{"id":23854,"date":"2022-08-10T07:07:21","date_gmt":"2022-08-10T07:07:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23854"},"modified":"2022-08-11T14:53:12","modified_gmt":"2022-08-11T14:53:12","slug":"stribild","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/stribild\/","title":{"rendered":"Stribild | elvitegravir\/cobicistat\/emtricitabine\/tenofovir disoproxil uses, dose and side effects"},"content":{"rendered":"\n<p>150 mg\/150 mg\/200 mg\/245 mg&nbsp;film-coated tablets<br>elvitegravir\/cobicistat\/emtricitabine\/tenofovir disoproxil<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Stribild is and what it is used for<\/h2>\n\n\n\n<p><strong>Stribild contains four active substances:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>elvitegravir,<\/strong>&nbsp;an antiretroviral medicine called an integrase inhibitor<\/li><li><strong>cobicistat,<\/strong>&nbsp;a booster&nbsp;<em>(&nbsp;pharmacokinetic&nbsp;enhancer)<\/em>&nbsp;of the effects of elvitegravir<\/li><li><strong>emtricitabine,<\/strong>&nbsp;an antiretroviral medicine called a nucleoside reverse transcriptase inhibitor (NRTI)<\/li><li><strong>tenofovir disoproxil,<\/strong>&nbsp;an antiretroviral medicine called a nucleotide reverse transcriptase inhibitor (NtRTI).<\/li><\/ul>\n\n\n\n<p>Stribild is a one-table treatment for human immunodeficiency virus (\u00a0HIV\u00a0) infection in adults.<\/p>\n\n\n\n<p>Stribild is also intended for the treatment of\u00a0HIV\u00a0&#8211; 1\u00a0infection\u00a0in adolescents from 12 to &lt; 18 years of age with a body weight of at least 35 kg and who have already been treated with other\u00a0HIV\u00a0medicines that have caused\u00a0side effects.<\/p>\n\n\n\n<p><strong>Stribild reduces the amount of\u00a0HIV\u00a0in the body.\u00a0This strengthens the immune system and reduces the risk<\/strong>\u00a0of\u00a0developing diseases associated with\u00a0HIV\u00a0infection.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Stribild<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Stribild<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are allergic<\/strong>\u00a0to\u00a0<strong>elvitegravir, cobicistat, emtricitabine, tenofovir, tenofovir disoproxil,<\/strong>\u00a0or any other ingredient in this medicine (listed in section 6 of the leaflet).<\/li><li>If you have stopped treatment with any medicine containing\u00a0<strong>tenofovir disoproxil<\/strong>\u00a0on the advice of a doctor after problems with kidney function.<\/li><li><strong>If you are taking any of these medicines:<\/strong><ul><li><strong>alfuzosin<\/strong>\u00a0(used to treat enlarged prostate gland)<\/li><li><strong>amiodarone<\/strong>,\u00a0quinidine\u00a0(used to correct irregular heartbeats)<\/li><li>dabigatran\u00a0(used to prevent and treat blood clots)<\/li><li>carbamazepine, phenobarbital,\u00a0phenytoin\u00a0(used to prevent seizures)<\/li><li>rifampicin\u00a0(used to prevent and treat\u00a0tuberculosis\u00a0and other\u00a0infections\u00a0)<\/li><li>dihydroergotamine,\u00a0ergotamine<strong>, ergometrine<\/strong>\u00a0(used to treat migraine headaches)<\/li><li><strong>cisapride<\/strong>\u00a0(used to relieve certain stomach problems)<\/li><li><strong>St. John&#8217;s wort\u00a0<\/strong><em>(Hypericum perforatum,<\/em>\u00a0a natural remedy used for depression and anxiety) or products containing\u00a0St. John&#8217;s wort<\/li><li><strong>lovastatin,\u00a0simvastatin<\/strong>\u00a0(used to lower blood cholesterol levels)<\/li><li><strong>pimozide, lurasidone<\/strong>\u00a0(used to treat abnormal thoughts or feelings)<\/li><li><strong>sildenafil<\/strong>\u00a0(used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension\u00a0&#8211; a lung disease that makes breathing difficult)<\/li><li><strong>midazolam<\/strong>\u00a0(administered orally), triazolam (used to help you sleep and\/or reduce anxiety)<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>\u2192 If any of these apply to you, do not take Stribild and inform your doctor immediately.