{"id":23793,"date":"2022-08-06T08:33:30","date_gmt":"2022-08-06T08:33:30","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23793"},"modified":"2022-08-10T06:49:35","modified_gmt":"2022-08-10T06:49:35","slug":"strefen-2","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/strefen-2\/","title":{"rendered":"Strefen &#8211; Flurbiprofen uses, dose and side effects"},"content":{"rendered":"\n<p>16.2 mg\/ml&nbsp;oral spray, solution<br>flurbiprofen<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Strefen is and what it is used for<\/h2>\n\n\n\n<p>The active ingredient is flurbiprofen.\u00a0Flurbiprofen belongs to a group of pain relievers called non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0), which affect how the body responds to pain, swelling, and fever.<\/p>\n\n\n\n<p>Strefen is used for short-term symptom relief in sore throats, for example, sore, painful and swollen throats and difficulty swallowing in adults aged 18 and over.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Strefen<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Strefen if you<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>are allergic to flurbiprofen, other non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0),\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a>,\u00a0or any other ingredient in this medicine (see section 6).<\/li><li>have previously had an\u00a0allergic reaction\u00a0after taking non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0) or\u00a0acetylsalicylic acid, e.g.\u00a0asthma, wheezing,\u00a0itching, runny nose, skin rash, or swelling<\/li><li>have or have previously had\u00a0peptic ulcers\u00a0or bleeding or ulcers in the gastrointestinal tract on at least two occasions.<\/li><li>have had severe\u00a0colitis\u00a0(intestinal inflammation).<\/li><li>have ever had problems with your blood&#8217;s clotting\u00a0ability\u00a0or bleeding problems after taking\u00a0NSAIDs<\/li><li>is in the last three months of pregnancy.<\/li><li>have severe\u00a0heart failure, severe\u00a0kidney failure,\u00a0or severe liver failure.<\/li><li>is under 18 years of age.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Strefen if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>already using any other type of non-steroidal anti-inflammatory drug (\u00a0NSAID\u00a0) or\u00a0acetylsalicylic acid.<\/li><li>have strep throat (inflamed tonsils) or suspect you have a bacterial throat infection (as you may need\u00a0antibiotics\u00a0).<\/li><li>are older (as you may be at greater risk of\u00a0side effects\u00a0).<\/li><li>have or have ever had\u00a0asthma\u00a0or\u00a0allergies.<\/li><li>Suffers from a skin disease called systemic lupus erythematosus or mixed connective tissue disease.<\/li><li>have high\u00a0blood pressure.<\/li><li>have had any history of bowel disease (\u00a0ulcerative colitis,\u00a0Crohn&#8217;s disease\u00a0).<\/li><li>have heart, kidney, or liver problems.<\/li><li>have had a\u00a0stroke.<\/li><li>are in the first 6 months of pregnancy or you are breastfeeding.<\/li><\/ul>\n\n\n\n<p><strong>When using Strefen<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>At the first sign of any type of skin reaction (rash, peeling skin, blistering) or signs of an\u00a0allergic reaction, stop using the spray immediately and consult a doctor.<\/li><li>Inform the doctor of any abnormal abdominal symptoms (especially bleeding).<\/li><li>If you do not get better, if you get worse or develop new symptoms, talk to a doctor.<\/li><li>Medicines such as flurbiprofen may cause a small increase in the risk of suffering a heart attack or\u00a0stroke.\u00a0All risks increase with higher\u00a0doses\u00a0or long-term treatment. <strong>Do not exceed the recommended\u00a0dose\u00a0or duration of treatment<\/strong>\u00a0(see section 3).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Children or adolescents should not use this medicine at 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Strefen<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or maybe thinking about using other medicines, including non-prescription ones.\u00a0This applies in particular to the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0) including selective\u00a0cyclooxygenase\u00a0-2 inhibitors\u00a0for pain or\u00a0inflammation, as these drugs may increase the risk of bleeding in the gastrointestinal tract<\/li><li>warfarin,\u00a0acetylsalicylic acid,\u00a0and other blood-thinning or anti-coagulant medicines<\/li><li>ACE inhibitors,\u00a0angiotensin\u00a0II\u00a0antagonists\u00a0(medicines that lower\u00a0blood pressure, etc.)<\/li><li>diuretics\u00a0(fluid-reducing drugs) including potassium-sparing diuretics\u00a0<\/li><li>SSRI\u00a0drugs (selective serotonin reuptake inhibitors) for depression<\/li><li>cardiac glycosides\u00a0(for heart problems), for example,\u00a0digoxin<\/li><li>ciclosporin (which prevents rejection after an organ transplant)<\/li><li>corticosteroids\u00a0(\u00a0anti-inflammatory\u00a0)<\/li><li>lithium (mood stabilizer)<\/li><li>methotrexate\u00a0(for\u00a0psoriasis, arthritis, or cancer)<\/li><li>mifepristone (used to terminate a pregnancy)\u00a0NSAID\u00a0medicines should not be used for 8-12 days after taking mifepristone, as they may reduce the effect of mifepristone<\/li><li>diabetes medicines are taken by mouth<\/li><li>phenytoin\u00a0(to treat\u00a0epilepsy\u00a0)<\/li><li>probenecid, sulfinpyrazone (for\u00a0gout\u00a0and joint inflammation)<\/li><li>quinolone antibiotics (against bacterial infections), for example,\u00a0ciprofloxacin\u00a0or levofloxacin<\/li><li>tacrolimus (drugs that suppress the immune system and are used after organ transplantation)<\/li><li>zidovudine (for\u00a0HIV\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Strefen with alcohol<\/h2>\n\n\n\n<p>Avoid alcohol while using this medicine, as alcohol can increase the risk of bleeding in the gastrointestinal tract.