{"id":23796,"date":"2022-08-06T08:36:30","date_gmt":"2022-08-06T08:36:30","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23796"},"modified":"2022-08-10T06:49:23","modified_gmt":"2022-08-10T06:49:23","slug":"strensiq","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/strensiq\/","title":{"rendered":"Strensiq &#8211; Asfotase alfa uses, dose and side effects"},"content":{"rendered":"\n<p>40 mg\/ml&nbsp;solution for injection&nbsp;(12 mg\/0.3 ml, 18 mg\/0.45 ml, 28 mg\/0.7 ml, 40 mg\/1 ml)<br>asfotase alfa<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Strensiq is and what it is used for<\/h2>\n\n\n\n<p><strong>What Strensiq is<\/strong><\/p>\n\n\n\n<p>Strensiq is a medicine used to treat the hereditary disease hypophosphatasia when it appears in childhood.&nbsp;It contains the active substance asfotase alfa.<\/p>\n\n\n\n<p><strong>What is hypophosphatasia<\/strong><\/p>\n\n\n\n<p>Patients with hypophosphatasia have low levels of an\u00a0enzyme\u00a0called alkaline phosphatase, which is important for various body functions, including\u00a0for bones and teeth to become properly hard.\u00a0Patients with the disease have problems with bone growth and strength, which can lead to broken bones, bone pain, and difficulty walking, as well as breathing difficulties and risk of seizures.<\/p>\n\n\n\n<p><strong>What Strensiq is used for<\/strong><\/p>\n\n\n\n<p>The active substance in Strensiq can replace the missing&nbsp;enzyme&nbsp;(alkaline phosphatase) in hypophosphatasia.&nbsp;It is used as a long-term enzyme replacement therapy to manage the symptoms.<\/p>\n\n\n\n<p><strong>What benefits Strensiq has shown in&nbsp;clinical studies<\/strong><\/p>\n\n\n\n<p>Strensiq has shown benefits for patients&#8217; bone mineralization and growth.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Strensiq<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Strensiq<\/h2>\n\n\n\n<p>If you are severely allergic to asfotase alfa (see section \u201cWarnings and precautions\u201d below) or any of the other ingredients of this medicine (listed in section 6).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before starting Strensiq.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Patients who have received asfotase alfa have experienced allergic reactions, including life-threatening allergic reactions similar to anaphylactic reactions, which required medical treatment.\u00a0Patients who have experienced anaphylaxis-like symptoms have experienced difficulty breathing, suffocation, nausea, swelling around the eyes, and dizziness.\u00a0The reactions occurred within minutes of asfotase alfa\u00a0injection\u00a0and may occur in patients who have received asfotase alfa for more than a year.\u00a0If you experience any of these symptoms, stop taking Strensiq immediately and seek medical attention.<\/li><li>If you have an\u00a0anaphylactic reaction\u00a0or a reaction with similar symptoms, your doctor will discuss with you what measures to take and the possibility of restarting Strensiq under medical supervision.\u00a0Always follow the instructions given to you by your doctor.<\/li><li>Development of blood proteins against Strensiq, also called drug antibodies, may occur during treatment.\u00a0Talk to your doctor if you feel that the effect of Strensiq is diminishing.<\/li><li>Fat pads or a decrease in the amount of fat tissue under the surface of the skin (localized lipodystrophy) have been reported at the injection site after several months in patients using Strensiq.\u00a0Carefully read section 3 on injection recommendations.\u00a0It is important to alternate between the following injection sites to reduce the risk of lipodystrophy: abdominal area, thigh, or upper arm.<\/li><li>In studies, some eye-related\u00a0side effects\u00a0have been reported that are probably related to hypophosphatasia (eg, calcium deposits in the eye [conjunctival and corneal calcification]), both in patients who used and those who did not use Strensiq.\u00a0Talk to your doctor if you experience vision problems.<\/li><li>Early fusion of the bones of the skull (craniosynostosis) in children under 5 years of age has been reported in\u00a0clinical trials\u00a0in infants with hypophosphatasia, with and without the use of Strensiq.