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Your treatment with Stribild must be followed up by a doctor at all times.<\/p>\n\n\n\n<p><strong>You can still transmit\u00a0HIV\u00a0when<\/strong>\u00a0taking this medicine, although the risk is reduced with effective\u00a0antiviral\u00a0treatment.\u00a0Discuss with your doctor the necessary measures to avoid infecting others.\u00a0<strong>This medicine does not\u00a0cure\u00a0HIV\u00a0infection<\/strong>.\u00a0While taking Stribild, you may still develop\u00a0an infection\u00a0or other diseases associated\u00a0with\u00a0HIV\u00a0infection.<\/p>\n\n\n\n<p><strong>Talk to your doctor before taking Stribild:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you have kidney problems<\/strong>&nbsp;or have had kidney problems in the past or if tests have shown that you have kidney problems.&nbsp;The doctor carefully considers whether you should receive treatment with Stribild.<br>Stribild can affect your kidneys.&nbsp;Before starting treatment, your doctor will order&nbsp;some&nbsp;blood tests to check that your kidneys are working normally.&nbsp;Your doctor will also order&nbsp;blood&nbsp;tests during treatment to check your kidneys.<br>Stribild is not usually taken together with other medicines that can damage the kidneys (see Other medicines and Stribild).&nbsp;If unavoidable, your doctor will check your kidney function more often.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Bone problems<\/strong>\u00a0(manifesting as persistent or worsening bone pain and sometimes leading to\u00a0fractures\u00a0) may also occur due to damage to renal tubule cells (see section 4, Possible\u00a0side effects\u00a0).\u00a0Tell your doctor if you have bone pain or\u00a0a fracture.<br>Tenofovir disoproxil can also cause loss of bone mass.<br>Overall, the effects of tenofovir disoproxil on long-term bone health and future fracture risk in adults and children are uncertain<br>Tell your doctor if you know you have osteoporosis.\u00a0Patients with osteoporosis are at higher risk of\u00a0fracture.<\/li><li>If you have liver problems or have had liver disease, including\u00a0hepatitis.\u00a0Patients with liver disease, including\u00a0chronic\u00a0hepatitis\u00a0B or C, who are treated with antiretroviral agents are at increased risk of severe and potentially fatal liver complications.\u00a0If you have\u00a0hepatitis\u00a0B, your doctor will carefully choose the best treatment for you.<br>If you have\u00a0a hepatitis\u00a0B\u00a0infection, your liver problems may get worse after you stop taking Stribild.\u00a0You mustn&#8217;t stop taking Stribild without talking to your doctor (see section 3, Do not stop taking Stribild).<\/li><li><strong>If you are over 65 years of age.\u00a0<\/strong>Stribild has not been studied in patients over 65 years of age.\u00a0If you are older than that and have been prescribed Stribild, your doctor will monitor you closely.<\/li><\/ul>\n\n\n\n<p><strong>\u2192 If any of these apply to you, talk to your doctor before taking Stribild.<\/strong><\/p>\n\n\n\n<p><strong>When you take Stribild<\/strong><\/p>\n\n\n\n<p>Once you have started taking Stribild, you must be observant of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>any&nbsp;<strong>signs of&nbsp;inflammation&nbsp;or&nbsp;infection<\/strong><\/li><li><strong>leg problems<\/strong><\/li><\/ul>\n\n\n\n<p><strong>\u2192 Contact a doctor immediately if you experience any of these symptoms.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>Do not give this medicine to children<\/strong>\u00a0under 12 years of age.\u00a0The use of Stribild in children under 12 years of age and weighing less than 35 kg has not been studied.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Stribild<\/h2>\n\n\n\n<p><strong>There are certain medicines that you must never take with Stribild<\/strong><\/p>\n\n\n\n<p>These are mentioned under the heading above &#8220;Do not take Stribild &#8211; If you are taking any of these medicines&#8221;.<\/p>\n\n\n\n<p><strong>Tell your doctor or pharmacist if you are taking<\/strong>\u00a0or have recently taken any\u00a0<strong>other medicines<\/strong>.