{"id":23531,"date":"2022-08-02T07:30:21","date_gmt":"2022-08-02T07:30:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23531"},"modified":"2022-08-03T07:36:02","modified_gmt":"2022-08-03T07:36:02","slug":"sprycel","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sprycel\/","title":{"rendered":"SPRYCEL &#8211; Dasatinib uses, dose and side effects"},"content":{"rendered":"\n<p>20, 50, 70, 80, 100, 140 mg\u00a0film-coated tablets<br>dasatinib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What SPRYCEL is and what it is used for<\/h2>\n\n\n\n<p>SPRYCEL contains the active substance dasatinib.\u00a0This medicine is used to treat\u00a0chronic myeloid leukemia\u00a0(CML) in adults, adolescents, and children older than 1 year.\u00a0Leukemia\u00a0is a cancer of white\u00a0blood cells.\u00a0The white\u00a0blood cells\u00a0normally help the body fight\u00a0infection.\u00a0Chronic myeloid leukemia\u00a0is a form of\u00a0leukemia\u00a0in which the\u00a0white blood cells\u00a0called\u00a0granulocytes\u00a0begin to form uncontrollably.\u00a0SPRYCEL inhibits the growth of these leukemia cells.<\/p>\n\n\n\n<p>SPRYCEL is also used to treat Philadelphia chromosome-positive (Ph+)&nbsp;acute&nbsp;lymphoblastic&nbsp;leukemia&nbsp;(ALL) in adults, adolescents, and children at least 1 year of age, and lymphoid blast CML in adults who have not responded to previous treatment.&nbsp;ALL is a form of&nbsp;leukemia&nbsp;in which the&nbsp;white blood cells&nbsp;called&nbsp;lymphocytes&nbsp;are formed too quickly and live too long.&nbsp;SPRYCEL inhibits the growth of these leukemia cells.<\/p>\n\n\n\n<p>Ask your doctor if you have any questions about how SPRYCEL works or why this medicine has been prescribed for you.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take SPRYCEL<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use SPRYCEL<\/h2>\n\n\n\n<p><strong>Do not take SPRYCEL<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to dasatinib or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p><strong>If you think you may be allergic, ask your doctor for advice.<\/strong><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking SPRYCEL.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are being treated with\u00a0<strong>medicines that thin the blood<\/strong>\u00a0or prevent blood clots (see &#8220;Other medicines and SPRYCEL&#8221;)<\/li><li>if you have or have ever had, liver or heart disease<\/li><li>if you\u00a0experience difficulty breathing, chest pain, or cough\u00a0while taking SPRYCEL.\u00a0It may be a sign of fluid accumulation in the lungs or chest (which may occur more often in patients 65 years of age or older), or due to changes in the blood vessels that supply the lungs.<\/li><li>if you have ever had or may now have a\u00a0hepatitis\u00a0B\u00a0infection.\u00a0This is because SPRYCEL can cause your\u00a0hepatitis\u00a0B to become active again, which in some cases can be fatal.\u00a0Patients will be closely monitored by their doctor for signs of this\u00a0infection\u00a0before starting treatment.<\/li><li>call your doctor if you experience bruising, bleeding, fever, tiredness, and confusion while taking SPRYCEL.\u00a0This can be a sign of damage to blood vessels, so-called thrombotic microangiopathy (TMA).<\/li><\/ul>\n\n\n\n<p>You will be checked regularly by your doctor to determine whether SPRYCEL is having the desired effect.&nbsp;You will also have regular blood tests while taking SPRYCEL.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children younger than 1 year.&nbsp;The experience of treatment with SPRYCEL in this age group is limited.&nbsp;Bone growth and development will be monitored in children treated with SPRYCEL.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and SPRYCEL<\/h2>\n\n\n\n<p><strong>Tell your doctor<\/strong>\u00a0if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>SPRYCEL is mainly processed in the liver.