{"id":23135,"date":"2022-07-21T07:01:03","date_gmt":"2022-07-21T07:01:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23135"},"modified":"2022-07-22T06:24:25","modified_gmt":"2022-07-22T06:24:25","slug":"simidon","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/simidon\/","title":{"rendered":"Simidon &#8211; Simvastatin uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg, 20 mg, 40 mg&nbsp;film-coated tablets<br>simvastatin<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Simidon is and what it is used for<\/h2>\n\n\n\n<p>Simidone contains the active substance\u00a0simvastatin\u00a0and belongs to a group of medicines called statins.\u00a0These drugs work by reducing the amount of total cholesterol, the &#8220;bad&#8221;\u00a0cholesterol\u00a0(\u00a0LDL\u00a0&#8211;\u00a0cholesterol\u00a0), and certain fats called\u00a0triglycerides\u00a0in the blood.\u00a0Simidon also increases the levels of the &#8220;good&#8221;\u00a0cholesterol\u00a0(\u00a0HDL\u00a0&#8211;\u00a0cholesterol\u00a0).\u00a0You should continue with a cholesterol-lowering diet while you are taking this medicine.<\/p>\n\n\n\n<p>Cholesterol\u00a0is one of several fats found in your blood.\u00a0Your total cholesterol consists mainly\u00a0of\u00a0LDL\u00a0and\u00a0HDL\u00a0cholesterol.<\/p>\n\n\n\n<p>LDL\u00a0cholesterol\u00a0is often called the &#8220;bad&#8221;\u00a0cholesterol\u00a0because\u00a0it causes fat storage in your vessel walls and forms plaque.\u00a0This plaque storage can eventually lead to a narrowing of your\u00a0vessels.\u00a0This narrowing can reduce or block blood flow to important organs such as the heart and brain.\u00a0Blockage of blood flow can result in a heart attack or\u00a0stroke.<\/p>\n\n\n\n<p>HDL&nbsp;cholesterol&nbsp;is often called the &#8220;good&#8221;&nbsp;cholesterol&nbsp;because it helps prevent the &#8220;bad&#8221;&nbsp;cholesterol&nbsp;from&nbsp;being stored in&nbsp;vessels&nbsp;and protects against heart disease.<\/p>\n\n\n\n<p>Triglycerides&nbsp;are another type of fat in the blood that can increase the risk of heart disease.<\/p>\n\n\n\n<p><strong>Simidone is used for:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>to lower\u00a0cholesterol\u00a0and triglyceride levels in the blood when a low-fat diet and other measures (eg exercise, weight loss) do not give the desired result (primary\u00a0hypercholesterolemia\u00a0or combined\u00a0hyperlipidemia\u00a0).<\/li><li>to lower hereditary levels of high\u00a0cholesterol\u00a0in the blood (\u00a0homozygous\u00a0familial\u00a0hypercholesterolemia\u00a0), in addition to diet and other treatments (eg\u00a0LDL\u00a0-apheresis), or when such treatments are not appropriate.<\/li><li>to reduce the risk of coronary heart disease if you have atherosclerosis (\u00a0arteriosclerosis\u00a0) or\u00a0diabetes, even if your cholesterol levels are normal, as a supplement to your diet and other treatments.<\/li><\/ul>\n\n\n\n<p>In most people, high\u00a0cholesterol\u00a0does not cause immediate symptoms.\u00a0Your doctor can measure your cholesterol level with a simple blood test.\u00a0Visit your doctor regularly, monitor your cholesterol levels, and discuss your goals with your doctor.<\/p>\n\n\n\n<p>Simvastatin\u00a0contained in Simidon may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Simidon<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Simidon:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to\u00a0simvastatin\u00a0or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have liver problems or continuous high levels of certain liver enzymes (serum transaminases).<\/li><li>if you are pregnant or breastfeeding.<\/li><li>if you are taking one or more of the following medicines at the same time:<ul><li>ketoconazole\u00a0, itraconazole, posaconazole or voriconazole (medicines for fungal infections)<\/li><li>HIV\u00a0protease inhibitors\u00a0such as indinavir,\u00a0nelfinavir, ritonavir, and saquinavir (medicines for\u00a0HIV\u00a0infections\u00a0)<\/li><li>boceprevir or telaprevir (used to treat\u00a0hepatitis\u00a0C virus infection)<\/li><li>erythromycin, clarithromycin, or telithromycin (\u00a0antibiotics\u00a0for\u00a0infection\u00a0)<\/li><li>nefazodone (an antidepressant)<\/li><li>gemfibrozil (a cholesterol-lowering drug)<\/li><li>ciclosporin (a medicine commonly used in organ transplant patients)<\/li><li>danazol (a manufactured\u00a0hormone\u00a0used in the treatment of\u00a0endometriosis\u00a0), a condition in which the uterine lining grows outside the uterus).