{"id":23241,"date":"2022-07-25T12:03:38","date_gmt":"2022-07-25T12:03:38","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23241"},"modified":"2022-07-26T06:16:36","modified_gmt":"2022-07-26T06:16:36","slug":"sixmo","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sixmo\/","title":{"rendered":"Sixmo &#8211; Buprenorphine uses, dose and side effects"},"content":{"rendered":"\n<p>74.2 mg&nbsp;implant<br>buprenorphine<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Sixmo is and what it is used for<\/h2>\n\n\n\n<p>Sixmo contains the active substance buprenorphine, which is a type of opioid medicine.\u00a0It is used to treat opioid addiction in adults who also receive medical, social, and psychological support.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Sixmo<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Sixmo<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to buprenorphine or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have severe breathing problems<\/li><li>if you have severely impaired liver function<\/li><li>if you are intoxicated with alcohol or have\u00a0delirium tremens\u00a0which is an\u00a0acute\u00a0state of confusion caused by alcohol withdrawal<\/li><li>if you are using naltrexone or nalmefene to treat alcohol or opioid dependence<\/li><li>if you have increased scarring or scar tissue.<\/li><li>Patients who cannot undergo an examination with magnetic resonance imaging (MRI) must not be treated with Sixmo.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and precautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Sixmo if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>asthma\u00a0or other breathing problems<\/li><li>mild or moderate liver problems<\/li><li>impaired kidney function<\/li><li>head injury or other conditions which mean that the pressure in the head may be elevated<\/li><li>previous seizures\u00a0<\/li><li>low\u00a0blood pressure<\/li><li>enlarged\u00a0prostate\u00a0or narrowing of the urethra (that the urethra has become narrower than usual in some places and urine becomes difficult to pass)<\/li><li>underactive\u00a0thyroid<\/li><li>impaired adrenal function, e.g.\u00a0Addison&#8217;s disease<\/li><li>reduced function of the bile ducts<\/li><li>general weakness and impaired general condition, or if you are elderly<\/li><li>or have had a connective tissue disease, e.g.\u00a0scleroderma<\/li><li>or have had recurrent\u00a0MRSA\u00a0infection\u00a0(\u00a0infection\u00a0caused by methicillin-resistant<\/li><li>Staphylococcus aureus\u00a0&#8211;\u00a0bacteria\u00a0)<\/li><li>depression or other conditions treated with antidepressants.<\/li><\/ul>\n\n\n\n<p>If these medicines are used together with Sixmo, this can lead to serotonin syndrome, a condition that can be life-threatening (see &#8220;Other medicines and Sixmo&#8221;).<\/p>\n\n\n\n<p><strong>Important information to consider during treatment:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Drowsiness<\/strong>\u00a0may occur, especially in the first week after insertion.\u00a0See &#8220;Driving ability and use of machines&#8221;.<\/li><li>The doctor must examine the\u00a0<strong>place where the\u00a0implant\u00a0was inserted<\/strong>\u00a0for signs of\u00a0infection\u00a0and wound problems:<ul><li>one week after insertion of\u00a0implants\u00a0and<\/li><li>at least once per month thereafter.<\/li><\/ul><\/li><li><strong>Infection<\/strong>\u00a0can occur<strong>\u00a0at the place where an\u00a0implant\u00a0is inserted or removed<\/strong>.\u00a0If you frequently touch the\u00a0implant\u00a0or the place where the\u00a0implant\u00a0was inserted, shortly after insertion, it can increase the risk of\u00a0infection.\u00a0Tell your doctor immediately if you develop signs of\u00a0infection\u00a0(such as\u00a0redness\u00a0or\u00a0inflammation\u00a0) at the site of insertion or removal.