{"id":23522,"date":"2022-08-02T07:21:35","date_gmt":"2022-08-02T07:21:35","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23522"},"modified":"2022-08-03T07:36:36","modified_gmt":"2022-08-03T07:36:36","slug":"spironolactone-pfizer","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/spironolactone-pfizer\/","title":{"rendered":"Spironolactone Pfizer &#8211; Spironolactone uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg, 50 mg and 100 mg&nbsp;tablets<br>spironolactone<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Spironolactone Pfizer is and what it is used for<\/h2>\n\n\n\n<p>Spironolactone\u00a0Pfizer contains the active substance\u00a0spironolactone.\u00a0Spironolactone\u00a0is a potassium-sparing,\u00a0diuretic\u00a0agent that affects the kidneys in such a way that more fluid (urine) is excreted through the body.\u00a0In addition to the\u00a0diuretic\u00a0effect,\u00a0spironolactone\u00a0has a blood pressure-lowering effect.<\/p>\n\n\n\n<p>Spironolactone\u00a0Pfizer is used for various forms of morbid fluid accumulation (\u00a0edema\u00a0) and high\u00a0blood pressure\u00a0when other treatment has no effect or is insufficient.\u00a0It is also used for increased production of the adrenal cortex hormone\u00a0aldosterone\u00a0(primary aldosteronism) where another\u00a0therapy\u00a0is insufficient or inappropriate.<\/p>\n\n\n\n<p>Children should only be treated by a pediatrician.<br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Spironolactone Pfizer<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Spironolactone Pfizer<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to\u00a0spironolactone\u00a0or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have\u00a0acute\u00a0kidney failure, severely impaired kidney function, or if you have no urine production<\/li><li>if you have\u00a0Addison&#8217;s disease\u00a0(reduced production of\u00a0the\u00a0hormones\u00a0cortisol\u00a0and\u00a0aldosterone\u00a0)<\/li><li>if you have elevated levels of potassium in your blood<\/li><\/ul>\n\n\n\n<p>Children with moderate to severe kidney disease should not use&nbsp;Spironolactone&nbsp;Pfizer.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using&nbsp;Spironolactone&nbsp;Pfizer:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you suffer from severe\u00a0heart failure<\/li><li>if you are elderly and\/or suffer from reduced kidney or liver function<\/li><li>if you suffer from kidney disease, especially children with high\u00a0blood pressure, or liver disease.\u00a0The doctor will routinely evaluate your condition.<\/li><\/ul>\n\n\n\n<p>In the above-mentioned condition, your doctor may perform regular blood tests to check the level of\u00a0potassium,\u00a0sodium,\u00a0and\/or\u00a0urea\u00a0in the blood.<\/p>\n\n\n\n<p>Concomitant use of\u00a0Spironolactone\u00a0Pfizer with certain medicines, potassium supplements, and food containing a lot of\u00a0potassium\u00a0can lead to severe\u00a0hyperkalemia\u00a0(increased level of potassium in the blood).\u00a0The symptoms of severe\u00a0hyperkalemia\u00a0may include muscle cramps, irregular heartbeat, diarrhea, nausea, dizziness, or headache.<\/p>\n\n\n\n<p>Spironolactone\u00a0Pfizer can in rare cases affect the white\u00a0blood cells\u00a0so that the defense against infection deteriorates.\u00a0If you get an\u00a0infection\u00a0with symptoms such as fever with a greatly worsened general condition or fever with local symptoms of infection such as sore throat\/pharynx\/mouth or vomiting, you should see a doctor as soon as possible so that a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0) can be ruled out via a blood test.\u00a0It is important that you then information about your medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Spironolactone Pfizer<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or might be using other medicines.