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Do not take more than 40 mg Simidon if you are taking lomitapide (used to treat a serious and rare genetic cholesterol condition).<\/p>\n\n\n\n<p>Consult a doctor if you are unsure if your medicine is listed above.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Simidon.<\/p>\n\n\n\n<p>Tell your doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>about all your medical ailments, including\u00a0allergies.<\/li><li>if you have high alcohol consumption.<\/li><li>if you have or have had a history of liver disease.\u00a0Simidon may not be the right medicine for you.<\/li><li>if you are going to have surgery.\u00a0Treatment interruption with Simidon may need to be done for a short time.<\/li><li>If you are of Asian descent, then another\u00a0dose\u00a0may apply to you.<\/li><li>if you are taking or in the last 7 days have taken a medicine called fusidic acid (used to treat bacterial\u00a0infections\u00a0) either by mouth or by\u00a0injection.\u00a0The combination of fusidic acid and Simidone can lead to serious muscle problems (\u00a0rhabdomyolysis\u00a0).<\/li><\/ul>\n\n\n\n<p>Your doctor should take a blood sample before you start taking Simidon, and if you have any symptoms of liver problems during treatment with Simidon.&nbsp;This blood test is taken to check your liver function.<\/p>\n\n\n\n<p>Your doctor may also need to take a blood test to check your liver function after you start taking Simidon.<\/p>\n\n\n\n<p>During treatment with this medicine, your doctor will closely monitor you if you have diabetes or are at risk of developing\u00a0diabetes.\u00a0You are more likely to be at risk for\u00a0diabetes\u00a0if you have high blood sugar and blood fat levels, are overweight, and have high\u00a0blood pressure.<\/p>\n\n\n\n<p>Tell your doctor if you have any serious lung disease.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you have persistent muscle weakness.&nbsp;<\/p>\n\n\n\n<p>Additional tests and medications may be needed to investigate and treat this.<\/p>\n\n\n\n<p><strong>Contact a doctor immediately if you experience unexplained muscle pain, sensitivity to pressure, or muscle weakness.\u00a0The reason for this is that in rare cases, muscle problems can be serious and involve the breakdown of muscles with kidney damage as a result and in very rare cases, deaths have occurred.<\/strong><\/p>\n\n\n\n<p>The risk of muscle breakdown may be greater for you with high&nbsp;doses&nbsp;of Simidon, especially with a&nbsp;dose of&nbsp;80 mg.&nbsp;The risk of muscle breakdown is also greater in some patients.&nbsp;Talk to your doctor if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you are over 65 years old<\/li><li>you have kidney problems<\/li><li>you have thyroid problems<\/li><li>you or close family members have a hereditary muscle disease<\/li><li>you are a woman<\/li><li>you have ever had muscle problems during treatment with cholesterol-lowering drugs called &#8220;statins&#8221; or fibrates<\/li><li>you have a high alcohol consumption<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if any of the above apply to you or have been done before.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Safety and efficacy have been studied in boys aged 10 to 17 years and in girls who have had menstruation for at least one year (see section 3: How to take Simidon).<\/p>\n\n\n\n<p>Simidon has not been studied in children under 10 years of age.&nbsp;For further information, consult a doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Simidon<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines with any of the following active ingredients.\u00a0Taking Simidon with any of these medicines may increase the risk of muscle problems (some of these have already been listed in the section above under the heading &#8220;Do not take Simidon&#8221;).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you need to take fusidic acid by mouth to treat a bacterial\u00a0infection<\/strong>, you will need to temporarily stop using this medicine.\u00a0Your doctor will tell you when it is safe to start taking Simidon again.\u00a0Taking Simidon with fusidic acid may in rare cases lead to weakness, soreness, or pain in the muscles (\u00a0rhabdomyolysis\u00a0).\u00a0See more information on\u00a0rhabdomyolysis\u00a0in section 4.