<ul><li>If an\u00a0implant\u00a0comes out (through the skin) after insertion, do the following:<\/li><li>Book an appointment with the doctor who inserted the\u00a0implant\u00a0as soon as possible.<\/li><li>Place the\u00a0implant\u00a0in a glass jar with a lid.\u00a0Keep the jar out of the reach of others, especially children.\u00a0Take it to the doctor who inserted the\u00a0implant\u00a0to determine if the entire\u00a0implant\u00a0has come out.<\/li><li>Note!\u00a0Buprenorphine can cause severe, possibly fatal,\u00a0respiratory depression\u00a0(shortness of breath or respiratory arrest) in children if accidentally exposed.<\/li><li>The doctor will monitor you until the\u00a0implant\u00a0is replaced with a new one to assess withdrawal symptoms.<\/li><\/ul><\/li><li>Do not move the\u00a0implant\u00a0around under the skin and do not gain too much weight after inserting Sixmo as this may make it difficult to locate the\u00a0implant.<\/li><li>Improper Use and Abuse: Misuse of buprenorphine can lead to overdose and death.\u00a0The risk increases if you use alcohol or other substances at the same time.<\/li><li>This drug can cause dependence, but at a lower level than other substances such as morphine.\u00a0If you stop treatment with Sixmo, your doctor will monitor you for\u00a0withdrawal symptoms.<\/li><li>Several deaths due to\u00a0respiratory depression\u00a0have been reported during treatment with buprenorphine.\u00a0This mainly occurs with the simultaneous use of alcohol, other\u00a0opioids,\u00a0or certain drugs that have a sedative, sleep-inducing, or muscle-relaxing effect.\u00a0Buprenorphine can lead to fatal breathing problems in non-addicted people or children.<\/li><li>Sixmo should be used with caution in patients with\u00a0asthma\u00a0or other breathing problems.<\/li><li>Liver damage,\u00a0including liver failure, has been reported with buprenorphine use.\u00a0This may be related to existing impaired liver function and ongoing injection drug abuse.\u00a0If liver problems are suspected, the doctor will take samples to decide whether treatment should be stopped.<\/li><li>During treatment with Sixmo, situations may arise which mean that you need\u00a0emergency\u00a0pain treatment or anesthesia.\u00a0Consult a doctor or pharmacist in these cases.<\/li><li>Substances such as buprenorphine can cause small\u00a0pupils,\u00a0<strong>change the level of consciousness<\/strong>\u00a0or change the way you experience\u00a0<strong>pain.<\/strong>\u00a0<\/li><li>Substances such as buprenorphine can cause a sudden drop in\u00a0<strong>blood pressure<\/strong>\u00a0that leads to dizziness when you stand up quickly.<\/li><\/ul>\n\n\n\n<p><strong>Patients over 65 years of age<\/strong><\/p>\n\n\n\n<p>Sixmo is not recommended for patients over 65 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Sixmo is not recommended for children under 18 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Sixmo<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are using, have recently used, or might be using other medicines.<\/p>\n\n\n\n<p>During treatment with Sixmo, it is especially important to&nbsp;<strong>inform the doctor<\/strong>&nbsp;before using:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines that have a sedative, sleep-inducing, or muscle-relaxing effect, with active substances whose names end in &#8220;-diazepam&#8221;.<\/li><li>This combination can lead to death due to\u00a0respiratory depression.\u00a0During treatment with Sixmo, these medicines should therefore only be used on the doctor&#8217;s advice and according to the prescribed\u00a0dose.