\u00a0Stribild can affect or be affected by other medicines.\u00a0This can lead to the amount of Stribild or other medicines in the blood being affected.\u00a0The medicines may then not work properly or any\u00a0side effects\u00a0may worsen.\u00a0In some cases, the doctor may need to change the\u00a0dose\u00a0or check the amount of medicine in the blood.<\/p>\n\n\n\n<p><strong>You must talk to your doctor<\/strong>\u00a0if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>all other medicines containing:<\/strong><ul><li><strong>tenofovir disoproxil<\/strong><\/li><li><strong>tenofovir alafenamide<\/strong><\/li><li><strong><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triumeq\/\">lamivudine<\/a><\/strong><\/li><li><strong>adefovir dipivoxil<\/strong><\/li><\/ul><\/li><li><strong>medicines that can damage the kidneys, such as:<\/strong><ul><li>aminoglycosides\u00a0(eg streptomycin,\u00a0neomycin,\u00a0and gentamicin), vancomycin (for bacterial infections)<\/li><li>foscarnet, ganciclovir, cidofovir (for viral infections)<\/li><li>amphotericin B, pentamidine (for fungal infections)<\/li><li>interleukin\u00a02 (also called aldesleukin) (to treat cancer)<\/li><li>non-steroidal anti-inflammatory agents (\u00a0NSAIDs, to relieve bone or muscle pain)<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>It is also important that you tell the doctor<\/strong>&nbsp;if you are taking any of the following types of medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>antifungals\u00a0<\/strong>used to treat fungal infections, such as:<ul><li>ketoconazole\u00a0, itraconazole, voriconazole,\u00a0fluconazole\u00a0and posaconazole<\/li><\/ul><\/li><li>antiviral agents,\u00a0used to treat\u00a0hepatitis\u00a0C infection:<ul><li>ledipasvir\/sofosbuvir, sofosbuvir\/velpatasvir and sofosbuvir\/velpatasvir\/voxilaprevir<\/li><\/ul><\/li><li>antibiotics\u00a0used to treat bacterial infections such as\u00a0tuberculosis\u00a0and include:<ul><li>rifabutin, clarithromycin, or telithromycin<\/li><\/ul><\/li><li>antidepressants\u00a0used to treat depression:<ul><li>medicines containing trazodone or escitalopram<\/li><\/ul><\/li><li>sedatives\u00a0and\u00a0hypnotics\u00a0used to treat anxiety:<ul><li>buspirone, clorazepate,\u00a0diazepam\u00a0, estazolam, flurazepam and zolpidem<\/li><\/ul><\/li><li>immunosuppressants\u00a0used to control the body&#8217;s immune system after a transplant, e.g.:<ul><li>ciclosporin, sirolimus and tacrolimus<\/li><\/ul><\/li><li>corticosteroids,\u00a0including:<ul><li>betamethasone, budesonide,\u00a0fluticasone, mometasone, prednisone, triamcinolone.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>These medicines are used to treat\u00a0allergies,\u00a0asthma, inflammatory bowel diseases, inflammatory conditions in the skin,\u00a0inflammation\u00a0in the eyes, joints, and muscles, and other inflammatory conditions.\u00a0These drugs are usually taken orally, inhaled, injected, or applied to the skin or eye.\u00a0If there are no alternatives, the drug should be used only after medical judgment and under close monitoring by your doctor for\u00a0side effects\u00a0of\u00a0corticosteroids.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>medicines used to treat diabetes:<\/strong><ul><li>metformin<\/li><\/ul><\/li><li><strong>birth control pills\u00a0<\/strong>used to prevent pregnancy<\/li><li>drugs against\u00a0erectile dysfunction\u00a0used to treat impotence, eg:<ul><li>sildenafil, tadalafil, and vardenafil<\/li><\/ul><\/li><li>heart medicines,\u00a0eg:<ul><li>digoxin\u00a0,\u00a0disopyramide\u00a0,\u00a0flecainide\u00a0,\u00a0lidocaine\u00a0, mexilitine,\u00a0propafenone\u00a0,\u00a0metoprolol\u00a0,\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/timosan\/\">timolol<\/a>\u00a0, amlodipine,\u00a0diltiazem\u00a0, felodipine, nicardipine, nifedipine and verapamil<\/li><\/ul><\/li><li>drugs used to treat\u00a0pulmonary\u00a0arterial\u00a0hypertension:<ul><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">bosentan<\/a><\/li><\/ul><\/li><li>anticoagulant\u00a0,\u00a0used