{"id":23575,"date":"2022-08-03T07:46:09","date_gmt":"2022-08-03T07:46:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23575"},"modified":"2022-08-04T07:20:18","modified_gmt":"2022-08-04T07:20:18","slug":"stayveer","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/stayveer\/","title":{"rendered":"STAYVEER &#8211; Bosentan uses, dose and side effects"},"content":{"rendered":"\n<p>62.5 mg&nbsp;film-coated tablets<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">bosentan<\/a><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What STAYVEER is and what it is used for<\/h2>\n\n\n\n<p>STAYVEER tablets contain\u00a0bosentan, which blocks a naturally occurring\u00a0hormone\u00a0called endothelin-1 (ET-1) that causes blood vessels to narrow.\u00a0STAYVEER, therefore, causes the blood vessels to dilate and belongs to a group of medicines called &#8220;endothelin receptor antagonists&#8221;.<\/p>\n\n\n\n<p>STAYVEER is used to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;<\/strong>(PAH): PAH is a disease that leads to severe narrowing of the blood vessels in the lungs.&nbsp;As a result, high&nbsp;blood pressure&nbsp;occurs in the blood vessels in the lungs (pulmonary arteries) that transport the blood from the heart to the lungs.&nbsp;This pressure reduces the amount of oxygen that can enter the blood in the lungs, making physical activity more difficult.&nbsp;STAYVEER dilates the pulmonary arteries and makes it easier for the heart to pump blood through them.&nbsp;This lowers&nbsp;blood pressure&nbsp;and relieves symptoms.<\/li><\/ul>\n\n\n\n<p>STAYVEER is used to treat patients with PAH class III to improve work capacity (the ability to perform physical activity) and symptoms.\u00a0The class shows the severity of the disease, where class III means that physical activity is markedly limited.\u00a0Some improvements have also been shown in patients with PAH class II.\u00a0Class II means that physical activity is slightly limited.\u00a0PAHs that STAYVEER is used for can be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>primary (without identified cause or hereditary);<\/li><li>caused by\u00a0scleroderma\u00a0(also called systemic sclerosis, a disease with abnormal growth of the connective tissue that supports the skin and other organs);<\/li><li>caused by congenital heart defects where\u00a0shunts\u00a0(abnormal connections) cause abnormal blood flow through the heart and lungs.<\/li><li><strong>Digital ulcers:<\/strong>\u00a0(sores on fingers and toes) in adult patients with a condition called\u00a0scleroderma.\u00a0STAYVEER reduces the number of new ulcers on fingers and toes that appear.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take STAYVEER<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take STAYVEER<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic to\u00a0bosentan<\/strong>\u00a0or any of the other ingredients of this medicine (listed in section 6)<\/li><li><strong>if you have liver problems<\/strong>\u00a0(ask your doctor)<\/li><li><strong>if you are pregnant or may become pregnant<\/strong>\u00a0because you are not using reliable contraceptive methods.\u00a0Read the information under &#8220;Contraceptives&#8221; and &#8220;Other medicines and STAYVEER&#8221;<\/li><li><strong>if you are taking ciclosporin A<\/strong>\u00a0(a medicine used after a transplant or to treat\u00a0psoriasis\u00a0)<\/li><\/ul>\n\n\n\n<p>If any of these apply to you, talk to your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><strong>Checks that your doctor will do before the treatment<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood tests to check liver function<\/li><li>blood test to check for&nbsp;anemia&nbsp;(low&nbsp;hemoglobin&nbsp;)<\/li><li>pregnancy test, if you are a woman of childbearing age<\/li><\/ul>\n\n\n\n<p>Some patients using STAYVEER have had abnormal liver function tests and&nbsp;anemia&nbsp;(low&nbsp;hemoglobin&nbsp;).<\/p>\n\n\n\n<p><strong>Checks your doctor will do during treatment<\/strong>&nbsp;<\/p>\n\n\n\n<p>Your doctor will arrange regular blood tests to check for changes in liver function and hemoglobin levels during treatment with STAYVEER.<\/p>\n\n\n\n<p>For all these samples, see also the patient card (in the pack of STAYVEER tablets).\u00a0These regular blood tests must be taken throughout the time you are taking STAYVEER.\u00a0We suggest that you write down the date of the last test and also the next test (ask your doctor about the date) on the patient card, as help to remember when the next test is to be taken.