{"id":23888,"date":"2022-08-11T15:28:33","date_gmt":"2022-08-11T15:28:33","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23888"},"modified":"2022-08-12T12:09:09","modified_gmt":"2022-08-12T12:09:09","slug":"sulfasalazine-medac%ef%bf%bc","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sulfasalazine-medac%ef%bf%bc\/","title":{"rendered":"Sulfasalazine medac &#8211; Sulfasalazine uses, dose and side effects"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>500 mg&nbsp;enteric tablet&nbsp;er<br>Sulfasalazine<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Sulfasalazine medac is and what it is used for<\/h2>\n\n\n\n<p>Sulfasalazine medac is used in the treatment of<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>active&nbsp;rheumatoid arthritis&nbsp;(&nbsp;rheumatoid arthritis&nbsp;) in adults.<\/li><li>active&nbsp;juvenile idiopathic arthritis&nbsp;(joint rheumatism in children and adolescents &#8211; JIA) in children from the age of 6 where standard treatment has not been sufficiently effective.<\/li><\/ul>\n\n\n\n<p>Rheumatoid arthritis&nbsp;(or&nbsp;joint rheumatism&nbsp;) is a&nbsp;chronic&nbsp;disease characterized by&nbsp;inflammation&nbsp;of the membranes of the joints.&nbsp;The membranes sit on the inside of the joint capsules and produce a fluid that acts as a lubricant for many joints.&nbsp;Inflammation&nbsp;causes the membranes to thicken and the joints to swell.<\/p>\n\n\n\n<p>Juvenile&nbsp;arthritis&nbsp;affects children and young people under the age of 16.&nbsp;The variant that affects 4 or fewer joints during the first 6 months of the disease is called oligoarthritic, while the one that affects 5 or more joints during the first 6 months of the disease is called polyarthritic.<\/p>\n\n\n\n<p>Sulfasalazine medac prevents joint damage and slowly reduces swelling and stiffness in the joints.<\/p>\n\n\n\n<p>The doctor may have prescribed a different use.&nbsp;Always follow your doctor&#8217;s instructions.<\/p>\n\n\n\n<p>Sulfasalazine, found in Sulfasalazine medac, may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Sulfasalazine medac<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Sulfasalazine medac<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are\u00a0<strong>allergic<\/strong>\u00a0to sulfasalazine, the substances formed when sulfasalazine is broken down in the body,\u00a0sulphonamides\u00a0(eg sulphonamide antibiotics) or salicylates (eg\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a>\u00a0), or any other ingredient of this medicine (listed in section 6).<\/li><li>if you currently have or have previously had,\u00a0an acute\u00a0skin reaction with\u00a0redness\u00a0and a ring-like rash\u00a0(erythema exudative multiforme).<\/li><li>if you suffer from a\u00a0rare blood disorder\u00a0called\u00a0porphyria.<\/li><li>if you currently have\u00a0changes in your blood status\u00a0such as a reduced number of white blood cells or\u00a0platelets.<\/li><li>if you suffer from\u00a0constipation.<\/li><li>if you have severe\u00a0liver or\u00a0kidney failure.<\/li><li>if you have\u00a0<strong>glucose\u00a0-6-phosphate dehydrogenase deficiency<\/strong>\u00a0(a rare enzyme deficiency disease).<\/li><li>if you are being treated with\u00a0<strong>methenamine<\/strong>\u00a0(used to prevent urinary tract infections).<\/li><\/ul>\n\n\n\n<p>Sulfasalazine medac must not be used for the treatment of systemic forms (with fever) of\u00a0juvenile idiopathic arthritis.<\/p>\n\n\n\n<p>Sulfasalazine medac should not be given to children under 6 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Sulfasalazine medac.<\/p>\n\n\n\n<p>Potentially life-threatening skin rash<\/p>\n\n\n\n<p>Potentially life-threatening skin rashes (\u00a0<strong>Stevens-Johnson syndrome<\/strong>,\u00a0toxic epidermal necrolysis\u00a0) have been reported with the use of Sulfasalazine medac.\u00a0The first signs of these reactions include\u00a0reddish target-like spots\u00a0or\u00a0circular spots, often with central blisters on the trunk.\u00a0Additional signs to look out for are\u00a0sores in the mouth, throat, nose, genitals, and red and swollen eyes\u00a0(\u00a0conjunctivitis\u00a0).\u00a0These potentially life-threatening skin rashes are often accompanied by\u00a0flu-like symptoms.\u00a0The rash may progress to widespread blistering or scaling of the skin.