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p><strong>Pregnant women should not use Strefen during the last three months of pregnancy<\/strong>.<\/p>\n\n\n\n<p>Ingestion of Strefen should be avoided by women planning a pregnancy or who are pregnant.<\/p>\n\n\n\n<p>The product belongs to a group of drugs (&nbsp;NSAIDs&nbsp;) that can make it harder to get pregnant.&nbsp;This effect ceases when the treatment is discontinued.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>This medicine should not affect your ability to drive or use machines.\u00a0Dizziness and visual disturbances are, however, possible\u00a0side effects\u00a0of\u00a0NSAID\u00a0medicines.\u00a0If you experience this type of\u00a0side effect, do not drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Strefen contains methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216)<\/h2>\n\n\n\n<p>May cause&nbsp;an allergic reaction&nbsp;(possibly delayed).<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) of\u00a0sodium\u00a0per\u00a0dose, i.e. it is almost &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<p>This medicine contains flavors with citral, limonene,\u00a0eugenol,\u00a0and linalool.\u00a0Citral, limonene,\u00a0eugenol,\u00a0and linalool can cause allergic reactions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Strefen<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Recommended&nbsp;dose<\/strong><\/p>\n\n\n\n<p><strong>Adults from the age of 18:<\/strong><\/p>\n\n\n\n<p>One\u00a0dose\u00a0(3 sprays) at the back of the throat at 3-6 hour intervals as needed, up to a maximum of 5\u00a0doses\u00a0during 24 hours.<\/p>\n\n\n\n<p>One&nbsp;dose&nbsp;(3 sprays) contains 8.75 mg flurbiprofen.<\/p>\n\n\n\n<p><strong>This meChildren or adolescents should not use this medicine18 years of age.<\/strong><\/p>\n\n\n\n<p><strong>To be used in the mouth only<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Should only be sprayed at the back of the throat.<\/li><li>Avoid inhalation when spraying<\/li><li>Do not take more than 5\u00a0doses\u00a0(a total of 15 sprays) in 24 hours.<\/li><\/ul>\n\n\n\n<p><strong>The strap<\/strong>\u00a0is intended for\u00a0<strong>short-term use<\/strong>\u00a0only.<\/p>\n\n\n\n<p>Use as few\u00a0doses\u00a0as possible for as short a time to relieve symptoms.\u00a0If irritation occurs in the mouth, treatment with flurbiprofen should be discontinued.<\/p>\n\n\n\n<p><strong>Do not use this medicine for more than 3 days<\/strong>\u00a0unless prescribed by a doctor.<\/p>\n\n\n\n<p>If you do not get better, if you get worse or if you develop new symptoms, talk to a doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Prepare the pump<\/strong><\/p>\n\n\n\n<p>When using the pump for the first time, or after it has been stored without use for a long time, you must prepare the pump.<\/p>\n\n\n\n<p>Point the nozzle away from you and spray at least four times until a fine, even mist is sprayed out.\u00a0Now the pump is prepared and can be used.\u00a0If you have not used the product for a long time, prime the pump by pointing the nozzle away and spraying at least once to check that a fine mist is being sprayed out.\u00a0Always check that a fine mist is sprayed out before using the medicine.<\/p>\n\n\n\n<p><strong>Use the spray<\/strong><\/p>\n\n\n\n<p>Aim the nozzle at a point at the back of the throat.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20170316000033#\" rel=\"noopener\"><\/a>Depress the pump&nbsp;<strong>three times<\/strong>&nbsp;in quick, even motions, being sure to fully depress the pump with each spray and to lift your finger from the pump between each spray.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20170316000033#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/e65f8eff-f8a6-4554-8e0f-268cc2f64766\" alt=\"press the pump down 3 times\" title=\"press the pump down 3 times\"\/><\/a><\/figure>\n\n\n\n<p>Do not inhale when spraying.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Strefen<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a missed&nbsp;dose<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Strefen<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>The symptoms of overdose may be nausea or vomiting, stomach pain, or (more rarely) diarrhea.\u00a0Ringing in the ears, headache, and bleeding in the gastrointestinal tract are also possible symptoms.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>STOP TAKING this medicine and call your doctor immediately if you develop:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>any serious skin reaction, such as\u00a0blistering (including Steven-Johnson syndrome and\u00a0toxic epidermal necrolysis, which are rare but severe skin and mucosal reactions due to severe\u00a0side effects\u00a0caused by drugs or by\u00a0infection\u00a0).