<\/li><li>Other medicines that have an inhibitory effect on the brain or spinal cord, as these reduce alertness and make it dangerous to drive and use machines, for example:<ul><li>other opioid derivatives such as\u00a0methadone, strong painkillers, and cough suppressants<\/li><li>certain medicines to treat depression<\/li><li>medicines called\u00a0antihistamines\u00a0which are used to treat allergic reactions, and sleep problems or to prevent and treat nausea and vomiting<\/li><li>drugs to treat\u00a0epilepsy\u00a0or to sedate (calm\/sleep), with active substances that usually end in &#8220;-tal&#8221;<\/li><li>medicines to treat anxiety, other than those described under the first point<\/li><li>medicines to treat mental illnesses or anxiety disorders, with a sedative effect, called\u00a0neuroleptics<\/li><li>clonidine: a medicine to treat high\u00a0blood pressure\u00a0and high pressure in the eyes.<\/li><\/ul><\/li><li>Naltrexone and nalmefene are used to treat addiction.<\/li><li>They can block the effects of buprenorphine.\u00a0Do not use these medicines during treatment with Sixmo as they can suddenly cause prolonged and intense withdrawal symptoms.<\/li><li>Medicines to treat\u00a0HIV\u00a0infection\u00a0with active substances whose names end in &#8221; &#8211;\u00a0never&#8221;, such as ritonavir, nelfinavir, amprenavir, and fosamprenavir.<\/li><li>Medicines to treat fungal infections, such as thrush, with active substances whose names end in &#8220;-azole&#8221;, such as\u00a0ketoconazole, itraconazole,\u00a0and fluconazole<\/li><li>Clarithromycin, erythromycin, troleandomycin: medicines to treat bacterial infections.<\/li><li>Nefazodone: a medicine to treat depression.<\/li><li>Verapamil,\u00a0diltiazem, amiodarone: drugs to treat high\u00a0blood pressure\u00a0and heart disease.<\/li><li>Aprepitant: a medicine to prevent nausea and vomiting.<\/li><li>Phenobarbital, carbamazepine, phenytoin: drugs to treat\u00a0epilepsy\u00a0and other disorders.<\/li><li>Rifampicin: a medicine to treat\u00a0tuberculosis\u00a0or some other\u00a0infections.<\/li><li>Certain medicines to treat depression or\u00a0Parkinson&#8217;s disease\u00a0are called\u00a0monoamine oxidase inhibitors, such as phenelzine, isocarboxazid, iproniazid, and <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tranylcypromine-glenmark\/\">tranylcypromine<\/a>.<\/li><li>Antidepressants such as moclobemide, tranylcypromine,\u00a0citalopram, escitalopram,\u00a0fluoxetine, fluvoxamine,\u00a0paroxetine, sertraline, duloxetine,\u00a0venlafaxine, amitriptyline, doxepin or trimipramine.\u00a0These medicines can affect or be affected by Sixmo and you may have symptoms such as involuntary rhythmic muscle twitching, including in the muscles that control eye movements, agitation,\u00a0<\/li><li>hallucinations,\u00a0coma, profuse sweating, tremors, increased reflexes, tense muscles, and body temperature above 38 \u00b0C.\u00a0Contact the doctor if you experience such symptoms.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Sixmo with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not drink alcohol during treatment with Sixmo as it increases the sedative (calming) effect.\u00a0Avoid grapefruit juice during treatment, as it may cause\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pregnancy<\/strong>Sixmo is not recommended during pregnancy or for fertile women who are not using contraception. When used during pregnancy, especially in late pregnancy, buprenorphine can cause withdrawal symptoms, including breathing problems, in the newborn baby.\u00a0This can occur several days after delivery.<\/li><li>Breast-feeding you should not breastfeed during treatment with Sixmo because buprenorphine passes into breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving ability and use of machinery<\/h2>\n\n\n\n<p>Buprenorphine can impair the ability to drive and use machines, especially during the first 24 to 48 hours and up to a week after\u00a0implant placement.\u00a0You may feel dizzy, drowsy, and tired.\u00a0Do not drive or perform any hazardous activities until you are sure that Sixmo will not impair your ability to perform such activities.