{"id":23885,"date":"2022-08-11T15:23:19","date_gmt":"2022-08-11T15:23:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23885"},"modified":"2022-08-12T12:09:18","modified_gmt":"2022-08-12T12:09:18","slug":"suboxone","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/suboxone\/","title":{"rendered":"Suboxone &#8211; Buprenorphine\/naloxone uses, dose and side effects"},"content":{"rendered":"\n<p>Suboxone 2 mg\/0.5 mg sublingual resorbable tablet, 8 mg\/2 mg&nbsp;sublingual&nbsp;resorbable tablet, Suboxone 16 mg\/4 mg&nbsp;sublingual&nbsp;resorbable tablet<br>buprenorphine\/naloxone<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Suboxone is and what it is used for<\/h2>\n\n\n\n<p>Suboxone is used to treat drug addicts who are addicted to&nbsp;opioids&nbsp;(narcotics) such as heroin or morphine, and who have consented to treatment for their addiction.<\/p>\n\n\n\n<p>Suboxone is used for adults and young people over the age&nbsp;<strong>of&nbsp;<\/strong><strong>15<\/strong>&nbsp;who also receive medical, social, and psychological support.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Suboxone<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Suboxone<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are\u00a0<strong>allergic<\/strong>\u00a0to\u00a0<strong>buprenorphine, naloxone,<\/strong>\u00a0or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have\u00a0<strong>severe breathing problems<\/strong><\/li><li>if you have\u00a0<strong>severe liver problems<\/strong><\/li><li>if you are under the influence of alcohol or suffer from tremors, sweating, anxiety, confusion, or hallucinations caused by alcohol<\/li><li>if you are taking naltrexone or nalmefene to treat alcohol or opiate addiction.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor before taking Suboxone if you have:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>asthma\u00a0or other respiratory problems<\/li><li>problems with the liver, e.g.\u00a0hepatitis<\/li><li>low\u00a0blood pressure<\/li><li>a recent head injury or brain disease<\/li><li>problems in the urinary tract (mainly linked to an enlarged\u00a0prostate\u00a0in men)<\/li><li>any kidney disease<\/li><li>problems with the thyroid gland<\/li><li>problems with the adrenal glands (eg\u00a0Addison&#8217;s disease\u00a0)<\/li><li>depression or other conditions treated with antidepressants.\u00a0If these medicines are used together with Suboxone, this can lead to serotonin syndrome, a condition that can be life-threatening (see \u201cOther medicines and Suboxone\u201d).<\/li><\/ul>\n\n\n\n<p><strong>Important to remember:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Contact the emergency department immediately in case of accidental ingestion or suspected ingestion.<\/li><li><strong>Extra follow-your<\/strong> doctor may want to monitor you more closely if you are over 65.<\/li><li>Misuse and abuse this medicine may be desirable for people who abuse prescription medicines and should be kept in a safe place to protect them from theft (see section 5).\u00a0Do not give\u00a0this medicine to anyone else.\u00a0This\u00a0can lead to death\u00a0or injury.<\/li><li>Breathing problems some people have died from respiratory failure (inability to breathe) after misusing buprenorphine or taking it with other substances that affect the\u00a0central nervous system, such as\u00a0alcohol,\u00a0and benzodiazepines\u00a0(sedatives), or other\u00a0opioids.<br>This medicine can cause severe, possibly fatal,\u00a0respiratory depression\u00a0(impaired ability to breathe) in children and non-addicted people who accidentally or intentionally take the medicine.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Sleep-related breathing problems<\/strong><br>Suboxone can cause sleep-related breathing problems such as\u00a0sleep apnea\u00a0(pauses in breathing during sleep) and sleep-related\u00a0hypoxemia\u00a0(low oxygen levels in the blood).\u00a0The symptoms can be breathing pauses during sleep, waking up at night due to shortness of breath, difficulty staying asleep, or pronounced fatigue during the day.\u00a0Contact the doctor if you or anyone else observes these symptoms.\u00a0The doctor may consider reducing the\u00a0dose.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Dependent<\/strong>This medicine can be addictive.<\/li><li><strong>Withdrawal symptoms this<\/strong> medicine can cause opioid withdrawal symptoms if you take it too soon after taking your\u00a0opioid.\u00a0It must be at least 6 hours after using a short-acting\u00a0opioid\u00a0(eg, morphine or heroin) or at least 24 hours after using a long-acting\u00a0opioid\u00a0such as\u00a0methadone.