{"id":23127,"date":"2022-07-21T06:52:21","date_gmt":"2022-07-21T06:52:21","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23127"},"modified":"2022-07-22T06:24:45","modified_gmt":"2022-07-22T06:24:45","slug":"simbrinza","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/simbrinza\/","title":{"rendered":"SIMBRINZA &#8211; Brinzolamide \/ Brimonidine tartrate uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg \/ ml + 2 mg \/ ml&nbsp;eye drops&nbsp;,&nbsp;suspension<br>brinzolamide \/ brimonidine tartrate<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What SIMBRINZA is and what it is used for<\/h2>\n\n\n\n<p>SIMBRINZA contains two active substances, brinzolamide and brimonidine tartrate.\u00a0Brinzolamide belongs to a group of medicines called\u00a0carbohydrase\u00a0inhibitors and brimonidine tartrate belongs to a group of medicines called alpha-2-adrenergic\u00a0receptor agonists.\u00a0Both substances work together to lower eye pressure.<\/p>\n\n\n\n<p>SABRINA is used to lower the pressure in the eyes in adult patients (18 years or older) who have eye diseases called\u00a0glaucoma\u00a0or\u00a0ocular\u00a0hypertension, and for whom it is not possible to effectively control the high pressure in the eyes with just one drug.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using SIMBRINZA<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use SIMBRINZA<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to brinzolamide or brimonidine tartrate or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to&nbsp;sulfonamides&nbsp;(for example medicines used to treat&nbsp;diabetes&nbsp;and&nbsp;infection&nbsp;and&nbsp;diuretics&nbsp;(diuretic tablets)<\/li><li>if you are taking&nbsp;monoamine oxidase inhibitors&nbsp;(&nbsp;MAOIs&nbsp;) (for example, medicines used to treat depression or&nbsp;Parkinson&#8217;s disease&nbsp;) or certain antidepressants.&nbsp;You must tell your doctor if you are taking medicines for depression<\/li><li>if you have severe kidney problems<\/li><li>if you have too much acidity in your blood (a condition called hyperchloraemic&nbsp;acidosis&nbsp;)<\/li><li>to newborns and children under 2 years.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, optician, or pharmacist before using SIMBRINZA if you have or have ever had:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver problem<\/li><li>a type of high pressure in the eyes called\u00a0narrow-angle glaucoma<\/li><li>dry eyes or corneal problems<\/li><li>coronary heart disease (symptoms may include chest pain, chest tightness, shortness of breath, or suffocation),\u00a0heart failure, high or low\u00a0blood pressure<\/li><li>Depression<\/li><li>disturbed or poor blood circulation (such as\u00a0Raynaud&#8217;s disease\u00a0or Raynaud&#8217;s syndrome or cerebral\u00a0insufficiency\u00a0)<\/li><\/ul>\n\n\n\n<p>If you wear soft contact lenses, do not use the drops with the contact lenses left in your eyes.&nbsp;See section \u201cUsing contact lenses &#8211; SIMBRINZA contains benzalkonium chloride\u201d below).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>SABRINA is not recommended for children and adolescents under 18 years of age as it has not been studied in this age group.\u00a0The medicine mustn&#8217;t be used in children under 2 years of age as it cannot be considered safe (see section \u201cDo not use SIMBRINZA\u201d above).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and SIMBRINZA<\/h2>\n\n\n\n<p>Tell your doctor, optician, or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>SIMBRINZA can affect or be affected by other medicines you use, including\u00a0other\u00a0eye\u00a0drops\u00a0for\u00a0glaucoma.