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Sixmo<\/h2>\n\n\n\n<p>Always use this medicine as directed by your doctor.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Sixmo&nbsp;implants&nbsp;must be inserted and removed, and patients monitored, by healthcare professionals knowledgeable about the procedure and experienced in the treatment of opioid addiction.<\/p>\n\n\n\n<p><strong>Before Sixmo&nbsp;implants&nbsp;are inserted<\/strong><\/p>\n\n\n\n<p>You must be on a stable buprenorphine dose, of between 2 and 8 mg\/day, which you receive under the tongue.&nbsp;You must stay on the stable&nbsp;dose&nbsp;for at least 30 days and this must be determined by the doctor.<\/p>\n\n\n\n<p>Treatment with sublingual buprenorphine will be discontinued 12 to 24 hours before Sixmo\u00a0implant\u00a0insertion.<\/p>\n\n\n\n<p><strong>Treatment with Sixmo&nbsp;implants<\/strong><\/p>\n\n\n\n<p>Each\u00a0dose\u00a0consists of\u00a0<strong>4\u00a0implants.<\/strong><\/p>\n\n\n\n<p>Before the doctor inserts Sixmo, you will be given a&nbsp;local anesthetic&nbsp;to numb the area.&nbsp;An implant&nbsp;is then inserted under the skin on the inside of the upper arm.<\/p>\n\n\n\n<p>After the&nbsp;implant&nbsp;is inserted, the doctor will apply a&nbsp;sterile&nbsp;gauze pad with a pressure bandage to reduce the risk of bruising.&nbsp;You can remove the pressure dressing after 24 hours and the adhesive dressing after five days.&nbsp;Apply a cooling bag to the arm for 40 minutes every two hours for the first 24 hours and then as needed.<\/p>\n\n\n\n<p>The doctor will also give you a patient card that informs you about<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the place of deposit and the date of deposit<\/li><li>date by which the\u00a0implant\u00a0must be removed at the latest.<\/li><\/ul>\n\n\n\n<p>Keep this card in a safe place as the information on the card may make it easier to remove the\u00a0implant.<\/p>\n\n\n\n<p>The doctor will examine the insertion site one week after the&nbsp;implant&nbsp;is inserted and then at least once a month for signs of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;or other problems with wound healing<\/li><li>signs of&nbsp;implant&nbsp;coming out through the skin.<\/li><\/ul>\n\n\n\n<p>Come up with all those necessary visits.&nbsp;Tell the doctor immediately if you think you have an&nbsp;infection&nbsp;at the implant site or if the&nbsp;implant&nbsp;starts to come out.<\/p>\n\n\n\n<p>If you feel you need additional buprenorphine doses, contact your doctor immediately.<\/p>\n\n\n\n<p><strong>Removal of Sixmo&nbsp;implants<\/strong><\/p>\n\n\n\n<p>Sixmo&nbsp;implants&nbsp;are intended to be in place for&nbsp;<strong>6 months<\/strong>&nbsp;and provide a&nbsp;continuous&nbsp;supply of buprenorphine.&nbsp;They are removed by the doctor after 6 months.<\/p>\n\n\n\n<p>Implants\u00a0should only be removed by a doctor who knows the procedure.\u00a0If the\u00a0implant\u00a0cannot be located, the doctor may use ultrasound or an examination with a magnetic camera (called magnetic resonance imaging &#8211; MRI).<\/p>\n\n\n\n<p>After the&nbsp;implant&nbsp;is removed, the doctor will apply a&nbsp;sterile&nbsp;gauze pad with a pressure bandage to reduce the risk of bruising.&nbsp;You can remove the pressure dressing after 24 hours and the adhesive dressing after five days.&nbsp;Apply a cooling bag to the arm for 40 minutes every two hours for the first 24 hours and then as needed.<\/p>\n\n\n\n<p><strong>Continued treatment with Sixmo&nbsp;implants<\/strong><\/p>\n\n\n\n<p>Once the first 6-month treatment period is over, you can get a new set of Sixmo&nbsp;implants&nbsp;after the old ones have been removed, preferably on the same day.&nbsp;New&nbsp;implants&nbsp;must be inserted in the other arm.