{"id":23891,"date":"2022-08-11T15:31:39","date_gmt":"2022-08-11T15:31:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23891"},"modified":"2022-08-12T12:08:57","modified_gmt":"2022-08-12T12:08:57","slug":"suliqua","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/suliqua\/","title":{"rendered":"Suliqua &#8211; Glargine, Lixisenatide uses, dose and side effects"},"content":{"rendered":"\n<p>100 units\/ml + 50 micrograms\/ml&nbsp;solution for injection&nbsp;, solution in pre-filled&nbsp;pen<br>Insulin&nbsp;glargine + lixisenatide<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Suliqua is and what it is used for<\/h2>\n\n\n\n<p>Suliqua is an injection medicine for&nbsp;diabetes&nbsp;that contains two active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toujeo-2\/\">insulin\u00a0glargine<\/a> \u2013 a type of long-acting\u00a0insulin\u00a0that helps regulate blood sugar throughout the day<\/li><li>lixisenatide \u2013 a so-called GLP-1\u00a0analog\u00a0that helps the body produce its insulin\u00a0in response to blood sugar increases, and prolongs the absorption of sugar from food.<\/li><\/ul>\n\n\n\n<p>Suliqua is used in the treatment of type 2\u00a0diabetes\u00a0in adults, to regulate blood sugar levels when they are too high and is a supplement to diet and exercise.\u00a0It is given with\u00a0metformin, with or without\u00a0sodium-glucose co-transporter 2 (SGLT-2) inhibitors (gliflozin products), when other medicines are not sufficient to control your blood sugar levels.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Suliqua<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Suliqua:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;insulin&nbsp;glargine or lixisenatide or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Suliqua<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have type 1\u00a0diabetes, as Suliqua is used for type 2\u00a0diabetes\u00a0and this medicine will therefore not be right for you.<\/li><li>you have diabetic\u00a0ketoacidosis\u00a0(a diabetes complication that occurs when the body is unable to use\u00a0glucose\u00a0because there is not enough\u00a0insulin\u00a0) because this medicine will not be right for you.<\/li><li>you have severe problems with your stomach or intestines, such as a disease of the stomach muscle called gastroparesis, which leads to delayed gastric emptying.\u00a0Because Suliqua can cause stomach side effects (see section 4), the medicine has not been studied in patients with severe stomach or intestinal problems.\u00a0See information regarding medicines that should not be left in the stomach for too long under the section &#8220;Other medicines and Suliqua&#8221;.<\/li><li>you have severe kidney disease or if you are receiving dialysis treatment, as the use of this medicine is not recommended then.<\/li><\/ul>\n\n\n\n<p>Carefully follow the instructions for\u00a0dosage, sampling (blood and urine tests), diet and physical activity (physical work and exercise), and injection technique as discussed with your doctor.<\/p>\n\n\n\n<p><strong>Pay particular attention to the following:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>too low blood sugar (hypoglycemia).\u00a0If your blood sugar is too low, follow the advice on treating\u00a0hypoglycemia\u00a0(see information in the box at the end of this leaflet).<\/li><li>too high blood sugar (hyperglycemia) If your blood sugar is too high, follow the advice on treating\u00a0hyperglycemia\u00a0(see information in the box at the end of this leaflet).<\/li><li>make sure you are using the right medicine.\u00a0Always check the label before each\u00a0injection, to avoid Suliqua being confused with other\u00a0insulins.<\/li><li>if you have poor vision, see section 3.<\/li><\/ul>\n\n\n\n<p><strong>Pay particular attention to the following when using this medicine and talk to your doctor, pharmacist, or nurse before using Suliqua:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe stomach pain that does not go away.\u00a0This may be a sign of an inflamed\u00a0pancreas\u00a0(\u00a0acute\u00a0pancreatitis\u00a0).<\/li><li>loss of fluid from your body (\u00a0dehydration\u00a0), for example in the case of vomiting and diarrhea.\u00a0It is important to avoid\u00a0dehydration\u00a0by drinking a lot, especially during the first weeks of treatment with Suliqua.<\/li><\/ul>\n\n\n\n<p><strong>Skin changes at the injection site<\/strong><\/p>\n\n\n\n<p>To prevent skin changes, e.g.\u00a0knots under the skin, you should constantly change the injection site.\u00a0Insulin\u00a0it may\u00a0not work as well if you inject it into an area with nodules (see How to use Suliqua).\u00a0Contact the doctor before changing the injection site if you are currently injecting into an area with nodules.