\u00a0You are most at risk of developing these severe skin reactions in the first weeks of treatment with Sulfasalazine medac.\u00a0If you have developed\u00a0Stevens-Johnson syndrome\u00a0or\u00a0toxic epidermal necrolysis\u00a0while using Sulfasalazine medac, you must never, ever be put on Sulfasalazine medac again.\u00a0If you develop a skin rash or these skin symptoms, consult a doctor immediately and tell him\/her that you are taking Sulfasalazine medac.<\/p>\n\n\n\n<p><strong>Take extra care with Sulfasalazine medac<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you tend to be hypersensitive (allergic)\u00a0or\u00a0asthma.<\/li><li>if you are\u00a0allergic\u00a0to\u00a0sulfonylureas.<\/li><li>if you have\u00a0slightly impaired liver or kidney function.<\/li><\/ul>\n\n\n\n<p>Your doctor will monitor you during treatment with Sulfasalazine medac.\u00a0Before and during treatment with Sulfasalazine medac, your\u00a0<strong>blood<\/strong>\u00a0count (including counting the number of\u00a0blood platelets\u00a0) and\u00a0white blood cells, as well as liver and kidney function, should be\u00a0checked regularly.\u00a0During the first 3 months of treatment, checks are recommended every fortnight, once a month during months 4 to 6 and then every quarter or when\u00a0side effects\u00a0occur.<\/p>\n\n\n\n<p><strong>Male<\/strong>\u00a0patients trying to conceive should stop taking Sulfasalazine medac after consulting a doctor, as\u00a0<strong>sperm production may decrease<\/strong>.\u00a0No birth defects have been reported as a result of this temporarily reduced sperm production.<\/p>\n\n\n\n<p>You should\u00a0<strong>drink plenty<\/strong>\u00a0during treatment with Sulfasalazine medac to avoid the formation of\u00a0kidney stones.<\/p>\n\n\n\n<p>Your\u00a0<strong>skin<\/strong>\u00a0and\u00a0<strong>body fluids<\/strong>\u00a0may turn\u00a0<strong>yellow<\/strong>, and even soft contact lenses may become discolored.<\/p>\n\n\n\n<p><strong>Talk to your doctor<\/strong>\u00a0if you develop\u00a0<strong>a sore throat, fever, paleness, bleeding into the skin<\/strong>\u00a0(purpura), or\u00a0<strong>yellowing of the skin and eyes<\/strong>\u00a0(jaundice) during treatment.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>\u00a0if you are taking or have recently taken Sulfasalazine medac, or any other medicines containing sulfasalazine, as they may\u00a0<strong>affect blood and urine test results<\/strong>.<\/p>\n\n\n\n<p>If you know that you are a so-called slow acetylator (NAT2 polymorphism), you may experience more\u00a0side effects\u00a0and the doctor may need to adjust your\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Treatment with Sulfasalazine medac in children should only be initiated and supervised by a physician experienced in treating\u00a0juvenile idiopathic arthritis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Sulfasalazine medac<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>This applies in particular to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Antibiotics\u00a0(against a bacterial infection).<\/li><li>Iron.<\/li><li>Calcium.<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triobe\/\">Folic acid<\/a>\u00a0(\u00a0vitamin\u00a0used for supplemental treatment during pregnancy or to reduce the\u00a0side effects\u00a0of methotrexate).<\/li><li>Medicines that are highly bound to blood proteins, such as methotrexate (used to treat autoimmune diseases (\u00a0allergy\u00a0to the body&#8217;s substances) or cancer), phenylbutazone (for joint inflammation and pain), and sulfinpyrazone (for\u00a0gout\u00a0).<\/li><li>Methenamine (to prevent urinary tract infection) should not be given at the same time as Sulfasalazine medac (see\u00a0<strong>Do not take Sulfasalazine medac<\/strong>\u00a0).<\/li><\/ul>\n\n\n\n<p>Additional medicines that affect or are affected by Sulfasalazine medac:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Digoxin\u00a0(in\u00a0heart failure\u00a0).<\/li><li>Certain medicines for the treatment of elevated blood lipids (so-called anion exchangers).<\/li><li>Anticoagulants (to thin the blood).<\/li><li>Medicines that inhibit blood cell production in the\u00a0bone marrow\u00a0a.<\/li><li>Cyclosporine (to suppress the immune system in autoimmune diseases or organ transplantation).<\/li><li>Live typhoid vaccine.<\/li><li>Hepatotoxic drugs (drugs that cause liver damage).