{"id":23520,"date":"2022-08-02T07:18:44","date_gmt":"2022-08-02T07:18:44","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23520"},"modified":"2022-08-03T07:36:46","modified_gmt":"2022-08-03T07:36:46","slug":"spironolactone-takeda","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/spironolactone-takeda\/","title":{"rendered":"Spironolactone Takeda &#8211; Spironolactone uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg, 50 mg, 100 mg tablets<br>spironolactone<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Spironolactone Takeda is and what it is used for<\/h2>\n\n\n\n<p>Spironolactone\u00a0Takeda contains the active substance\u00a0spironolactone.\u00a0It is a potassium-sparing,\u00a0diuretic\u00a0agent that affects the kidneys in such a way that more fluid (urine) is secreted through the body.\u00a0In addition to the\u00a0diuretic\u00a0effect,\u00a0spironolactone\u00a0has a blood pressure-lowering effect.<\/p>\n\n\n\n<p>Spironolactone\u00a0Takeda is used for various forms of morbid fluid accumulation (\u00a0edema\u00a0) and high\u00a0blood pressure\u00a0when other treatment has no effect or is insufficient.\u00a0It is also used for increased production of the adrenal cortex hormone\u00a0aldosterone\u00a0(primary aldosteronism) where another\u00a0therapy\u00a0is insufficient or inappropriate.<\/p>\n\n\n\n<p>Children should only be treated by a pediatrician.<\/p>\n\n\n\n<p>Spironolactone\u00a0may also be approved to treat other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Spironolactone Takeda<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Spironolactone Takeda<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to\u00a0spironolactone\u00a0or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have\u00a0acute\u00a0kidney failure, severely impaired kidney function, or have no urine production<\/li><li>if you have\u00a0Addison&#8217;s disease\u00a0(reduced production of\u00a0the\u00a0hormones\u00a0cortisol\u00a0and\u00a0aldosterone\u00a0)<\/li><li>if you have elevated levels of potassium in your blood<\/li><\/ul>\n\n\n\n<p>Concomitant use of\u00a0Spironolactone\u00a0Takeda with certain medicines, potassium supplements, and food containing a lot of\u00a0potassium\u00a0can lead to severe\u00a0hyperkalemia\u00a0(increased level of potassium in the blood).\u00a0The symptoms of severe\u00a0hyperkalemia\u00a0may include muscle cramps, irregular heartbeat, diarrhea, nausea, dizziness, or headache.<\/p>\n\n\n\n<p>Children with moderate to severe kidney disease should not use&nbsp;Spironolactone&nbsp;Takeda.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using&nbsp;Spironolactone&nbsp;Takeda<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have severe\u00a0heart failure<\/li><li>if you are elderly and\/or suffer from reduced kidney or liver function<\/li><li>if you have kidney disease, especially in children with high\u00a0blood pressure, or liver disease.\u00a0The doctor will routinely evaluate your condition.<\/li><\/ul>\n\n\n\n<p>In the above-mentioned condition, your doctor may perform regular blood tests to check the level of\u00a0potassium,\u00a0sodium,\u00a0and\/or\u00a0urea\u00a0in the blood.<\/p>\n\n\n\n<p>In rare cases, spironolactone\u00a0can affect the white\u00a0blood cells\u00a0so that the defense against infection deteriorates.\u00a0If you get an\u00a0infection\u00a0with fever and a greatly worsened general condition or fever and local symptoms of infection such as sore throat\/pharynx\/mouth or vomiting, you should see a doctor as soon as possible so that a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0) can be ruled out via a blood test.\u00a0It is important that you then information about your medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Spironolactone Takeda<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or might be using other medicines.\u00a0The effect of the treatment can be affected if\u00a0Spironolactone\u00a0Takeda is taken at the same time as certain other medicines, e.g<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines containing\u00a0potassium\u00a0or medicines that can cause excessive levels of\u00a0potassium\u00a0in the blood<\/li><li>non-steroidal anti-inflammatory drugs called NSAIDs (used for pain and\u00a0inflammation\u00a0)<\/li><li>ACE inhibitors,\u00a0angiotensin\u00a0II\u00a0antagonists, aldosterone inhibitors,\u00a0digoxin\u00a0(used for high\u00a0blood pressure\u00a0and\u00a0heart failure\u00a0)<\/li><li>potassium-sparing\u00a0diuretics<\/li><li>norepinephrine\u00a0(used in anesthesia)<\/li><li>ammonium chloride (used in conditions with too high a\u00a0pH\u00a0in the body)<\/li><li>cholestyramine (e.g. used for elevated blood lipids)<\/li><li>carbenoxolone (e.g. used in diseases of the esophagus)<\/li><li>heparin, low molecular weight\u00a0heparin\u00a0(blood thinner)<\/li><li>tacrolimus (used after a transplant)<\/li><li>trimethoprim and trimethoprim-sulfamethoxazole (used against\u00a0infections\u00a0)<\/li><li>abiraterone for the treatment of prostate cancer.