<\/p>\n\n\n\n<p>Tell your doctor if you are taking or plan to take any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs that lower\u00a0blood pressure\u00a0et<\/li><li>cardiac drugs including\u00a0digoxin\u00a0(used to treat heart disease)<\/li><li>other anti-\u00a0glaucoma\u00a0medicines that also treat altitude sickness are called acetazolamide, methazolamide, and <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/torzkom\/\">dorzolamide<\/a><\/li><li>drugs that may affect\u00a0metabolisms, such as chlorpromazine, methylphenidate, and reserpine<\/li><li>antiviral, antiretroviral medicines (medicines used to treat\u00a0HIV\u00a0), or\u00a0antibiotics<\/li><li>drugs against yeasts and fungi<\/li><li>monoamine oxidase inhibitors\u00a0(\u00a0MAOIs\u00a0), or antidepressants including amitriptyline, nortriptyline, clomipramine, mianserin,\u00a0venlafaxine,\u00a0and duloxetine<\/li><li>drugs for anesthesia<\/li><li>sedatives, opiates, or\u00a0barbiturates.<\/li><\/ul>\n\n\n\n<p>You should tell your doctor if the&nbsp;dose&nbsp;of any of your current medicines changes.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SIMBRINZA with alcohol<\/h2>\n\n\n\n<p>If you drink alcohol regularly, consult your doctor, optician, or pharmacist before taking this medicine.\u00a0SIMBRINZA can be affected by alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor, optician, or pharmacist for advice before taking this medicine.\u00a0Women who may become pregnant should use effective contraception while being treated with SIMBRINZA.\u00a0The use of SIMBRINZA is not recommended during pregnancy.\u00a0Do not use SIMBRINZA unless your doctor prescribes it.<\/p>\n\n\n\n<p>If you are breastfeeding, SIMBRINZA may pass into breast milk.\u00a0The use of SIMBRINZA is not recommended during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>When you use SIMBRINZA, you may notice that your vision becomes blurred or abnormal for a while.\u00a0SIMBRINZA may also cause dizziness, drowsiness, or fatigue in some patients.<\/p>\n\n\n\n<p>Do not drive or use machines until the symptoms have passed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use of contact lenses &#8211; SIMBRINZA contains benzalkonium chloride<\/h2>\n\n\n\n<p>This medicine contains 0.15 mg of benzalkonium chloride per 5 ml, which is equivalent to 0.03 mg\/ml.<\/p>\n\n\n\n<p>Benzalkonium chloride can be absorbed by soft contact lenses and discolor the contact lenses.\u00a0Remove contact lenses before using the medicine and wait at least 15 minutes before re-inserting the contact lenses.\u00a0Benzalkonium chloride can be irritating to the eyes, especially if you have dry eyes or problems with the cornea (the clear membrane at the front of the eye).\u00a0If you experience irritation, tingling, or pain in the eye after using the medicine, consult a doctor.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use SIMBRINZA<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor, optician or pharmacist has told you.\u00a0If you are not sure, talk to your doctor, optician, or pharmacist.<\/p>\n\n\n\n<p>SIMBRINZA should only be used in the eyes.&nbsp;It must not be swallowed or injected.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;<\/strong>is one drop in the affected eye or eyes twice a day.&nbsp;Use the drops at the same time each day.<\/p>\n\n\n\n<p><strong>Instructions for use<\/strong><\/p>\n\n\n\n<p>Wash your hands before you start.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20130613000013#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/7d09358c-044e-4c83-9eb2-c1fc3a2511d0\" alt=\"Instructions for use\" title=\"Instructions for use\"\/><\/a><\/figure>\n\n\n\n<p>Shake well before use.<\/p>\n\n\n\n<p>Turn off the bottle cap.&nbsp;If the safety collar is loose after removing the cover, remove the collar before using the medicine.<\/p>\n\n\n\n<p>Avoid touching the drip tip with your fingers when opening or closing the bottle.&nbsp;It can contaminate the drops.<\/p>\n\n\n\n<p>Hold the bottle upside down between your thumb and fingers.<\/p>\n\n\n\n<p>Tilt your head back.<\/p>\n\n\n\n<p>Pull down the lower eyelid with a clean finger until a &#8220;pocket&#8221; is formed between the eyelid and the eye.&nbsp;The drop should end up in the pocket (picture 1).