<br>This medicine can also cause withdrawal symptoms if you suddenly stop taking it.\u00a0See section 3 \u201cIf you stop taking Suboxone\u201d.<\/li><li>Liver damage liver damage has been reported after using Suboxone, especially if the drug is used incorrectly.\u00a0Liver damage can also be caused by viral infections (eg\u00a0chronic\u00a0hepatitis\u00a0C), alcohol abuse,\u00a0anorexia,\u00a0or the use of other drugs that can damage the liver (see section 4).\u00a0Doctors may take blood tests regularly to check your liver.\u00a0Tell your doctor if you have any liver problems before starting Suboxone.<\/li><li>Blood pressure this medicine can cause your\u00a0blood pressure\u00a0to drop suddenly, which may make you feel dizzy if you get up quickly from sitting or lying down.<\/li><li>Diagnosis of unrelated medical conditions this medicine can mask pain symptoms that could facilitate the diagnosis of certain diseases.\u00a0You must tell the doctor that you are taking this medicine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>Do not give<\/strong>\u00a0this medicine to\u00a0<strong>children under 15 years of age<\/strong>.\u00a0If you are between 15 and 18 years old, your doctor may want to monitor you extra closely during treatment as there is no data on this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Suboxone<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Some medications can increase the&nbsp;side effects&nbsp;of Suboxone.&nbsp;These can become serious.&nbsp;Do not take any other medications while taking Suboxone without first talking to your doctor.&nbsp;This applies in particular to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Benzodiazepines<\/strong>\u00a0(used to treat anxiety or sleep disorders), eg\u00a0diazepam, temazepam, or alprazolam.\u00a0Using Suboxone at the same time as sedatives such as\u00a0benzodiazepines\u00a0or similar drugs can increase the risk of drowsiness, difficulty breathing, and\u00a0coma, and it can be life-threatening.\u00a0Concomitant treatment should therefore only be considered if there are no other treatment options. However, if the doctor prescribes Suboxone together with sedative drugs, the doctor should limit the\u00a0dose of\u00a0one and the duration of treatment of the other drug. Inform the doctor about all sedatives you are taking and follow the doctor&#8217;s\u00a0prescription\u00a0very carefully.\u00a0It may be helpful to inform family and friends that they should be aware of the signs and symptoms described above.\u00a0Contact the doctor if you experience any such symptoms.<\/li><li>Other medicines that can make you feel sleepy\u00a0are used to treat conditions such as anxiety, insomnia, convulsions\/seizures, or pain.\u00a0These types of drugs reduce your alertness and make it more difficult to drive and use machines.\u00a0They can also lead to\u00a0central nervous system depression, which is very serious.\u00a0Below is a list of examples of these types of drugs:<ul><li>Other opioid-containing medicines, e.g.\u00a0methadone, some pain relievers, and cough suppressants.<\/li><li>Antidepressants (used to treat depression), eg\u00a0isocarboxazid, phenelzine,\u00a0selegiline, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tranylcypromine-glenmark\/\">tranylcypromine<\/a>, and\u00a0valproate, may enhance the effects of this drug.<\/li><li>Attenuating H\u00a0<sub>1<\/sub>\u00a0-receptor antagonists (used to treat allergic reactions), e.g.\u00a0diphenhydramine and chlorphenamine.<\/li><li>Barbiturates\u00a0(used to induce sleep or for sedative effect), e.g.\u00a0phenobarbital and secobarbital.<\/li><li>Sedatives (used to induce sleep or for sedative effect), e.g.\u00a0chloral hydrate.<\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Antidepressants<\/strong>\u00a0such as moclobemide, tranylcypromine,\u00a0citalopram, escitalopram,\u00a0fluoxetine, fluvoxamine,\u00a0paroxetine,\u00a0sertraline, duloxetine,\u00a0venlafaxine, amitriptyline, doxepin or trimipramine.\u00a0These medicines can affect or be affected by Suboxone and you may have symptoms such as involuntary rhythmic muscle twitching, including in the muscles that control eye movements, agitation, hallucinations,\u00a0coma, profuse sweating, tremors, increased reflexes, tense muscles, and body temperature above 38\u00b0C.\u00a0Contact the doctor if you experience such symptoms.<\/li><li>Clonidine\u00a0(used to treat high\u00a0blood pressure\u00a0) may prolong the effects of this medicine.<\/li><li>Antiretrovirals (used to treat\u00a0HIV\u00a0), e.g.