<\/li><\/ul>\n\n\n\n<p>Therefore, consult a doctor before the simultaneous use of other medicines and also dietary supplements.<\/p>\n\n\n\n<p>Spironolactone&nbsp;Takeda may affect certain laboratory tests.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Spironolactone Takeda with food and drink<\/h2>\n\n\n\n<p>The tablets should be taken with a meal.\u00a0Avoid\u00a0potassium-rich diet or salt substitutes containing\u00a0potassium\u00a0because of the risk of\u00a0hyperkalemia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em>&nbsp;<\/p>\n\n\n\n<p>There is no or limited amount of data on the use of\u00a0spironolactone\u00a0in pregnant women.\u00a0Spironolactone\u00a0Takeda should therefore not be used during pregnancy.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em>&nbsp;<\/p>\n\n\n\n<p>Spironolactone&nbsp;passes into breast milk.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Side effects\u00a0in the form of dizziness and fatigue may occur in some patients.\u00a0This should be taken into account when increased attention is required, e.g. when driving.\u00a0You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with a doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Spironolactone Takeda contains lactose and sodium<\/h2>\n\n\n\n<p>The tablets contain\u00a0lactose.\u00a0If you have an intolerance to some sugars, you should consult your doctor before taking this medicine.<\/p>\n\n\n\n<p>Spironolactone&nbsp;Takeda contains less than 23 mg of&nbsp;sodium&nbsp;per tablet, i.e. it is almost &#8220;sodium-free&#8221;.&nbsp;This amount of sodium also applies to&nbsp;doses&nbsp;of up to 350 mg daily.<br>A&nbsp;dose&nbsp;of 400 mg of&nbsp;Spironolactone&nbsp;Takeda contains 23.9 mg of&nbsp;sodium&nbsp;(the main ingredient in common\/table salt).&nbsp;This corresponds to 1.2% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Spironolactone Takeda<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The dose&nbsp;is determined by the doctor, who adjusts it individually for you.&nbsp;The tablets should be taken with a meal.<\/p>\n\n\n\n<p><em>The usual&nbsp;dose&nbsp;for adults<\/em>&nbsp;is 50 &#8211; 100 mg daily, but higher or lower&nbsp;doses&nbsp;may be used in some cases.<\/p>\n\n\n\n<p>The tablets can be split by light pressure.\u00a0The tablet can be divided into two equal\u00a0doses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<p>Spironolactone&nbsp;Takeda is used in some cases for the treatment of children, and the&nbsp;dose&nbsp;is then adjusted according to the child&#8217;s weight.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Spironolactone Takeda &nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0if a child has ingested the medicine by mistake, immediately contact a doctor or hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Spironolactone Takeda<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a missed tablet.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Stop taking&nbsp;Spironolactone&nbsp;Takeda and contact your doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you experience the following symptoms:<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe fatigue, nausea, and\u00a0itching,\u00a0or if you urinate less than usual.\u00a0It could be a sign of kidney damage.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring&nbsp;<\/em><em>in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><em>Stevens-Johnson syndrome\u00a0\/ Lyell&#8217;s syndrome (\u00a0toxic epidermal necrolysis\u00a0) \/ DRESS: <\/em>Extremely strong and serious skin side effects such as\u00a0Stevens-Johnson syndrome,\u00a0toxic epidermal necrolysis, or drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms (DRESS) have been reported with the use of\u00a0spironolactone. The skin side effects can consist of a rash with or without blisters.\u00a0Skin redness, sores or swelling in the mouth, throat, eyes, nose, and around the genitals (\u00a0Stevens-Johnson syndrome\u00a0),\u00a0edema\u00a0(DRESS), and fever and flu-like symptoms can also occur.\u00a0The skin rash can develop into serious widespread skin damage (skin peeling of the epidermis and superficial mucous membranes) with life-threatening consequences.\u00a0Symptoms of DRESS usually develop around 2-6 weeks (possibly up to 8 weeks) after starting treatment.<\/li><li>Agranulocytosis:<br>fever in combination with the greatly worsened general condition or fever in combination with sore throat\/pharynx\/mouth or difficulty urinating, which are signs of\u00a0infection.\u00a0As\u00a0spironolactone\u00a0can in rare cases lead to a weakened defense against infection due to a lack of\u00a0white blood cells,\u00a0infections\u00a0can become serious.