<\/p>\n\n\n\n<p>Move the tip of the bottle close to the eye.\u00a0You can stand in front of a mirror if that helps.<\/p>\n\n\n\n<p>Do not touch the eye or eyelid, surrounding areas, or other surfaces with the bottle tip.\u00a0It can contaminate the drops.<\/p>\n\n\n\n<p>Gently press the bottom of the bottle to release a drop of SIMBRINZA.<\/p>\n\n\n\n<p>Do not squeeze the bottle;&nbsp;it is designed so that a light pressure at the bottom is sufficient (Fig. 2).<\/p>\n\n\n\n<p>To reduce the amount of medicine that can get into the rest of your body after using the eye drop, close your eyes and press lightly with a finger in the corner of your eye at your nose for at least 2 minutes.<\/p>\n\n\n\n<p><strong>If you use the drops in both eyes<\/strong>, repeat the different steps for your other eye.\u00a0You do not need to close and shake the bottle before administering the drop to the other eye.\u00a0Tighten the bottle cap carefully immediately after use.<\/p>\n\n\n\n<p><strong>If you use other\u00a0eye drops\u00a0besides SIMBRINZA<\/strong>, wait at least five minutes between\u00a0administering\u00a0one off and the other drops.<\/p>\n\n\n\n<p><strong>If the drop misses the eye,<\/strong>&nbsp;try again.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more SIMBRINZA than you should&nbsp;<\/h2>\n\n\n\n<p>Rinse the eye with lukewarm water.\u00a0Do not take any more drops until it is time for your next regular\u00a0dose.<\/p>\n\n\n\n<p>Adults who inadvertently swallowed drugs containing brimonidine had a slower heart rate and decreased\u00a0blood pressure\u00a0which may be followed by high\u00a0blood pressure,\u00a0heart failure, difficulty breathing, and effects on the nervous system.\u00a0If this happens, consult a doctor immediately.<\/p>\n\n\n\n<p>Serious\u00a0side effects\u00a0have been reported in children who have swallowed brimonidine.\u00a0Signs include drowsiness, lethargy, low body temperature, pallor, and difficulty breathing.\u00a0If this happens, consult a doctor immediately.<\/p>\n\n\n\n<p>If you have accidentally swallowed SIMBRINZA, contact your doctor immediately.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use SIMBRINZA<\/h2>\n\n\n\n<p>Continue with the next\u00a0dose\u00a0as planned.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.\u00a0Do not use more than one drop in the affected eye (s) twice daily.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using SIMBRINZA<\/h2>\n\n\n\n<p>Do not stop using SIMBRINZA without talking to a doctor.&nbsp;If you stop using SIMBRINZA, the pressure in your eye will not be checked, which could lead to vision loss.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, optician, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you get any of the following\u00a0side effects, stop using the medicine and seek medical attention immediately, as it may be a sign of a reaction to the medicine.\u00a0The frequency of\u00a0allergic reactions\u00a0to the drug is unknown (can not be calculated from the available data).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe skin reactions, including rash or&nbsp;redness&nbsp;or&nbsp;itching&nbsp;of the body or eyes.<\/li><li>Hard to breathe.<\/li><li>Chest pain, irregular heartbeat.<\/li><\/ul>\n\n\n\n<p>Contact a doctor immediately if you become extremely tired or dizzy.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported with SIMBRINZA and other medicines containing brinzolamide or brimonidine alone:<\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Effects on the eye: allergic\u00a0conjunctivitis\u00a0(eye allergy), superficial eye inflammation, eye pain, eye discomfort, blurred or abnormal vision, and red eyes.<\/li><li>General side effects: drowsiness, dizziness, bad taste in the mouth,\u00a0dry mouth.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Effects in the eye: superficial eye damage with loss of cells,\u00a0inflammation\u00a0of the eyelid, deposits on the surface of the eye, photosensitivity, swelling of the eye (in the cornea or eyelid), dry eye, discharge from the eye, watery eye,\u00a0redness\u00a0of the eyelid, abnormal or decreased sensation in the eye, fatigue in the eye, impaired vision, double vision, product particles in the eyes.