\u00a0ritonavir, nelfinavir, and indinavir, may increase the effects of this medicine.<\/li><li>Some\u00a0antifungals\u00a0(used to treat fungal infections), e.g.\u00a0ketoconazole, itraconazole, and certain\u00a0antibiotics, may prolong the effects of this drug.<\/li><li>Some medicines can reduce the effectiveness of Suboxone.\u00a0These include medicines for the treatment of\u00a0epilepsy\u00a0(e.g. carbamazepine and\u00a0phenytoin\u00a0) and medicines for the treatment of\u00a0tuberculosis\u00a0(rifampicin).<\/li><li>Naltrexone and nalmefene (drugs to treat addiction) can counteract the therapeutic effect of Suboxone.\u00a0They should not be taken at the same time as you are being treated with Suboxone because then you may suddenly suffer long-term and severe withdrawal symptoms.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Suboxone with food, drink, and alcohol<\/h2>\n\n\n\n<p><strong>Do not use alcohol<\/strong>&nbsp;while being treated with this medicine.&nbsp;Alcohol can increase drowsiness and increase the risk of respiratory failure if used at the same time as Suboxone.&nbsp;Do not swallow or consume food or drink of any kind until the tablet has completely dissolved.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before taking this medicine.\u00a0The risks of using Suboxone during pregnancy are not known.\u00a0The doctor will decide whether the treatment should be continued with another medicine.<\/p>\n\n\n\n<p>If drugs such as Suboxone are taken during pregnancy, especially during the latter part of pregnancy, they can cause withdrawal symptoms and breathing problems in the newborn baby.&nbsp;These problems can occur several days after birth.<\/p>\n\n\n\n<p>Do not breastfeed while taking this medicine because buprenorphine passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p><strong>You should not<\/strong>\u00a0drive, ride a bicycle, use any tools or machinery, or perform dangerous activities\u00a0<strong>until you know how this medicine affects you<\/strong>.\u00a0Suboxone can cause drowsiness, dizziness, or impaired thinking.\u00a0This may happen more often during the first few weeks of treatment when the\u00a0dose\u00a0is changed, but may also occur if you drink alcohol or take other sedative drugs while taking Suboxone.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Suboxone contains lactose and sodium.<\/h2>\n\n\n\n<p>This medicine contains\u00a0lactose.\u00a0If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Suboxone<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The treatment is prescribed and supervised by doctors with experience in the treatment of drug addiction.<\/p>\n\n\n\n<p>The doctor will decide which&nbsp;dose&nbsp;is best for you.&nbsp;During your treatment, the doctor may adjust your&nbsp;dose&nbsp;depending on how you respond to the treatment.<\/p>\n\n\n\n<p><strong>Start of treatment<\/strong><\/p>\n\n\n\n<p>The recommended starting dose for adults and adolescents over 15 years of age is two Suboxone 2 mg\/0.5 mg sublingual resorbable tablets.<\/p>\n\n\n\n<p>Dose&nbsp;one can be taken up to three times on day 1, depending on your needs.<\/p>\n\n\n\n<p>You should feel clear signs of\u00a0withdrawal\u00a0before taking the first\u00a0dose of\u00a0Suboxone.\u00a0The doctor tells you when it is time to take the first\u00a0dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Starting Suboxone for\u00a0<strong>heroin addiction<\/strong><br>If you are addicted to heroin or a short-acting\u00a0opioid, take the first\u00a0dose\u00a0when you experience\u00a0withdrawal symptoms, but\u00a0at least\u00a06 hours must have passed since you last used\u00a0an opioid<strong>.<\/strong><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Starting Suboxone for\u00a0<strong>methadone addiction<\/strong><br>If you have been taking\u00a0methadone\u00a0or a long-acting\u00a0opioid, the methadone dose should preferably be reduced to less than 30 mg\/day before Suboxone treatment begins.\u00a0The first\u00a0dose of\u00a0Suboxone should be taken when you experience\u00a0withdrawal symptoms, but it must have been\u00a0at least\u00a024\u00a0hours\u00a0since\u00a0you last used\u00a0methadone.<\/li><\/ul>\n\n\n\n<p><strong>How to take Suboxone<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take one\u00a0dose\u00a0once daily by placing the tablets under the tongue.<\/li><li>Keep the tablets in place under the tongue until they have\u00a0<strong>completely\u00a0<\/strong><strong>dissolved<\/strong>.\u00a0This may take 5-10 minutes.<\/li><li>You must not chew or swallow the tablets.