<\/p>\n\n\n\n<p>If a new set of&nbsp;implants&nbsp;is not inserted on the same day as the previous ones are removed, a&nbsp;dose&nbsp;of between 2 and 8 mg of buprenorphine daily, given under the tongue, is recommended until you continue treatment with Sixmo.&nbsp;This treatment should be discontinued 12 to 24 hours before the next set of Sixmo&nbsp;implants&nbsp;is inserted.<\/p>\n\n\n\n<p><strong>If you get more Sixmo than you need<\/strong><\/p>\n\n\n\n<p>In some cases, the&nbsp;dose&nbsp;delivered by the&nbsp;implant&nbsp;may be greater than you need.&nbsp;Symptoms of overdose include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>little&nbsp;pupils&nbsp;_<\/li><li>sedation&nbsp;(drowsiness)<\/li><li>low&nbsp;blood pressure<\/li><li>difficulty breathing, slow breathing.<\/li><\/ul>\n\n\n\n<p>In the worst case, it can lead to respiratory arrest,\u00a0heart failure,\u00a0and death.<\/p>\n\n\n\n<p>Tell the doctor immediately if you get any of the above symptoms or go to the nearest hospital and take this leaflet and your patient card with you.&nbsp;Do not try to remove&nbsp;implants&nbsp;yourself as it can be very dangerous.<\/p>\n\n\n\n<p>If you have any further questions about this medicine, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects&nbsp;can occur with the following frequencies:<\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>constipation, nausea, vomiting, diarrhea<\/li><li>other stomach and intestinal problems, dental disease<\/li><li>pain such as abdominal pain, bone pain, muscle pain, chest pain, headache<\/li><li>dizziness, drowsiness<\/li><li>insomnia, anxiety, hostility, nervousness<\/li><li>a mental state characterized by delusions and irrationality<\/li><li>high\u00a0blood pressure, palpitations<\/li><li>fainting<\/li><li>dilated\u00a0pupils\u00a0_<\/li><li>hot flushes, bruising, dilated blood vessels<\/li><li>withdrawal symptoms such as sweating, feeling hot or cold<\/li><li>fatigue, chills, weakness, increased muscle tension<\/li><li>infection\u00a0such as viral infection (e.g.\u00a0influenza\u00a0)<\/li><li>cough, shortness of breath<\/li><li>inflammation\u00a0of the respiratory tract (in the lungs, pharynx, or nasal mucosa)<\/li><li>increased sweating, malaise<\/li><li>reduced appetite<\/li><li>increased levels of a liver enzyme,\u00a0alanine aminotransferase, are seen in blood tests<\/li><li>reactions at the implant site<ul><li>pain,\u00a0itching<\/li><li>reactions at the procedure site such as pain during insertion<\/li><li>bruises, skin redness, scars<\/li><li>bleeding.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dry mouth, flatulence, indigestion, bloody stools<\/li><li>migraine, tremors<\/li><li>severe sleepiness<\/li><li>abnormal sensations such as numbness and tingling, tingling and\u00a0itching<\/li><li>reduced level of consciousness<\/li><li>sleep problems, lack of interest<\/li><li>depression,\u00a0euphoria<\/li><li>reduced sex drive, reduced sense of orgasm<\/li><li>restlessness, excitement, irritability, deviant thoughts<\/li><li>drug addiction<\/li><li>reduced sense of touch<\/li><li>fever, chills, discomfort<\/li><li>swelling, including tissue swelling in the arms, legs, or face due to increased fluid<\/li><li>muscle spasms, discomfort in arms and legs<\/li><li>pain affecting muscles and bones, neck, arms and legs, and joints<\/li><li>pain and problems in masticatory muscles and jaw joint called temporomandibular joint syndrome<\/li><li>respiratory depression, yawning<\/li><li>cellulitis, skin infection, abscess<\/li><li>tonsil complications<\/li><li>rash, permanent rash, skin damage<\/li><li>cold sweats, dry skin<\/li><li>small bleeding under the skin\u00a0<\/li><li>changed levels in the blood:<ul><li>elevated enzyme levels (of\u00a0aspartate aminotransferase, gamma-glutamyltransferase,\u00a0lactate dehydrogenase\u00a0in blood,\u00a0lipase, amylase)<\/li><li>decreased enzyme levels (of alkaline phosphatase)<\/li><li>an