\u00a0Talk to the doctor if you notice any change in the shape of your child&#8217;s head.<\/li><li>If you are treated with Strensiq, you may have a reaction at the injection site (pain, lump, rash, discoloration) during the\u00a0injection\u00a0of the medicine or in the hours after the\u00a0injection.\u00a0If you experience severe reactions at the injection site, talk to your doctor immediately.<\/li><li>An increased concentration of parathyroid hormones and low calcium levels have been reported in studies.\u00a0For that reason, your doctor may ask you to take\u00a0calcium\u00a0and vitamin D supplements as needed.<\/li><li>Weight gain may occur when you are treated with Strensiq.\u00a0Your doctor can give you dietary advice as needed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Strensiq<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or might be using other medicines.<\/p>\n\n\n\n<p>If you need to undergo laboratory tests (give blood samples), tell the doctor that you are being treated with Strensiq.&nbsp;Strensiq can cause some samples to show falsely higher or lower results.&nbsp;Therefore, a different type of test may need to be used if you are treated with Strensiq.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<p>Strensiq should not be used during pregnancy.&nbsp;An effective method of contraception during treatment should be considered for women who may become pregnant.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Breast-feeding<\/h2>\n\n\n\n<p>It is unknown whether Strensiq can pass into breast milk.\u00a0Tell the doctor if you are breastfeeding or plan to breastfeed.\u00a0The doctor will help you decide whether to stop breastfeeding or to stop taking Strensiq, taking into account the benefit of breastfeeding for the baby and the benefit of Strensiq for the mother.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>This medicine is not expected to have any effect on the ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the excipients in Strensiq<\/h2>\n\n\n\n<p>This medicinal product contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0vial\u00a0, meaning it is essentially &#8216;sodium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Strensiq<\/h2>\n\n\n\n<p>Always use this medicine exactly as described in this leaflet or as directed by your doctor, pharmacist, or nurse.\u00a0Consult a doctor, pharmacist, or nurse if you are unsure.<\/p>\n\n\n\n<p>A doctor experienced in treating patients with metabolic or bone-related diseases will explain to you how to use Strensiq.&nbsp;After receiving instructions from the doctor or a specialist nurse, you can inject Strensiq yourself at home.<\/p>\n\n\n\n<p><strong>Dose<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The\u00a0dose\u00a0you receive is based on your body weight.<\/li><li>The correct\u00a0dose\u00a0is calculated by the doctor and consists of a total of 6 mg asfotase alfa per kg of body weight each week, given either as an\u00a0injection\u00a0of 1 mg\/kg asfotase alfa 6 times per week or as 2 mg\/kg asfotase alfa 3 times per week, depending on the doctor&#8217;s recommendation.\u00a0Each\u00a0dose\u00a0is given by\u00a0injection\u00a0under the skin (\u00a0subcutaneously\u00a0).\u00a0(The dosage chart below provides detailed information on the volume to inject and the type of bottle to use, depending on your weight.)<\/li><li>The doctor needs to adjust the\u00a0dose\u00a0at regular intervals as the body weight changes.<\/li><li>The maximum volume per\u00a0injection\u00a0must not exceed 1 ml.\u00a0If more than 1 ml is needed, you should give several\u00a0injections\u00a0right after each other.<\/li><\/ul>\n\n\n\n<p><strong>At 3\u00a0injections\u00a0per week<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Body weight (kg)<\/strong><\/td><td><strong>Volume to be injected<\/strong><\/td><td><strong>Color code of the bottle to be used<\/strong><\/td><\/tr><tr><td><strong>3<\/strong><\/td><td>0.15 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>4<\/strong><\/td><td>0.20 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>5<\/strong><\/td><td>0.25 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>6<\/strong><\/td><td>0.30 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>7<\/strong><\/td><td>0.35 