<\/li><li>ciclosporin (often used by patients who have had an organ transplant),<\/li><li>danazol (a synthetic\u00a0hormone\u00a0used to treat\u00a0endometriosis, a condition in which the lining of the uterus grows outside the uterus),<\/li><li>drugs with an active ingredient such as itraconazole,\u00a0ketoconazole,\u00a0fluconazole, posaconazole, or voriconazole (used to treat fungal infections),<\/li><li>fibrates with an active ingredient such as gemfibrozil and bezafibrate (used to lower cholesterol),<\/li><li>erythromycin, clarithromycin, or telithromycin (used to treat bacterial\u00a0infections\u00a0),<\/li><li>HIV\u00a0&#8211;\u00a0protease inhibitors\u00a0such as indinavir, nelfinavir, ritonavir, and saquinavir (used to treat\u00a0HIV\u00a0),<\/li><li>Hepatitis\u00a0C medicines\u00a0such as boceprevir, telaprevir, elbasvir, or grazoprevir (used to treat\u00a0hepatitis\u00a0C virus infection),<\/li><li>\u03b1miodarone (used to treat irregular heartbeat),<\/li><li>verapamil,\u00a0diltiazem,\u00a0or amlodipine (used to treat high\u00a0blood pressure, chest pain associated with cardiovascular disease or other heart problems),<\/li><li>lomitapide (used to treat a serious and rare genetic cholesterol condition),<\/li><li>daptomycin (a medicine used to treat complicated skin and soft tissue infections and\u00a0bacteremia\u00a0(the presence of bacteria in the blood) the risk of\u00a0side effects\u00a0affecting muscles may be higher when this medicine is taken during treatment\u00a0with\u00a0simvastatin\u00a0Your doctor may decide that you should stop taking Simidon for a while.<\/li><li>colchicine (used in the treatment of\u00a0gout\u00a0).<\/li><\/ul>\n\n\n\n<p>As with the medicines mentioned above, tell your doctor or pharmacist if you are taking, or have recently taken any other medicines, including medicines obtained without a prescription.&nbsp;It is especially important to tell your doctor if you are taking medicines with any of the following active ingredients:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anticoagulants with an active ingredient such as\u00a0warfarin, phenprocoumon, or acenocoumarol (\u00a0anticoagulants\u00a0),<\/li><li>fenofibrate (also used to lower cholesterol)<\/li><li>niacin\u00a0(also used to lower cholesterol)<\/li><li>rifampicin (used to treat\u00a0tuberculosis\u00a0)<\/li><\/ul>\n\n\n\n<p>Also, tell your doctor if you are taking\u00a0niacin\u00a0(\u00a0nicotinic acid\u00a0) or a product that contains\u00a0niacin\u00a0and is of Chinese origin.<\/p>\n\n\n\n<p>Also, tell your doctor who is prescribing new medicines that you are taking Simidon.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Simidon with food and drink:<\/h2>\n\n\n\n<p>Grapefruit juice contains one or more ingredients that can increase the amount of Simidon in the blood.&nbsp;Therefore, do not drink grapefruit juice, as it may increase the risk of muscle damage.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not take Simidon if you are pregnant, trying to conceive, or suspect you may be pregnant.\u00a0If you become pregnant while taking Simidon, you must stop taking the tablets immediately and consult a doctor.<\/p>\n\n\n\n<p>Do not take Simidon if you are breastfeeding as it is unknown if the medicine passes into breast milk.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Simidone is not expected to affect the ability to drive and use machines.&nbsp;However, keep in mind that some people get dizzy when they take Simidon.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Simidone contains lactose:<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Simidon<\/h2>\n\n\n\n<p>Your doctor will decide which\u00a0dose\u00a0is right for you, depending on your condition, your current treatment, and your risk profile<strong>.<\/strong><\/p>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>You should continue your cholesterol-lowering diet while you are taking Simidon.<\/p>\n\n\n\n<p>Dosage:<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is\u00a0simvastatin\u00a05 mg, 10 mg, 20 mg, 40 mg, or 80 mg once daily.<\/p>\n\n\n\n<p>Adults:<\/p>\n\n\n\n<p>The most common starting dose is 10 mg, 20 mg, or in some cases 40 mg daily.\u00a0Your doctor may, after at least 4 weeks, need to adjust your\u00a0dose\u00a0to a maximum of 80 mg per day.\u00a0<strong>Do not take more is 80 mg per day.<\/strong>\u00a0<\/p>\n\n\n\n<p>Your doctor may prescribe a lower&nbsp;dose&nbsp;for you, especially if you are taking certain medicines listed above or have certain kidney problems.<\/p>\n\n\n\n<p>A dose\u00a0of 80 mg is only recommended for adult patients with very high cholesterol levels and who are at high risk for cardiovascular disease and who have not achieved their treatment goals at lower\u00a0doses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>For children (10-17 years) with a hereditary disease called familial hypercholesterolemia, the usual recommended starting dose is 10 mg daily in the evening.