\u00a0The doctor may advise you to check your blood sugar more often and to adjust your insulin dose or the\u00a0dose\u00a0of other diabetes medicines.<\/p>\n\n\n\n<p><strong>Trip<\/strong><\/p>\n\n\n\n<p>Consult your doctor before you travel.&nbsp;You may need to raise questions about:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the availability of your medicine in the country you are visiting,<\/li><li>the availability of medicines, syringes, and other items,<\/li><li>correct storage of the medicine during the trip,<\/li><li>times for meals and medication use during the trip,<\/li><li>possible consequences of traveling to other time zones,<\/li><li>any new health risks in the countries you visit,<\/li><li>what to do in an emergency if you feel unwell or become ill.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Experience from treatment with Suliqua in children and adolescents under 18 is lacking, Suliqua is therefore not recommended for this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Suliqua<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0If you are using any other diabetes medicine, talk to your doctor about whether you should stop taking the medicine when you start using Suliqua.<\/p>\n\n\n\n<p>Some medicines can change your blood sugar level.\u00a0This may mean that your doctor needs to change your Suliqua\u00a0dose.\u00a0Therefore, consult a doctor before starting to take any medicine.\u00a0Ask if it will affect your blood sugar and what possible measures you need to take if so.\u00a0You also need to pay attention when you stop taking a medicine.<\/p>\n\n\n\n<p>The effect of some medicines that you swallow can be affected by Suliqua.\u00a0Certain drugs such as\u00a0antibiotics,\u00a0birth control pills, statins (cholesterol-lowering drugs such as atorvastatin) or enteric-resistant tablets, capsules,\u00a0granules, oral powder, or\u00a0suspension\u00a0that should not remain in the stomach for too long may need to be taken at least one hour before or four hours after\u00a0injection\u00a0with Suliqua.<\/p>\n\n\n\n<p><strong>Medicines that can cause your blood sugar level to drop (hypoglycemia) include:\u00a0<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>All other medicines for the treatment of\u00a0diabetes.<\/li><li>Disopyramide\u00a0&#8211; in certain heart conditions.<\/li><li>Fluoxetine\u00a0&#8211; for depression.<\/li><li>Sulfonamide antibiotics &#8211; to treat\u00a0the infection.<\/li><li>Fibrates &#8211; to lower high blood fat levels.<\/li><li>MAO inhibitors\u00a0&#8211; in depression or\u00a0Parkinson&#8217;s disease.<\/li><li>ACE inhibitors\u00a0&#8211; in certain heart conditions or high\u00a0blood pressure.<\/li><li>Pain relievers and antipyretics such as pentoxifylline, propoxyphene, and salicylates (such as\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/treo-comp\/\">aspirin<\/a>\u00a0).<\/li><li>Pentamidine &#8211; in certain parasitic infections.\u00a0This can cause low blood sugar which is sometimes accompanied by high blood sugar.<\/li><\/ul>\n\n\n\n<p><strong>Medicines that can cause your blood sugar level to rise (hyperglycemia) include:<\/strong>\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Corticosteroids\u00a0such as\u00a0cortisone\u00a0and\u00a0prednisolone\u00a0&#8211; for\u00a0inflammation.<\/li><li>Danazol &#8211; for\u00a0endometriosis\u00a0(misplaced endometrium).<\/li><li>Diazoxide &#8211; in case of high\u00a0blood pressure.<\/li><li>Protease inhibitors\u00a0&#8211; in\u00a0HIV.<\/li><li>Diuretics\u00a0&#8211; fluid-reducing drugs for high\u00a0blood pressure\u00a0or fluid retention.<\/li><li>Glucagon &#8211; in case of very low blood sugar.<\/li><li>Isoniazid\u00a0&#8211; for tuberculosis.<\/li><li>Somatropin, is a\u00a0growth hormone.<\/li><li>Thyroid hormones &#8211; in thyroid diseases.<\/li><li>Estrogens\u00a0and progestogens, e.g.\u00a0birth control pills\u00a0used for birth control or use of\u00a0estrogen\u00a0for osteoporosis.<\/li><li>Clozapine, olanzapine, and phenothiazine derivatives &#8211; in mental illness.<\/li><li>Sympathomimetic drugs e.g.\u00a0adrenaline\u00a0(\u00a0epinephrine\u00a0),\u00a0salbutamol,\u00a0and\u00a0terbutaline\u00a0&#8211; in\u00a0asthma.<\/li><\/ul>\n\n\n\n<p><strong>Blood sugar levels may either increase or decrease if you use:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Beta-blockers\u00a0or\u00a0clonidine\u00a0&#8211; in case of high\u00a0blood pressure.<\/li><li>Lithium salts &#8211; in case of mental illness.<\/li><\/ul>\n\n\n\n<p><strong>Medicines that can affect the warning signals of low blood sugar<\/strong><\/p>\n\n\n\n<p>Beta-blockers\u00a0and some other drugs (eg\u00a0clonidine, guanethidine, reserpine &#8211; in high\u00a0blood pressure\u00a0) can make it harder to recognize the first warning signs of low blood sugar levels (hypoglycemia).