{"id":23513,"date":"2022-08-02T07:10:14","date_gmt":"2022-08-02T07:10:14","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23513"},"modified":"2022-08-03T07:37:07","modified_gmt":"2022-08-03T07:37:07","slug":"spironolactone-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/spironolactone-accord\/","title":{"rendered":"Spironolactone Accord uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg, 50 mg and 100 mg&nbsp;film-coated tablets<br>spironolactone<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Read this leaflet carefully before you start using this medicine.&nbsp;It contains information that is important to you.<\/h2>\n\n\n\n<p>&#8211; Save this information, you may need to read it again.<\/p>\n\n\n\n<p>&#8211; If you have further questions, ask your doctor or pharmacist.<\/p>\n\n\n\n<p>&#8211; This medicine has been prescribed only for you.&nbsp;Do not give it to others.&nbsp;It can harm them, even if they show signs of illness similar to yours.<\/p>\n\n\n\n<p>&#8211; If you get any&nbsp;side effects&nbsp;, talk to a doctor, pharmacist or nurse.&nbsp;This also applies to any&nbsp;side effects&nbsp;that are not mentioned in this information.&nbsp;See section 4.<\/p>\n\n\n\n<p>In this leaflet you will find information on:<br>1. What Spironolactone Accord is and what it is used for<br>2. What you need to know before taking Spironolactone Accord<br>3. How to take Spironolactone Accord<br>4. Possible side effects<br>5. How to store Spironolactone Accord<br>6. Contents of the packaging and other information<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Spironolactone Accord is and what it is used for<\/h2>\n\n\n\n<p>The active ingredient in these tablets is&nbsp;spironolactone&nbsp;.&nbsp;Spironolactone&nbsp;belongs to a group of drugs called aldosterone antagonists, which counteract the effect of the&nbsp;hormone&nbsp;et&nbsp;aldosterone&nbsp;.&nbsp;One of the functions of&nbsp;aldosterone&nbsp;is to ensure that the body retains&nbsp;sodium&nbsp;(salt).&nbsp;It forms part of a system that regulates the body&#8217;s balance of fluids and salts (RAAS,&nbsp;the renin&nbsp;&#8211;&nbsp;angiotensin&nbsp;-aldosterone system).&nbsp;Spironolactone&nbsp;promotes the excretion of urine in patients who have an accumulation of fluid in the&nbsp;tissues&nbsp;(&nbsp;edema&nbsp;) or in the abdominal cavity (&nbsp;ascites) by increasing the amount of&nbsp;sodium&nbsp;excreted in the urine.&nbsp;The loss of potassium that can occur due to the use of certain&nbsp;diuretics&nbsp;(&nbsp;diuretics&nbsp;) is reduced.&nbsp;The blood pressure-lowering effect is dependent on the excretion of water and salt.<\/p>\n\n\n\n<p>Spironolactone Accord can be prescribed by a doctor for the treatment of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fluid accumulation in the&nbsp;tissues&nbsp;as a result of heart disease<\/li><li>Moderate to severe&nbsp;heart failure&nbsp;(NYHA class III-IV)<\/li><li>elevated&nbsp;blood pressure&nbsp;, in addition to a salt-free diet and&nbsp;diuretic&nbsp;drugs<\/li><li>certain kidney diseases<\/li><li>fluid accumulation in the&nbsp;tissues&nbsp;in the abdominal cavity<\/li><\/ul>\n\n\n\n<p>Spironolactone Accord can also be used during medical examinations to confirm the presence of diseases in which too much&nbsp;aldosterone&nbsp;is produced in the&nbsp;adrenal cortex&nbsp;(a condition called Conn&#8217;s disease), and to treat these diseases.<\/p>\n\n\n\n<p>Children should only be treated by a paediatrician.<\/p>\n\n\n\n<p>The spironolactone contained&nbsp;in Spironolactone Accord may also be approved to treat other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you take Spironolactone Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Spironolactone Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;spironolactone&nbsp;or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have severely impaired kidney function or if your kidney disease worsens rapidly or suddenly, which may mean that no urine or very little urine is produced.<\/li><li>if you have low levels of&nbsp;sodium&nbsp;in your blood (&nbsp;hyponatremia&nbsp;)<\/li><li>if you have&nbsp;hyperkalemia&nbsp;(increased potassium levels in the blood) or other conditions that may occur in association with&nbsp;hyperkalemia&nbsp;.