\u00a0Therefore, it is important that in these situations you also information about your medication.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur:<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>High levels of potassium in the blood, can cause abnormal heart rhythms.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Confusion, headache, dizziness,\u00a0itching, skin rash, muscle cramps, trouble getting and keeping an\u00a0erection, male breast enlargement, male breast pain, general malaise, drowsiness, tiredness, diarrhea, nausea, and vomiting.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Benign breast lumps in men, missed\/absent periods, post-menopause vaginal bleeding and irregular periods, breast pain in women,\u00a0hives, redness of the skin which is often a sign of\u00a0infection\u00a0or\u00a0inflammation\u00a0(irritation), abnormal levels of certain salts (e.g.\u00a0calcium,\u00a0potassium,\u00a0and\u00a0magnesium\u00a0) which are necessary for the body to function normally, reduced sodium content in the blood, tingling and tingling in the skin, abnormal blood test results (increased\u00a0creatinine\u00a0), abnormal liver function.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe decrease in the number of\u00a0white blood cells\u00a0(\u00a0leukopenia\u00a0) which increases the risk of\u00a0infection, decrease in the number of\u00a0platelets, change in sexual desire, gastrointestinal problems, hair loss, abnormal hair growth, and\u00a0pemphigus\u00a0(a condition that causes fluid-filled blisters on the skin).<\/li><\/ul>\n\n\n\n<p>Dry mouth, thirst, headache, fatigue, and drowsiness may occur due to sodium deficiency, during simultaneous treatment with other\u00a0diuretics.\u00a0In that case, contact a doctor who may be able to change the\u00a0dosage.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Spironolactone Takeda<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is\u00a0spironolactone\u00a025 mg, 50 mg, and 100 mg respectively per tablet.<\/li><li>Other ingredients are\u00a0lactose monohydrate\u00a053 mg, 24 mg, and 48 mg respectively, microcrystalline cellulose, rice starch, sodium lauryl sulfate, povidone, magnesium stearate,\u00a0colloidal\u00a0anhydrous silica, and peppermint oil.\u00a0Spironolactone\u00a0Takeda tablets 25 mg also contain agar.\u00a0Spironolactone\u00a0Takeda tablets 50 mg and 100 mg also contain menthol and sodium starch glycolate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Spironolactone&nbsp;Takeda 25 mg is a white, round tablet with a score and a diameter of 8 mm.&nbsp;It is stamped with AB 43 on one side.<\/p>\n\n\n\n<p>Spironolactone&nbsp;Takeda 50 mg is a white, round tablet with a score and a diameter of 8 mm.&nbsp;It is stamped with AB 72 on one side.<\/p>\n\n\n\n<p>Spironolactone&nbsp;Takeda 100 mg is a white, round tablet with a score and a diameter of 11 mm.<\/p>\n\n\n\n<p>Package size: 100 tablets in a plastic jar.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Orifarm Healthcare A\/S<\/p>\n\n\n\n<p>Energizer 15<\/p>\n\n\n\n<p>5260 Odense S<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p>info@orifarm.com<\/p>\n\n\n\n<p><strong>Local Representative<\/strong><\/p>\n\n\n\n<p>Orifarm Healthcare<\/p>\n\n\n\n<p>Box 56048<\/p>\n\n\n\n<p>102 17 Stockholm<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Takeda Pharma AS<\/p>\n\n\n\n<p>Jaama in 55b<\/p>\n\n\n\n<p>P\u00f5lva linn<\/p>\n\n\n\n<p>P\u00f5lvamaa 63308<\/p>\n\n\n\n<p>Estonia<\/p>\n\n\n\n<p>Takeda GmbH, Production Site Oranienburg<\/p>\n\n\n\n<p>Lehnitzstr.&nbsp;70-98<\/p>\n\n\n\n<p>16515 Oranienburg<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Spironolactone\u00a0Takeda contains the active substance\u00a0spironolactone\u00a0.\u00a0It is a potassium-sparing,\u00a0diuretic\u00a0agent that affects the kidneys in such a way that more fluid (urine) is secreted through the body.\u00a0In addition to the\u00a0diuretic\u00a0effect,\u00a0spironolactone\u00a0has a blood pressure-lowering effect.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[11197,24639,11200,24642,24644,24643,11198,24640,11199,24641],"class_list":["post-23520","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-spironolactone","tag-spironolactone-side-effects","tag-spironolactone-tablet","tag-spironolactone-takeda","tag-spironolactone-takeda-side-effects","tag-spironolactone-takeda-tablet","tag-what-is-spironolactone","tag-what-is-spironolactone-takeda","tag-what-spironolactone-is-used-for","tag-what-spironolactone-takeda-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23520"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23520\/revisions"}],"predecessor-version":[{"id":23565,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23520\/revisions\/23565"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}