\u00a0The medicine will then not work and you may experience withdrawal symptoms.<\/li><\/ul>\n\n\n\n<p>Do not eat or drink anything until the tablets are completely dissolved.<\/p>\n\n\n\n<p><strong>This is how you take the tablet out of the blister pack<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20051206000015#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/8f730092-0dc3-4201-8de6-0bf33ffa65e0\" alt=\"Picture 1\" title=\"Picture 1\"\/><\/a><\/figure>\n\n\n\n<p>1&nbsp;&#8211; Do not push the tablet through the foil.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20051206000015#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/9a6b78d7-233f-49bc-b279-1b6734ada68a\" alt=\"Picture 2\" title=\"Picture 2\"\/><\/a><\/figure>\n\n\n\n<p>2 &#8211; Simply remove a portion from the blister pack by tearing along the perforation line.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20051206000015#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/110290e3-0e27-4686-a372-2f83653e5bef\" alt=\"Image 3\" title=\"Image 3\"\/><\/a><\/figure>\n\n\n\n<p>3 &#8211; Starting from the edge where the seal lifts, pull the foil back on the back to remove the tablet.<\/p>\n\n\n\n<p>Discard the tablet if the blister pack is damaged.<\/p>\n\n\n\n<p><strong>Dose adjustment and maintenance treatment:<\/strong>\u00a0During the first days after starting treatment, the doctor may increase the\u00a0dose\u00a0of Suboxone to adapt it to your needs.\u00a0Talk to your doctor or pharmacist if you think the effect of Suboxone is too strong or too weak.\u00a0<strong>The highest daily\u00a0dose\u00a0is 24 mg\u00a0<\/strong><strong>of buprenorphine<\/strong><strong>.<\/strong><\/p>\n\n\n\n<p>After a period of successful treatment, you can agree with the doctor to gradually reduce the\u00a0dose\u00a0to a lower maintenance dose.<\/p>\n\n\n\n<p><strong>If you stop treatment<\/strong><\/p>\n\n\n\n<p>Depending on your condition, the Suboxone\u00a0dose\u00a0may continue to be reduced under close medical supervision, until treatment can be stopped completely.<\/p>\n\n\n\n<p>Do not change the treatment in any way and do not stop it without the consent of the doctor responsible for your treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Suboxone<\/h2>\n\n\n\n<p>If you or someone else takes too much of this medicine, you must see or be taken to an emergency room or hospital for treatment as an&nbsp;<strong>overdose<\/strong>&nbsp;of Suboxone can cause serious and life-threatening breathing problems.<\/p>\n\n\n\n<p>Symptoms of overdose may include drowsiness and uncoordinated movements with slow reflexes, blurred vision, and\/or slurred speech.\u00a0You may have difficulty thinking clearly and your breathing may become much slower than normal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Suboxone<\/h2>\n\n\n\n<p>Inform the doctor as soon as possible if you have forgotten a\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Suboxone<\/h2>\n\n\n\n<p>Do not change the treatment in any way and do not stop it without the consent of the doctor responsible for your treatment.&nbsp;<strong>If you stop&nbsp;<\/strong><strong>treatment&nbsp;<\/strong><strong>suddenly, you may experience withdrawal symptoms.<\/strong><\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor or seek\u00a0<\/strong><strong>medical attention<\/strong>\u00a0right away \u00a0if you experience\u00a0side effects, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, lips, tongue, or throat which may make it difficult to swallow or breathe, or cause severe\u00a0hives.\u00a0This could be a sign of a life-threatening\u00a0allergic reaction.<\/li><li>sleepiness and uncoordinated movements, blurred vision, slurred speech, difficulty thinking clearly, or breathing much slower than normal.<\/li><\/ul>\n\n\n\n<p><strong>Also inform your doctor immediately<\/strong>\u00a0if you experience\u00a0side effects, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe fatigue, or&nbsp;itching&nbsp;with yellowing of the skin or eyes.&nbsp;It could be a sign of liver damage.<\/li><li>seeing or hearing things that are not there (hallucinations).<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><em>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10 users):<\/em><\/td><\/tr><tr><td>insomnia, constipation, nausea, profuse sweating, headache, and drug withdrawal syndrome.