to prevent and treat blood clots, eg:<ul><li>warfarin\u00a0, edoxaban, apixaban and rivaroxaban<\/li><\/ul><\/li><li>bronchodilators\u00a0used to treat\u00a0asthma\u00a0and other lung problems:<ul><li>salmeterol<\/li><\/ul><\/li><li>cholesterol-lowering medicines,\u00a0such as:<ul><li>rosuvastatin, atorvastatin, pravastatin, fluvastatin and pitavastatin<\/li><\/ul><\/li><li>drugs used to treat gout:<ul><li>colchicine<\/li><\/ul><\/li><li>antiplatelet medicines\u00a0used to reduce the risk of blood clots, e.g.:<ul><li>clopidogrel<\/li><\/ul><\/li><li>medicines or dietary supplements containing minerals (such as\u00a0magnesium, aluminum,\u00a0calcium, iron, and zinc), for example:<ul><li>mineral supplements,\u00a0vitamins\u00a0(including multivitamins), antacids (medicines for stomach acid), and\u00a0laxatives<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>\u2192 If\u00a0<\/strong><strong>you take medicines, dietary supplements, antacids,<\/strong> or\u00a0laxatives\u00a0that contain minerals (such as\u00a0magnesium, aluminum,\u00a0calcium, iron, and zinc), take them at least 4 hours after Stribild.<\/p>\n\n\n\n<p><strong>\u2192 Tell the doctor if you are taking any of these or other medicines.&nbsp;<\/strong>You should not stop treatment without talking to your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor immediately\u00a0<\/strong><strong>if\u00a0<\/strong><strong>you are pregnant, think you may be pregnant, or are planning to have a baby.\u00a0<\/strong>Pregnant women should not take Stribild.\u00a0The amount of this medicine in the blood may decrease during pregnancy, which may cause it to stop working properly.<\/li><li><strong>Use an effective method of contraception<\/strong>\u00a0while taking Stribild.<\/li><\/ul>\n\n\n\n<p><strong>Do not breastfeed during treatment with Stribild.&nbsp;<\/strong>This is because some of the active substances in this medicine are excreted in human breast milk.&nbsp;If you are an&nbsp;HIV&nbsp;-infected woman, you should not breastfeed your infant to avoid transmission of&nbsp;HIV&nbsp;to the baby through breast milk.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Stribild may cause dizziness, fatigue, or insomnia.\u00a0Do not drive or use tools or machines if you feel affected by taking Stribild.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Stribild contains lactose<\/h2>\n\n\n\n<p>If you have an intolerance to certain sugars, you should consult your doctor before taking this medication.<\/p>\n\n\n\n<p><strong>Stribild contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Stribild<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended\u00a0dose\u00a0for adults and adolescents aged 12 to less than 18 years who weigh at least 35 kg:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>One tablet a day by mouth with food.&nbsp;<\/strong>You must not chew, crush or split the tablet.<\/li><\/ul>\n\n\n\n<p><strong>Always take the&nbsp;dose&nbsp;prescribed by the doctor<\/strong>&nbsp;to ensure that the medicine is effective and to reduce the development of&nbsp;resistance&nbsp;to the treatment.&nbsp;Do not change the&nbsp;dose&nbsp;unless your doctor tells you to.<\/p>\n\n\n\n<p><strong>If you take\u00a0<\/strong><strong>medicines, dietary supplements, antacids,<\/strong> or\u00a0laxatives\u00a0that contain minerals\u00a0(such as\u00a0magnesium, aluminum,\u00a0calcium, iron, and zinc), take them at least 4 hours before or at least 4 hours after Stribild.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Stribild<\/h2>\n\n\n\n<p>If you accidentally take more than the prescribed&nbsp;dose&nbsp;of Stribild, the risk of&nbsp;side effects&nbsp;with this medicine may increase (see section 4, Possible&nbsp;side effects&nbsp;).<\/p>\n\n\n\n<p>Contact your doctor or nearest emergency department immediately for advice.&nbsp;Save the jar so you can easily describe what you have taken.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Stribild<\/h2>\n\n\n\n<p>You mustn&#8217;t miss a\u00a0dose\u00a0of Stribild.