<\/li><li>if you are taking potassium-sparing&nbsp;diuretics&nbsp;(including eplerenone) or potassium supplements or if you have a double blockade of the RAAS due to a combination of two antihypertensive drugs: an&nbsp;ACE inhibitor&nbsp;(angiotensin-converting enzyme inhibitor) and an ARB (angiotensin receptor blocker).<\/li><\/ul>\n\n\n\n<p><strong>Children<\/strong><\/p>\n\n\n\n<p>Children with moderate to severe kidney disease must not take Spironolactone Accord.<\/p>\n\n\n\n<p><strong>Take special care with Spironolactone Accord<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a kidney disease, this applies especially to children with high&nbsp;blood pressure&nbsp;.&nbsp;The doctor will check you regularly.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Spironolactone Accord<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you need to use Spironolactone Accord for a longer period, your doctor will do regular checks (eg checking the levels of&nbsp;potassium&nbsp;and&nbsp;sodium&nbsp;in your blood), especially if you are elderly.<\/li><li>if you have liver disease, your doctor will use caution when treating you<\/li><li>if you have kidney disease, your doctor will use caution when treating you<\/li><li>if you have an elevated level of&nbsp;potassium&nbsp;in your blood or impaired kidney function, treatment with Spironolactone Accord is not recommended (see also &#8220;Do not take Spironolactone Accord&#8221;)<\/li><li>if you have severely impaired kidney function and are being treated with potassium supplements, as severe&nbsp;hyperkalaemia&nbsp;can occur which can lead to cardiac arrest (sometimes fatal)<\/li><li>if you are using certain&nbsp;diuretic&nbsp;medicines called potassium-sparing diuretics (eg amiloride and triamterene) simultaneous use with Spironolactone Accord is not allowed because the risk of very high levels of&nbsp;potassium&nbsp;in the blood (&nbsp;hyperkalemia&nbsp;) increases<\/li><li>for long-term use of Spironolactone Accord in young patients, the doctor should carefully weigh the benefits against the long-term disadvantages.<\/li><li>Concomitant&nbsp;administration&nbsp;of Spironolactone Accord with certain medicines, potassium supplements and foods high in&nbsp;potassium&nbsp;can cause severe&nbsp;hyperkalaemia&nbsp;(increased level of potassium in the blood).&nbsp;Symptoms of severe&nbsp;hyperkalemia&nbsp;may include muscle cramps, irregular heartbeat, diarrhea, nausea, dizziness, or headache.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if any of the above warnings apply to you, or if they have ever applied to you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Spironolactone Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.&nbsp;Your doctor may change your&nbsp;dose&nbsp;of Spironolactone Accord if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines for high&nbsp;blood pressure&nbsp;including ACE inhibitors and medicines called ganglion blocking medicines<\/li><li>other&nbsp;diuretic&nbsp;medicines<\/li><li>non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;), e.g.&nbsp;aspirin&nbsp;and&nbsp;ibuprofen<\/li><li>potassium supplements<\/li><li>heparin&nbsp;or low molecular weight&nbsp;heparin&nbsp;(medicines used to prevent blood clots)<\/li><li>drugs that inhibit the blood&#8217;s ability to clot (&nbsp;anticoagulants&nbsp;, blood thinners),&nbsp;norepinephrine&nbsp;(an agent with a stimulating effect on certain parts of the nervous system)<\/li><li>lithium (used to treat depression)<\/li><li>digoxin&nbsp;(used to treat various heart conditions)<\/li><li>alcohol,&nbsp;barbiturates&nbsp;(e.g. used in&nbsp;epilepsy&nbsp;), or narcotics<\/li><li>medicines known to cause&nbsp;hyperkalaemia&nbsp;(increased levels of&nbsp;potassium&nbsp;in the blood)<\/li><li>cholestyramine (used to reduce cholesterol levels in the blood)<\/li><li>corticosteroids&nbsp;, ACTH (adrenocorticotropic&nbsp;hormone&nbsp;, used in various epileptic conditions)<\/li><li>ammonium chloride (e.g. found in licorice)<\/li><li>ciclosporin (used after transplant)<\/li><li>trimethoprim and trimethoprim-sulfamethoxazole<\/li><li>if you are using abiraterone to treat prostate cancer<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Spironolactone Accord with food<\/h2>\n\n\n\n<p>The effect of Spironolactone Accord is not affected by food.