<\/td><\/tr><tr><td><em>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 users):<\/em><\/td><\/tr><tr><td>weight loss, swollen hands, and feet, drowsiness, worry\/anxiety, nervousness, tingling, depression, decreased sex drive, increased muscle tension, abnormal thoughts, increased tear flow (watery eyes) or other disturbance in tear production, blurred vision,\u00a0flushing, increased\u00a0blood pressure,\u00a0migraine, running nose, sore throat and pain when swallowing, increased cough, upset stomach or other stomach problems, diarrhea, abnormal liver function, flatulence, vomiting, skin rash,\u00a0itching,\u00a0hives, pain, joint pain, muscle pain, leg cramps, difficulty getting or maintaining an\u00a0erection, abnormal urine, stomach pain, back pain, weakness,\u00a0infection, chills, chest pain, fever,\u00a0flu-like symptoms, general malaise, accidental injury caused by reduced attention or impaired coordination, fainting and dizziness.<\/td><\/tr><tr><td><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/td><\/tr><tr><td>swollen\u00a0lymph nodes, agitation, tremors, abnormal dreams, excessive muscle activity, depersonalization (not feeling like yourself), drug addiction, memory loss, lack of interest, an exaggerated sense of well-being, seizures, speech problems, small\u00a0pupils, difficulty urinating, eye inflammation or &#8211;\u00a0infection, fast or slow heartbeat, low\u00a0blood pressure, heart palpitations, heart attack, chest tightness, shortness of breath,\u00a0asthma, yawning, mouth problems (sores, blisters, numbness, tingling, swelling or pain), tongue discoloration or pain,\u00a0acne, lumps in the skin, hair loss, dry or scaly skin, joint inflammation, urinary tract infection, abnormal blood tests, blood in the urine, abnormal ejaculation, menstrual or vaginal problems,\u00a0kidney stones,\u00a0protein\u00a0in the urine, pain when urinating or difficulty urinating, sensitivity to heat or cold, heat stroke, loss of appetite, feeling hostile.<\/td><\/tr><tr><td><em>Has been reported (occurring in an unknown number of users):<\/em><\/td><\/tr><tr><td>sudden withdrawal syndrome caused by taking Suboxone too soon after using illicit\u00a0opioids, drug withdrawal syndrome in newborns, slow breathing or difficulty breathing, liver damage with or without jaundice, hallucinations, swelling of the face or throat, or life-threatening allergic reactions, drops in blood pressure that causes dizziness when changed position from sitting or lying down to standing.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Misuse by\u00a0injection\u00a0of the drug can cause withdrawal symptoms,\u00a0infection, other skin reactions, and potentially serious liver problems (see \u201cWarnings and precautions\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Suboxone<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children and other members of the household.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.&nbsp;However, Suboxone may be desirable for people who abuse prescription drugs.&nbsp;Keep this medicine in a safe place to protect it from theft.<\/p>\n\n\n\n<p>Keep the blister pack in a safe place.<\/p>\n\n\n\n<p>Never open the blister pack in advance.<\/p>\n\n\n\n<p>Do not take the medicine in front of children.<\/p>\n\n\n\n<p>Contact the emergency department immediately in case of accidental ingestion or suspected ingestion.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are buprenorphine and naloxone. Each 2 mg\/0.5 mg\u00a0sublingual\u00a0resorbable tablet contains 2 mg buprenorphine (as hydrochloride) and 0.5 mg naloxone (as hydrochloride dihydrate). Each 8 mg\/2 mg\u00a0sublingual\u00a0resorbable tablet contains 8 mg buprenorphine (as hydrochloride) and 2 mg naloxone (as hydrochloride dihydrate). Each 16 mg\/4 mg\u00a0sublingual\u00a0resorbable tablet contains 16 mg buprenorphine (as hydrochloride) and 4 mg naloxone (as hydrochloride dihydrate).<\/li><li>Other ingredients are\u00a0lactose monohydrate, mannitol, corn starch, povidone K 30, anhydrous citric acid, sodium citrate, magnesium stearate, acesulfame potassium, and natural flavoring from lemon and lime.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Suboxone 2 mg\/0.5 mg sublingual resorbable tablet is a white hexagonal biconvex tablet of 6.5 mm marked with &#8220;N2&#8221; on one side.<\/p>\n\n\n\n<p>Suboxone 8 mg\/2 mg&nbsp;sublingual&nbsp;resorbable is a white hexagonal biconvex tablet of 11 mm marked with &#8220;N8&#8221; on one side.<\/p>\n\n\n\n<p>Suboxone 16 mg\/4 mg&nbsp;sublingual&nbsp;resorbable tablet is a white round biconvex tablet of 10.5 mm marked with &#8220;N16&#8221; on one side.<\/p>\n\n\n\n<p>Packaged in packs of 7 and 28 packs.