<\/p>\n\n\n\n<p>If you miss a dose:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>and you notice it within 18 hours<\/strong>\u00a0of the time you usually take Stribild, you must take the tablet as soon as possible.\u00a0The tablet must always be taken with food.\u00a0Then take the next\u00a0dose\u00a0as usual.<\/li><li><strong>If<\/strong> you notice it 18 hours or more\u00a0after the time you usually take Stribild, do not take the missed\u00a0dose.\u00a0Wait and take the next\u00a0dose\u00a0with food at its regular time.<\/li><\/ul>\n\n\n\n<p><strong>If you vomit within less than 1 hour after a&nbsp;dose&nbsp;of Stribild,<\/strong>&nbsp;take another tablet with food.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking Stribild<\/h2>\n\n\n\n<p><strong>Do not stop taking Stribild without talking to your doctor.&nbsp;<\/strong>If you stop taking Stribild, it may seriously affect your response to future treatment.&nbsp;If you stop taking Stribild for any reason, talk to your doctor before you start taking Stribild tablets again.<\/p>\n\n\n\n<p><strong>When your supply of Stribild starts to run out,<\/strong>&nbsp;get more from your doctor or pharmacist.&nbsp;This is very important because the amount of&nbsp;virus&nbsp;can start to increase even if you only stop the drug for a short time.&nbsp;The disease can then become more difficult to treat.<\/p>\n\n\n\n<p><strong>If you have\u00a0HIV\u00a0infection\u00a0and\u00a0chronic\u00a0hepatitis\u00a0B\u00a0infection<\/strong>,\u00a0it\u00a0is especially important that you do not stop Stribild treatment without first talking to your doctor.\u00a0You may need to provide blood samples for several months after the end of treatment.\u00a0In some patients with advanced liver disease or\u00a0cirrhosis, stopping treatment is not recommended as this may lead to worsening of\u00a0hepatitis\u00a0A, which may be life-threatening.<\/p>\n\n\n\n<p><strong>\u2192 Tell your doctor immediately<\/strong>&nbsp;about any new and unexpected symptoms that appear after stopping treatment, especially symptoms that you usually associate with your&nbsp;hepatitis&nbsp;B&nbsp;infection&nbsp;(e.g. if your skin or the whites of your eyes turn yellow, you have dark \u201ctea-colored\u201d urine, light stools, loss of appetite for several days or longer, nausea or vomiting, or stomach pain).<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of&nbsp;lipids&nbsp;and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but in the case of blood lipids, there can sometimes be a connection with the&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will do tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0When treating\u00a0HIV\u00a0infection,\u00a0it is not always possible to know which of the unwanted effects are caused by Stribild, by other medicines you are taking, or by the\u00a0HIV\u00a0disease.<\/p>\n\n\n\n<p><strong>Any serious side effects: Contact a doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Lactic acidosis<\/strong>&nbsp;(too much&nbsp;lactic acid&nbsp;in the blood) is a rare but potentially life-threatening&nbsp;side effect&nbsp;of some&nbsp;HIV&nbsp;drugs.&nbsp;Lactic acidosis occurs more often in women &#8211; especially if they are overweight and in people with liver disease.&nbsp;The following may be signs of lactic acidosis:<ul><li>deep, rapid breathing<\/li><li>tiredness or drowsiness<\/li><li>nausea, vomiting<\/li><li>stomach pain<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>\u2192 Contact your doctor immediately if you think you may have lactic acidosis.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Any sign of\u00a0inflammation\u00a0or\u00a0infection<\/strong>.\u00a0In some patients with advanced\u00a0HIV\u00a0infection\u00a0(\u00a0AIDS\u00a0) who previously had opportunistic\u00a0infections\u00a0(\u00a0infections\u00a0that occur in people with weakened immune systems), signs and symptoms of\u00a0inflammation\u00a0from previous\u00a0infections\u00a0may\u00a0appear shortly after\u00a0HIV\u00a0treatment is started.