<\/li><li>Sulfonylurea (to treat\u00a0diabetes\u00a0).<\/li><li>Azathioprine (to suppress the immune system in autoimmune diseases or organ transplantation).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Sulfasalazine medac with food, drink, and alcohol<\/h2>\n\n\n\n<p>Take the tablets at least 1 hour before a meal, together with plenty of water.&nbsp;Swallow the tablets whole.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>Talk to the doctor if you are pregnant or become pregnant during treatment.<\/p>\n\n\n\n<p>The doctor will prescribe sulfasalazine with caution if you are pregnant.\u00a0Available data have not shown that treatment with sulfasalazine during pregnancy entails risks either for the pregnancy, the fetus, or the newborn baby.\u00a0Treatment with sulfasalazine can lead to folic acid deficiency, which in turn can cause congenital malformations.\u00a0Therefore, women of childbearing age and pregnant women during the first three months of pregnancy should take extra\u00a0folic acid\u00a0during simultaneous treatment with sulfasalazine.<\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>Consult a doctor before taking any medicine.&nbsp;Sulfasalazine and its&nbsp;metabolite&nbsp;are excreted in breast milk.&nbsp;Caution is recommended when breastfeeding premature babies or babies with&nbsp;neonatal&nbsp;icterus (jaundice).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Responsiveness may be impaired in some patients.\u00a0If you experience dizziness or other disturbances in the\u00a0central nervous system\u00a0such as sleepiness or reduced ability to concentrate while taking sulfasalazine, you should not drive a car, operate machinery, or perform any other activity that may be dangerous when attention is reduced.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sulfasalazine medac contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per coated tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Sulfasalazine medac<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>Your doctor will\u00a0prescribe\u00a0the\u00a0dose\u00a0you should take.\u00a0Usually, you can start with a low\u00a0dose, e.g.\u00a0500 mg (one tablet a day), and the doctor will tell you how to increase the\u00a0dose\u00a0gradually.\u00a0This is usually done over about 4 weeks:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td>&nbsp;<\/td><td>1st week<\/td><td>2nd week<\/td><td>3rd week<\/td><td>4th week and following weeks<\/td><\/tr><\/thead><tbody><tr><td>morning\/daily&nbsp;dose<\/td><td>&#8212;&#8212;&#8212;<\/td><td>1 tablet<\/td><td>1 tablet<\/td><td>2 tablets<\/td><\/tr><tr><td>evening\/daily&nbsp;dose<\/td><td>1 tablet<\/td><td>1 tablet<\/td><td>2 tablets<\/td><td>2 tablets<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>After 3 months, the daily&nbsp;dose&nbsp;can be increased to 2 tablets 3 times a day if the doctor considers that 2 tablets 2 times a day is not enough.&nbsp;Do not take more than 8 tablets per day.<\/p>\n\n\n\n<p>For children from the age of 6, the recommended daily&nbsp;dose&nbsp;is 50 mg\/kg body weight divided into two partial doses.&nbsp;The maximum daily&nbsp;dose&nbsp;should not exceed 2 g. To reduce&nbsp;side effects&nbsp;from the gastrointestinal tract, treatment should be initiated with a quarter to a third of the planned maintenance dose and increased weekly until the maintenance dose is reached after four weeks.<\/p>\n\n\n\n<p><strong>How to take the medicine<\/strong><\/p>\n\n\n\n<p>Take the tablets at least 1 hour before a meal, together with plenty of liquid.\u00a0The tablet should not be split or crushed but swallowed whole.<\/p>\n\n\n\n<p>Treatment with Sulfasalazine usually has an effect within 1\u20133 months.&nbsp;It may therefore be necessary to take additional pain-relieving or anti-inflammatory medicines, at least until Sulfasalazine medac starts to take effect.<\/p>\n\n\n\n<p>Sulfasalazine medac is usually used for long-term treatment.&nbsp;The drug can be taken for many years if it works and is well tolerated.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Sulfasalazine medac<\/h2>\n\n\n\n<p>Symptoms of overdose may include nausea, vomiting, stomach upset, and abdominal pain.\u00a0In more severe cases, you may experience symptoms from the\u00a0central nervous system\u00a0(brain and spinal cord) such as drowsiness and convulsions.