<\/p>\n\n\n\n<p><strong>Blood tests for liver function<\/strong><\/p>\n\n\n\n<p>These will be taken once a month throughout your treatment with STAYVEER.&nbsp;After an increase in&nbsp;dose&nbsp;one, an additional sample will be taken after 2 weeks.<\/p>\n\n\n\n<p><strong>Blood test for&nbsp;anemia&nbsp;( lack of&nbsp;blood&nbsp;)<\/strong><\/p>\n\n\n\n<p>This will be done once a month for the first 4 months of treatment and then once every 3 months, as patients taking STAYVEER can develop\u00a0anemia.<\/p>\n\n\n\n<p>If the results are abnormal, your doctor may decide to reduce the&nbsp;dose&nbsp;or stop treatment with STAYVEER and do further tests to investigate the cause.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>STAYVEER is not recommended for children with systemic sclerosis and ongoing digital ulcer disease.&nbsp;See also section 3, How to take STAYVEER.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and STAYVEER<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription.\u00a0You must tell your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ciclosporin A (a medicine used after transplants and to treat\u00a0psoriasis\u00a0), which should not be used with STAYVEER.<\/li><li>sirolimus or tacrolimus, which are medicines used after transplants, as are not recommended for use with STAYVEER.<\/li><li>glibenclamide (to treat\u00a0diabetes\u00a0), rifampicin (to treat\u00a0tuberculosis\u00a0),\u00a0fluconazole\u00a0(to treat fungal infections),\u00a0ketoconazole\u00a0(to treat Cushing&#8217;s syndrome), or nevirapine (to treat\u00a0HIV\u00a0), as these medicines are not recommended for use with STAYVEER.<\/li><li>other medicines for the treatment of\u00a0HIV\u00a0&#8211;\u00a0infection\u00a0may need to be checked especially if they are used together with STAYVEER.<\/li><li>hormonal contraceptives, which are not effective as a sole method of contraception while taking STAYVEER.\u00a0Inside your STAYVEER package is a patient card that you should read carefully.\u00a0Your doctor and\/or gynecologist will determine which contraceptives are suitable for you.<\/li><li>other drugs for the treatment of pulmonary hypertension: sildenafil and tadalafil<\/li><li>warfarin\u00a0(a blood thinner)<\/li><li>simvastatin\u00a0(used to treat\u00a0hypercholesterolemia).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>STAYVEER has no or negligible influence on the ability to drive or use machines.\u00a0STAYVEER can cause\u00a0hypotension\u00a0(low\u00a0blood pressure\u00a0) which can make you feel dizzy, and affect your vision and your ability to drive and use machines.\u00a0If you feel dizzy or if your vision is impaired while taking STAYVEER, you should therefore not drive a car or operate tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>Women of&nbsp;childbearing&nbsp;age<\/strong><\/p>\n\n\n\n<p>DO NOT take STAYVEER if you are pregnant or plan to become pregnant.<\/p>\n\n\n\n<p><strong>Pregnancy test<\/strong><\/p>\n\n\n\n<p>STAYVEER can harm unborn babies born before or during treatment.&nbsp;If you are female and could become pregnant, your doctor will ask you to take a pregnancy test before you start taking STAYVEER, and regularly while you are taking STAYVEER.<\/p>\n\n\n\n<p><strong>Contraceptive<\/strong><\/p>\n\n\n\n<p>If it is possible that you could become pregnant, use a safe method of birth control while taking STAYVEER.\u00a0Your doctor or gynecologist can advise you on reliable methods of contraception while using STAYVEER.\u00a0Because STAYVEER can make hormonal contraceptives (eg, oral, injectable, implantable, or contraceptive\u00a0patch\u00a0) ineffective, this alone is not a safe method.\u00a0Therefore, if you use hormonal contraceptives, you must also use a\u00a0barrier method\u00a0(eg female condoms,\u00a0pessaries, birth control pad or your partner must also use a condom).\u00a0Inside your STAYVEER package is a patient card.\u00a0You should complete this card and take it with you to your doctor at your next visit so that your doctor or gynecologist can assess whether you need additional or alternative reliable methods of contraception.\u00a0Pregnancy testing is recommended every month while taking STAYVEER if you are of\u00a0childbearing potential.<\/p>\n\n\n\n<p>Tell your doctor immediately if you become pregnant during treatment with STAYVEER or if you plan to become pregnant shortly.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p><strong>Tell<\/strong>\u00a0your doctor immediately\u00a0<strong>if you are breastfeeding.