{"id":23729,"date":"2022-08-04T07:32:51","date_gmt":"2022-08-04T07:32:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23729"},"modified":"2022-08-06T08:04:30","modified_gmt":"2022-08-06T08:04:30","slug":"stesolid-rectal-prefill","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/stesolid-rectal-prefill\/","title":{"rendered":"Stesolid Rectal Prefill &#8211; Diazepam uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg\/ml&nbsp;rectal solution<br>diazepam<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Stesolid Rectal Prefill is and what it is used for<\/h2>\n\n\n\n<p>Stolid belongs to a drug group called\u00a0benzodiazepines.\u00a0It works by enhancing the effect of a depressant substance (\u00a0GABA\u00a0) in the brain.\u00a0As a result, it acts as a tension reliever, sedative, muscle relaxant, and antispasmodic.\u00a0Stolid Rectal Prefill contains a solution of\u00a0diazepam\u00a0intended for administration in the rectum.\u00a0The effect comes faster and is more pronounced than after the same\u00a0dose\u00a0in tablet form.<\/p>\n\n\n\n<p>Stesolid Rectal Prefill is used when a quick effect of\u00a0diazepam\u00a0is desired, for example in the case of febrile convulsions,\u00a0epilepsy,\u00a0and the like, but also as a sedative and relaxant, among other things, just before unpleasant examinations, sampling, and operative interventions.<\/p>\n\n\n\n<p>The diazepam contained\u00a0in Stesolid may also be approved to treat other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Stesolid Rectal Prefill<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Stesolid Rectal Prefill if you:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>are allergic to\u00a0diazepam\u00a0or other\u00a0benzodiazepines\u00a0or any of the other ingredients of this medicine (listed in section 6).<\/li><li>have a disease called\u00a0myasthenia gravis, which causes the muscles to weaken and tire quickly.<\/li><li>suffer from\u00a0sleep apnea\u00a0(a sleep disorder that involves abnormal pauses in breathing during sleep).<\/li><li>have serious liver disease.<\/li><li>have\u00a0acute\u00a0respiratory depression\u00a0(slow and\/or shallow breathing).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Stesolid Rectal Prefill if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have suffered from alcoholism or drug abuse<\/li><li>are older.\u00a0Stesolid Rectal Prefill can confuse and affect muscles which can lead to falls and fall injuries.<\/li><li>have breathing problems<\/li><li>suffering from depression<\/li><li>have suicidal thoughts<\/li><li>have\u00a0epilepsy\u00a0or have previously had seizures<\/li><\/ul>\n\n\n\n<p><strong>Other important aspects<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Mental\u00a0side effects\u00a0&#8211; contact your doctor if you experience\u00a0side effects\u00a0such as agitation, restlessness, aggressiveness, nightmares, or hallucinations.\u00a0Such\u00a0side effects\u00a0occur more often in children or the elderly.\u00a0See section 4 &#8221;\u00a0Possible\u00a0side effects\u00a0&#8220;.<\/li><li>Memory loss &#8211; during treatment you may experience memory loss, which occurs more often during treatment with high\u00a0doses\u00a0of Stesolid.\u00a0Symptoms often occur several hours after taking the drug, so make sure you can get an uninterrupted 7-8 hour period of sleep to reduce the risks.<\/li><li>Dependence &#8211; with treatment with this medicine there is a risk of dependence.\u00a0The risk increases with\u00a0dose\u00a0and duration of treatment and also in patients who previously had alcohol and drug problems.\u00a0You should therefore take Stesolid Rectal Prefill for as short a time as possible.<\/li><li>Tolerance &#8211; if after a few weeks you notice that the effect of the medicine is not as strong as at the beginning of the treatment, you should talk to your doctor.<\/li><li>Withdrawal\u00a0&#8211; withdrawal symptoms such as a relapse in sleep problems and anxiety can occur even at normal\u00a0doses\u00a0during a short treatment period, and to reduce the risk of withdrawal symptoms, the treatment must be gradually tapered.\u00a0See section 3, \u201c\u00a0<strong>If you stop taking Stesolid Rectal Prefill<\/strong>\u00a0\u201d.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Stesolid Rectal Prefill<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or might be using other medicines.