\u00a0If you experience any of the above symptoms, contact a doctor or hospital immediately for information on the necessary measures.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Sulfasalazine medac<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.\u00a0Inform the doctor and continue taking the prescribed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Sulfasalazine medac<\/h2>\n\n\n\n<p>The treatment as well as the additional treatment takes place on a doctor&#8217;s prescription and is supervised by your doctor.\u00a0You should not stop treatment without consulting a doctor, as the symptoms may return.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Sulfasalazine medac can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Many\u00a0side effects\u00a0are dose-dependent and can be reduced by lowering the\u00a0dose.<\/p>\n\n\n\n<p>If you experience severe poisoning or\u00a0hypersensitivity reaction\u00a0(e.g. severe skin reaction, shortness of breath),\u00a0<strong>stop treatment with Sulfasalazine medac immediately and contact your doctor<\/strong>.<\/p>\n\n\n\n<p>In case of dose-dependent\u00a0side effects, treatment with Sulfasalazine medac must stop for 1 week.\u00a0If the doctor decides to continue the treatment, Sulfasalazine medac can be given again in small\u00a0doses\u00a0that should be increased slowly, preferably under clinical supervision.<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Nausea, vomiting, abdominal pain<\/li><li>Itching, rash<\/li><li>Loss of appetite<\/li><li>Weakness, fatigue<\/li><li>Decreased sperm production in men, temporarily impaired\u00a0fertility<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduced number of\u00a0red blood cells\u00a0caused by folic acid deficiency with large\u00a0blood cells\u00a0as a result, as well as reduced number of\u00a0white blood cells, and elevated liver enzymes.<\/li><li>Drowsiness, dizziness, difficulty concentrating, difficulty sleeping<\/li><li>Hives increased sensitivity to light<\/li><li>Fever<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The heartbeat is felt (palpitations), increased\u00a0pulse<\/li><li>Severe decrease in the number of\u00a0white blood cells, decreased number of all blood cells, decreased number of red blood cells caused by the breakdown of the cells, decreased ability of the red blood cells to transport oxygen, decreased number of\u00a0platelets, a reaction similar to viral infection with fever, sore throat, swollen\u00a0glands\u00a0and fatigue (mononucleosis-like reaction)<\/li><li>Disorders in the\u00a0peripheral nervous system\u00a0(nerves that conduct signals from the brain and spinal cord to the body, they also conduct signals from the body to the brain) can cause changes in sensation, pain or muscle weakness, crawling, tingling, or numbness in the skin, changes in taste\/smell<\/li><li>Red irritated eyes<\/li><li>Ringing in the ears (\u00a0tinnitus\u00a0)<\/li><li>Allergic\u00a0pneumonia, cough,\u00a0asthma, shortness of breath<\/li><li>Flatulence, diarrhea,\u00a0inflammation\u00a0of the pancreas<\/li><li>Bluish skin, rapid swelling of the face and throat<\/li><li>Muscle weakness, joint pain,\u00a0autoimmune\u00a0reaction with joint pain, sore muscles, fever, and red rash on the face (lupus erythematosus)<\/li><li>Increased\u00a0blood pressure<\/li><li>Reaction with fever, rash, and joint pain (disorder similar to serum sickness)<\/li><li>Impaired liver function, reduced number of\u00a0antibodies, presence of\u00a0antibodies\u00a0against the body&#8217;s cells,\u00a0tissues,\u00a0or organs<\/li><li>Depression<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased blood cell production in the\u00a0bone marrow, excess of certain immune cells in the blood (plasmacytosis), severe reduction of blood cells due to disturbances in blood cell formation<\/li><li>Metallic taste<\/li><li>In a single case, yellowing of soft contact lenses was reported<\/li><li>Inflammation\u00a0in the alveoli (alveoli) and scarring of the connective tissue between the lungs (fibrosing alveolitis)<\/li><li>Inflammation\u00a0of the oral mucosa (\u00a0stomatitis\u00a0)<\/li><li>Blood in the urine, crystals in the urine, yellow-orange discoloration of the urine<\/li><li>Inflammatory\u00a0skin reaction, yellow-orange discoloration of the skin, hair loss<\/li><li>Muscle pain<\/li><li>Acute attacks of\u00a0porphyria\u00a0(a