor may then need to give you other medicines.<\/li><li>if you have or have previously had liver problems such as\u00a0hepatitis\u00a0(inflammation of the liver) or\u00a0cirrhosis\u00a0(a condition where the liver cells are successively replaced by connective tissue cells, causing the liver to lose function).<\/li><li>if you have a certain type of change in the heart that can affect the heart rhythm (so-called &#8220;QT prolongation&#8221;, can be seen on the\u00a0ECG\u00a0).<\/li><li>if you have abnormally low levels of\u00a0potassium\u00a0in your blood<\/li><\/ul>\n\n\n\n<p>If you feel pain after you wake up from the anesthesia, your doctor will give you pain medication.<\/p>\n\n\n\n<p>Contact a doctor as soon as possible if you experience unexplained muscle pain, muscle cramps, or muscle weakness.<\/p>\n\n\n\n<p><strong>Children<\/strong><\/p>\n\n\n\n<p>In children (especially children 6 years of age or younger), Suprane should not be given via a mask during the maintenance of anesthesia because it increases the risk of\u00a0side effects\u00a0in the respiratory tract such as coughing and\u00a0laryngospasm\u00a0(spasm in the muscles of the larynx which prevents air from the pass), see also section\u00a0Side effect\u00a0ar.\u00a0The doctor will instead give Suprane via a throat tube that is inserted into the trachea.\u00a0When a mask is used for children, the doctor will be extra careful and remove the mask only when the child is fully awake.\u00a0Talk to the anesthesiologist if your child has\u00a0asthma\u00a0or has recently had an\u00a0infection in the airways.\u00a0The anesthetist will then be extra careful because there is then a risk that the airways will become narrower and that the resistance in the airways will increase.<\/p>\n\n\n\n<p>In children, awakening from\u00a0anesthesia\u00a0can induce a brief state of irritation that can make a cooperation with doctors and nurses difficult after awakening.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Suprane<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The medicines or active substances included in medicines, listed below can affect each other&#8217;s effect when they are used together with Suprane.\u00a0Some of these medicines are given to you by the anesthetist during the surgical procedure, as stated in the description.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nitrous oxide (nitrous oxide): This is a drug used in general anesthesia that induces sleep and relieves pain.<\/li><li>Depolarizing and non-depolarizing muscle relaxants (for example, pancuronium, atracurium, suxamethonium, and vecuron): These drugs are used under general anesthesia to make your muscles relax.<\/li><li>Tranquilizers (for example,\u00a0fentanyl\u00a0and midazolam)<\/li><li>Calcium-blocking drugs (for example, verapamil).\u00a0These are drugs that are often given to treat high\u00a0blood pressure\u00a0or irregular heart rhythms.<\/li><li>Beta-receptor blocking\u00a0agents, (eg propranolol).\u00a0These are heart medications that are often given to treat high\u00a0blood pressure.<\/li><li>Medicines that can cause\u00a0QT\u00a0prolongation (a heart problem that can affect the heart rhythm, can be seen on the\u00a0EKG\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before you are given this medicine.<\/p>\n\n\n\n<p>You should not be given Suprane if you are pregnant or breastfeeding.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Suprane has a strong influence on your ability to drive and use tools or machines.&nbsp;Do not drive or use tools or machines until your doctor tells you it is safe.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Suprane<\/h2>\n\n\n\n<p>Suprane is given to you by an anesthesiologist.\u00a0The anesthetist will decide how many doses\u00a0you need and when you will receive it.\u00a0The dose\u00a0varies depending on your age, the type of surgery you are having, and the other medications you are taking during the surgery.<\/p>\n\n\n\n<p>Suprane is made from liquid desflurane using a gasifier specifically designed to be used for desflurane.\u00a0You may be asked to breathe in desflurane gas through a mask to put you to sleep.\u00a0You may also receive an\u00a0injection\u00a0of another anesthetic to put you to sleep before receiving desflurane through a mask or a so-called nasopharyngeal tube.<\/p>\n\n\n\n<p>During the anesthesia, your doctor will check your&nbsp;blood pressure&nbsp;and&nbsp;heart rate&nbsp;to determine if your&nbsp;dose&nbsp;needs to be adjusted.