<\/li><li>Common side effects: decreased\u00a0blood pressure, chest pain, irregular heartbeat, slow or fast heartbeat, palpitations, difficulty sleeping (insomnia), nightmares, depression, general weakness, headache, dizziness, nervousness, irritability, general malaise, memory loss, shortness of breath, shortness of breath, shortness\u00a0of\u00a0breath, cold symptoms, dry nose or throat, sore throat, throat irritation, cough, runny nose, stuffy nose, sneezing, sinusitis, chest tightness, ringing in the ears, indigestion, gas in the intestines or stomach pain, nausea, diarrhea, vomiting, abnormal vomiting, mouth, increased allergic symptoms in the skin, rash, abnormal sensation in the skin, hair loss, general\u00a0itching, elevated levels of chlorine in the blood, or decreased number of red blood cells during blood tests, pain, back pain, muscle pain or &#8211;\u00a0spasm, kidney pain such as.\u00a0low back pain, decreased sexual drive, sexual problems for men<\/li><\/ul>\n\n\n\n<p><strong>Very rare<\/strong>&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Eye effects: reduced pupil size.<\/li><li>General side effects: fainting, high\u00a0blood pressure.<\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong>&nbsp;(can not be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Effects in the eye: decreased growth of the\u00a0eyelashes.<\/li><li>Common side effects: shaking, decreased sensation, loss of taste, abnormal liver function values \u200b\u200bin blood tests, swelling of the face, joint pain, need to urinate frequently, chest pain and swelling in the\u00a0extremities.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store SIMBRINZA<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the bottle and carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Discard the bottle 4 weeks after opening it, to prevent\u00a0infection, and use a new bottle.\u00a0Write down the date you opened it in the space provided on the box.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your optician or pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are brinzolamide and brimonidine tartrate.\u00a0One ml\u00a0of suspension\u00a0contains 10 mg of brinzolamide and 2 mg of brimonidine tartrate corresponding to 1.3 mg of brimonidine.<\/li><li>The other ingredients are benzalkonium chloride (see section 2 &#8220;Use of contact lenses &#8211; SIMBRINZA contains benzalkonium chloride&#8221;), propylene glycol, carbomer 974P, boric acid, mannitol, sodium chloride, tyloxapol,\u00a0hydrochloric acid\u00a0and\/or sodium hydroxide and purified water.<\/li><\/ul>\n\n\n\n<p>Small amounts of\u00a0hydrochloric acid\u00a0and\/or sodium hydroxide are added to keep the acidity (\u00a0pH\u00a0) normal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>SIMBRINZA\u00a0eye drops,\u00a0the suspension\u00a0is a liquid (white to off-white\u00a0suspension\u00a0) that is delivered in a package containing one or three 5 ml plastic bottles with screw caps.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Europharm Limited<\/p>\n\n\n\n<p>Vista Building<\/p>\n\n\n\n<p>Elm Park, Merrion Road<\/p>\n\n\n\n<p>Dublin 4<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Novartis Pharmac\u00e9utica, SA<\/p>\n\n\n\n<p>Gran Via de Les Corts Catalanes, 764<\/p>\n\n\n\n<p>08013 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>SA Alcon-Couvreur NV<\/p>\n\n\n\n<p>Rijksweg 14<\/p>\n\n\n\n<p>BE-2870 Puurs<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p>Novartis Pharma GmbH<\/p>\n\n\n\n<p>Roonstra\u00dfe 25<\/p>\n\n\n\n<p>D-90429 Nuremberg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Siegfried El Masnou, SA<\/p>\n\n\n\n<p>Camil Fabra 58<\/p>\n\n\n\n<p>El Masnou<\/p>\n\n\n\n<p>08320 Barcelona<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Novartis