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.<\/p>\n\n\n\n<p>Spironolactone&nbsp;should not be used during pregnancy.<\/p>\n\n\n\n<p>Spironolactone&nbsp;should only be used during pregnancy if absolutely necessary.<\/p>\n\n\n\n<p>If you are breast-feeding, you should discuss the use of&nbsp;spironolactone&nbsp;with the doctor, who will advise you to consider another method of feeding the baby while taking this medicine.<\/p>\n\n\n\n<p>If you are planning to have children, you should be aware that&nbsp;spironolactone&nbsp;can induce&nbsp;impotence&nbsp;and irregular menstruation.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Side effects&nbsp;such as dizziness, headache and confusion can sometimes occur when using Spironolactone Accord.&nbsp;If this happens, do not drive or use machinery.&nbsp;<\/p>\n\n\n\n<p>You yourself are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects&nbsp;.&nbsp;Description of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;Discuss with your doctor or pharmacist if you are unsure<\/p>\n\n\n\n<p><strong>Spironolactone Accord contains&nbsp;lactose<\/strong><\/p>\n\n\n\n<p>The medicine contains&nbsp;lactose&nbsp;.&nbsp;If you have an intolerance to certain sugars, you should consult your doctor before taking this medication<a><\/a><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Spironolactone Accord<\/h2>\n\n\n\n<p>Always take this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<p><em><strong>Adults<\/strong><\/em><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 100 mg daily, as a single dose or multiple&nbsp;doses&nbsp;.&nbsp;Dosage&nbsp;for adults varies from 25 mg to 400 mg of&nbsp;spironolactone&nbsp;per day.&nbsp;If you do not know how much to take, ask your doctor or pharmacist for advice.<\/p>\n\n\n\n<p>The tablets should be taken with a meal.&nbsp;If the total&nbsp;dose&nbsp;is more than 100 mg per day, the&nbsp;dose&nbsp;must be given as divided&nbsp;doses&nbsp;spread throughout the day.<\/p>\n\n\n\n<p><strong><em>Use for children<\/em><\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 3 mg per kg of body weight daily, in several divided&nbsp;doses&nbsp;.&nbsp;To make it easier for children to take the tablets, they can first be crumbled or crushed and then dissolved in a glass of water by stirring.<\/p>\n\n\n\n<p><strong><em>Older<\/em><\/strong><\/p>\n\n\n\n<p>Elderly patients should start with the lowest possible&nbsp;dose&nbsp;which is gradually increased until the desired effect is achieved.&nbsp;Caution and regular medical check-ups are recommended, especially in case of impaired renal function.<\/p>\n\n\n\n<p>Remember to take the medicine.&nbsp;You get the best effect if you take the tablets at the same time every day.&nbsp;It also helps you remember to take the tablets.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have taken too much Spironolactone Accord<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example,&nbsp;a child has accidentally ingested the medicine, immediately contact a doctor, pharmacist, hospital or the Poison Information Center (tel. 112) for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Keep the packaging so that healthcare professionals know which medicine you have taken.&nbsp;Symptoms of overdose may include nausea and vomiting and, in rare cases, drowsiness, confusion, rash or diarrhoea.&nbsp;Disturbances of the fluid and salt balance and dehydration may occur.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Spironolactone Accord<\/h2>\n\n\n\n<p>If you have forgotten to take a&nbsp;dose&nbsp;, take it as soon as you remember, provided it is not soon time to take the next&nbsp;dose&nbsp;.&nbsp;If it is almost time to take the next&nbsp;dose&nbsp;, do not take the missed&nbsp;dose&nbsp;, but instead continue according to the treatment schedule.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a missed&nbsp;dose&nbsp;.&nbsp;Ask your doctor or pharmacist if you are unsure.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Spironolactone Accord<\/h2>\n\n\n\n<p>If you stop taking Spironolactone Accord, the original symptoms may return.&nbsp;Always contact a doctor if you want to stop using this medicine.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects&nbsp;depend on&nbsp;dose&nbsp;and duration of treatment.