\u00a0It can even hide or prevent the first warning signs that your blood sugar is too low.<\/p>\n\n\n\n<p>If you are unsure whether the above applies to you, consult a doctor, pharmacist, or nurse before using this medicine.<\/p>\n\n\n\n<p><strong>Warfarin&nbsp;or other blood-thinning drugs<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you are using\u00a0warfarin\u00a0or other blood thinners (medicines that prevent the blood from forming clots).\u00a0You may need to take blood samples more often to measure the clotting ability of the blood (called the INR test \u2013 which stands for International Normalized Ratio).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Suliqua with alcohol<\/h2>\n\n\n\n<p>Your blood sugar can either rise or fall if you drink alcohol.&nbsp;You should check your blood sugar more often.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Suliqua should not be used during pregnancy.\u00a0It is not known whether Suliqua can harm your unborn baby.<br>Suliqua should not be used if you are breastfeeding.\u00a0It is not known whether Suliqua passes into breast milk.<br>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Having too low or too high blood sugar (see information box at the end of this leaflet) can affect your ability to drive and operate tools or machines.&nbsp;Your ability to concentrate may be affected.&nbsp;This can pose a danger to yourself and others.<\/p>\n\n\n\n<p>Ask your doctor for advice on whether you should overtake:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your blood sugar is often too low<\/li><li>You have a hard time feeling when your blood sugar is too low<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Suliqua contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<p><strong>Suliqua contains metacresol<\/strong><\/p>\n\n\n\n<p>This medicine contains metacresol which can cause allergic reactions.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Suliqua<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.\u00a0Your doctor may tell you to use a different\u00a0dose\u00a0compared to your previous dose of insulin or glucose-lowering medicine.\u00a0Consult a doctor, pharmacist, or nurse if you are unsure.<\/p>\n\n\n\n<p>Depending on your lifestyle, the results of your blood sugar test, and previous insulin treatment, the doctor will tell you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>How much Suliqua you will need each day and at what time of day?<\/li><li>When to check your blood sugar level and if you need to do a urine test.<\/li><li>When you may have to increase or decrease the\u00a0dose\u00a0a.<\/li><\/ul>\n\n\n\n<p>Your doctor may recommend that you use Suliqua together with other medicines for high blood sugar.<\/p>\n\n\n\n<p><strong>How much to use<\/strong><\/p>\n\n\n\n<p>Suliqua 100 units\/ml + 50 micrograms\/ml&nbsp;solution for injection&nbsp;in pre-filled pen:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This pen gives you\u00a0doses\u00a0from 10 to 40 dose steps in one\u00a0injection, in steps of 1 dose step.<\/li><li>Each dose step you turn forward contains 1 unit\u00a0of insulin\u00a0glargine and 0.5 micrograms of lixisenatide<\/li><\/ul>\n\n\n\n<p>Your Suliqua&nbsp;dose&nbsp;is given as &#8220;dose steps&#8221;.&nbsp;The dosing window of the injection pen shows the number of dose steps.<\/p>\n\n\n\n<p>Do not inject a lower\u00a0dose\u00a0than 10 dose increments.\u00a0Do not inject a larger\u00a0dose\u00a0than 40 dose increments.\u00a0If a larger\u00a0dose\u00a0than 40 dose increments is required, your doctor will prescribe a different strength.\u00a0For dose steps between 30-60 units, Suliqua 100 units\/ml + 33 micrograms\/ml\u00a0solution for injection\u00a0in the pre-filled\u00a0pen is\u00a0available.<\/p>\n\n\n\n<p>Many factors can affect blood sugar levels.\u00a0You need to know these factors to react correctly when the blood sugar level changes and to prevent the level from becoming too high or too low.\u00a0See the box at the end of this leaflet for more information.<\/p>\n\n\n\n<p><strong>Use in elderly patients (65 years and older)<\/strong>&nbsp;<\/p>\n\n\n\n<p>Talk to your doctor if you are 65 or older, as you may need a lower\u00a0dose.<\/p>\n\n\n\n<p><strong>If you have kidney or liver problems<\/strong>&nbsp;<\/p>\n\n\n\n<p>Talk to your doctor if you have kidney or liver problems, as you may need a lower\u00a0dose.<\/p>\n\n\n\n<p><strong>When to inject Suliqua<\/strong><\/p>\n\n\n\n<p>Use Suliqua once daily, within an hour before a meal.&nbsp;Ideally, inject Suliqua before the same meal every day, when you have selected the most suitable meal.<\/p>\n\n\n\n<p><strong>Before injecting Suliqua<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Always follow the instructions for use that come with this leaflet and use the pen as described<\/li><li>If you do not follow all directions, you may receive too much or too little Suliqua.