Pharma NVTel: +32 2 246 16 11<\/td><td><strong>Lithuania<\/strong>SIA Novartis Baltics Lithuanian branches tell: +370 5 269 16 50<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Novartis Bulgaria EOODTel .: +359 2 489 98 28<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Novartis Pharma NVTel: +32 2 246 16 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Novartis sroTel: +420 225 775 111<\/td><td><strong>Hungary<\/strong>Novartis Hungary Kft.Tel .: +36 1 457 65 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Novartis Healthcare A \/ STel: +45 39 16 84 00<\/td><td><strong>Malta<\/strong>Novartis Pharma Services Inc.Tel: +356 2122 2872<\/td><\/tr><tr><td><strong>Germany<\/strong>Novartis Pharma GmbHTel: +49 911 273 0<\/td><td><strong>The Netherlands<\/strong>Novartis Pharma BVTel: +31 88 04 52 111<\/td><\/tr><tr><td><strong>Eesti<\/strong>SIA Novartis Baltics Eesti subsidiaryTel: +372 66 30 810<\/td><td><strong>Norway<\/strong>Novartis Norge ASTel: +47 23 05 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Novartis (Hellas) AEBE:\u0397\u03bb: +30 210 281 17 12<\/td><td><strong>Austria<\/strong>Novartis Pharma GmbHTel: +43 1 86 6570<\/td><\/tr><tr><td><strong>Spain<\/strong>Novartis Pharmac\u00e9utica, SATel: +34 93 306 42 00<\/td><td><strong>Poland<\/strong>Novartis Poland Sp.\u00a0z hotel .: +48 22 375 4888<\/td><\/tr><tr><td><strong>France<\/strong>Novartis Pharma SASTel: +33 1 55 47 66 00<\/td><td><strong>Portugal<\/strong>Novartis Farma &#8211; Pharmaceutical Products, Satel: +351 21 000 8600<\/td><\/tr><tr><td><strong>Croatia<\/strong>Novartis Hrvatska doodle.\u00a0+385 1 6274 220<\/td><td><strong>Romania<\/strong>Novartis Pharma Services Romania SRLTel: +40 21 31299 01<\/td><\/tr><tr><td><strong>Ireland<\/strong>Novartis Ireland LimitedTel: +353 1 260 12 55<\/td><td><strong>Slovenia<\/strong>Novartis Pharma Services Inc.Tel: +386 1 300 75 50<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Novartis Slovakia sroTel: + 421 2 5542 5439<\/td><\/tr><tr><td><strong>Italy<\/strong>Novartis Farma SpATel: +39 02 96 54 1<\/td><td><strong>Finland \/ Finland<\/strong>Novartis Finland OyPuh \/ Tel: +358 (0) 10 6133 200<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Novartis Pharma Services Inc.:\u0397\u03bb: +357 22 690 690<\/td><td><strong>Sweden<\/strong>Novartis Sverige ABTel: +46 8 732 32 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Novartis BalticsTel: +371 67 887 070<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Novartis Ireland LimitedTel: +44 1276 698370<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>10 mg \/ ml + 2 mg \/ ml&nbsp;eye drops&nbsp;,&nbsp;suspensionbrinzolamide \/ brimonidine tartrate What SIMBRINZA is and what it is used for SIMBRINZA contains two active substances, brinzolamide and brimonidine tartrate.\u00a0Brinzolamide belongs to a group of medicines called\u00a0carbohydrase\u00a0inhibitors and brimonidine tartrate belongs to a group of medicines called alpha-2-adrenergic\u00a0receptor agonists.\u00a0Both substances work together to lower [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[8308,8310,8370,8372,24169,24172,8311,8373,8371,24170,24171],"class_list":["post-23127","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-brimonidine-tartrate","tag-brimonidine-tartrate-side-effects","tag-brinzolamide","tag-brinzolamide-side-effects","tag-simbrinza","tag-simbrinza-side-effects","tag-what-brimonidine-tartrate-is-used-for","tag-what-brinzolamide-is-used-for","tag-what-is-brinzolamide","tag-what-is-simbrinza","tag-what-simbrinza-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23127"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23127\/revisions"}],"predecessor-version":[{"id":23173,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23127\/revisions\/23173"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23127"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23127"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}