{"id":23034,"date":"2022-07-19T06:54:35","date_gmt":"2022-07-19T06:54:35","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23034"},"modified":"2022-07-20T06:00:13","modified_gmt":"2022-07-20T06:00:13","slug":"sifrol","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sifrol\/","title":{"rendered":"SIFROL &#8211; Pramipexole uses, dose and side effects"},"content":{"rendered":"\n<p>0.088 mg;&nbsp;0.18 mg;&nbsp;0.35 mg;&nbsp;respectively 0.7 mg tablets<br>pramipexole<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What SIFROL is and what it is used for<\/h2>\n\n\n\n<p>SIFROL contains the active substance pramipexole and belongs to a group of medicines called dopamine agonists, which stimulate the dopamine receptors in the brain.&nbsp;By stimulating dopamine receptors, nerve impulses are triggered in the brain that can help control the body&#8217;s movements.<\/p>\n\n\n\n<p><strong>SIFROL is used to:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>treat symptoms of&nbsp;Parkinson&#8217;s disease&nbsp;in adults.&nbsp;It can be used alone or in combination with&nbsp;levodopa&nbsp;(another medicine for&nbsp;Parkinson&#8217;s disease&nbsp;).<\/li><li>treat symptoms of moderate to severe primary restless legs syndrome in adults (ant crawls in the legs).<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking SIFROL<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take SIFROL<\/h2>\n\n\n\n<p>-if you are allergic to pramipexole or any of the other ingredients of this medicine (listed in section 6).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to a doctor before taking SIFROL.&nbsp;Tell your doctor if you have (have had) or have had any medical symptoms, especially any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kidney disease.<\/li><li>Hallucinations (seeing, hearing, or perceiving things that do not exist).\u00a0Most hallucinations are visual hallucinations.<\/li><li>Dyskinesia\u00a0(eg abnormal, uncontrolled movements of the arms and legs).\u00a0If you have advanced\u00a0Parkinson&#8217;s disease\u00a0and are also taking\u00a0levodopa, you may develop\u00a0dyskinesia\u00a0during the titration period with SIFROL.<\/li><li>Dystonia\u00a0(inability to keep body and neck straight and upright (\u00a0axial\u00a0dystonia\u00a0)).\u00a0In particular, you may experience a forward flexion of the head and neck (also called Nate Collis), forward flexion of the lumbar spine (also known as combat tachormy), or lateral flexion of the back (also known as pleurototonus or Pisa syndrome).<\/li><li>Sleepiness and episodes of suddenly falling asleep.<\/li><li>Psychosis\u00a0(eg comparable to symptoms of schizophrenia).<\/li><li>Visual impairment.\u00a0Your eyes should be examined regularly during treatment with SIFROL.<\/li><li>Severe cardiovascular disease.\u00a0You will need to check\u00a0your blood pressure\u00a0regularly, especially at the beginning of treatment.\u00a0The reason is that you want to avoid a drop in blood pressure when you stand up.<\/li><li>Exacerbated symptoms.\u00a0You may find that the symptoms start earlier than usual, become more intense, and affect other parts of the body.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you or your family\/caregiver notice that you are developing impulses or want to behave in a way that is unusual for you and that you cannot resist the impulse, the drive, or the temptation to perform activities that may harm you or others.\u00a0This is called impaired impulse control and can include behavior such as gambling addiction, excessive eating or buying behavior, abnormally high sex drive, or increased preoccupation with constant thoughts of sex or sexual feelings.\u00a0Your doctor may need to adjust the\u00a0dose\u00a0one or stop the medication.<\/p>\n\n\n\n<p>Tell your doctor if you or your family \/ caregiver notice that you are developing mania (feeling upset, excited or overexcited) or&nbsp;delirium&nbsp;(decreased consciousness, confusion or loss of reality).&nbsp;Your doctor may need to adjust the&nbsp;dose&nbsp;one or stop the medication.<\/p>\n\n\n\n<p>Tell your doctor if you experience symptoms such as depression,\u00a0apathy, anxiety, fatigue, sweating, or pain after you have stopped taking or reduced the\u00a0dose\u00a0of SIFROL.\u00a0If the problems persist for more than a few weeks, your doctor may need to adjust your treatment.<\/p>\n\n\n\n<p>Tell your doctor if you develop an inability to keep your body and neck straight and upright (&nbsp;axial&nbsp;dystonia&nbsp;).&nbsp;If this happens, your doctor may want to change your medication.