{"id":23275,"date":"2022-07-26T06:27:39","date_gmt":"2022-07-26T06:27:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23275"},"modified":"2022-07-27T06:15:48","modified_gmt":"2022-07-27T06:15:48","slug":"skyrizi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/skyrizi\/","title":{"rendered":"Skyrizi &#8211; Risankizumab uses, dose and side effects"},"content":{"rendered":"\n<p>risankizumab 150 mg solution for injection&nbsp;in<\/p>\n\n\n\n<p>&nbsp;pre-filled<br>pen<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Skyrizi is and what it is used for<\/h2>\n\n\n\n<p>Skyrizi contains the active substance risankizumab.<\/p>\n\n\n\n<p>Skyrizi is used to treat the following inflammatory diseases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Plaque psoriasis<\/li><li>Psoriatic arthritis<\/li><\/ul>\n\n\n\n<p><strong>How Skyrizi works<\/strong><\/p>\n\n\n\n<p>This drug works by\u00a0inhibiting\u00a0a\u00a0protein\u00a0in the body called IL-23, which causes\u00a0inflammation.<\/p>\n\n\n\n<p><em>Plaque psoriasis<\/em><\/p>\n\n\n\n<p>Skyrizi is used to treat adult patients with moderate to severe plaque psoriasis.\u00a0Skyrizi suppresses\u00a0inflammation\u00a0and can thus reduce the symptoms of plaque psoriasis such as burning,\u00a0itching, pain,\u00a0redness,\u00a0and scaling.<\/p>\n\n\n\n<p><em>Psoriatic arthritis<\/em><\/p>\n\n\n\n<p>Skyrizi is used to treat adult patients with psoriatic arthritis.\u00a0Psoriatic arthritis is a disease that causes\u00a0inflammation\u00a0of the joints and\u00a0psoriasis.\u00a0If you have active psoriatic arthritis, you may have been given other medicines first.\u00a0If these medicines have not worked well enough, you can be given Skyrizi, either as a single medicine or together with other medicines to treat your psoriatic arthritis.<\/p>\n\n\n\n<p>Skyrizi suppresses\u00a0inflammation\u00a0and can therefore help reduce pain, stiffness, and swelling in and around your joints, pain, and stiffness in your spine,\u00a0psoriasis\u00a0on the skin, and damage caused by\u00a0psoriasis\u00a0on the nails, and slow down damage to bones and\u00a0cartilage\u00a0in your joints.\u00a0These effects can facilitate your daily activities, reduce your fatigue and improve your quality of life.<br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Skyrizi<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Skyrizi<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to risankizumab or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have an\u00a0infection\u00a0that your doctor considers significant, such as active\u00a0tuberculosis.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before and while using Skyrizi:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have an ongoing\u00a0infection\u00a0or if you have an\u00a0infection\u00a0that recurs.<\/li><li>if you have\u00a0tuberculosis\u00a0(TB).<\/li><li>if you have recently received or are about to receive vaccination (immunization).\u00a0You should not receive certain types of vaccines while using Skyrizi.<\/li><\/ul>\n\n\n\n<p>It is important to document the Skyrizi manufacturing batch number.<\/p>\n\n\n\n<p>Each time you receive a new package of Skyrizi, you must record the date and batch number (which is on the package after &#8220;Lot&#8221;) and keep this information in a safe place.<\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<p>Tell your doctor or seek medical attention immediately if you notice signs of an&nbsp;allergic reaction&nbsp;while taking Skyrizi such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing or swallowing<\/li><li>swelling of the face, lips, tongue, or throat<\/li><li>severe skin itching, with red rashes or raised nodules<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Skyrizi is not recommended for children and adolescents under 18 years of age as Skyrizi has not been studied in this age group.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Skyrizi<\/h2>\n\n\n\n<p>Tell the doctor, pharmacist, or nurse:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are taking, have recently taken, or may be taking other medicines.<\/li><li>if you have recently received or are about to receive a vaccination.\u00a0You should not receive certain types of vaccines while using Skyrizi.<\/li><\/ul>\n\n\n\n<p>If you are not sure, talk to your doctor, pharmacist, or nurse before and while using Skyrizi.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, contraception, and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.\u00a0This is because it is not known how this medicine affects the baby.<\/p>\n\n\n\n<p>If you are a woman who could become pregnant, you should use birth control while you are using this medicine and for at least 21 weeks after your last&nbsp;dose&nbsp;of Skyrizi.<\/p>\n\n\n\n<p>If you are breastfeeding or plan to breastfeed, talk to your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Skyrizi is unlikely to affect your ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Skyrizi contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0of sodium\u00a0per pre-filled\u00a0pen, i.e. it is almost &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Skyrizi<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor or pharmacist.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>This medicine is given as an&nbsp;injection&nbsp;under the skin (so-called &#8220;subcutaneous injection&#8221;).