\u00a0The effect of the treatment can be affected if\u00a0Spironolactone\u00a0Pfizer is taken at the same time as certain other medicines, such as<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines containing\u00a0potassium\u00a0or medicines that can cause excessive levels of\u00a0potassium\u00a0in the blood, a diet rich in\u00a0potassium\u00a0or salt substitutes containing\u00a0potassium<\/li><li>non-steroidal anti-inflammatory drugs called NSAIDs (used for pain and\u00a0inflammation\u00a0)<\/li><li>ACE inhibitors,\u00a0angiotensin\u00a0II\u00a0antagonists, aldosterone inhibitors,\u00a0digoxin\u00a0(used for high\u00a0blood pressure\u00a0and\u00a0heart failure\u00a0)<\/li><li>potassium-sparing\u00a0diuretics<\/li><li>norepinephrine\u00a0(used in anesthesia)<\/li><li>ammonium chloride (used in conditions with too high a\u00a0pH\u00a0in the body)<\/li><li>cholestyramine (e.g. used for elevated blood lipids)<\/li><li>carbenoxolone (used e.g. in case of the disease in the esophagus)<\/li><li>heparin, low molecular weight\u00a0heparin\u00a0(blood thinner)<\/li><li>abiraterone (used to treat prostate cancer)<\/li><li>tacrolimus (used after a transplant)<\/li><li>trimethoprim and trimethoprim-sulfamethoxazole<\/li><\/ul>\n\n\n\n<p>Spironolactone&nbsp;Pfizer may affect certain laboratory tests.<\/p>\n\n\n\n<p>Therefore, consult a doctor before the simultaneous use of other medicines, including dietary supplements.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Spironolactone Pfizer with food, drink, and alcohol<\/h2>\n\n\n\n<p>The tablets should be taken with a meal.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>There is no or limited amount of data on the use of\u00a0spironolactone\u00a0in pregnant women.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Spironolactone&nbsp;passes into breast milk.<\/p>\n\n\n\n<p><em>Fertility<\/em><\/p>\n\n\n\n<p>There are no clinical data available on the effect of spironolactone on\u00a0fertility.\u00a0Animal studies have shown reduced\u00a0fertility\u00a0in females, but there are no animal data regarding male\u00a0fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Side effects&nbsp;in the form of dizziness and fatigue may occur in some patients, especially at the beginning of treatment.&nbsp;This should be taken into account when increased attention is required, e.g.&nbsp;when driving.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Spironolactone Pfizer contains lactose<\/h2>\n\n\n\n<p>Spironolactone\u00a0Pfizer tablets contain\u00a0lactose.\u00a0If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Spironolactone Pfizer<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The dose&nbsp;is determined by the doctor, who adjusts it individually for you.&nbsp;The tablets should be taken with a meal.<\/p>\n\n\n\n<p><em>The usual&nbsp;dose&nbsp;for adults<\/em>&nbsp;is 50-100 mg daily, but higher or lower&nbsp;doses&nbsp;may be used in some cases.&nbsp;It may take a certain amount of time before the treatment has an effect, it is therefore important not to interrupt the treatment or change the&nbsp;dose&nbsp;without consulting a doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Spironolactone&nbsp;Pfizer is used in some cases for the treatment of children and the&nbsp;dose&nbsp;is then adjusted according to the child&#8217;s weight.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Spironolactone Pfizer &nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Spironolactone Pfizer<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a missed tablet.<\/p>\n\n\n\n<p>If you have further questions about this medicine, contact your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact your\u00a0doctor immediately<\/strong>\u00a0if you experience any of the following\u00a0side effects\u00a0symptoms after taking this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Stevens-Johnson syndrome:<br><\/em>An extremely strong\u00a0allergic reaction\u00a0with a skin rash is usually in the form of blisters or sores in the mouth and eyes as well as other mucous membranes such as the genitals.\u00a0Occurs in an unknown number of users.<\/li><li>Lyell\u00b4s syndrome (\u00a0toxic epidermal necrolysis\u00a0):<br>Severe widespread skin damage (skin shedding of the epidermis and superficial mucous membranes).\u00a0Occurs in an unknown number of users.<\/li><li>Drug reaction causing skin rash, fever,\u00a0inflammation\u00a0of internal organs, altered blood count (\u00a0eosinophilia\u00a0), and systemic disease (DRESS).\u00a0Occurs in an unknown number of users.<\/li><li>Agranulocytosis\u00a0:<br>Spironolactone\u00a0Pfizer can in rare cases affect the white\u00a0blood cells\u00a0so that the defense against infection deteriorates.