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Indivior Europe Limited&nbsp;<\/p>\n\n\n\n<p>27 Windsor Place<\/p>\n\n\n\n<p>Dublin 2<\/p>\n\n\n\n<p>D02 DK44<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Indivior Europe LimitedTel\/Tel: 0800 780 41Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Lithuania<\/strong>Indivior Europe LimitedPhone: 88003079Email:\u00a0<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Indivior Europe LimitedTel.: 00800 110 4104Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Indivior Europe LimitedTel\/Tel: 800 245 43Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Indivior Europe LimitedPhone: 800 143 737Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Magyarorsz\u00e1g<\/strong>Indivior Europe LimitedTel.: 6800 19301Email:\u00a0<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Denmark<\/strong>Indivior Europe LimitedPhone: 80826653Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Malta<\/strong>Indivior Europe LimitedPhone: 80062185Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Deutschland<\/strong>Indivior Europe LimitedPhone: 0 800 181 3799Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>The Netherlands<\/strong>Indivior Europe LimitedPhone: 0800 022 87 83Email:\u00a0<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Estonia<\/strong>Indivior Europe LimitedPhone: 8000041004Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Norway<\/strong>Indivior Europe LimitedPhone: 80016773Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Greece<\/strong>Indivior Europe LimitedTel: 800 206 281 901Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Austria<\/strong>Indivior Europe LimitedPhone: 800 296551Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Spain<\/strong>Indivior Europe LimitedPhone: 900 994 121Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Polish<\/strong>Indivior Europe LimitedPhone: 0800 4111237Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>France<\/strong>Indivior Europe Limited<strong>Phone:<\/strong>&nbsp;0800 909 972Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Portugal<\/strong>Indivior Europe LimitedPhone: 800 841 042Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Indivior Europe LimitedPhone: 0800 222 899Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Romania<\/strong>Indivior Europe LimitedPhone: 800 477 029Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Ireland<\/strong>Indivior Europe LimitedPhone: 1800554156Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Slovenija<\/strong>Indivior Europe LimitedPhone: 080080715Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Iceland<\/strong>Indivior Europe LimitedTelephone: 8009875Email address:&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Slovenian Republic<\/strong>Indivior Europe LimitedPhone: 800110286Email:\u00a0<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Italy<\/strong>Indivior Europe LimitedPhone: 800 789 822Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Finland\/Finland<\/strong>Indivior Europe LimitedPh: 0800417489Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Cyprus<\/strong>Indivior Europe LimitedPhone: 80091515Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>Sweden<\/strong>Indivior Europe LimitedPhone: 020791680Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><tr><td><strong>Latvia<\/strong>Indivior Europe LimitedPhone: 800 05612Email :&nbsp;<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><td><strong>United Kingdom\u00a0<\/strong><strong>(Northern Ireland)<\/strong>Indivior Europe LimitedPhone: 0808 234 9243Email:\u00a0<a href=\"http:\/\/PatientSafetyRoW@indivior.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PatientSafetyRoW@indivior.com<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Suboxone is used to treat drug addicts who are addicted to\u00a0opioids\u00a0(narcotics) such as heroin or morphine, and who have consented to treatment for their addiction.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[3584,24890,8219,24891,24886,24888,8115,8114,8220,24887,8222,24889],"class_list":["post-23885","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-buprenorphine","tag-buprenorphine-tablet","tag-naloxone","tag-naloxone-tablet","tag-suboxone","tag-suboxone-tablet","tag-what-buprenorphine-is-used-for","tag-what-is-buprenorphine","tag-what-is-naloxone","tag-what-is-suboxone","tag-what-naloxone-is-used-for","tag-what-suboxone-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23885"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23885\/revisions"}],"predecessor-version":[{"id":23931,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23885\/revisions\/23931"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}