<\/p>\n\n\n\n<p><strong>How much Skyrizi to use<\/strong><\/p>\n\n\n\n<p>Each\u00a0dose\u00a0is 150 mg and is given as a single\u00a0injection.\u00a0After the first\u00a0dose, you will receive the next\u00a0dose\u00a04 weeks later, and then every 12 weeks.<\/p>\n\n\n\n<p>Together with your doctor, pharmacist, or nurse, you will be able to decide when you are ready to start injecting the medicine yourself.\u00a0Do not inject yourself with this medicine unless you have been trained by your doctor, pharmacist, or nurse.\u00a0A healthcare provider can also give you your\u00a0injection\u00a0after receiving training.<\/p>\n\n\n\n<p><strong>Read section 7 \u201cInstructions for use\u201d at the end of this information before injecting Skyrizi yourself.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used too much Skyrizi&nbsp;<\/h2>\n\n\n\n<p>Talk to your doctor if you have used more Skyrizi than you should or if a&nbsp;dose&nbsp;has been given earlier than prescribed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Skyrizi<\/h2>\n\n\n\n<p>If you forget to use Skyrizi, inject a&nbsp;dose&nbsp;as soon as you remember.&nbsp;Talk to your doctor if you are not sure what to do.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Skyrizi<\/h2>\n\n\n\n<p>Do not stop using Skyrizi without first talking to your doctor.&nbsp;If you stop treatment, your symptoms may return.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Talk to a doctor or seek medical attention immediately if you have symptoms of a serious&nbsp;infection&nbsp;such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever,\u00a0flu-like symptoms, night sweats<\/li><li>feeling tired or short of breath, cough that does not go away<\/li><li>hot, red, and painful skin, or a painful rash with blisters<\/li><\/ul>\n\n\n\n<p>The doctor will then decide whether you can continue to use Skyrizi.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0ar<\/strong><\/p>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you get any of the following\u00a0side\u00a0effects<\/p>\n\n\n\n<p><strong>Very common:<\/strong>&nbsp;may affect more than 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>upper respiratory tract infections with symptoms such as sore throat and stuffy nose<\/li><\/ul>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>feeling of fatigue<\/li><li>fungal infection of the skin<\/li><li>injection site reactions (such as&nbsp;redness&nbsp;or pain)<\/li><li>itching<\/li><li>headache<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>small raised bumps on the skin<\/li><\/ul>\n\n\n\n<p><strong>Reporting of&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>If you get\u00a0side effects, talk to your doctor, pharmacist, or nurse.\u00a0This also applies to any\u00a0side effects\u00a0that are not mentioned in this information.\u00a0You can also report\u00a0side effects\u00a0directly via the national reporting system listed in Appendix V. By reporting\u00a0side effects, you can contribute to increasing information about drug safety.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Skyrizi<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the pen label and the outer packaging after &#8220;EXP&#8221;.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0C-8 \u00b0C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Store the pre-filled pen in the original packaging.&nbsp;Light sensitive.<\/p>\n\n\n\n<p>If necessary, you can also store the pre-filled injection pen outside the refrigerator (up to a maximum of 25\u00b0C) for up to 24 hours in the original packaging to protect it from light.<\/p>\n\n\n\n<p>Do not use this medicine if the solution is cloudy, and contains flakes or large particles.<\/p>\n\n\n\n<p>Medicines must not be thrown into the drain or among the household waste.\u00a0Ask the pharmacist how to dispose of medicines that are no longer used.\u00a0These measures will help to protect the environment.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is risankizumab.\u00a0Each pre-filled\u00a0pen\u00a0contains 150 mg of risankizumab in 1 ml of solution.<\/li><li>Other ingredients are sodium acetate trihydrate, acetic acid, trehalose dihydrate, polysorbate 20, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Skyrizi is a clear and colorless to yellow liquid in a pre-filled\u00a0pen.\u00a0The solution may contain small white or transparent particles.<\/p>\n\n\n\n<p>Each pack contains 1 pre-filled\u00a0pen.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>AbbVie Deutschland GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Knollstrasse<\/p>\n\n\n\n<p>67061 Ludwigshafen<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Skyrizi contains the active substance risankizumab<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24325,24330,24321,24324,24326,24329,24322,24327,24323,24328],"class_list":["post-23275","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-risankizumab","tag-benefits-of-skyrizi","tag-risankizumab","tag-risankizumab-side-effects","tag-skyrizi","tag-skyrizi-side-effects","tag-what-is-risankizumab","tag-what-is-skyrizi","tag-what-risankizumab-is-used-for","tag-what-skyrizi-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23275"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23275\/revisions"}],"predecessor-version":[{"id":23314,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23275\/revisions\/23314"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}