{"id":23517,"date":"2022-08-02T07:15:22","date_gmt":"2022-08-02T07:15:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23517"},"modified":"2022-08-03T07:36:55","modified_gmt":"2022-08-03T07:36:55","slug":"spironolactone-orion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/spironolactone-orion\/","title":{"rendered":"Spironolactone Orion &#8211; Spironolactone uses, dose and side effects"},"content":{"rendered":"\n<p>25, 50, and 100 mg\u00a0tablets<br>spironolactone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Spironolactone Orion is and what it is used for<\/h2>\n\n\n\n<p>The active substance in this drug,\u00a0spironolactone, reduces excess fluid in the body by increasing urine output.\u00a0It differs from many other\u00a0diuretics\u00a0in that no\u00a0potassium\u00a0is lost in the urine.<\/p>\n\n\n\n<p>This medicine is used to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high\u00a0blood pressure\u00a0or\u00a0heart failure, as an additional treatment for patients who do not respond adequately to other treatments<\/li><li>swelling associated with kidney, liver, or other diseases, when other treatments have not been effective<\/li><li>primary aldosteronism (overactivity of aldosterone secretion in the adrenal glands).<\/li><\/ul>\n\n\n\n<p>The spironolactone contained\u00a0in Spironolactone Orion may also be approved to treat other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Spironolactone Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Spironolactone Orion<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to\u00a0spironolactone\u00a0or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have\u00a0acute\u00a0or\u00a0chronic\u00a0renal insufficiency<\/li><li>if your urine output has stopped<\/li><li>if the potassium concentration in your blood is too high<\/li><li>if you have low levels of sodium in your blood<\/li><li>if it has been shown that you suffer from\u00a0acute\u00a0adrenal insufficiency (so-called Addisonian crisis)<\/li><li>if you have an inherited disease of the red blood pigment\u00a0hemoglobin, which causes skin blisters, abdominal pain, and nerve disease (\u00a0porphyria\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p><em>Talk to your doctor or pharmacist before taking Spironolactone Orion<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have liver or&nbsp;kidney failure<\/li><li>if you have&nbsp;diabetes&nbsp;and also impaired kidney function<\/li><li>if you have a&nbsp;stomach ulcer&nbsp;or duodenal ulcer<\/li><\/ul>\n\n\n\n<p>Concomitant\u00a0administration\u00a0of Spironolactone Orion with certain medicines, potassium supplements, and foods high in\u00a0potassium\u00a0can cause severe\u00a0hyperkalemia\u00a0(increased level of potassium in the blood).\u00a0Symptoms of severe\u00a0hyperkalemia\u00a0may include muscle cramps, irregular heartbeat, diarrhea, nausea, dizziness, and headache.<\/p>\n\n\n\n<p>Also, tell your doctor if you have any other diseases or\u00a0allergies.<\/p>\n\n\n\n<p><em>If you need surgical treatment<\/em><\/p>\n\n\n\n<p>If you need surgical treatment while using this medicine, tell the attending physician that you are using this medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Spironolactone Orion<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0The simultaneous use of certain medicines can affect their effect or the effect of Spironolactone Orion or cause\u00a0side effects.<\/p>\n\n\n\n<p>The attending physician needs to know if you are using any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines used to treat high\u00a0blood pressure,\u00a0heart failure,\u00a0and kidney disease, especially so-called\u00a0ACE inhibitors\u00a0(such as\u00a0enalapril,\u00a0captopril, lisinopril, perindopril, or <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triatec\/\">ramipril<\/a>) and\u00a0angiotensin\u00a0II receptor blockers (such as irbesartan, candesartan,\u00a0losartan, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tolura\/\">telmisartan<\/a> or valsartan)<\/li><li>digoxin\u00a0to treat\u00a0heart failure<\/li><li>other potassium-sparing\u00a0diuretics\u00a0(amiloride or triamterene)<\/li><li>aldosterone blockers<\/li><li>heparin\u00a0or low molecular weight\u00a0heparin\u00a0(medicines used to prevent blood clots)<\/li><li>simultaneous potassium supplementation<\/li><li>warfarin\u00a0to inhibit blood clotting<\/li><li>tacrolimus to reduce rejection after transplantation<\/li><li>anti-inflammatory painkillers (e.g.