&nbsp;Some medicines can affect the effect of SPRYCEL when used at the same time.<\/p>\n\n\n\n<p><strong>The following medicines should not be used at the same time as SPRYCEL:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ketoconazole, itraconazole \u2013 these are\u00a0drugs against\u00a0fungal diseases<\/li><li>erythromycin, clarithromycin, telithromycin \u2013 these are\u00a0antibiotics<\/li><li>ritonavir \u2013 this is a\u00a0drug against\u00a0viral diseases<\/li><li>phenytoin, carbamazepine, phenobarbital \u2013 these are for treating\u00a0<strong>epilepsy<\/strong><\/li><li>rifampicin \u2013 this is for the treatment of\u00a0<strong>tuberculosis<\/strong><\/li><li>famotidine, omeprazole \u2013 these are drugs that\u00a0<strong>inhibit stomach acid production<\/strong><\/li><li>St. John&#8217;s wort- an over-the-counter herbal remedy used to treat\u00a0<strong>mild depression<\/strong>\u00a0\u00a0and mild anxiety (also known as Hypericum perforatum)<\/li><\/ul>\n\n\n\n<p>Do not use medicines that neutralize stomach acid (\u00a0<strong>antacids<\/strong>\u00a0such as aluminum hydroxide or\u00a0magnesium hydroxide\u00a0) from\u00a0<strong>2 hours before to 2 hours after taking SPRYCEL<\/strong>.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you are taking&nbsp;<strong>medicines that thin the blood<\/strong>&nbsp;or prevent blood clots.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SPRYCEL with food and drink<\/h2>\n\n\n\n<p>Do not take SPRYCEL with grapefruit or grapefruit juice.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p><strong>If you are pregnant<\/strong>\u00a0or think you may be pregnant,\u00a0<strong>tell your doctor immediately<\/strong>.\u00a0SPRYCEL should not be used during pregnancy\u00a0unless necessary.\u00a0Your doctor will discuss the possible risks of taking SPRYCEL during pregnancy.\u00a0Both women and men will be advised to use effective contraception during treatment with SPRYCEL.<\/p>\n\n\n\n<p><strong>Tell your doctor if you are breastfeeding<\/strong>.\u00a0Breast-feeding should be discontinued if you are treated with SPRYCEL.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>If you experience&nbsp;side effects&nbsp;such as dizziness and blurred vision, be especially careful when driving or using machinery.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SPRYCEL contains lactose<\/h2>\n\n\n\n<p>If you have an intolerance to some sugars, you should contact your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take SPRYCEL<\/h2>\n\n\n\n<p>SPRYCEL will only be prescribed to you by doctors experienced in the treatment of\u00a0leukemia.\u00a0Always take this medicine as directed by your doctor.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0SPRYCEL is prescribed for adults and children over 1 year of age.<\/p>\n\n\n\n<p><strong>The recommended starting dose for&nbsp;<\/strong><strong>adult&nbsp;<\/strong><strong>patients with CML in the&nbsp;chronic&nbsp;phase is 100 mg once daily.<\/strong><\/p>\n\n\n\n<p><strong>The recommended starting dose for&nbsp;<\/strong><strong>adult&nbsp;<\/strong><strong>patients with CML in accelerated phase or&nbsp;blast crisis&nbsp;or Ph+ ALL is 140 mg once daily.<\/strong><\/p>\n\n\n\n<p><strong>Dosage\u00a0for children with CML in\u00a0the <\/strong>chronic\u00a0phase\u00a0or Ph+ ALL\u00a0is based on body weight.\u00a0SPRYCEL is taken by mouth once a day either as tablets or as a powder for\u00a0oral\u00a0suspension.\u00a0SPRYCEL tablets are not recommended for patients weighing less than 10 kg.\u00a0Powder for\u00a0oral\u00a0suspension\u00a0should be used in patients who weigh less than 10 kg and in patients who cannot swallow tablets.\u00a0A dose change may be necessary when switching between formulations (tablets or powder to\u00a0oral\u00a0suspension\u00a0), so do not switch from one formulation to another.<\/p>\n\n\n\n<p>Your doctor will determine the right\u00a0dose\u00a0based on your weight, any side effects, and your response to treatment.