\u00a0Above all:<\/p>\n\n\n\n<p>If the following medicines are taken in combination with Stesolid, they can affect your mental health, make you very drowsy and worsen your breathing and blood pressure:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>antidepressants (eg, fluvoxamine,&nbsp;fluoxetine&nbsp;)<\/li><li>antipsychotics such as clozapine (for treating mental health problems)<\/li><li>antihistamines&nbsp;(for treating&nbsp;allergies&nbsp;)<\/li><li>anesthetic<\/li><li>sedative (used for calming effect)<\/li><li>sleeping pills (for sleeping problems)<\/li><li>muscle relaxants (eg suxamethone, tubocurarine)<\/li><li>some strong painkillers such as morphine (&nbsp;opioids&nbsp;)<\/li><li>phenobarbital (to treat&nbsp;epilepsy&nbsp;or mental disorders)<\/li><\/ul>\n\n\n\n<p>Simultaneous use of Stesolid and opioid medicines (strong painkillers, medicines for the treatment of opioid dependence, and certain cough medicines) increases the risk of drowsiness, breathing difficulties (\u00a0respiratory depression\u00a0),\u00a0coma,\u00a0and can be life-threatening.\u00a0Because of this, concomitant use should only be considered when other treatment options are not possible.<\/p>\n\n\n\n<p>If the doctor prescribes Stesolid at the same time as opioid drugs, the&nbsp;dose&nbsp;and duration of treatment must be limited by the doctor.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any opioid medication and follow your doctor&#8217;s dosage recommendations carefully.&nbsp;It may be helpful to inform friends or relatives to be aware of the signs and symptoms described above.&nbsp;Contact a doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>Stesolid can affect or be affected by certain medicines that contain the following active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>disulfiram\u00a0(for the treatment of alcohol dependence)<\/li><li>medicines against\u00a0epilepsy\u00a0such as\u00a0phenytoin\u00a0and carbamazepine<\/li><li>theophylline (for treating\u00a0asthma\u00a0and other breathing problems)<\/li><li>cimetidine, omeprazole, or esomeprazole (medicines that reduce stomach acid)<\/li><li>rifampicin\u00a0(\u00a0antituberculosis\u00a0antibiotic\u00a0)<\/li><li>atazanavir, ritonavir, delavirdine, efavirenz, indinavir, nelfinavir or saquinavir (antiviral medicines)<\/li><li>fluconazole\u00a0, itraconazole,\u00a0ketoconazole\u00a0or voriconazole (medicines for fungal infections)<\/li><li>isoniazid\u00a0(for the treatment of\u00a0tuberculosis\u00a0)<\/li><li>oral contraceptives (\u00a0birth control pills\u00a0), as they can make\u00a0diazepam\u00a0leave the body more slowly and increase its effect.\u00a0Breakthrough bleeding can occur during simultaneous treatment with\u00a0diazepam\u00a0and oral contraceptives, but the preventive effect remains.<\/li><li>corticosteroids\u00a0(anti-inflammatory drugs)<\/li><li>levodopa\u00a0(for the treatment of\u00a0Parkinson&#8217;s disease\u00a0)<\/li><li>valproic acid\u00a0(for the treatment of\u00a0epilepsy\u00a0and mental disorders)<\/li><li>ketamine (an anesthetic)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Stesolid Rectal Prefill with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not drink alcohol during treatment with Stesolid.&nbsp;Alcohol can increase the sedative effect of Stesolid Rectal Prefill and make you very drowsy.<\/p>\n\n\n\n<p>Grapefruit and grapefruit juice should be avoided when taking Stesolid.&nbsp;Grapefruit can increase the effect of Stesolid.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>If you take Stesolid Rectal Prefill late in pregnancy or during delivery, the baby may have a low body temperature, and suffer from muscle weakness and breathing difficulties.\u00a0If the medicine is taken regularly during the latter part of the pregnancy, the child may develop\u00a0abstinence.<\/p>\n\n\n\n<p>Your doctor will decide whether the benefit of the treatment outweighs the risk to the unborn child and whether the medicine is suitable for you.<\/p>\n\n\n\n<p>Do not use Stesolid if you are breast-feeding<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Stesolid Rectal Prefill can make you feel sleepy and can affect your ability to concentrate.\u00a0It can also affect the muscles.\u00a0These\u00a0side effects\u00a0may persist for several days even after treatment with\u00a0diazepam\u00a0has ended.