<\/p>\n\n\n\n<p>The anesthetist will decide when it is time to stop giving you Suprane.&nbsp;You will then wake up after a few minutes.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<p>If your child is under 6 years of age, she\/he will first be given another anesthetic to put them to sleep, and then the anesthetist will give Suprane via a nasogastric tube.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have received too much Suprane<\/h2>\n\n\n\n<p>Suprane will be given by a healthcare professional and it is unlikely that you will be given too much Suprane.&nbsp;If you should still receive too much Suprane, the anesthesiologist will take the necessary measures.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Very common (affects more than 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Vomiting.&nbsp;This side effect has been reported during induction and maintenance of anesthesia with Suprane.<\/li><li>Nausea.&nbsp;This side effect has been reported during induction and maintenance of anesthesia with Suprane.<\/li><\/ul>\n\n\n\n<p><strong>Common (affects 1 to 10 users in 100):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation\u00a0of the throat (\u00a0pharyngitis\u00a0)<\/li><li>Headache<\/li><li>Inflammation\u00a0of the\u00a0conjunctiva of the eye<\/li><li>Irregular heartbeats (\u00a0nodular\u00a0arrhythmia\u00a0)<\/li><li>Slow heartbeat<\/li><li>Palpitation<\/li><li>Increased\u00a0blood pressure<\/li><li>Temporary, transient cessation of breathing (\u00a0apnea\u00a0).\u00a0This side effect has been reported during induction and maintenance of anesthesia with Suprane.<\/li><li>Cough.\u00a0This side effect has been reported during induction and maintenance of anesthesia with Suprane.<\/li><li>Spasm of the muscles of the larynx, which prevents air from passing (\u00a0laryngospasm\u00a0).\u00a0This side effect has been reported during induction of anesthesia with Suprane.<\/li><li>Increased salivation.\u00a0This side effect has been reported during induction and maintenance of anesthesia with Suprane.<\/li><li>Elevated levels of the\u00a0enzyme\u00a0et creatinine phosphokinase<\/li><li>A certain type of change in the heart can affect the heart rhythm (so-called &#8220;QT prolongation&#8221;, can be seen on the\u00a0EKG\u00a0).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (affects 1 to 10 users in 1,000):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Motor restlessness, restless and excessive movements (&nbsp;agitation&nbsp;)<\/li><li>Dizziness<\/li><li>Myocardial infarction<\/li><li>Lack of oxygen in the heart muscle (myocardial&nbsp;ischemia&nbsp;)<\/li><li>Irregular heart rhythm (&nbsp;arrhythmia&nbsp;)<\/li><li>Widening of blood vessels<\/li><li>Oxygen deficiency.&nbsp;This side effect has been reported during induction and maintenance of anesthesia with Suprane.<\/li><li>Muscle pain<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurring in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Coagulation disorder (disorder in the clotting ability of the blood)<\/li><li>Too high a level of\u00a0potassium\u00a0in the blood<\/li><li>Too low level of\u00a0potassium\u00a0in the blood<\/li><li>Lowered\u00a0pH\u00a0in the body is caused by high levels of acidic substances<\/li><li>Cramps<\/li><li>Cardiac arrest<\/li><li>An unusual form of\u00a0arrhythmia\u00a0where the heart beats very fast (\u00a0Torsade de pointes\u00a0)<\/li><li>The chambers of the heart stop working<\/li><li>Impaired movement in the chambers of the heart with abnormally small or slow movements<\/li><li>Atrial fibrillation\u00a0(a form of heart rhythm disorder due to irregular activation of the front chamber of the heart, the atria, causing the heart to contract at irregular intervals)<\/li><li>Very high\u00a0blood pressure\u00a0(\u00a0malignant\u00a0hypertension\u00a0)<\/li><li>Bleeding<\/li><li>Low\u00a0blood pressure<\/li><li>Shock.\u00a0A life-threatening condition that occurs when\u00a0blood pressure\u00a0drops and circulation decreases<\/li><li>Breathing stops working as it should and the body, therefore, does not get a normal supply of oxygen and\u00a0elimination\u00a0of\u00a0carbon dioxide.<\/li><li>Respiratory distress<\/li><li>Spasms in the muscles of the trachea can make it harder to breathe.\u00a0Common symptoms are wheezing, and wheezing.