\u00a0The starting dose of SPRYCEL for children is calculated based on body weight as below:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td><strong>Body weight (kg)<\/strong>&nbsp;a<\/td><td><strong>Daily&nbsp;dose&nbsp;(mg)<\/strong><\/td><\/tr><\/thead><tbody><tr><td>10 &#8211; under 20 kg<\/td><td>40 mg<\/td><\/tr><tr><td>20 &#8211; under 30 kg<\/td><td>60 mg<\/td><\/tr><tr><td>30 &#8211; under 45 kg<\/td><td>70 mg<\/td><\/tr><tr><td>45 kg and over<\/td><td>100 mg<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><sup>Tablets are not recommended for patients weighing less than 10 kg;\u00a0powder for\u00a0oral\u00a0suspension\u00a0should be used in these patients.<\/sup><\/p>\n\n\n\n<p>There is no recommended&nbsp;dose&nbsp;of SPRYCEL for children younger than 1 year.<\/p>\n\n\n\n<p>Depending on how you respond to treatment, your doctor may recommend a higher or lower\u00a0dose.\u00a0The treatment can also be temporarily interrupted.\u00a0For higher or lower\u00a0dosages, it may be necessary to combine tablets of different strengths.<\/p>\n\n\n\n<p><strong>The tablets may be packed in calendar blisters.&nbsp;<\/strong>These are blisters that show the days of the week.&nbsp;Arrows show which tablet you should take next according to your treatment schedule.<\/p>\n\n\n\n<p><strong>How to take SPRYCEL<\/strong><\/p>\n\n\n\n<p><strong>Take the tablets at the same time each day.\u00a0<\/strong>\u00a0Swallow the tablets whole.\u00a0<strong>Do not crush<\/strong>, split or chew them.\u00a0Do not slurp up the tablets.\u00a0You cannot be sure that you will get the correct\u00a0dose\u00a0if you crush, split, chew, or slurp up the tablets.\u00a0SPRYCEL tablets can be taken with or without food.<\/p>\n\n\n\n<p><strong>Special instructions for handling SPRYCEL<\/strong><\/p>\n\n\n\n<p>SPRYCEL tablets are unlikely to break.&nbsp;If this should still occur, people other than the patient should use gloves when handling SPRYCEL.<\/p>\n\n\n\n<p><strong>How long take SPRYCEL<\/strong><\/p>\n\n\n\n<p>Take SPRYCEL every day until your doctor tells you to stop.&nbsp;Make sure you take SPRYCEL for as long as prescribed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much SPRYCEL<\/h2>\n\n\n\n<p>Contact your doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you accidentally take too many tablets.&nbsp;You may need medical attention.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take SPRYCEL<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a missed\u00a0dose.\u00a0Take the next\u00a0dose\u00a0as usual according to\u00a0prescription\u00a0one.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>The following may be signs of serious side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have chest pain, difficulty breathing, cough, fainting spells<\/li><li>if you experience\u00a0<strong>unexpected bleeding or bruising<\/strong>\u00a0without having injured yourself<\/li><li>if you notice blood in vomit, stool, or urine, or if the stool is black<\/li><li>if you get\u00a0signs of\u00a0infection, eg fever or severe chills<\/li><li>if you develop a fever, sore mouth or throat, blisters, or scaling of the skin and\/or mucous membranes<\/li><\/ul>\n\n\n\n<p><strong>Contact your doctor immediately<\/strong>&nbsp;if you notice any of the above.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(may affect more than 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Infections\u00a0(<\/strong>\u00a0including\u00a0infections\u00a0caused by bacteria,\u00a0viruses,\u00a0and fungi)<\/li><li>Heart and lungs:\u00a0shortness of breath<\/li><li>Problems with digestion:\u00a0diarrhea, nausea, vomiting<\/li><li>Skin, hair, eyes, general symptoms:\u00a0rash, fever, swelling of the face, hands, and feet, headache, tiredness or weakness, bleeding<\/li><li>Pain:\u00a0muscle pain (during or after treatment), pain in the stomach (abdomen)<\/li><li>Tests may show\u00a0low\u00a0platelet count, low\u00a0white blood cell count\u00a0(\u00a0neutropenia\u00a0),\u00a0anemia, and fluid around the lungs.