\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/treo-comp\/\">aspirin<\/a>,\u00a0ibuprofen,\u00a0or\u00a0ketoprofen\u00a0) with regular and long-term use<\/li><li>lithium for the treatment of mood disorders<\/li><li>norepinephrine<\/li><li>certain anesthetics<\/li><li>mitotane for the treatment of cancer<\/li><li>trimethoprim and trimethoprim-sulfamethoxazole<\/li><li>abiraterone for the treatment of prostate cancer.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Spironolactone Orion with food, drink, and alcohol<\/h2>\n\n\n\n<p>Potassium-rich diet is not recommended due to the risk of\u00a0hyperkalemia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Dizziness, fatigue, or other adverse effects (see section 4) may occur especially when starting a treatment or when adjusting the dose.\u00a0Such effects may impair the ability to drive or use machines.\u00a0Avoid driving or operating machinery when starting this medication and after increasing the dose until you know how this medicine affects you.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0Discuss with your doctor or pharmacist if you are unsure<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Spironolactone Orion contains lactose<\/h2>\n\n\n\n<p>The tablets contain&nbsp;lactose&nbsp;(in the form of monohydrate) 57 mg (25 mg tablet), 114 mg (50 mg tablet) or 228 mg (100 mg tablet).&nbsp;If you have an intolerance to certain sugars, you should consult your doctor before taking this medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Spironolactone Orion<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The daily\u00a0dose\u00a0can be taken either as a single dose or divided into two\u00a0doses.\u00a0Drink a glass of water or other liquid with the tablet.<\/p>\n\n\n\n<p>The tablets should be taken with food.&nbsp;Note that the medicine is better absorbed when taken with food.<\/p>\n\n\n\n<p>Always take the medicine at the same time to maintain an even medical effect.\u00a0It is also the best way to remember to take the medicine.<\/p>\n\n\n\n<p>Dosage\u00a0one of Spironolactone Orion is individual, depending on your illness and general health.\u00a0The\u00a0dosages\u00a0mentioned below are the usual recommended\u00a0dosages.<\/p>\n\n\n\n<p>Your doctor will regularly monitor the levels of various chemicals (eg, serum electrolytes and creatinine concentrations) in your body during treatment.<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p><em>Severe heart failure:<\/em>&nbsp;the initial&nbsp;dose&nbsp;is usually 25 mg per day.&nbsp;The doctor may decide to increase the&nbsp;dose once&nbsp;to 50 mg a day or reduce it to 25 mg every other day if necessary.<\/p>\n\n\n\n<p><em>High&nbsp;blood pressure&nbsp;and swelling:<\/em>&nbsp;the recommended&nbsp;dose&nbsp;is 25-100 mg per day.<\/p>\n\n\n\n<p><em>Severe swelling:<\/em>&nbsp;200-400 mg per day for a short time.<\/p>\n\n\n\n<p><em>Treatment of increased secretion of&nbsp;aldosterone&nbsp;(a&nbsp;hormone&nbsp;secreted by the adrenal gland):<\/em>&nbsp;100-400 mg one day before surgery.&nbsp;The doctor determines an individual&nbsp;dose&nbsp;for each patient so that the lowest effective&nbsp;dose&nbsp;is used if surgical treatment is not suitable.<\/p>\n\n\n\n<p><strong>Older<\/strong><\/p>\n\n\n\n<p>Dose adjustment is usually not necessary if you do not have kidney or liver failure.<\/p>\n\n\n\n<p><strong>Children<\/strong><\/p>\n\n\n\n<p>The doctor prescribes a&nbsp;dose&nbsp;based on the child&#8217;s body weight and illness.<\/p>\n\n\n\n<p>The tablet can be divided into two equal\u00a0doses.<\/p>\n\n\n\n<p><strong>Kidney failure<\/strong><\/p>\n\n\n\n<p>The doctor takes\u00a0kidney failure\u00a0into account when determining the\u00a0dose\u00a0and when following up on the treatment.<\/p>\n\n\n\n<p>Do not use this medicine if the doctor has told you that you have severe\u00a0kidney failure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Spironolactone Orion&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,\u00a0a child has ingested the medicine by mistake, contact a doctor, or hospital for an assessment of the risk and advice.\u00a0Symptoms of overdose are fatigue, confusion, unsteadiness, vomiting, dizziness, skin rash, and diarrhea.<\/p>\n\n\n\n<p>Take the tablet container with you if you seek care at a doctor&#8217;s office or a hospital.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Spironolactone Orion<\/h2>\n\n\n\n<p>Take the missed\u00a0dose\u00a0as soon as possible.\u00a0If it is almost time to take the next\u00a0dose, do not take the missed\u00a0dose.\u00a0Never take a double\u00a0dose\u00a0or two\u00a0doses\u00a0in a row.\u00a0Make sure you have enough medication available before you go on vacation or travel.