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>8<\/strong><\/td><td>0.40 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>9<\/strong><\/td><td>0.45 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>10<\/strong><\/td><td>0.50 ml<\/td><td>Light blue<\/td><\/tr><tr><td><strong>11<\/strong><\/td><td>0.55 ml<\/td><td>Light blue<\/td><\/tr><tr><td><strong>12<\/strong><\/td><td>0.60 ml<\/td><td>Light blue<\/td><\/tr><tr><td><strong>13<\/strong><\/td><td>0.65 ml<\/td><td>Light blue<\/td><\/tr><tr><td><strong>14<\/strong><\/td><td>0.70 ml<\/td><td>Light blue<\/td><\/tr><tr><td><strong>15<\/strong><\/td><td>0.75 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>16<\/strong><\/td><td>0.80 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>17<\/strong><\/td><td>0.85 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>18<\/strong><\/td><td>0.90 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>19<\/strong><\/td><td>0.95 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>20<\/strong><\/td><td>1 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>25<\/strong><\/td><td>0.50 ml<\/td><td>Green<\/td><\/tr><tr><td><strong>30<\/strong><\/td><td>0.60 ml<\/td><td>Green<\/td><\/tr><tr><td><strong>35<\/strong><\/td><td>0.70 ml<\/td><td>Green<\/td><\/tr><tr><td><strong>40<\/strong><\/td><td>0.80 ml<\/td><td>Green<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>At 6\u00a0injections\u00a0per week<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Body weight (kg)<\/strong><\/td><td><strong>Volume to be injected<\/strong><\/td><td><strong>Color code of the bottle to be used<\/strong><\/td><\/tr><tr><td><strong>6<\/strong><\/td><td>0.15 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>7<\/strong><\/td><td>0.18 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>8<\/strong><\/td><td>0.20 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>9<\/strong><\/td><td>0.23 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>10<\/strong><\/td><td>0.25 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>11<\/strong><\/td><td>0.28 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>12<\/strong><\/td><td>0.30 ml<\/td><td>Dark blue<\/td><\/tr><tr><td><strong>13<\/strong><\/td><td>0.33 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>14<\/strong><\/td><td>0.35 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>15<\/strong><\/td><td>0.38 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>16<\/strong><\/td><td>0.40 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>17<\/strong><\/td><td>0.43 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>18<\/strong><\/td><td>0.45 ml<\/td><td>Orange<\/td><\/tr><tr><td><strong>19<\/strong><\/td><td>0.48 ml<\/td><td>Light blue<\/td><\/tr><tr><td><strong>20<\/strong><\/td><td>0.50 ml<\/td><td>Light blue<\/td><\/tr><tr><td><strong>25<\/strong><\/td><td>0.63 ml<\/td><td>Light blue<\/td><\/tr><tr><td><strong>30<\/strong><\/td><td>0.75 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>35<\/strong><\/td><td>0.88 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>40<\/strong><\/td><td>1 ml<\/td><td>Pink<\/td><\/tr><tr><td><strong>50<\/strong><\/td><td>0.50 ml<\/td><td>Green<\/td><\/tr><tr><td><strong>60<\/strong><\/td><td>0.60 ml<\/td><td>Green<\/td><\/tr><tr><td><strong>70<\/strong><\/td><td>0.70 ml<\/td><td>Green<\/td><\/tr><tr><td><strong>80<\/strong><\/td><td>0.80 ml<\/td><td>Green<\/td><\/tr><tr><td><strong>90<\/strong><\/td><td>0.90 ml<\/td><td>Green (x2)<\/td><\/tr><tr><td><strong>100<\/strong><\/td><td>1 ml<\/td><td>Green (x2)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Injection recommendations<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You may react to the injection site.\u00a0Read section 4 carefully to find out what\u00a0side effects\u00a0may occur before using this medicine.<\/li><li>For regular\u00a0injections, you should vary the injection site between different parts of the body to reduce possible pain and irritation.<\/li><li>Areas with a decent amount of fat under the skin (thighs, arms [outside of the upper arms], abdomen and buttocks) are the most suitable areas to inject in. Discuss with your doctor or nurse which are the best places for you.