\u00a0You should not drive a car or use tools or machines if you experience such\u00a0side effects.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure.<br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Stesolid Rectal Prefill<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Dosage instructions<\/strong><\/p>\n\n\n\n<p>Dose&nbsp;and treatment time are determined by the doctor, who adjusts it individually for you.<\/p>\n\n\n\n<p><strong>Instructions for use<\/strong><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19780303000010#\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p><strong>Elderly patients<\/strong><\/p>\n\n\n\n<p>If you are older or frail, there is a greater risk that you are sensitive to the&nbsp;side effects&nbsp;of Stesolid Rectal Prefill and the&nbsp;dose&nbsp;may therefore need to be reduced.&nbsp;Your doctor decides which&nbsp;dosage&nbsp;of Stesolid Rectal Prefill is right for you and how often you should dose.<\/p>\n\n\n\n<p><strong>Impaired kidney function<\/strong><\/p>\n\n\n\n<p>Dose\u00a0in normally does not need to be adjusted.<\/p>\n\n\n\n<p><strong>Impaired liver function<\/strong><\/p>\n\n\n\n<p>If you have&nbsp;liver cirrhosis&nbsp;or impaired liver function, the&nbsp;dose&nbsp;must be lowered.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Stesolid Rectal Prefill<\/h2>\n\n\n\n<p>If you have taken too large a\u00a0dose, or if you think a child has swallowed the liquid, you should immediately contact the nearest doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Signs of overdose include impaired coordination, sleep-like drowsiness, fatigue, confusion, slurred speech, muscle weakness, and low\u00a0blood pressure.\u00a0Severe overdose can lead to\u00a0coma\u00a0(unconsciousness that cannot be lifted), cardiac arrest, and severe breathing difficulties.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have forgotten to use Stesolid Rectal Prefill<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, you should take it as soon as you realize that you previously forgot to take the medicine.\u00a0If it is almost time for the next\u00a0dose, skip the missed\u00a0dose.\u00a0Do not take a double\u00a0dose\u00a0to make up for the missed\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Stesolid Rectal Prefill<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not stop treatment with the drug without consulting your doctor.\u00a0Does\u00a0one should be reduced gradually before stopping treatment completely.\u00a0If you suddenly stop treatment with Stesolid, the risk of withdrawal symptoms increases.<\/li><li><br>With withdrawal symptoms, you may experience the following, among other things: headache, anxiety, panic, palpitations, sweating, tremors, stomach problems, irritation, aggression, sensory disturbances, muscle spasms, general malaise, loss of appetite, insomnia, mental\u00a0side effects\u00a0such as severe confusion, seizures. The probability of\u00a0withdrawal\u00a0and its severity depends on the duration of treatment, dosage strength, and degree of dependence.<\/li><li>If you have\u00a0epilepsy\u00a0or have previously had seizures and discontinue treatment with Stesolid Rectal Prefill, there is a risk of convulsions or prolonged epileptic seizures.\u00a0There is also a risk of seizures if you have alcohol or drug problems and suddenly stop treatment with Stesolid Rectal Prefill.<\/li><\/ul>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Contact your doctor immediately or go to the nearest emergency department if any of the following occur:<\/p>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Respiratory depression&nbsp;(very slow and\/or shallow breathing)<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Respiratory arrest (respiratory arrest)<\/li><li>Unconsciousness<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactic reaction\u00a0(severe\u00a0allergic reaction\u00a0) with symptoms such as sudden wheezing, swelling of the lips, tongue, and throat or the rest of the body, rash, fainting, or difficulty swallowing.