<\/p>\n\n\n\n<p>The most common&nbsp;side effects&nbsp;are&nbsp;hyperkalemia&nbsp;and problems in the reproductive organs and mammary gland, including&nbsp;gynecomastia&nbsp;(enlarged mammary glands in men).&nbsp;Gynecomastia appears to be related to both dose level and duration of treatment, and usually returns to normal when treatment is discontinued.&nbsp;Other very common&nbsp;side effects&nbsp;are headache, indigestion, diarrhea, fatigue and sleepiness.<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hyperkalemia&nbsp;in patients with severely impaired renal function who are simultaneously receiving treatment with potassium supplements<\/li><li>Headache<\/li><li>Indigestion, diarrhea<\/li><li>Men: decreased&nbsp;libido&nbsp;(sex drive), erection problems (&nbsp;impotence&nbsp;), enlargement of mammary glands (&nbsp;gynecomastia&nbsp;)<\/li><li>Women: mammary gland problems, breast tenderness, menstrual disorders, darker voice (irreversible in many cases)<\/li><li>Fatigue, sleepiness<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low levels of&nbsp;sodium&nbsp;in the blood (&nbsp;hyponatremia&nbsp;occurs mainly during combined intensive treatment with&nbsp;diuretics&nbsp;called thiazide diuretics),&nbsp;hyperkalemia&nbsp;in:<br>&#8211; patients with severe renal impairment,<br>&#8211; patients receiving treatment with ACE inhibitors or potassium chloride,<br>&#8211; the elderly,<br>&#8211; diabetic patients .<\/li><li>Nausea and vomiting<\/li><li>Women: changes in vaginal secretions (e.g. discharge), decreased&nbsp;libido&nbsp;(sex drive), absence of periods (&nbsp;amenorrhea&nbsp;),&nbsp;postmenopausal&nbsp;bleeding (abdominal bleeding after menopause)<\/li><li>Weakness, sleepiness (lethargy) in patients with cirrhosis (&nbsp;cirrhosis&nbsp;), tingling,&nbsp;itching&nbsp;or tickling for which there is no cause (&nbsp;paresthesia&nbsp;)<\/li><li>General weakness<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Acid poisoning in the blood (&nbsp;acidosis&nbsp;) in patients with liver problems<\/li><li>Confusion<\/li><li>Skin rash,&nbsp;hives&nbsp;(&nbsp;urticaria&nbsp;), redness of the skin (&nbsp;erythema&nbsp;), chloasma (pigmented spots on the skin, especially on the face), generalized&nbsp;itching<\/li><li>Muscle cramps<\/li><li>Leg cramps<\/li><li>Elevated levels of&nbsp;serum creatinine<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Very serious abnormalities in the content of the blood (lack of&nbsp;white blood cells&nbsp;) accompanied by sudden high fever, severe throat pain and mouth ulcers (&nbsp;agranulocytosis&nbsp;), other abnormalities in the content of the blood (lack of&nbsp;platelets&nbsp;) accompanied by bruising and a tendency to bleed (&nbsp;thrombocytopenia&nbsp;)<\/li><li>Allergic reactions<\/li><li>Insufficient fluid in the&nbsp;tissues&nbsp;(dehydration), metabolic disease (&nbsp;porphyria&nbsp;), temporary increase in nitrogen levels in the blood and urine, increased levels of&nbsp;uric acid&nbsp;in the blood (hyperuricemia).&nbsp;This can lead to gout attacks (joint inflammation) in sensitive patients.<\/li><li>Paralysis, bilateral paralysis (paraplegia) in e.g.&nbsp;arms and legs due to&nbsp;hyperkalemia<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Breast cancer<\/li><li>Inflammation&nbsp;of blood vessel walls (&nbsp;vasculitis&nbsp;)<\/li><li>Stomach inflammation,&nbsp;peptic ulcer&nbsp;, intestinal bleeding, cramps<\/li><li>Liver inflammation (&nbsp;hepatitis&nbsp;)<\/li><li>Hair loss (&nbsp;alopecia&nbsp;),&nbsp;eczema&nbsp;, EAC (annular erythema)<\/li><li>Systemic lupus erythematosus (&nbsp;SLE&nbsp;, a disease in which the immune system attacks various organs in the body)<\/li><li>Acute&nbsp;renal failure<\/li><li>Increased hair growth (hypertrichosis)<\/li><li>Softening of bone tissue (&nbsp;osteomalacia&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurring in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Mild androgenic effects (development of male characteristics), including&nbsp;hirsutism&nbsp;(strongly increased hair growth that is hormonally determined)<\/li><li>In some patients with decompensated&nbsp;liver cirrhosis&nbsp;(severe symptoms\/complications of cirrhosis),&nbsp;reversible&nbsp;hyperchloraemic metabolic&nbsp;acidosis&nbsp;(disturbed&nbsp;acid-base balance&nbsp;with low blood&nbsp;pH&nbsp;) and usually also abnormally high levels of&nbsp;potassium&nbsp;in the blood have been reported.