<\/li><li>Inflammation\u00a0of the pancreas<\/li><li>Stomach pains<\/li><li>Impaired or insufficient liver function (liver failure)<\/li><li>Tissue death in the liver<\/li><li>Inflammation\u00a0of the liver (\u00a0hepatitis\u00a0and cytolytic\u00a0hepatitis\u00a0)<\/li><li>Bile stasis (blockage of bile flow to the intestine)<\/li><li>Jaundice (yellowing of the skin and whites of the eyes)<\/li><li>Abnormal liver function<\/li><li>Liver disorder<\/li><li>Hives or\u00a0hives.\u00a0The symptoms are\u00a0redness, swelling, and strong\u00a0itching.<\/li><li>Redness\u00a0of the skin<\/li><li>Dissolution of muscle tissue with precipitation of myoglobin as a result, can lead to\u00a0acute\u00a0kidney failure\u00a0(\u00a0rhabdomyolysis\u00a0).<\/li><li>A sudden and dangerous rise in body temperature during or shortly after a surgical procedure (\u00a0malignant\u00a0hyperthermia\u00a0)<\/li><li>Weakness<\/li><li>Feeling of illness<\/li><li>A certain type of change (so-called ST-T change) in the heart is seen on an\u00a0electrocardiogram\u00a0(\u00a0ECG\u00a0).\u00a0An EKG\u00a0is an examination that is done to see and monitor how the heart&#8217;s electrical activity, which among other things controls the heart&#8217;s rhythm, works.<\/li><li>A certain type of change (so-called T-wave inversion) in the heart is seen on an\u00a0electrocardiogram\u00a0(\u00a0ECG\u00a0).\u00a0An EKG\u00a0is an examination that is done to see and monitor how the heart&#8217;s electrical activity, which among other things controls the heart&#8217;s rhythm, works.<\/li><li>Increased\u00a0alanine aminotransferase\u00a0(an\u00a0enzyme\u00a0mainly found in liver cells)<\/li><li>Increased\u00a0aspartate aminotransferase\u00a0(an\u00a0enzyme\u00a0mainly found in liver and heart cells)<\/li><li>Increased level of\u00a0bilirubin\u00a0in the blood<\/li><li>Abnormal blood\u00a0coagulation test result<\/li><li>Ammonium increase<\/li><li>Irritation after completed surgery<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Suprane<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label after Ex.&nbsp;dat.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Suprane should be stored upright with the lid tightly closed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is desflurane.\u00a0The medicine consists only of the active substances.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Suprane is supplied in a glass bottle (made of brown glass type III with a protective coating of PVC plastic) or an aluminum bottle (made of aluminum coated with an inner protective varnish of epoxy phenolic resin) 240 ml or 6 x 240 ml respectively.\u00a0Both the glass and aluminum bottles are fitted with a valve cap compatible with the special carburetor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Baxter Medical AB<\/p>\n\n\n\n<p>Box 63<\/p>\n\n\n\n<p>164 94 Coffin<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Baxter SA<\/p>\n\n\n\n<p>Lessin&#8217;s<\/p>\n\n\n\n<p>Belgium<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Suprane contains desflurane.\u00a0Suprane is a drug for anesthesia used in surgical procedures.\u00a0It is an\u00a0inhalation anesthetic\u00a0(it is given as a vapor you inhale).\u00a0By inhaling Suprane, you sleep deeply and feel no pain.\u00a0Suprane also maintains the deep, pain-free sleep (naesthesia) so that you can undergo a surgical procedure.\u00a0In adults, Suprane is used to initiate and maintain anesthesia and in children only to maintain anesthesia.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24948,24952,24944,24947,24946,24951,24945,24950,24949,24953],"class_list":["post-24003","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-desflurane","tag-benefits-of-suprane","tag-desflurane","tag-desflurane-side-effects","tag-suprane","tag-suprane-side-effects","tag-what-desflurane-is-used-for","tag-what-is-desflurane","tag-what-is-suprane","tag-what-suprane-is-used-ffor"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24003","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=24003"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24003\/revisions"}],"predecessor-version":[{"id":24019,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/24003\/revisions\/24019"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=24003"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=24003"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=24003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}