<\/li><\/ul>\n\n\n\n<p><strong><em>Other side effects:<\/em><\/strong><\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drowsiness<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fatigue<\/li><li>Withdrawal symptoms (for symptoms see \u201cIf you stop taking Stesolid Rectal Prefill\u201d in section 3)<\/li><li>Confusion<\/li><li>Impaired coordination of muscle movements (&nbsp;ataxia&nbsp;) and other movement disorders, tremors<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Muscle weakness (\u00a0Myasthenia gravis\u00a0)<\/li><li>Memory loss<\/li><li>Concentration difficulties<\/li><li>Balance disorders<\/li><li>Dizziness<\/li><li>Headache<\/li><li>Slurred speech<\/li><li>Stomach and intestinal problems such as nausea, vomiting, constipation, diarrhea<\/li><li>Increased saliva production<\/li><li>Allergic skin reactions are in the form of\u00a0itching,\u00a0redness,\u00a0and swelling as well as rashes.<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Mental\u00a0side effects\u00a0such as excitement, agitation, restlessness, irritation, aggressiveness, memory loss, delusions, tantrums,\u00a0psychoses, nightmares, inappropriate behavior, or hallucinations.\u00a0Can become serious.\u00a0Children and the elderly are at higher risk of being affected.\u00a0Talk to your doctor if this happens.<\/li><li>Decreased alertness<\/li><li>Depression<\/li><li>The feeling of emotional emptiness<\/li><li>Insomnia<\/li><li>Heart problems such as slow heart rhythm (\u00a0bradycardia\u00a0),\u00a0heart failure,\u00a0and cardiac arrest.<\/li><li>Low\u00a0blood pressure, fainting<\/li><li>The increased amount of mucus in the airways<\/li><li>Dry mouth<\/li><li>Increased appetite<\/li><li>Jaundice (yellowing of the skin and whites of the eyes)<\/li><li>Changes in liver enzymes shown in blood test results<\/li><li>Inability to empty the bladder, poor bladder control\u00a0(\u00a0urine leakage)<\/li><li>Enlargement of mammary glands in men<\/li><li>Impotence, altered sex drive<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low&nbsp;white blood cell count&nbsp;(&nbsp;leukopenia&nbsp;)<\/li><li>High levels of certain&nbsp;enzymes&nbsp;in the blood (&nbsp;transaminases&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurring in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blurred vision, double vision, and involuntary eye movements (these\u00a0side effects\u00a0disappear after the end of treatment with\u00a0diazepam\u00a0)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How Stesolid Rectal Prefill should be stored<\/h2>\n\n\n\n<p>Store at a maximum of 25 \u00b0C.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and label after EXP or EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<p>1 ml contains:<\/p>\n\n\n\n<p><em>Active ingredient:&nbsp;<\/em>Diazepam&nbsp;5 mg\/ml.<\/p>\n\n\n\n<p><em>Other ingredients:<\/em>\u00a0Glycofurol,\u00a0ethanol\u00a096%, water, sodium hydroxide, and\u00a0hydrochloric acid\u00a0(for the correct\u00a0pH value\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Colorless solution.<\/p>\n\n\n\n<p>Rectal syringes with attached rectal tips.<\/p>\n\n\n\n<p>Instructions for use are included in the packaging.<\/p>\n\n\n\n<p>Rectal solution 5 mg\/ml:<\/p>\n\n\n\n<p>2 ml<\/p>\n\n\n\n<p>5&#215;2 ml<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Actavis Group PTC EHF.<\/p>\n\n\n\n<p>Reykjavikurvegi 76-78<\/p>\n\n\n\n<p>IS-220 Hafnarfjordur<\/p>\n\n\n\n<p>Iceland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stolid belongs to a drug group called\u00a0benzodiazepines.\u00a0It works by enhancing the effect of a depressant substance (\u00a0GABA\u00a0) in the brain.\u00a0As a result, it acts as a tension reliever, sedative, muscle relaxant and antispasmodic.\u00a0Stolid Rectal Prefill contains a solution of\u00a0diazepam\u00a0intended for administration in the rectum.\u00a0The effect comes faster and is more pronounced than after the same\u00a0dose\u00a0in tablet form.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24732,5650,5652,5653,24728,24730,24727,5651,24729,24731],"class_list":["post-23729","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-stesolid-rectal-prefill","tag-diazepam","tag-diazepam-side-effects","tag-diazepam-tablet","tag-stesolid-rectal-prefill","tag-stesolid-rectal-prefill-side-effects","tag-what-diazepam-is-used-for","tag-what-is-diazepam","tag-what-is-stesolid-rectal-prefill","tag-what-stesolid-rectal-prefill-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23729"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23729\/revisions"}],"predecessor-version":[{"id":23769,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23729\/revisions\/23769"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}