&nbsp;This has also occurred in cases where kidney function was normal.<\/li><li>Dizziness, coordination difficulties (&nbsp;ataxia&nbsp;)<\/li><li>Slight lowering of&nbsp;blood pressure&nbsp;et<\/li><li>Itching&nbsp;and blistering of the skin around the lips and the rest of the body (Stevens-Johnson syndrome)<\/li><li>Detachment of the upper skin layer from the lower skin layers over the entire body (&nbsp;toxic epidermal necrolysis&nbsp;)<\/li><li>Skin rash, fever and swelling (which can be symptoms of something more serious, drug-induced rash and changes in blood count and systemic symptoms)<\/li><li>Pemphigoid&nbsp;(a condition that causes fluid-filled blisters on the skin)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get side effects, talk to your doctor, pharmacist or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Swedish Medicines Agency,&nbsp;<a target=\"_blank\" href=\"http:\/\/www.lakemedelsverket.se\/\" rel=\"noreferrer noopener\">www.lakemedelsverket.se<\/a>.&nbsp;By reporting side effects, you can help increase information about drug safety.<a href=\"javascript:void(0);\">Postal address<\/a><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Spironolactone Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>No particular storage temperature.&nbsp;Store in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>Use before the expiry date stated on the carton and blister after EXP or EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among household waste.&nbsp;Ask the pharmacist how to dispose of medicines that are no longer used.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;spironolactone&nbsp;.&nbsp;Spironolactone Accord contains 25 mg, 50 mg or 100 mg&nbsp;of spironolactone&nbsp;.<\/li><li>Other ingredients are:<br><em>Tablet core:<\/em>Lactose monohydrate&nbsp;, pregelatinized corn starch, anhydrous calcium hydrogen phosphate, povidone K25, peppermint oil, purified talc,&nbsp;colloidal&nbsp;anhydrous silica, magnesium stearate (E470b).<br><em>Coating:<\/em>Hypromellose, macrogol, titanium dioxide (E171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Spironolactone Accord 25 mg film-coated tablets are white to off-white, round, biconvex tablets debossed with \u201cAD\u201d on one side and plain on the other side.&nbsp;The 25 mg tablet has a diameter of approximately 8.1 mm.<\/p>\n\n\n\n<p>Spironolactone Accord 50 mg film-coated tablets are white to off-white, round, biconvex tablets debossed with \u201cAE\u201d on one side and plain on the other side.&nbsp;The 50 mg tablet has a diameter of approximately 10.1 mm.<\/p>\n\n\n\n<p>Spironolactone Accord 100 mg film-coated tablets are white to off-white, round, biconvex tablets debossed with \u201cAF\u201d on one side and plain on the other side.&nbsp;The 100 mg tablet has a diameter of approximately 11.2 mm.<\/p>\n\n\n\n<p>The tablets are packed in PVC\/aluminium blisters and HDPE cans.<\/p>\n\n\n\n<p>Pack sizes:<br>Blisters: 20, 28, 30, 50, 60, 90 and 100 tablets.<br>HDPE cans: 250, 500 and 1000 tablets (intended for hospital use and dose dispensing only).<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomirska 50,95-200 Pabianice, Poland<\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>25 mg, 50 mg and 100 mg&nbsp;film-coated tabletsspironolactone Read this leaflet carefully before you start using this medicine.&nbsp;It contains information that is important to you. &#8211; Save this information, you may need to read it again. &#8211; If you have further questions, ask your doctor or pharmacist. &#8211; This medicine has been prescribed only for [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200],"tags":[],"class_list":["post-23513","post","type-post","status-publish","format-standard","hentry","category-medicines"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23513"}],"version-history":[{"count":2,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23513\/revisions"}],"predecessor-version":[{"id":23567,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23513\/revisions\/23567"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}