&nbsp;The maximum recommended&nbsp;dose&nbsp;is 40 mg per day.<\/p>\n\n\n\n<p><strong>Method of administration:<\/strong><\/p>\n\n\n\n<p>Take Simidon in the evening.&nbsp;Simidone can be taken with or without food.&nbsp;Continue to take Simidon unless your doctor tells you to stop.<\/p>\n\n\n\n<p>If your doctor has prescribed Simidon with another cholesterol-lowering medicine that contains bile acid sequestrants, you should take Simidon at least 2 hours before or 4 hours after taking the bile acid sequestrant.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Simidon than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for risk assessment and advice.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Simidon<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.&nbsp;Just take your usual&nbsp;dose&nbsp;of Simidon at the time you usually take the next day.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Simidon<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist as your cholesterol levels may rise again.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following classification is used to describe how often&nbsp;side effects&nbsp;have been reported:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rare (may affect up to 1 in 1,000 people)<\/li><li>Very rare (may affect up to 1 in 10,000 people),<\/li><li>No known frequency (cannot be calculated from the available data).<\/li><\/ul>\n\n\n\n<p>The following rare serious&nbsp;side effects&nbsp;have been reported.<\/p>\n\n\n\n<p><strong>If any of the following serious\u00a0side effects\u00a0occur, stop taking the medicine and contact a doctor immediately or go to the nearest emergency department:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle pain, tenderness, weakness, cramping, or muscle strain (very rare).\u00a0In rare cases, these muscle problems can be serious and involve muscle breakdown (\u00a0rhabdomyolysis\u00a0) with kidney damage as a result and in very rare cases, deaths have occurred.<\/li><li>hypersensitivity (allergic reactions) including:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, and throat, which may cause difficulty breathing<\/li><li>severe muscle pain, usually in the shoulders and hips<\/li><li>rash with weakness in arms, legs, and neck muscles<\/li><li>rash that may occur on the skin or sores in the mouth (drug-related lichenoid rash) (very rare),<\/li><li>joint pain or\u00a0inflammation\u00a0(rheumatic polymyalgia)<\/li><li>inflammation\u00a0of blood vessels (\u00a0vasculitis\u00a0)<\/li><li>bruising of unknown cause, skin rash, and swelling (\u00a0dermatomyositis\u00a0),\u00a0hives, skin sensitivity to sun exposure, fever,\u00a0redness<\/li><li>shortness of breath (\u00a0dyspnoea\u00a0) and general malaise<\/li><li>lupus-like disease picture (including rash, joint problems, and effects on\u00a0blood cells\u00a0)<\/li><\/ul>\n\n\n\n<p>inflammation\u00a0of the liver with yellowish skin and eyes,\u00a0itching,\u00a0dark urine or pale stools, and liver failure (very rare).<\/p>\n\n\n\n<p>&#8211;\u00a0inflammation\u00a0of the pancreas (severe abdominal pain radiating to the back, nausea, and vomiting).<\/p>\n\n\n\n<p>The following very rare serious&nbsp;side effects&nbsp;have been reported:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a severe&nbsp;allergic reaction&nbsp;that causes difficulty breathing or dizziness (&nbsp;anaphylaxis&nbsp;)<\/li><li>gynecomastia&nbsp;(breast augmentation in men)<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have also been reported rarely:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low\u00a0red blood cell count\u00a0(\u00a0anemia\u00a0)<\/li><li>numbness or weakness in the arms and legs,<\/li><li>headache, &#8220;ant crawls&#8221;, dizziness<\/li><li>blurred vision, impaired vision<\/li><li>indigestion (abdominal pain, constipation, flatulence,\u00a0dyspepsia, diarrhea, nausea, vomiting),<\/li><li>rash,\u00a0itching, hair loss,<\/li><li>weakness,<\/li><li>difficulty sleeping (very rare),<\/li><li>poor memory (very rare), memory loss, confusion<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have also been reported, but the frequency cannot be determined with available information (no known frequency):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>erectile dysfunction,<\/li><li>Depression,<\/li><li>inflammation\u00a0of the lungs that causes breathing problems including persistent cough and\/or shortness of breath or fever,<\/li><li>problems with the tendons, sometimes aggravated by tendon rupture.