\u00a0Incidence: No known frequency (ie incidence cannot be estimated from available data).<\/li><li>signs of anaphylactic\u00a0shock, which causes, for example, swelling of the face, tongue, or throat with subsequent difficulty breathing, palpitations, and a drop in blood pressure leading to\u00a0shock\u00a0(note that this can also happen when the medicine is used for the first time).\u00a0Occurrence: Rare (occurs in no more than 1 in 1,000 people).<\/li><li>signs of hypersensitivity and skin reactions such as\u00a0redness, swelling, scaly skin, blisters, peeling skin, or sores on the skin and mucous membranes.\u00a0Incidence: Uncommon (occurs in up to 1 in 100 people).<\/li><li>signs of allergic reactions such as\u00a0asthma, wheezing or shortness of breath for no reason,\u00a0itching, runny nose, or skin rash.\u00a0Incidence: Uncommon (may affect up to 1 in 100 people)<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor or pharmacist if you notice any of the following&nbsp;side effects&nbsp;or any&nbsp;side effects&nbsp;not mentioned here:<\/strong><\/p>\n\n\n\n<p><strong>Common&nbsp;<\/strong><em>(may affect up to 1 in 10 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness, headache<\/li><li>throat irritation<\/li><li>mouth sores, pain or numbness in the mouth<\/li><li>sore throat<\/li><li>discomfort in the mouth (warming or burning sensation or tingling)<\/li><li>nausea or diarrhea<\/li><li>tingling and itching sensation in the skin.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong><em>(may affect up to 1 in 100 users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drowsiness<\/li><li>blisters in the mouth or throat, numbness in the throat<\/li><li>bloating, abdominal pain, gas, constipation, indigestion, vomiting<\/li><li>dry mouth<\/li><li>burning sensation in the mouth, altered sense of taste<\/li><li>fever, pain<\/li><li>feeling sleepy or having difficulty falling asleep<\/li><li>worsening\u00a0asthma, wheezing, shortness of breath<\/li><li>decreased feeling in the throat.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported&nbsp;<\/strong><em>(occurring in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anemia\u00a0( lack of\u00a0blood\u00a0),\u00a0thrombocytopenia\u00a0(low levels of\u00a0platelets\u00a0that lead to bruising and bleeding)<\/li><li>swelling (\u00a0edema\u00a0), high\u00a0blood pressure,\u00a0heart failure,\u00a0or heart attack<\/li><li>hepatitis\u00a0(\u00a0inflammation\u00a0of the liver).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Strefen should be stored<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the bottle and the carton after\u00a0EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store protected from cold.&nbsp;Do not freeze.<\/p>\n\n\n\n<p>An opened bottle may be used for a maximum of 6 months.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is flurbiprofen.\u00a0One\u00a0dose\u00a0(3 sprays) contains 8.75 mg flurbiprofen, corresponding to 16.2 mg\/ml flurbiprofen.<\/li><li>Other ingredients are Betadex, disodium phosphate dodecahydrate, citric acid monohydrate, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), sodium hydroxide, mint flavor (contains flavorings, flavor preparation, propylene glycol (E1520)), N,2,3-trimethyl-2-isopropylbutanamide, saccharin sodium, hydroxypropyl betadex, and purified water.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>In the oral spray, the solution is clear, andcolorless to a slightly yellow solution with a cherry and mint flavor.<\/p>\n\n\n\n<p>The strip consists of a white, opaque plastic bottle with a pump and a polypropylene cap.<\/p>\n\n\n\n<p>Each bottle contains 15 ml of solution, which is enough for about 83 sprays.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Reckitt Benckiser Healthcare (Scandinavia) A\/S<\/p>\n\n\n\n<p>Vandt\u00e5rnsvej 83 A<\/p>\n\n\n\n<p>2860 S\u00f8borg<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>RB NL Brands BV<\/p>\n\n\n\n<p>WTC Schiphol Airport,<\/p>\n\n\n\n<p>Schiphol Boulevard 207,<\/p>\n\n\n\n<p>1118 BH Schiphol,<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active ingredient is flurbiprofen.\u00a0Flurbiprofen belongs to a group of pain relievers called non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0), which affect how the body responds to pain, swelling and fever.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24784,24788,24780,24783,24781,24787,24782,24779,24785,24786],"class_list":["post-23793","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-flurbiprofen","tag-benefits-of-strefen","tag-flurbiprofen","tag-flurbiprofen-side-effects","tag-strefen","tag-strefen-side-effects","tag-what-flurbiprofen-is-used-for","tag-what-is-flurbiprofen","tag-what-is-strefen","tag-what-strefen-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23793"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23793\/revisions"}],"predecessor-version":[{"id":23834,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23793\/revisions\/23834"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}