<\/li><\/ul>\n\n\n\n<p>To avoid mistakes: always check the medicine package and the pen label before each&nbsp;injection&nbsp;to make sure you have the right pen, especially if you use more than one injection.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How to inject<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Suliqua is injected under the skin (\u00a0subcutaneous\u00a0use, \u201cSC\u201d).<\/li><li>Give an\u00a0injection\u00a0in the front of the thighs, in the upper arms, or the front of the waist (abdomen).<\/li><li>Vary the injection site within the area of \u200b\u200bskin you use for\u00a0injection\u00a0each day.\u00a0It reduces the risk of developing bumps or nodules in the skin at the injection site (for more information, see \u201cOther side effects\u201d in section 4).<\/li><\/ul>\n\n\n\n<p><strong>Do not use Suliqua<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If there are particles in Suliqua.\u00a0The solution should be clear, colorless, and water-like.<\/li><\/ul>\n\n\n\n<p><strong>Other important information about using pre-filled pens<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Always attach a new needle before each\u00a0injection.\u00a0Reusing needles increases the risk of clogged needles, which can cause under- or overdosing.\u00a0Dispose of used needles safely after each\u00a0injection.<\/li><li>To prevent the transmission of disease from one person to another, the injection pens should never be used for more than one person, even if the injection needle is changed.<\/li><li>Use only needles designed for the Suliqua pen (see instructions for use).<\/li><li>A safety test must be performed before each\u00a0injection.<\/li><li>Dispose of the used needle in a needle container or according to current procedures.<\/li><\/ul>\n\n\n\n<p>Never use a&nbsp;syringe&nbsp;to draw up medicine from the injection pen, to avoid dosing errors and potential overdose.<\/p>\n\n\n\n<p>If the pen is damaged or has not been stored properly, if you are not sure if it is working properly, or if you notice that your blood sugar control has unexpectedly worsened:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Discard the pen and use a new one.<\/li><li>Talk to your doctor, pharmacist, or nurse if you think you have a problem with the pen.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Suliqua<\/h2>\n\n\n\n<p>If you have injected too much of this medicine, your blood sugar level may become too low (hypoglycemia).\u00a0Check your blood sugar and eat more food to prevent blood sugar from getting too low.\u00a0If your blood sugar gets too low, read the advice in the box at the end of this leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Suliqua<\/h2>\n\n\n\n<p>If you have forgotten a\u00a0dose\u00a0of Suliqua or if you have not injected enough\u00a0insulin, your blood sugar level may become too high (hyperglycemia).<\/p>\n\n\n\n<p>If necessary, Suliqua can be injected before the next meal.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not inject a double\u00a0dose\u00a0to make up for a missed\u00a0dose.<\/li><li>Do not take two\u00a0injections\u00a0per day.<\/li><li>Check the blood sugar and then inject the next\u00a0dose\u00a0at the usual time.<\/li><li>For information on the treatment of\u00a0hyperglycemia, see the box at the end of this leaflet.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Suliqua<\/h2>\n\n\n\n<p>Do not stop taking this medicine without talking to your doctor.\u00a0If you stop taking the medicine, it can lead to very high blood sugar (hyperglycemia) and acid build-up in the blood (\u00a0ketoacidosis\u00a0).<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>If you notice that your blood sugar is getting too low (hypoglycemia<\/strong>),\u00a0take immediate action to raise your blood sugar level (see the box at the end of this leaflet).\u00a0Hypoglycemia\u00a0can be very serious and is very common with insulin treatment (may affect more than 1 in 10 people).\u00a0Low blood sugar means that there is not enough sugar in your blood.\u00a0If your blood sugar level gets too low, you may faint (pass out).\u00a0If your blood sugar is very low for a long time, it can cause brain damage and can be life-threatening.\u00a0For more information, see the box at the end of this leaflet.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Skin changes at the injection site:<\/strong><br>If you inject\u00a0insulin\u00a0too often at the same site, the skin may either shrink (lipoatrophy) or thicken (lipohypertrophy).\u00a0Nodules under the skin can also be caused by the accumulation of a\u00a0protein\u00a0called amyloid (\u00a0cutaneous\u00a0amyloidosis).