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>SIFROL is not recommended for children and adolescents under 18 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and SIFROL<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken, or might take any other medicines.\u00a0This also applies to medicines, herbal medicines, health foods or dietary supplements that you have received without a prescription.<\/p>\n\n\n\n<p>Avoid taking SIFROL with antipsychotic medicines.<\/p>\n\n\n\n<p>Be careful if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cimetidine (for the treatment of excess stomach acid and&nbsp;ulcers&nbsp;)<\/li><li>amantadine (which can be used to treat&nbsp;Parkinson&#8217;s disease&nbsp;)<\/li><li>mexiletine (for the treatment of irregular heartbeat, a condition called ventricular arrhythmia)<\/li><li>zidovudine (which can be used to treat&nbsp;AIDS&nbsp;(acquired immune deficiency syndrome), an immunodeficiency disease)<\/li><li>cisplatin (for the treatment of various types of cancer)<\/li><li>quinine (which can be used to prevent painful nocturnal calf cramps and to treat a type of&nbsp;malaria&nbsp;known as&nbsp;falciparum&nbsp;malaria&nbsp;)<\/li><li>procainamide&nbsp;(for the treatment of irregular heartbeats).<\/li><\/ul>\n\n\n\n<p>If you are taking\u00a0levodopa, the\u00a0dose\u00a0of one of\u00a0levodopa\u00a0should be reduced when you start treatment with SIFROL.<\/p>\n\n\n\n<p>Be careful when using drugs that have a sedative effect or when consuming alcoholic beverages.&nbsp;In these cases, SIFROL may affect your ability to drive and use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SIFROL with food, drink, and alcohol<\/h2>\n\n\n\n<p>Be careful with alcoholic beverages during treatment with SIFROL.<\/p>\n\n\n\n<p>SIFROL can be taken with or without food.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.\u00a0Your doctor will then discuss with you whether you should continue to take SIFROL.<\/p>\n\n\n\n<p>The effect of SIFROL on the unborn baby is unknown.&nbsp;Therefore, you should not take SIFROL if you are pregnant unless your doctor advises you to do so.<\/p>\n\n\n\n<p>SIFROL should not be used during breast-feeding.\u00a0SIFROL may reduce the production of breast milk.\u00a0It can also pass to the breast milk and reach your baby.\u00a0If the use of SIFROL is necessary, breastfeeding should be discontinued.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>SIFROL can cause hallucinations (seeing, hearing, or perceiving things that do not exist).\u00a0If this happens to you, do not drive or use machines.<\/p>\n\n\n\n<p>SIFROL has been associated with drowsiness and episodes of sudden drowsiness, especially in patients with\u00a0Parkinson&#8217;s disease.\u00a0If you experience these\u00a0side effects, do not drive or use machines.\u00a0You should tell your doctor if this happens.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take SIFROL<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.\u00a0Consult a doctor if you are unsure.\u00a0Your doctor will inform you about the correct\u00a0dosage.<\/p>\n\n\n\n<p>You can take SIFROL with or without food.&nbsp;The tablets should be swallowed with water.<\/p>\n\n\n\n<p><strong>Parkinson&#8217;s disease<\/strong><\/p>\n\n\n\n<p>The daily dose should always be divided into 3 equal\u00a0doses.<\/p>\n\n\n\n<p>During the first week, the usual\u00a0dose of\u00a01 tablet of SIFROL is 0.088 mg three times daily (equivalent to 0.264 mg per day).<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\">The first week<\/th><\/tr><tr><td>Number of tablets<\/td><td>1 tablet SIFROL 0.088 mg3 times daily<\/td><\/tr><\/thead><tbody><tr><td>Total daily dose (mg)<\/td><td>0.264<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The dose\u00a0is increased every 5 to 7 days according to your doctor&#8217;s instructions until the symptoms are checked (maintenance dose).<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><strong>Second week<\/strong><\/th><th scope=\"col\"><strong>Third week<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Number of tablets<\/td><td>1 tablet SIFROL 0.18 mg3 times daily<strong>OR<\/strong>2 tablets SIFROL 0.088 mg3 times daily<\/td><td>1 tablet SIFROL 0.35 mg3 times daily<strong>OR<\/strong>2 tablets SIFROL 0.18 mg3 times daily<\/td><\/tr><tr><td>Total daily dose (mg)<\/td><td>0.54<\/td><td>1.1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The usual maintenance dose is 1.1 mg per day.\u00a0However, your doctor may need to increase the\u00a0dose\u00a0one further.\u00a0If necessary, your doctor may increase your\u00a0dose\u00a0up to a maximum of 3.3 mg per day.