<\/li><\/ul>\n\n\n\n<p><strong>Common\u00a0side effects\u00a0(may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Infections:\u00a0<\/strong>pneumonia, a herpes virus infection (including\u00a0cytomegalovirus\u00a0\u2013\u00a0CMV\u00a0), upper respiratory tract infection, a serious\u00a0infection\u00a0of blood or\u00a0tissue\u00a0(including rare cases with fatal outcomes)<\/li><li>Heart and lungs:\u00a0palpitations, irregular heartbeats,\u00a0heart failure, impaired heart function, high\u00a0blood pressure, increased\u00a0blood pressure\u00a0in the lungs, cough<\/li><li>Digestive problems:\u00a0appetite disturbances, taste disturbances, flatulence or distended abdomen,\u00a0inflammation\u00a0of the colon, constipation, heartburn, mouth ulcers, weight gain, weight loss, gastritis<\/li><li>Skin, hair, eyes,\u00a0general symptoms:\u00a0tingling of the skin,\u00a0itching, dry skin,\u00a0acne,\u00a0inflammation\u00a0of the skin, persistent ringing in the ears, hair loss, excessive sweating, vision problems (including blurred vision and changes in vision), dry eyes, bruising, depression, insomnia, flushing, dizziness, bruising,\u00a0anorexia\u00a0(loss of appetite), sleepiness, generalized\u00a0edema<\/li><li>Pain:\u00a0joint pain, muscle weakness, pain in the chest, pain around hands and feet, chills, stiffness in muscles and joints, muscle cramps<\/li><li>Tests may show:\u00a0fluid around the heart, fluid in the lungs, irregular heartbeat, febrile\u00a0neutropenia, bleeding in the gastrointestinal tract, high levels of\u00a0uric acid\u00a0in the blood<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Heart and lungs:<\/strong>\u00a0heart attack (sometimes fatal),\u00a0inflammation\u00a0of the pericardium, irregular heartbeat, chest pain due to reduced blood supply to the heart (angina), low\u00a0blood pressure, narrowing of the airways which can cause breathing difficulties,\u00a0asthma,\u00a0increased\u00a0blood pressure in the\u00a0arteries\u00a0of the lungs\u00a0(blood vessel)<\/li><li>Problems with digestion:\u00a0inflammation\u00a0of the pancreas,\u00a0stomach ulcer,\u00a0inflammation\u00a0of the esophagus, swollen stomach (abdomen), ulceration of the lining of the rectum,\u00a0difficulty swallowing,\u00a0inflammation\u00a0of the gallbladder, blockage of the bile ducts,\u00a0gastroesophageal reflux\u00a0(a condition where acid and other stomach contents come back up into the throat )<\/li><li>Skin, hair, eyes,\u00a0general symptoms:\u00a0allergic reaction\u00a0including soreness, lumpy reddening of the skin (rubella), anxiety, confusion, mood swings, decreased sex drive, fainting, tremors,\u00a0inflammation\u00a0of the eye which can cause redness and pain, a skin disease characterized by sore, red, sharply demarcated and raised skin patches with rapid onset of fever and elevated levels of\u00a0white blood cells\u00a0(\u00a0neutrophil\u00a0dermatosis\u00a0) hearing loss, light sensitivity, vision loss, increased tear flow, change in skin color,\u00a0inflammation\u00a0of the fatty tissue of the skin, wounds on the skin, blistering on the skin, nail problems, hair disorders, hand-foot syndrome,\u00a0kidney failure, affected urination frequency, breast enlargement in men, menstrual disorders, general weakness and discomfort, low thyroid function, balance problems when walking, osteonecrosis (a condition where skeletal bones die and collapse due to reduced blood supply), joint inflammation, skin swelling anywhere on the body<\/li><li>Pain:\u00a0inflammation\u00a0of the blood vessels which can cause redness, tenderness and swelling, tendonitis (tendinitis)<\/li><li>Brain:\u00a0memory loss<\/li><li>Tests may show:\u00a0abnormal blood levels and possibly impaired kidney function caused by residual products of the disintegrating\u00a0tumor\u00a0(tumor lysis