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Spironolactone Orion can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects\u00a0are usually more likely in patients in poor condition and with multiple diseases.\u00a0Neurological\u00a0side effects, such as confusion, headache, and lack of enthusiasm (\u00a0apathy\u00a0), occur mainly in patients with impaired liver function caused by long-term damage (\u00a0liver cirrhosis\u00a0).<\/p>\n\n\n\n<p>Side effects&nbsp;are listed below by frequency:<\/p>\n\n\n\n<p><strong>Common&nbsp;<\/strong>&nbsp;<em>(may affect up to 1 in 10 users)<\/em>&nbsp;:<\/p>\n\n\n\n<p>Headache, gastrointestinal discomfort, nausea, diarrhea, vomiting, dry skin, sleepiness, growth of breast tissue in men, sore breasts, menstrual disorders,\u00a0and impotence.<\/p>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong>&nbsp;<em>(may affect up to 1 in 100 users)<\/em>&nbsp;:<\/p>\n\n\n\n<p>Too much potassium in the blood or too little sodium in the blood, confusion, abnormal sensation of touch, skin rash,\u00a0itching, hives, leg cramps, and changes in blood creatinine or renin concentrations.<\/p>\n\n\n\n<p><strong>Rare&nbsp;<\/strong><em>(may affect up to 1 in 1,000 users)<\/em>&nbsp;:<\/p>\n\n\n\n<p>Dehydration,\u00a0apathy\u00a0(ie, unresponsiveness, loss of initiative), altered sex drive, dizziness,\u00a0kidney failure, and decreased\u00a0white blood cell\u00a0or\u00a0platelet counts.<\/p>\n\n\n\n<p><strong>Very rare&nbsp;<\/strong><em>(may affect up to 1 in 10,000 users)<\/em>&nbsp;:<\/p>\n\n\n\n<p>Impaired liver function, hair loss, increased body hair, benign breast tumors.<\/p>\n\n\n\n<p><strong>Has been reported&nbsp;<\/strong><em>(occurring in an unknown number of users)<\/em>&nbsp;:<\/p>\n\n\n\n<p>Toxic epidermal necrolysis\u00a0(TEN),\u00a0Stevens-Johnson syndrome, drug reaction with\u00a0eosinophilia\u00a0and systemic symptoms (DRESS),\u00a0pemphigoid\u00a0(a condition that causes fluid-filled blisters on the skin).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Spironolactone Orion<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is\u00a0spironolactone.\u00a0Each tablet contains 25, 50, or 100 mg\u00a0of spironolactone.<\/li><li>Other ingredients are\u00a0lactose monohydrate, corn starch, povidone, polysorbate 80, peppermint oil, silicon dioxide (\u00a0colloidal, anhydrous), and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>25 mg tablet: white or off-white, round, flat tablet with a beveled edge and a score line, with a diameter of 7 mm, imprinted with ORN85.<\/p>\n\n\n\n<p>50 mg tablet: white or off-white, round, flat tablet with a beveled edge and a score line, with a diameter of 9 mm, imprinted with ORN213.<\/p>\n\n\n\n<p>100 mg tablet: white or off-white, round, slightly convex, and scored, with a diameter of 11 mm, imprinted with ORN352.<\/p>\n\n\n\n<p>The tablet can be divided into two equal\u00a0doses.<\/p>\n\n\n\n<p>The tablets are packaged in HDPE plastic cans and closures.<\/p>\n\n\n\n<p>Package sizes<\/p>\n\n\n\n<p>25 mg: 30, 50, 100 and 250 tablets<\/p>\n\n\n\n<p>50 mg and 100 mg: 30, 50 and 100 tablets<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>Orion Corporation<\/p>\n\n\n\n<p>Orion Indie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Orion Corporation, Orion Pharma<\/p>\n\n\n\n<p>Orion Indie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Joensuunkatu 7<\/p>\n\n\n\n<p>FI-24100 Salo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>For further information about this medicine, contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd, medinfo@orionpharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in this drug,\u00a0spironolactone\u00a0, reduces excess fluid in the body by increasing urine output.\u00a0It differs from many other\u00a0diuretics\u00a0in that no\u00a0potassium\u00a0is lost in the urine.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[11197,24646,24650,24648,24639,11200,11198,24647,11199,24649],"class_list":["post-23517","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-spironolactone","tag-spironolactone-orion","tag-spironolactone-orion-side-effects","tag-spironolactone-orion-tablet","tag-spironolactone-side-effects","tag-spironolactone-tablet","tag-what-is-spironolactone","tag-what-is-spironolactone-orion","tag-what-spironolactone-is-used-for","tag-what-spironolactone-orion-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23517"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23517\/revisions"}],"predecessor-version":[{"id":23566,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23517\/revisions\/23566"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}