\u00a0It is believed that these symptoms are due to the body&#8217;s immune system having been strengthened so that the body can fight\u00a0infections\u00a0that may have existed without giving any obvious symptoms.\u00a0In addition to the opportunistic ones infections\u00a0, autoimmune diseases (a condition that occurs when the immune system attacks healthy body tissue) can also occur after you start taking medicines to treat\u00a0your\u00a0HIV\u00a0infection.\u00a0Autoimmune diseases can appear many months after treatment has begun.\u00a0If you notice any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, a weakness that starts in the hands and feet and moves to the trunk, palpitations, tremors, or hyperactivity, see a doctor immediately to get the necessary treatment.<\/li><\/ul>\n\n\n\n<p><strong>\u2192 If you notice any symptoms of\u00a0inflammation\u00a0or\u00a0infection, inform your doctor immediately.<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may occur in at least 1 in 10 treated patients)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><li>vomiting<\/li><li>nausea<\/li><li>feeling of weakness<\/li><li>headache, dizziness<\/li><li>rash<\/li><\/ul>\n\n\n\n<p>Samples may also show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lowering of the phosphate level in the blood<\/li><li>increased levels of creatine kinase in the blood which can cause muscle pain and muscle weakness<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>(&nbsp;<em>may occur in 1 to 10 out of 100 treated patients)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduced appetite<\/li><li>difficulty sleeping\u00a0<em>(insomnia),<\/em>\u00a0abnormal dreams<\/li><li>pain, abdominal pain<\/li><li>indigestion resulting in discomfort after meals\u00a0<em>(\u00a0dyspepsia\u00a0)<\/em><\/li><li>feeling of bloating<\/li><li>constipation\u00a0<em>,\u00a0<\/em><em>flatulence<\/em><em>\u00a0_<\/em><\/li><li>skin rash (including red dots or patches of skin sometimes with blistering and swelling of the skin) which may be allergic reactions,\u00a0itching, skin discoloration including dark spots on the skin<\/li><li>other allergic reactions<\/li><li>fatigue<\/li><\/ul>\n\n\n\n<p>Samples may also show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low\u00a0white blood cell count\u00a0(which may mean you are more likely to get\u00a0an infection\u00a0)<\/li><li>increased blood sugar, increased levels of fatty acids (\u00a0triglycerides\u00a0),\u00a0bilirubin\u00a0in the blood<\/li><li>liver and pancreas problems<\/li><li>increased levels of\u00a0creatinine\u00a0in the blood<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may occur in up to 1 in 100 treated patients)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>suicidal thoughts and suicide attempts (in patients who have had depression or psychiatric problems in the past), depression<\/li><li>back pain caused by kidney problems, including\u00a0kidney failure.\u00a0The doctor may take blood tests to see if the kidneys are working properly.<\/li><li>damage to the kidney (renal tubule cells)<\/li><li>swelling of the face, lips, tongue, or throat<\/li><li>pain in the abdomen (stomach) caused by\u00a0inflammation\u00a0of the pancreas (\u00a0pancreatitis\u00a0)<\/li><li>muscle breakdown, muscle pain, or muscle weakness<\/li><\/ul>\n\n\n\n<p>Samples may also show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anemia&nbsp;(low&nbsp;red blood cell count&nbsp;)<\/li><li>decreased levels of&nbsp;potassium&nbsp;in the blood<\/li><li>changes in urine<\/li><\/ul>\n\n\n\n<p><strong>Rare\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p><em>(may occur in up to 1 in 1,000 treated patients)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lactic acidosis (see Possible serious side effects: Get medical attention immediately)<\/li><li>yellow skin or eyes,\u00a0itching, or pain in the abdomen (stomach) caused by\u00a0inflammation\u00a0of the liver\u00a0<em>(\u00a0hepatitis\u00a0)<\/em><\/li><li>fatty liver<\/li><li>kidney inflammation\u00a0<em>(nephritis)<\/em><\/li><li>you urinate a lot and feel thirsty (nephrogenic\u00a0diabetes insipidus\u00a0)<\/li><li>decreased bone hardness (which causes bone pain and sometimes leads to\u00a0fractures\u00a0)<\/li><\/ul>\n\n\n\n<p>Breakdown of muscle cells decreased bone hardness (which causes bone pain and sometimes leads to\u00a0fractures\u00a0), muscle pain, muscle weakness, and lowered\u00a0potassium\u00a0or phosphate levels in the blood can occur due to damage to the kidney (renal tubule cells).