\u00a0If you get an\u00a0infection\u00a0with symptoms such as fever with a greatly worsened general condition or fever with local symptoms of infection such as sore throat\/pharynx\/mouth or difficulty urinating, you should see a doctor as soon as possible so that a lack of\u00a0white blood cells\u00a0can be ruled out via a blood test (\u00a0agranulocytosis\u00a0).\u00a0It is important that you then information about your medication.\u00a0Occurs in an unknown number of users.<\/li><li>Severe fatigue, nausea, and\u00a0itching,\u00a0or if you urinate less than usual.\u00a0It could be a sign of kidney damage.\u00a0May affect up to 1 in 10 users.<\/li><\/ul>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users):<\/em>&nbsp;<\/p>\n\n\n\n<p>High levels of potassium in the blood, can cause abnormal heart rhythms.<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<br><\/em>Confusion, headache, dizziness,\u00a0itching, skin rash, muscle cramps, problems getting and keeping an\u00a0erection, breast enlargement in men, pain in the breasts in men, feeling generally unwell, drowsiness, tiredness, diarrhea, nausea, and vomiting.<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em>&nbsp;<\/p>\n\n\n\n<p>Benign breast lumps in men, missed\/absent periods, post-menopause vaginal bleeding and irregular periods, breast pain in women,\u00a0hives, redness of the skin which is often a sign of\u00a0infection\u00a0or\u00a0inflammation\u00a0(irritation), abnormal levels of certain salts (e.g.\u00a0calcium,\u00a0potassium,\u00a0and\u00a0magnesium\u00a0) which are necessary for the body to function normally, reduced sodium content in the blood, tingling and tingling in the skin, abnormal blood test results (increased\u00a0creatinine\u00a0), abnormal liver function.<\/p>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em>\u00a0<br>Severe decrease in the number of\u00a0white blood cells\u00a0(\u00a0leukopenia\u00a0) which increases the risk of\u00a0infection, decrease in the number of\u00a0platelets, change in sexual desire, gastrointestinal upset, hair loss, abnormal hair growth, and\u00a0pemphigus\u00a0(a condition that causes fluid-filled blisters on the skin).<\/p>\n\n\n\n<p>Dry mouth, thirst, headache, fatigue, and drowsiness may occur due to sodium deficiency, during simultaneous treatment with other\u00a0diuretics.\u00a0In that case, contact a doctor who may be able to change the\u00a0dosage.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Spironolactone Pfizer<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is\u00a0spironolactone\u00a025 mg, 50 mg, and 100 mg respectively per tablet.<\/li><li>Other ingredients are\u00a0lactose monohydrate\u00a097 mg, 125 mg, and 136 mg respectively, corn starch, magnesium stearate, peppermint aroma, povidone,\u00a0and colloidal\u00a0silicon dioxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Tablet<\/p>\n\n\n\n<p>Package sizes for all strengths are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blister, 49 x 1 tablets<\/li><li>Jar, 100 tablets<\/li><li>Jar, 250 tablets<\/li><\/ul>\n\n\n\n<p>Not all pack sizes and strengths may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Phone: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Spironolactone\u00a0Pfizer contains the active substance\u00a0spironolactone.\u00a0Spironolactone\u00a0is a potassium-sparing,\u00a0diuretic\u00a0agent that affects the kidneys in such a way that more fluid (urine) is excreted through the body.\u00a0In addition to the\u00a0diuretic\u00a0effect,\u00a0spironolactone\u00a0has a blood pressure-lowering effect.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[11197,24635,24637,24638,11200,11198,24634,11199,24636],"class_list":["post-23522","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-spironolactone","tag-spironolactone-pfizer","tag-spironolactone-pfizer-side-effects","tag-spironolactone-pfizer-tablet","tag-spironolactone-tablet","tag-what-is-spironolactone","tag-what-is-spironolactone-pfizer","tag-what-spironolactone-is-used-for","tag-what-spironolactone-pfizer-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23522"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23522\/revisions"}],"predecessor-version":[{"id":23564,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23522\/revisions\/23564"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23522"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23522"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}