elevated level of\u00a0bicarbonate<\/li><li>an elevated level of\u00a0bilirubin\u00a0&#8211; a yellow breakdown substance in the blood pigment<\/li><li>an elevated level of\u00a0glucose\u00a0(blood sugar)<\/li><li>lowered cholesterol level<\/li><li>lowered\u00a0hematocrit\u00a0\u2013 the percentage of\u00a0blood cells\u00a0in the blood volume<\/li><li>decreased\u00a0hemoglobin\u00a0(the red pigment in the\u00a0blood cells\u00a0), increased mean cell hemoglobin<\/li><li>increase in certain\u00a0white blood cells\u00a0(\u00a0monocytes, neutrophils,\u00a0leukocytes\u00a0)<\/li><li>decrease in the number of\u00a0blood cells\u00a0(\u00a0platelets,\u00a0red blood cells,\u00a0lymphocytes\u00a0)<\/li><\/ul><\/li><li>abnormal mean cell volume (seen in a blood test)<\/li><li>weight gain or loss, including abnormal weight gain<\/li><li>dehydration decreased appetite<\/li><li>painful periods,\u00a0erectile dysfunction\u00a0(\u00a0impotence\u00a0)<\/li><li>watery eyes, blurred vision, problems with tear flow<\/li><li>slow heartbeat, an abnormal heart rhythm that starts in the atria of the heart<\/li><li>bladder emptying problems, urinary retention, frequent bladder emptying with a small amount of urine<\/li><li>urinary tract infection<\/li><li>fungal infection in the external genitalia and vagina<\/li><li>lymph node disease<\/li><li>lack of a type of\u00a0white blood cell\u00a0called neutrophil\u00a0leukocyte\u00a0er<\/li><li>complications after the procedure<\/li><li>displacement of\u00a0implants, fracture of\u00a0implants,\u00a0or expulsion of\u00a0implants<\/li><li>opening of a closed wound<\/li><li>reactions at the implant site<ul><li>infection\u00a0including wound infection<\/li><li>rash, scarring<\/li><li>poorer healing<\/li><li>the swollen area containing var.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Sixmo<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Use before the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Contents declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is buprenorphine.Each\u00a0implant\u00a0contains buprenorphine hydrochloride equivalent to 74.2 mg of buprenorphine.\u00a0<\/li><li>Another ingredient is ethylene vinyl acetate copolymer.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Appearance and package sizes of the medicine<\/h2>\n\n\n\n<p>Sixmo is a white\/off-white to pale yellow, rod-shaped\u00a0implant, 26.5 mm long and 2.4 mm in diameter.<\/p>\n\n\n\n<p>Sixmo is supplied in a box.&nbsp;It consists of four individually packaged&nbsp;implants&nbsp;packaged in laminated foil pouches and an individually packaged&nbsp;sterile&nbsp;applicator&nbsp;for single use.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing authorization holder and manufacturer<\/h2>\n\n\n\n<p>L. Molteni &amp; C. dei F.lli Alitti Soc.Es.SpA, Strada Statale 67,<\/p>\n\n\n\n<p>50018 Scandicci (Florence), Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sixmo contains the active substance buprenorphine, which is a type of opioid medicine.\u00a0It is used to treat opioid addiction in adults who also receive medical, social and psychological support.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[19122,24239,3584,3587,2212,24235,24238,8115,8114,24236,24237],"class_list":["post-23241","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-buprenorphine","tag-benefits-of-sixmo","tag-buprenorphine","tag-buprenorphine-side-effects","tag-medicine","tag-sixmo","tag-sixmo-side-effects","tag-what-buprenorphine-is-used-for","tag-what-is-buprenorphine","tag-what-is-sixmo","tag-what-sixmo-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23241"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23241\/revisions"}],"predecessor-version":[{"id":23262,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23241\/revisions\/23262"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}