<\/li><li>persistent muscle weakness<\/li><\/ul>\n\n\n\n<p>Additional possible&nbsp;side effects&nbsp;that have been reported with certain statins:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sleep disorders including nightmares,<\/li><li>sexual problems,<\/li><li>diabetes.\u00a0This is more likely if you have high blood sugar and high blood fat levels, are overweight and have high\u00a0blood pressure.\u00a0Your doctor will check you while you are taking this medicine.<\/li><\/ul>\n\n\n\n<p><em>Laboratory values<\/em><\/p>\n\n\n\n<p>Elevated values \u200b\u200bof liver function and a muscle enzyme (creatinine kinase) have been observed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Simidon<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store below 30 \u00b0 C. Store in the original package.&nbsp;Sensitive to light.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>After first opening, the tablet can: Do not store it above 25 \u00b0 C and use it within 6 months.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is\u00a0simvastatin.\u00a0Each film-coated tablet contains 10 mg, 20 mg, or 40 mg\u00a0of simvastatin.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>lactose monohydrate, microcrystalline cellulose (E460), pregelatinized maize starch, butyl hydroxy anisole (E320),\u00a0ascorbic acid\u00a0(E300), anhydrous citric acid (E330),\u00a0colloidal\u00a0anhydrous silica (E551), talc (E70bearate).<\/p>\n\n\n\n<p><em>Coating<\/em>: hypromellose (E464), red iron oxide (E172), yellow iron oxide (E172), triethyl citrate (E1505), titanium dioxide (E171), talc (E553b), povidone K-30.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Simidon 10 mg is a peach-colored, oval, biconvex, film-coated tablet with a score line on one side.<\/p>\n\n\n\n<p>The tablet can be divided into two equal parts along the breaking groove.<\/p>\n\n\n\n<p>Simidone 20 mg is a medium brown, oval, biconvex, film-coated tablet with a score line on one side.<\/p>\n\n\n\n<p>The tablet can be divided into two equal parts along the breaking groove.<\/p>\n\n\n\n<p>Simidon 40 mg is a brick red, oval, biconvex, film-coated tablet with a score line on one side.<\/p>\n\n\n\n<p>The tablet can be divided into two equal parts along the breaking groove.<\/p>\n\n\n\n<p>The tablets are packaged in blister packs in a carton or HPDE can.<\/p>\n\n\n\n<p>Blister packs:<\/p>\n\n\n\n<p>Simidone 10 mg film-coated tablets: 10, 20, 28, 30, 50, 60, 98 or 100 tablets.<\/p>\n\n\n\n<p>Simidone 20 mg film-coated tablets: 10, 20, 28, 30, 50, 60, 98 or 100 tablets.<\/p>\n\n\n\n<p>Simidone 40 mg film-coated tablets: 10, 20, 28, 30, 50, 60, 98 or 100 tablets.<\/p>\n\n\n\n<p>Tablet jars:<\/p>\n\n\n\n<p>Simidone 10 mg film-coated tablets: 100, 250 or 500 tablets.<\/p>\n\n\n\n<p>Simidone 20 mg film-coated tablets: 100, 250 or 500 tablets.<\/p>\n\n\n\n<p>Simidone 40 mg, film-coated tablets: 100, 250 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Rivopharm Ltd.<\/p>\n\n\n\n<p>17 Corrig Road<\/p>\n\n\n\n<p>Sandyford, Dublin 18<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Balkanpharma-Dupnitsa AD<\/p>\n\n\n\n<p>3, Samokovsko shosse Str.<\/p>\n\n\n\n<p>2600 Dupnitsa<\/p>\n\n\n\n<p>Bulgaria<\/p>\n\n\n\n<p><strong>Agent:<\/strong><\/p>\n\n\n\n<p>SanoSwiss UAB<\/p>\n\n\n\n<p>Love 25-701<\/p>\n\n\n\n<p>LT-09320 Vilnius<\/p>\n\n\n\n<p>Lithuania<\/p>\n\n\n\n<p>info@sanoswiss.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>10 mg, 20 mg, 40 mg\u00a0film-coated tablets<br \/>\nsimvastatin<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24153,24154,24158,24157,24122,24125,24155,24123,24156,24124],"class_list":["post-23135","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-simvastatin","tag-simidon","tag-simidon-side-effects","tag-simidon-tablet","tag-simvastatin","tag-simvastatin-tablet","tag-what-is-simidon","tag-what-is-simvastatin","tag-what-simidon-is-used-for","tag-what-simvastatin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23135"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23135\/revisions"}],"predecessor-version":[{"id":23171,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23135\/revisions\/23171"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23135"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23135"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}