<\/li><\/ul>\n\n\n\n<p><strong>Read the following instructions carefully before injecting Strensiq<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Each\u00a0vial\u00a0is for single use only and should be punctured only once.\u00a0Strensiq liquid should be clear, slightly opalescent or opalescent, colorless to slightly yellow, and may contain some small clear or white particles.\u00a0The liquid must not be used if it is discolored or contains lumps or large particles.\u00a0In that case, take a new\u00a0injection vial.\u00a0Unused medicines and waste must be disposed of according to current instructions.<\/li><li>If you inject this medicine yourself, your doctor, pharmacist, or nurse will show you how to prepare and inject the medicine.\u00a0Do not inject this medicine yourself unless you have been trained and understand the procedure.<\/li><\/ul>\n\n\n\n<p><strong>How Strensiq is injected<\/strong><\/p>\n\n\n\n<p>Step 1: Prepare Strensiq&nbsp;dose&nbsp;one<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Wash your hands thoroughly with soap and water.<\/li><li>Remove the unopened Strensiq vial(s) from the refrigerator 15 to 30 minutes before the\u00a0injection\u00a0is to be given to allow the liquid to reach room temperature.\u00a0Do not heat Strensiq in any other way (eg in a microwave or hot water).\u00a0Once the medicine has been taken out of the refrigerator, it must be used within a maximum of 3 hours.<\/li><li>Remove the protective cap from the vial(s) of Strensiq.\u00a0Remove the plastic protective sleeve from the\u00a0syringe\u00a0to be used.<\/li><li>Always use a new\u00a0syringe\u00a0enclosed in protective plastic.<\/li><li>Attach a larger injection needle (eg 25 G) to the empty syringe, with the protective cap still on the needle.\u00a0Press firmly and turn the needle clockwise until it is securely seated on the syringe.<\/li><li>Remove the protective cap from the needle on the syringe.\u00a0Be careful not to stick yourself to the needle.<\/li><li>Pull out the plunger so that as much air is drawn into the syringe as corresponds to your\u00a0dose.<\/li><\/ol>\n\n\n\n<p>Step 2: Withdraw the Strensiq solution from the vial<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140726000022#\" rel=\"noopener\"><\/a><\/td><td><br>1. Grasp the syringe and vial and insert the needle through the sterile rubber membrane and into the vial.<br>2. Push the plunger in so that all the air is emptied into the vial.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140726000022#\" rel=\"noopener\"><\/a><\/td><td><br>3. Turn the&nbsp;vial over&nbsp;and&nbsp;spray&nbsp;upside down.&nbsp;The needle should be in the liquid.&nbsp;Pull out the plunger until you have the correct&nbsp;dose&nbsp;in the syringe.&nbsp;<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140726000022#\" rel=\"noopener\"><\/a><\/td><td>4. Check that the correct volume has been drawn up and that there are no air bubbles in the syringe before withdrawing the needle from the vial.&nbsp;If there are bubbles in the syringe, hold the syringe with the needle pointing up, then gently tap the side of the syringe so that the bubbles float to the surface.<br>5. When all the bubbles are at the top of the syringe, gently push the plunger to push the bubbles out of the syringe and back into the bottle.&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>6. When the bubbles have been removed, recheck the\u00a0dose\u00a0in the syringe and that you have drawn up the correct amount of liquid.\u00a0You may need to use several vials to draw up the full amount needed for the correct\u00a0dose.<\/p>\n\n\n\n<p>Step 3: Attach the injection needle to the syringe<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Withdraw the needle from the vial.\u00a0Replace the protective cap with one hand by placing the cap on a flat surface, inserting the needle into the cap, lifting it and snapping it securely using only one hand.<\/li><li>Carefully remove the large injection needle by pushing in and turning counterclockwise.\u00a0Discard the needle with the protective cap on in a sharps container.<\/li><li>Attach a narrower needle (eg 27 or 29 G) to the prefilled syringe.\u00a0Leave the protective cap in place, push the needle and turn clockwise until the needle is securely on the syringe.\u00a0Pull the protective cap straight off the needle.