\u00a0A lower maintenance dose of 3 0.088 mg SIFROL tablets is also possible.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><strong>Minimum maintenance dose<\/strong><\/th><th scope=\"col\"><strong>Maximum maintenance dose<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Number of tablets<\/td><td>1 tablet SIFROL 0.088 mg3 times daily<\/td><td>1 tablet SIFROL 0.7 mg and 1 tablet SIFROL 0.35 mg 3 times daily<\/td><\/tr><tr><td>Total daily dose (mg)<\/td><td>0.264<\/td><td>3.15<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><em>Patients with kidney disease<\/em><\/p>\n\n\n\n<p>If you have moderate or severe kidney disease, your doctor will prescribe a lower\u00a0dose.\u00a0In this case, you will take the tablets only once or twice daily.\u00a0If you have moderate kidney disease, the usual starting dose is 1 tablet of SIFROL 0.088 mg twice daily.\u00a0In severe kidney disease, the usual starting dose is only 1 tablet of SIFROL 0.088 mg per day.<\/p>\n\n\n\n<p><strong>Restless legs<\/strong>&nbsp;syndrome<\/p>\n\n\n\n<p>Dose&nbsp;one is usually taken once a day, 2-3 hours before bedtime.<\/p>\n\n\n\n<p>During the first week, the usual\u00a0dose of\u00a01 tablet SIFROL is 0.088 mg once daily (equivalent to 0.088 mg daily):<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><strong>The first week<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Number of tablets<\/td><td>1 tablet SIFROL 0.088 mg<\/td><\/tr><tr><td>Total daily dose (mg)<\/td><td>0.088<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The dose\u00a0is increased every 4 to 7 days according to your doctor&#8217;s instructions, until the symptoms are checked (maintenance dose).<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><\/th><th scope=\"col\"><strong>Second week<\/strong><\/th><th scope=\"col\"><strong>Third week<\/strong><\/th><th scope=\"col\"><strong>Fourth week<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Number of tablets<\/td><td>1 tablet SIFROL 0.18 mg<strong>OR<\/strong>2 tablets SIFROL 0.088 mg<\/td><td>1 tablet SIFROL 0.35 mg<strong>OR<\/strong>2 tablets SIFROL 0.18 mg<strong>OR<\/strong>4 tablets SIFROL 0.088 mg<\/td><td>1 tablet SIFROL 0.35 mg and 1 tablet SIFROL 0.18 mg<strong>OR<\/strong>3 tablets SIFROL 0.18 mg<strong>OR<\/strong>6 tablets SIFROL 0.088 mg<\/td><\/tr><tr><td>Total daily dose (mg)<\/td><td>0.18<\/td><td>0.35<\/td><td>0.54<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The daily dose should not exceed 6 tablets SIFROL 0.088 mg or a&nbsp;dose&nbsp;of 0.54 mg (0.75 mg pramipexole salt).<\/p>\n\n\n\n<p>If you stop taking your tablets for more than a few days and want to resume treatment, you will need to start again with the lowest\u00a0dose.\u00a0You can then step up\u00a0dose\u00a0one again, as you did the first time.\u00a0Ask your doctor for advice.<\/p>\n\n\n\n<p>Your doctor will evaluate the treatment after 3 months to decide if you should continue with the treatment or not.<\/p>\n\n\n\n<p><em>Patients with kidney disease:<\/em><\/p>\n\n\n\n<p>If you have severe kidney disease, SIFROL may not be a suitable treatment for you.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more SIFROL than you should<\/h2>\n\n\n\n<p>If you accidentally take too many tablets,<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Contact your doctor or nearest emergency department immediately for advice.<\/li><li>You may experience vomiting, inability to stand still, or any of the&nbsp;side effects&nbsp;described in section 4, Possible&nbsp;side effects&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take SIFROL<\/h2>\n\n\n\n<p>Do not worry.\u00a0Simply skip the current\u00a0dose\u00a0one completely and then take the next\u00a0dose\u00a0at the right time.\u00a0Do not try to compensate for missed\u00a0doses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking SIFROL<\/h2>\n\n\n\n<p>Do not stop taking SIFROL without talking to your doctor first.\u00a0If you need to stop treatment, your doctor will reduce the\u00a0dose\u00a0gradually.\u00a0This reduces the risk of worsening symptoms.<\/p>\n\n\n\n<p>If you have\u00a0Parkinson&#8217;s disease, do not stop treatment with SIFROL abruptly.\u00a0A sudden interruption can cause you to develop a disease condition called malignant neuroleptic syndrome, this condition can pose a major health risk.\u00a0Symptoms include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>akinesia&nbsp;(loss of muscle mobility)<\/li><li>stiff muscles<\/li><li>fever<\/li><li>varying&nbsp;blood pressure<\/li><li>tachycardia&nbsp;(increased heart rate)<\/li><li>confusion<\/li><li>decreased level of consciousness (eg&nbsp;coma&nbsp;).