syndrome), low levels of albumin in the blood, low levels of\u00a0lymphocytes\u00a0(a type of\u00a0white blood cell\u00a0) in the blood, high cholesterol levels, swollen\u00a0lymph nodes, bleeding in the brain, irregular electrical impulses to the heart, enlarged heart,\u00a0inflammation\u00a0of the liver,\u00a0protein\u00a0in the urine, increased levels of creatinine phosphokinase (an\u00a0enzyme\u00a0mainly found in the heart, brain, and skeletal muscle), increased levels of troponin (an\u00a0enzyme mainly found in the heart and skeletal muscles), increased gamma-glutamyltransferase (an\u00a0enzyme\u00a0mainly found in the liver), milky fluid around the lungs (chylothorax)<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Heart and lungs:<\/strong>\u00a0enlarged upper chamber of the heart, inflammation of the heart muscle, the combined effect of various conditions that block the blood supply to the heart (\u00a0acute\u00a0cardiac syndrome), cardiac arrest (stopping of blood flow from the heart), coronary artery disease,\u00a0inflammation\u00a0of the\u00a0tissue\u00a0that covers the heart and lungs, blood clots, blood clots in the lungs<\/li><li><strong>Problems with digestion<\/strong>:\u00a0reduced absorption of important nutrients, such as\u00a0protein, from the gastrointestinal tract, irritable bowel, anal fistula (an abnormal opening from the anus to the skin around the anus), impaired kidney function,\u00a0diabetes<\/li><li>Skin, hair, eyes,\u00a0general symptoms:\u00a0convulsions,\u00a0inflammation\u00a0of\u00a0optic nerve\u00a0one which can cause a complete or partial loss of vision, blue-violet spots on the skin, abnormally high thyroid function,\u00a0inflammation\u00a0of the thyroid gland,\u00a0ataxia\u00a0(a condition associated with lack of muscle coordination), difficulty walking, miscarriage,\u00a0inflammation\u00a0of the blood vessels of the skin, skin fibrosis<\/li><li>Brain:\u00a0stroke, temporary events of the disturbed function of the nervous system caused by reduced blood flow, facial paralysis, dementia<\/li><li>Immune system: severe\u00a0allergic reaction<\/li><li>Muscles, bones, and connective tissue: delayed joining of the bone ends that form joints (epiphyses);\u00a0slower or delayed growth<\/li><\/ul>\n\n\n\n<p>Other reported&nbsp;side effects&nbsp;are&nbsp;<strong>with no<\/strong>&nbsp;known frequency&nbsp;<strong>(occurring in an unknown number of users<\/strong>&nbsp;)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammatory changes in the lungs<\/li><li>bleeding in the stomach or intestines that can lead to death<\/li><li>recurrence (reactivation) of\u00a0hepatitis\u00a0B\u00a0infection\u00a0when you previously had\u00a0hepatitis\u00a0B (a liver infection)<\/li><li>a reaction with fever, blisters on the skin, and sores on the mucous membranes<\/li><li>Kidney disease with symptoms including\u00a0edema\u00a0and abnormal laboratory test results such as\u00a0protein\u00a0in the urine and low protein in the blood.<\/li><li>Damage to blood vessels, so-called thrombotic microangiopathy (TMA), including reduced number of\u00a0red blood cells, reduced number of\u00a0blood platelets,\u00a0and blood clot formation.<\/li><\/ul>\n\n\n\n<p>Your doctor will check if you have any of these&nbsp;side effects&nbsp;during your treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store SPRYCEL<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the can label, blister or carton after &#8220;EXP&#8221; or &#8220;EXP&#8221;.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>The medicine must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is dasatinib.\u00a0Each film-coated tablet contains 20 mg, 50 mg, 70 mg, 80 mg, 100 mg or 140 mg dasatinib (as monohydrate).