<\/li><li>Hold the syringe with the needle pointing up and tap the syringe to remove any air bubbles.<\/li><\/ol>\n\n\n\n<p>Check that the volume in the syringe is correct.<\/p>\n\n\n\n<p>The volume per&nbsp;injection&nbsp;must not exceed 1 ml.&nbsp;If it does, several&nbsp;injections&nbsp;must be given at different injection sites.<\/p>\n\n\n\n<p>You are now ready to inject the correct\u00a0dose.<\/p>\n\n\n\n<p>Step 4: Inject Strensiq<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><br><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140726000022#\" rel=\"noopener\"><\/a><br><\/td><td><br>1. Choose an injection site (thighs, abdomen, arms, [outer upper arm], buttocks).\u00a0The most suitable places for\u00a0injection\u00a0are marked in gray in the image.\u00a0Your doctor will inform you about possible injection sites.<br>NOTE: do not use areas where you feel lumps, hard knots, or pain.\u00a0Talk to your doctor if you notice anything like this.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140726000022#\" rel=\"noopener\"><\/a><\/td><td><br>2. Gently pinch the skin of the chosen injection area between your thumb and forefinger.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140726000022#\" rel=\"noopener\"><\/a><\/td><td><br>3. Holding the syringe like a pencil or dart, insert the needle into the raised skin so that its angle to the skin surface is between 45\u00ba and 90\u00ba.<br>For patients who have little subcutaneous fat or who have thin skin, an angle of 45\u00ba may be preferable.<\/td><\/tr><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140726000022#\" rel=\"noopener\"><\/a><\/td><td>4. While maintaining your grip on the skin, push the syringe plunger to inject the medicine slowly and steadily in.<br>5. Withdraw the needle, release the skin fold and gently press with a cotton ball or gauze over the injection site for a few seconds. This helps to close the punctured\u00a0tissue\u00a0and prevent leakage.\u00a0Do not rub the injection site after\u00a0injection.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>If you need another\u00a0injection\u00a0to get the prescribed\u00a0dose, take a new\u00a0vial\u00a0of Strensiq and repeat steps 1 through 4.<\/p>\n\n\n\n<p>Step 5: Discard the remaining material<\/p>\n\n\n\n<p>Collect the syringes, vials, and needles in a sharps container.\u00a0Your doctor, pharmacist, or nurse will tell you how to access a sharps container.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Strensiq&nbsp;<\/h2>\n\n\n\n<p>If you suspect that you have accidentally received a higher&nbsp;dose&nbsp;of Strensiq than prescribed, contact your doctor for advice.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Strensiq<\/h2>\n\n\n\n<p>Do not inject a double dose to make up for a missed\u00a0dose.\u00a0Contact your doctor for advice.<\/p>\n\n\n\n<p>Further information is available here: strensiqpatient.se<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140726000022#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/be560dcb-7c8a-4a96-a51d-a3bbac527cb3\" alt=\"Image 9\" title=\"Image 9\"\/><\/a><\/figure>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you are not sure what the&nbsp;side effects&nbsp;below mean, ask the doctor to explain them to you.<\/p>\n\n\n\n<p>The most serious\u00a0side effects\u00a0that have occurred in patients receiving asfotase alfa have been allergic reactions, including life-threatening allergic reactions similar to anaphylactic reactions that required medical treatment.\u00a0This\u00a0side effect\u00a0is common (may affect up to 1 in 10 people).\u00a0Patients who have experienced these severe allergic reactions have experienced difficulty breathing, choking, nausea, swelling around the eyes, and dizziness.\u00a0The reactions occurred within minutes of asfotase alfa\u00a0injection\u00a0and may occur in patients who have used asfotase alfa for more than a year.\u00a0<strong>If you experience any of these symptoms, stop using Strensiq immediately and seek medical attention.<\/strong><\/p>\n\n\n\n<p>Other allergic reactions (hypersensitivity) can also be common and appear in the form of&nbsp;redness&nbsp;(&nbsp;erythema&nbsp;), fever (&nbsp;pyrexia&nbsp;), skin rash,&nbsp;itching&nbsp;(&nbsp;pruritus&nbsp;), irritability, nausea, vomiting, pain, chills, numbness in the mouth (&nbsp;oral&nbsp;hypoesthesia&nbsp;), headache, facial flushing, fast&nbsp;pulse&nbsp;(&nbsp;tachycardia&nbsp;) and cough.