<\/p>\n\n\n\n<p><strong>\u2192 If any&nbsp;side effects&nbsp;get worse, talk to the doctor.<\/strong><\/p>\n\n\n\n<p><strong>Other effects that can be seen during&nbsp;HIV&nbsp;treatment<\/strong><\/p>\n\n\n\n<p>The frequency of the following&nbsp;side effects&nbsp;is not known (the frequency cannot be calculated from the available data).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Leg problems.\u00a0<\/strong>Some patients taking combination antiretroviral medicines such as Stribild may develop a bone disease called\u00a0osteonecrosis\u00a0(bone tissue dies due to loss of blood supply to the bone).\u00a0Some of the many risk factors for developing this disease are long-term use of this type of medicine, treatment with corticosteroids, alcohol consumption, a very weak immune system, and being overweight.\u00a0Signs of\u00a0osteonecrosis\u00a0are:<ul><li>joint stiffness<\/li><li>aches and pains (especially in hips, knees, and shoulders)<\/li><li>movement difficulties<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Other effects on children<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>It is very common in children who have received emtricitabine to experience changes in the color of their skin, including<ul><li>patchy darkening of the skin<\/li><\/ul><\/li><li>It is common for children to have a reduced number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0)<ul><li>this can make the child tired or short of breath<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>\u2192 Inform your doctor if you notice any of these symptoms.<\/strong><\/p>\n\n\n\n<p><strong>\u2192 If you experience\u00a0side effects, talk to your doctor or pharmacist.\u00a0This also applies to any\u00a0side effects\u00a0that are not mentioned in this information.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Stribild should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the can and carton after {EXP}.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Moisture sensitive.&nbsp;Close the jar well.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p><strong>The active substances<\/strong>&nbsp;are elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil.&nbsp;One Stribild film-coated tablet contains 150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine and 245 mg tenofovir disoproxil (equivalent to 300 mg tenofovir disoproxil fumarate or 136 mg tenofovir).<\/p>\n\n\n\n<p><strong>Other ingredients are<\/strong><\/p>\n\n\n\n<p><em>Tablet core:<\/em><\/p>\n\n\n\n<p>Croscarmellose sodium, hydroxypropyl cellulose (E463),\u00a0lactose monohydrate, magnesium stearate, microcrystalline cellulose (E460), silicon dioxide (E551), sodium lauryl sulfate.<\/p>\n\n\n\n<p><em>Film coating:<\/em><\/p>\n\n\n\n<p>Indigo carmine (E132), macrogol 3350 (E1521), polyvinyl alcohol (partially hydrolyzed) (E1203), talc (E553b), titanium dioxide (E171), yellow iron oxide (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Stribild film-coated tablets are green, capsule-shaped tablets.&nbsp;Embossed on one side with &#8220;GSI&#8221; and on the other side with the number &#8220;1&#8221; surrounded by a square box.&nbsp;Stribild is supplied in tins containing 30 tablets (with silica gel desiccant which must be kept in the tin to protect the tablets from moisture).&nbsp;The desiccant (silica gel) is in a separate&nbsp;sachet&nbsp;or container and should not be swallowed.<\/p>\n\n\n\n<p>The following pack sizes are available: Outer cartons containing 1 bottle of 30 film-coated tablets and 90 (3 bottles of 30) film-coated tablets.