<\/li><li>Other ingredients are:<ul><li><em>Tablet core<\/em>:\u00a0lactose monohydrate\u00a0(see section 2 &#8220;SPRYCEL contains lactose&#8221;), microcrystalline cellulose, croscarmellose sodium, hydroxypropyl cellulose, magnesium stearate<\/li><li><em>Film coating<\/em>\u00a0: hypromellose, titanium dioxide (E171), macrogol 400<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>SPRYCEL 20 mg: the film-coated tablet is white to off-white, biconvex, round, and marked with \u201cBMS\u201d on one side and \u201c527\u201d on the other side.<\/p>\n\n\n\n<p>SPRYCEL 50 mg: the film-coated tablet is white to off-white, biconvex, oval, and marked with \u201cBMS\u201d on one side and \u201c528\u201d on the other side.<\/p>\n\n\n\n<p>SPRYCEL 70 mg: the film-coated tablet is white to off-white, biconvex, round, and marked with \u201cBMS\u201d on one side and \u201c524\u201d on the other side.<\/p>\n\n\n\n<p>SPRYCEL 80 mg: the film-coated tablet is white to off-white, biconvex, triangular, and debossed with \u201cBMS 80\u201d on one side and \u201c855\u201d on the other side.<\/p>\n\n\n\n<p>SPRYCEL 100 mg: the film-coated tablet is white to off-white, biconvex, oval, and marked with &#8220;BMS 100&#8221; on one side and &#8220;852&#8221; on the other side.<\/p>\n\n\n\n<p>SPRYCEL 140 mg: the film-coated tablet is white to off-white, biconvex, round, and marked with \u201cBMS 140\u201d on one side and \u201c857\u201d on the other side.<\/p>\n\n\n\n<p>SPRYCEL 20 mg, 50 mg or 70 mg film-coated tablets are available in cartons containing 56 film-coated tablets in 4 calendar blisters of 14 film-coated tablets each, and in cartons containing 60 x 1 film-coated tablets in perforated unit-dose blisters.&nbsp;They are also available in a jar with a child-resistant closure containing 60 film-coated tablets.&nbsp;Each carton contains one can.<\/p>\n\n\n\n<p>SPRYCEL 80 mg, 100 mg or 140 mg film-coated tablets are available in cartons containing 30 x 1 film-coated tablets in perforated single-dose blisters.&nbsp;They are also available in a jar with a child-resistant closure containing 30 film-coated tablets.&nbsp;Each carton contains one can.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bristol\u2011Myers Squibb Pharma EEIG<br>Plaza 254<br>Blanchardstown Corporate Park 2<\/p>\n\n\n\n<p>Dublin 15, D15 T867<br>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Swords Laboratories Unlimited Company T\/A Bristol-Myers Squibb Pharmaceutical Operations, External Manufacturing<\/p>\n\n\n\n<p>Plaza 254<\/p>\n\n\n\n<p>Blanchardstown Corporate Park 2<\/p>\n\n\n\n<p>Dublin 15, D15 T867<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>CATALENT ANAGNI SRL<\/p>\n\n\n\n<p>Loc.&nbsp;Fontana del Ceraso snc<\/p>\n\n\n\n<p>Strada Provinciale 12 Casilina, 41<\/p>\n\n\n\n<p>03012 Anagni (FR)<\/p>\n\n\n\n<p>Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SPRYCEL contains the active substance dasatinib.\u00a0This medicine is used to treat\u00a0chronic myeloid leukemia\u00a0(CML) in adults, adolescents and children older than 1 year.\u00a0Leukemia\u00a0is a cancer of the white\u00a0blood cells\u00a0.\u00a0The white\u00a0blood cells\u00a0normally help the body fight\u00a0infection\u00a0.\u00a0Chronic myeloid leukemia\u00a0is a form of\u00a0leukemia\u00a0in which the\u00a0white blood cells\u00a0called\u00a0granulocytes\u00a0begin to form uncontrollably.\u00a0SPRYCEL inhibits the growth of these leukemia cells.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24607,24611,24610,24612,24616,24615,24609,24608,24613,24614],"class_list":["post-23531","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-dasatanib","tag-dasatanib-side-effects","tag-dasatanib-tablet","tag-sprycel","tag-sprycel-side-effects","tag-sprycel-tablet","tag-what-dasatanib-is-used-for","tag-what-is-dasatanib","tag-what-is-sprycel","tag-what-sprycel-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23531"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23531\/revisions"}],"predecessor-version":[{"id":23561,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23531\/revisions\/23561"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}