\u00a0<\/strong>You are advised to stop breastfeeding if you are prescribed STAYVEER.\u00a0It is not known whether this medication is passed on to breast milk.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>If you are a man and using STAYVEER, the medicine may reduce the number of sperm.\u00a0It cannot be ruled out that this may affect your ability to have children.\u00a0Talk to your doctor if you have any questions or concerns about this.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">STAYVEER contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;of sodium&nbsp;per tablet, i.e. it is almost &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take STAYVEER<\/h2>\n\n\n\n<p>Treatment with STAYVEER should only be initiated and monitored by a physician experienced in the treatment of PAH or systemic sclerosis.&nbsp;Always take this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>STAYVEER with food and drink<\/strong><\/p>\n\n\n\n<p>STAYVEER can be taken with or without food.<\/p>\n\n\n\n<p><strong>Recommended&nbsp;dose<\/strong><\/p>\n\n\n\n<p><strong><em>Adults<\/em><\/strong><\/p>\n\n\n\n<p>Treatment is usually started with 62.5 mg twice daily (morning and evening) for the first 4 weeks.&nbsp;After that, your doctor will usually prescribe one 125 mg tablet twice a day, depending on how you respond to STAYVEER.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Does\u00a0one recommended for children applies only to PAH?\u00a0In children aged 1 year and older, treatment is usually started with 2 mg\/kg body weight twice daily (morning and evening).\u00a0The doctor will tell you how to dose.<\/p>\n\n\n\n<p>If you have the impression that the effect of STAYVEER is too strong or too weak, talk to your doctor as your&nbsp;dose&nbsp;may need to be changed.<\/p>\n\n\n\n<p><strong>How to take STAYVEER<\/strong><\/p>\n\n\n\n<p>The tablets must be taken twice daily (morning and evening), must be swallowed with water, and can be taken with or without food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much STAYVEER<\/h2>\n\n\n\n<p>If you take more tablets than you were instructed to take, contact your doctor immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take STAYVEER<\/h2>\n\n\n\n<p>If you forget to take STAYVEER, take a&nbsp;dose&nbsp;as soon as you remember.&nbsp;Then continue to take your tablets at the usual times.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for missed tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking STAYVEER<\/h2>\n\n\n\n<p>If you suddenly stop your STAYVEER\u00a0<strong>treatment<\/strong>, symptoms may worsen.\u00a0Do not stop using STAYVEER unless your doctor tells you to.\u00a0The doctor may instruct you to reduce the\u00a0dose\u00a0for a few days before stopping completely.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The most serious\u00a0side effects\u00a0of STAYVEER are<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abnormal liver function, which may affect more than 1 in 10 people<\/li><li>Anemia\u00a0(low blood count), may affect up to 1 in 10 people.\u00a0Anemia\u00a0can sometimes require a\u00a0blood transfusion.<\/li><\/ul>\n\n\n\n<p>Your liver and blood counts will be monitored during your treatment with STAYVEER (see section 2).\u00a0You must take these tests as prescribed by your doctor.<\/p>\n\n\n\n<p>Symptoms that indicate your liver is not working normally include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea (feeling the need to vomit)<\/li><li>vomiting<\/li><li>fever<\/li><li>stomach ache<\/li><li>jaundice (yellowing of the skin or whites of the eyes)<\/li><li>dark colored urine<\/li><li>skin itching<\/li><li>lethargy or tiredness (unusual tiredness or exhaustion)<\/li><li>flu-like symptoms&nbsp;(muscle and joint pain with fever)<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor immediately if<\/strong>\u00a0you experience any of these\u00a0side effects.