disorder of hemoglobin formation)<\/li><li>Skin reaction with abnormal white blood cell count (\u00a0eosinophilia\u00a0), fever and involvement of internal organs (DRESS syndrome), severe\u00a0allergic reaction<\/li><li>Liver inflammation<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Myocarditis, pericarditis<\/li><li>Inflammation\u00a0of protective\u00a0membranes\u00a0covering the brain and spinal cord, brain disease leading to an altered mental state (\u00a0encephalopathy\u00a0), inflammation of the spinal cord<\/li><li>Inflammation\u00a0in the finest branching of the tracheal tree (bronchioles) in the lungs<\/li><li>Worsened recurrent\u00a0inflammatory\u00a0bowel disease<\/li><li>Nephritis, a kidney disease that causes water to accumulate in the body (\u00a0nephrotic syndrome\u00a0),\u00a0protein\u00a0in the urine<\/li><li>Potentially life-threatening skin rash (\u00a0Stevens-Johnson syndrome, toxic\u00a0epidermal\u00a0necrolysis\/Lyell&#8217;s syndrome), see section 2<\/li><li>Impaired blood cell formation due to bone marrow disease (\u00a0myelodysplastic syndrome\u00a0)<\/li><li>Impaired blood circulation in toes and fingers<\/li><li>Severe inflammation of the liver (potentially fatal)<\/li><li>Psychosis<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurring in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lung complications with shortness of breath (called interstitial lung disease)<\/li><li>Prolonged, often severely itchy skin with small angular flat nodules.\u00a0Often ulcers in the oral mucosa.\u00a0In rare cases, it can occur on the scalp, which can cause scarring with hairless patches (\u00a0lichen\u00a0planus).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Sulfasalazine medac<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00b0C.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to deal with medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is sulfasalazine.\u00a0One tablet contains 500 mg.<\/li><li>Other ingredients are crospovidone, stearic acid, povidone, anhydrous\u00a0colloidal\u00a0silicon dioxide, purified water, magnesium stearate, titanium dioxide, talc, carmellose sodium, sodium citrate, macrogol, propylene glycol, methacrylic acid-ethyl acrylate copolymer (1:1)\u00a0dispersion\u00a030%.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Sulfasalazine medac are white,\u00a0coated, oval tablets.\u00a0The enteric coating protects the tablet from dissolving in the stomach.\u00a0Therefore, the active substance is not released until the tablet has reached the intestine.<\/p>\n\n\n\n<p>Pack sizes: 100 \/300 tablets in a white plastic jar closed with a white plastic screw cap.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>medac<\/p>\n\n\n\n<p>Gesellschaft f\u00fcr klinische<\/p>\n\n\n\n<p>Spezialpr\u00e4parate mbH<\/p>\n\n\n\n<p>Theaterstr.&nbsp;6<\/p>\n\n\n\n<p>22880 Wedel<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Phone: +49 4103 8006-0<\/p>\n\n\n\n<p>Fax: +49 4103 8006-100<\/p>\n\n\n\n<p>Additional information is provided by:<\/p>\n\n\n\n<p>medac GmbH, branch<\/p>\n\n\n\n<p>Box 120<\/p>\n\n\n\n<p>432 23 Varberg<\/p>\n\n\n\n<p>Phone: 0340-64 54 70<\/p>\n\n\n\n<p>Fax: 0340-64 54 79<\/p>\n\n\n\n<p><strong>This medicine is approved in the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Denmark: Sulfasalazine &#8220;medac&#8221;, 500 mg\u00a0enteric\u00a0tablet<\/p>\n\n\n\n<p>Germany: Sulfasalazine medac 500 mg gastro-resistant film-coated tablet<\/p>\n","protected":false},"excerpt":{"rendered":"<p>500 mg\u00a0enteric tablet\u00a0er<br \/>\nSulfasalazine<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[23620,24881,24885,24882,23624,23623,23621,24883,23622,24884],"class_list":["post-23888","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-sulfasalazine","tag-sulfasalazine-medac","tag-sulfasalazine-medac-side-effects","tag-sulfasalazine-medac-tablet","tag-sulfasalazine-side-effects","tag-sulfasalazine-tablet","tag-what-is-sulfasalazine","tag-what-is-sulfasalazine-medac","tag-what-sulfasalazine-is-used-for","tag-what-sulfasalazine-medac-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23888"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23888\/revisions"}],"predecessor-version":[{"id":23930,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23888\/revisions\/23930"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}