&nbsp;Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork, T45 DP77<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Gilead Sciences Ireland UC<\/p>\n\n\n\n<p>IDA Business &amp; Technology Park<\/p>\n\n\n\n<p>Carrigtohill<\/p>\n\n\n\n<p>County Cork<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>Contact the representative of the Marketing Authorization Holder if you would like to know more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb\/Belgique\/Belgien<\/strong>Gilead Sciences Belgium SPRL-BVBATel\/Tel: + 32 (0) 24 01 35 50<\/td><td><strong>Lithuania<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Gilead Sciences Ireland UCTel.: + 353 (0) 1 686 1888<\/td><td><strong>Luxembourg\/Luxembourg<\/strong>Gilead Sciences Belgium SPRL-BVBATel\/Tel: + 32 (0) 24 01 35 50<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Gilead Sciences s.r.oPhone: + 420 910 871 986<\/td><td><strong>Magyarorsz\u00e1g<\/strong>Gilead Sciences Ireland UCTel.: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Denmark<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><td><strong>Malta<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Deutschland<\/strong>Gilead Sciences GmbHPhone: + 49 (0) 89 899890-0<\/td><td><strong>The Netherlands<\/strong>Gilead Sciences Netherlands BVPhone: + 31 (0) 20 718 36 98<\/td><\/tr><tr><td><strong>Estonia<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><td><strong>Norway<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Greece<\/strong>Gilead Sciences \u0395\u03bb\u03bb\u03ac\u03c2 \u039c.\u0395\u03a0\u0395.Tel: + 30 210 8930 100<\/td><td><strong>Austria<\/strong>Gilead Sciences GesmbHPhone: + 43 1 260 830<\/td><\/tr><tr><td><strong>Spain<\/strong>Gilead Sciences, SLPhone: + 34 91 378 98 30<\/td><td><strong>Polish<\/strong>Gilead Sciences Poland Sp.&nbsp;z o. oTel.: + 48 22 262 8702<\/td><\/tr><tr><td><strong>France<\/strong>Gilead SciencesTel: + 33 (0) 1 46 09 41 00<\/td><td><strong>Portugal<\/strong>Gilead Sciences, Lda.Phone: + 351 21 7928790<\/td><\/tr><tr><td><strong>Hrvatska<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><td><strong>Romania<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Ireland<\/strong>Gilead Sciences Ireland UCPhone: + 353 (0) 214 825 999<\/td><td><strong>Slovenija<\/strong>Gilead Sciences Ireland UCTel: + 353 (0) 1 686 1888<\/td><\/tr><tr><td><strong>Iceland<\/strong>Gilead Sciences Sweden telephone: + 46 (0) 8 5057 1849<\/td><td><strong>Slovenian Republic<\/strong>Gilead Sciences Slovakia s.r.oPhone: + 421 232 121 210<\/td><\/tr><tr><td><strong>Italy<\/strong>Gilead Sciences SrlPhone: + 39 02 439201<\/td><td><strong>Finland\/Finland<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Cyprus<\/strong>Gilead Sciences \u0395\u03bb\u03bb\u03ac\u03c2 \u039c.\u0395\u03a0\u0395.Tel: + 30 210 8930 100<\/td><td><strong>Sweden<\/strong>Gilead Sciences Sweden ABTel: + 46 (0) 8 5057 1849<\/td><\/tr><tr><td><strong>Latvia<\/strong>Gilead Sciences Poland Sp.\u00a0z o. iPhone: + 48 22 262 8702<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Gilead Sciences Ireland UCTel: + 44 (0) 8000 113 700<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>150 mg\/150 mg\/200 mg\/245 mg\u00a0film-coated tablets<br \/>\nelvitegravir\/cobicistat\/emtricitabine\/tenofovir disoproxil<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24830,3362,14490,3398,24826,24828,24831,3389,24827,24829],"class_list":["post-23854","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-stribild","tag-cobicistat","tag-elvitegravir","tag-emtricitabine","tag-stribild","tag-stribild-dosage","tag-stribild-side-effects","tag-tenofovir-disoproxil","tag-what-is-stribild","tag-what-stribild-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23854"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23854\/revisions"}],"predecessor-version":[{"id":23877,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23854\/revisions\/23877"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}