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect&nbsp;<strong>more than 1 in 10<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Edema&nbsp;(swelling of the legs and ankles or other symptoms of fluid retention)<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1 in 10<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Facial or skin flushing<\/li><li>Hypersensitivity reaction\u00a0(with skin inflammation,\u00a0itching,\u00a0and rash)<\/li><li>Gastroesophageal reflux disease\u00a0(acid reflux)<\/li><li>Diarrhea<\/li><li>Short-term loss of consciousness (fainting)<\/li><li>Palpitations (rapid or irregular heartbeats)<\/li><li>Low\u00a0blood pressure<\/li><li>Nasal congestion<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1 in 100<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Thrombocytopenia&nbsp;(lack of&nbsp;platelets&nbsp;)<\/li><li>Neutropenia\/leukopenia (low&nbsp;white blood cell count&nbsp;)<\/li><li>Elevated liver enzyme levels with&nbsp;hepatitis&nbsp;(&nbsp;inflammation&nbsp;of the liver) including possible worsening of underlying&nbsp;hepatitis&nbsp;and\/or jaundice (yellowing of the skin or whites of the eyes).<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect&nbsp;<strong>up to 1 in 1,000<\/strong>&nbsp;people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactic reactions (general\u00a0allergic reaction\u00a0),\u00a0angioedema\u00a0(swelling, usually around the eyes, lips, tongue, or throat)<\/li><li>Cirrhosis\u00a0(scarring) of the liver, liver failure (serious disturbance of liver function)<\/li><\/ul>\n\n\n\n<p>Blurred vision has also been reported at an unknown frequency (frequency cannot be estimated from the available data).<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Side effects in children and adolescents<\/h2>\n\n\n\n<p>Children treated with STAYVEER have the same reported&nbsp;side effects&nbsp;as adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store STAYVEER<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and blister after \u201cEXP\u201d.<\/p>\n\n\n\n<p>The white HDPE bottles should be used within 30 days of opening.<\/p>\n\n\n\n<p>For PVC\/PE\/PVDC aluminum blisters:<\/p>\n\n\n\n<p>Store at a maximum of 30 \u00b0C.<\/p>\n\n\n\n<p>For white HDPE bottles:<\/p>\n\n\n\n<p>This medical product does not require any special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>STAYVEER 62.5 mg film-coated tablets:<\/strong>\u00a0The active substance is\u00a0bosentan, as a monohydrate.\u00a0Each tablet contains 62.5 mg\u00a0bosentan\u00a0(as monohydrate)<\/li><li>Other ingredients\u00a0in the tablet are corn starch, pregelatinized\u00a0starch, sodium starch glycolate (Type A), povidone, glycerol behenate, and magnesium stearate.\u00a0The film coating\u00a0contains hypromellose, glycerol triacetate, talc, titanium dioxide (E171), yellow iron oxide (E172), red iron oxide (E172), and ethyl cellulose.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>STAYVEER 62.5 mg film-coated tablets are orange-white, round film-coated tablets debossed with \u201c62.5\u201d on one side.<\/p>\n\n\n\n<p><strong>PVC\/PE\/PVDC\/aluminum<\/strong> blister card\u00a0with\u00a014 film-coated tablets.\u00a0The cartons contain 56 or 112 film-coated tablets (STAYVEER 62.5 mg film-coated tablets).<\/p>\n\n\n\n<p><strong>White high-density polyethylene bottles with desiccant (silica gel)<\/strong>&nbsp;containing 56 film-coated tablets.&nbsp;The boxes contain 56 film-coated tablets (STAYVEER 62.5 mg film-coated tablets).<\/p>\n\n\n\n<p>Do not swallow the desiccant.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Janssen\u2011Cilag International NV<\/p>\n\n\n\n<p>Turnhoutseweg 30<\/p>\n\n\n\n<p>B\u20112340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Janssen Pharmaceutica NV<br>Turnhoutseweg 30<br>B-2340 Beerse<\/p>\n\n\n\n<p>Belgium<\/p>\n","protected":false},"excerpt":{"rendered":"<p>STAYVEER tablets contain\u00a0bosentan\u00a0, which blocks a naturally occurring\u00a0hormone\u00a0called endothelin-1 (ET-1) that causes blood vessels to narrow.\u00a0STAYVEER therefore causes the blood vessels to dilate and belongs to a group of medicines called &#8220;endothelin receptor antagonists&#8221;.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[8559,8561,8563,24705,24708,24709,8562,8560,24706,24707],"class_list":["post-23575","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-bosentan","tag-bosentan-side-effects","tag-bosentan-tablet","tag-stayveer","tag-stayveer-side-effects","tag-stayveer-tablet","tag-what-bosentan-is-used-for","tag-what-is-bosentan","tag-what-is-stayveer","tag-what-stayveer-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23575"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23575\/revisions"}],"predecessor-version":[{"id":23710,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23575\/revisions\/23710"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23575"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23575"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}