&nbsp;<strong>If you experience any of these symptoms, stop using Strensiq immediately and seek medical attention.<\/strong><\/p>\n\n\n\n<p><strong>Very common: may affect more than 1 in 10 people<\/strong><\/p>\n\n\n\n<p>Reactions at the injection site during\u00a0injection\u00a0of the drug or during the hours after\u00a0injection\u00a0(which may lead to\u00a0redness, discoloration,\u00a0itching, pain, fat pads or a reduced amount of fat tissue under the skin surface, lighter skin area [hypopigmentation of the skin] and\/or swelling)<\/p>\n\n\n\n<p>Fever (&nbsp;pyrexia&nbsp;)<\/p>\n\n\n\n<p>Irritability<\/p>\n\n\n\n<p>Skin redness (&nbsp;erythema&nbsp;)<\/p>\n\n\n\n<p>Pain in the hands and feet (pain in the&nbsp;extremities&nbsp;)<\/p>\n\n\n\n<p>bruise (contusion)<\/p>\n\n\n\n<p>Headache<\/p>\n\n\n\n<p><strong>Common: may affect up to 1 in 10 people<\/strong><\/p>\n\n\n\n<p>Tight skin, skin discoloration<\/p>\n\n\n\n<p>Nausea<\/p>\n\n\n\n<p>Numbness in the mouth (&nbsp;oral&nbsp;hypoesthesia&nbsp;)<\/p>\n\n\n\n<p>Muscle pain (&nbsp;myalgia&nbsp;)<\/p>\n\n\n\n<p>Scar<\/p>\n\n\n\n<p>Increased tendency to bruise<\/p>\n\n\n\n<p>Bleeding<\/p>\n\n\n\n<p>Injection site skin&nbsp;infection (injection site&nbsp;cellulitis&nbsp;)<\/p>\n\n\n\n<p>Decreased amount of&nbsp;calcium&nbsp;in the blood (&nbsp;hypocalcemia&nbsp;)<\/p>\n\n\n\n<p>Kidney stones&nbsp;(&nbsp;nephrolithiasis&nbsp;)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Strensiq should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton and vial label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C\u20138 \u00b0C).<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>After opening the vial, the medicine should be used immediately (within no more than 3 hours at room temperature, between 23 \u00b0C and 27 \u00b0C).<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>The active substance is asfotase alfa.\u00a0Each ml of solution contains 40 mg of asfotase alfa.<\/p>\n\n\n\n<p>Each&nbsp;vial&nbsp;of 0.3 ml solution (40 mg\/ml) contains 12 mg asfotase alfa.<\/p>\n\n\n\n<p>Each&nbsp;vial&nbsp;of 0.45 ml solution (40 mg\/ml) contains 18 mg asfotase alfa.<\/p>\n\n\n\n<p>Each&nbsp;vial&nbsp;of 0.7 ml solution (40 mg\/ml) contains 28 mg asfotase alfa.<\/p>\n\n\n\n<p>Each&nbsp;vial&nbsp;of 1 ml solution (40 mg\/ml) contains 40 mg asfotase alfa.<\/p>\n\n\n\n<p>Other ingredients are sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate heptahydrate, and water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Strensiq\u00a0solution for injection\u00a0is a clear, slightly opalescent or opalescent, colorless to slightly yellow water-like solution in vials containing 0.3 ml, 0.45 ml, 0.7 ml, and 1 ml of solution.\u00a0Some small transparent or white particles may be present.<\/p>\n\n\n\n<p>Pack sizes of 1 or 12 vials.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Alexion Europe SAS<\/p>\n\n\n\n<p>103-105 rue Anatole France<\/p>\n\n\n\n<p>92300 Levallois-Perret<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Alexion Pharma International Operations Unlimited Company<\/p>\n\n\n\n<p>College Business and Technology Park, Blanchardstown<\/p>\n\n\n\n<p>Dublin 15<\/p>\n\n\n\n<p>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Strensiq is a medicine used to treat the hereditary disease hypophosphatasia when it appears in childhood.\u00a0It contains the active substance asfotase alfa.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24769,24771,24773,24778,24774,24777,24770,24772,24775,24776],"class_list":["post-23796","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-asfotase-alfa","tag-asfotase-alfa-side-effects","tag-benefits-of-asfotase-alfa","tag-benefits-of-strensiq","tag-strensiq","tag-strensiq-sdie-effects","tag-what-asfotase-alfa-is-used-for","tag-what-is-asfotase-alfa","tag-what-is-strensiq","tag-what-strensiq-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23796"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23796\/revisions"}],"predecessor-version":[{"id":23833,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23796\/revisions\/23833"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}