\u00a0It is not known how often these skin changes occur.\u00a0Insulin\u00a0it may\u00a0not work as well if you inject it into an area with nodules.\u00a0Change the injection site for each\u00a0injection\u00a0to prevent these skin changes.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Diarrhea<\/li><li>Skin side effects and allergic reactions at the injection site: The reactions may include\u00a0redness, unusually intense pain during\u00a0injection,\u00a0itching,\u00a0hives, swelling, and\u00a0inflammation.\u00a0These reactions may spread around the injection site.\u00a0Most less serious insulin reactions usually go away within a few days to a few weeks.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cold symptoms, runny nose, sore throat<\/li><li>Hives&nbsp;(&nbsp;urticaria&nbsp;)<\/li><li>Headache<\/li><li>Poor digestion (&nbsp;dyspepsia&nbsp;)<\/li><li>Stomach ache<\/li><li>Fatigue<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Suliqua<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and the pen label after \u201cEXP\u201d.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Before first use<\/strong>&nbsp;<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C-8 \u00b0C).<\/p>\n\n\n\n<p>May not be frozen or stored in direct contact with freezer compartments or cooling clamps.<\/p>\n\n\n\n<p>Store the injection pen in the outer carton.&nbsp;Light sensitive.<\/p>\n\n\n\n<p><strong>After first use<\/strong><\/p>\n\n\n\n<p>Store the injection pen you are using at a maximum of 25\u00b0C for a maximum of 28 days.&nbsp;Discard the pen after this time.<\/p>\n\n\n\n<p>Must not be put back in the refrigerator and must not be frozen.\u00a0Store the injection pen away from direct heat or direct light.\u00a0The protective cap must be put back on the injection pen after each\u00a0injection.\u00a0Light sensitive.<\/p>\n\n\n\n<p>Do not leave the pen in a car on an unusually hot or cold day.<\/p>\n\n\n\n<p>Do not store the pen with the needle attached.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">What Suliqua contains<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are\u00a0insulin\u00a0glargine and lixisenatide. Each\u00a0injection pen\u00a0contains 300 units of\u00a0insulin\u00a0glargine and 150 micrograms of lixisenatide in a 3 ml\u00a0solution for injection. Each ml contains 100 units\u00a0of insulin\u00a0glargine and 50 micrograms of lixisenatide. Each dose step contains 1 unit\u00a0of insulin\u00a0glargine and 0.5 micrograms of lixisenatide.<\/li><li>Other excipients are glycerol (85%), methionine, metacresol, zinc chloride, concentrated\u00a0hydrochloric acid\u00a0and sodium hydroxide (for\u00a0pH\u00a0adjustment), and water for injections.\u00a0See also section 2 &#8220;What you need to know before you use Suliqua&#8221; for information on\u00a0sodium\u00a0and meta cresol.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and pack sizes of Suliqua<\/h2>\n\n\n\n<p>Suliqua is a clear, colorless solution for\u00a0injection\u00a0(for\u00a0injection\u00a0) filled in a glass\u00a0cartridge\u00a0and inserted into a pre-filled\u00a0injection\u00a0pen (SoloStar).<\/p>\n\n\n\n<p>Pack sizes of 3, 5, and 10 pre-filled pens.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<p>Injection needles are not included in the package.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>sanofi-aventis groupe<\/p>\n\n\n\n<p>54, rue La Bo\u00e9tie<\/p>\n\n\n\n<p>75008 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Sanofi-Aventis Deutschland GmbH<\/p>\n\n\n\n<p>Industriepark H\u00f6chst &#8211; 65926 Frankfurt am Main<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<p>Sanofi AB<\/p>\n\n\n\n<p>Phone: +46 (0)8 634 50 00<\/p>\n","protected":false},"excerpt":{"rendered":"<p>100 units\/ml + 50 micrograms\/ml\u00a0solution for injection\u00a0, solution in pre-filled\u00a0pen<br \/>\nInsulin\u00a0glargine + lixisenatide<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[15369,16593,24877,24878,15371,15370,16594,24880,16595,24879],"class_list":["post-23891","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-glargine","tag-lixisenatide","tag-suliqua","tag-suliqua-side-effects","tag-what-glargine-is-used-for","tag-what-is-glargine","tag-what-is-lixisenatide","tag-what-is-suliqua","tag-what-lixisenatide-is-used-for","tag-what-suliqua-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23891","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23891"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23891\/revisions"}],"predecessor-version":[{"id":23929,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23891\/revisions\/23929"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23891"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23891"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}