<\/li><\/ul>\n\n\n\n<p>If you stop taking SIFROL or reduce your\u00a0dose\u00a0, you may also develop a medical condition called withdrawal syndrome after treatment with a dopamine agonist.\u00a0Symptoms include depression,\u00a0apathy\u00a0, anxiety, fatigue, sweating, or pain.\u00a0If you get these symptoms, consult a doctor.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects\u00a0, although not everybody gets them.\u00a0Evaluation of these\u00a0side effects\u00a0is based on the following frequencies:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\">Name<\/th><th scope=\"col\">A number of users affected:<\/th><\/tr><\/thead><tbody><tr><td><strong>Very common:<\/strong><\/td><td>may occur in more than 1 in 10 users<\/td><\/tr><tr><td><strong>Usual:<\/strong><\/td><td>may affect up to 1 in 10 users<\/td><\/tr><tr><td><strong>Uncommon:<\/strong><\/td><td>may affect up to 1 in 100 users<\/td><\/tr><tr><td><strong>Rare<\/strong>&nbsp;:<\/td><td>can occur in up to 1 in 1,000 users<\/td><\/tr><tr><td><strong>Very rare:<\/strong><\/td><td>may affect up to 1 in 10,000 users<\/td><\/tr><tr><td><strong>Has been reported:<\/strong><\/td><td>occurs in an unknown number of users<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>If you have\u00a0Parkinson&#8217;s disease, you can get the following side effects:<\/strong><\/p>\n\n\n\n<p><strong>Very common:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dyskinesia&nbsp;(eg abnormal involuntary movements of the arms and legs)<\/li><li>Somnolence<\/li><li>Dizziness<\/li><li>Nausea<\/li><\/ul>\n\n\n\n<p><strong>Usual:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Strong need to behave in an unusual way<\/li><li>Hallucinations (abnormal vision, sound, or sensations)<\/li><li>Confusion<\/li><li>Fatigue<\/li><li>Insomnia (insomnia)<\/li><li>Excess fluid, usually in the legs (peripheral\u00a0edema\u00a0)<\/li><li>Headache<\/li><li>Low\u00a0blood pressure\u00a0(\u00a0hypotension\u00a0)<\/li><li>Abnormal dreams<\/li><li>Constipation<\/li><li>Visual impairment<\/li><li>Vomiting<\/li><li>Weight loss including decreased appetite<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Paranoia\u00a0(eg excessive concern for their health)<\/li><li>Abnormal perception of reality<\/li><li>Excessive sleepiness during the day and suddenly falling asleep<\/li><li>Memory loss (\u00a0amnesia\u00a0)<\/li><li>Hyperkinesia (increased movement and inability to stand still)<\/li><li>Weight gain<\/li><li>Allergic reactions (eg rash,\u00a0itching, hypersensitivity)<\/li><li>Fainting<\/li><li>Heart failure\u00a0(heart problems that can cause shortness of breath and swollen ankles) *<\/li><li>Altered secretion of antidiuretic hormone *<\/li><li>Restlessness<\/li><li>Dyspnoea\u00a0(difficulty breathing)<\/li><li>Hiccup<\/li><li>Pneumonia\u00a0(\u00a0pneumonia\u00a0)<\/li><li>Inability to resist the impulse, drive or desire to perform an act that may be harmful to yourself and others, which may include:<ul><li>Strong impulse to play excessively despite serious personal consequences or consequences for the family<\/li><li>Altered or increased sexual interest and behavior, of significant inconvenience to you or others, such as increased sexual drive<\/li><li>Uncontrollable excessive buying behavior or wasting money<\/li><li>Binge eating (eating large amounts of food for a short time) or compulsive eating (eating larger amounts of food than normal and more than is needed to satisfy hunger) *<\/li><\/ul><\/li><li>Delirium\u00a0(decreased consciousness, confusion, loss of reality)<\/li><\/ul>\n\n\n\n<p><strong>Rare:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Mania (feeling upset, elated or overexcited)<\/li><\/ul>\n\n\n\n<p><strong>Has been reported:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>After discontinuation or reduction of treatment with SIFROL: depression,\u00a0apathy, anxiety, fatigue, sweating or pain may occur (withdrawal syndrome after dopamine agonist treatment).<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor if you experience any of the above behaviors, and he will discuss how to manage or reduce the symptoms.<\/strong><\/p>\n\n\n\n<p>For&nbsp;side effects&nbsp;marked with *, an exact frequency estimate is not possible as these&nbsp;side effects&nbsp;have not been seen in&nbsp;clinical trials&nbsp;in 2762 patients treated with pramipexole.&nbsp;The frequency is probably not higher than &#8220;less common&#8221;.<\/p>\n\n\n\n<p><strong>If you have restless legs syndrome, you can get the following side effects:<\/strong><\/p>\n\n\n\n<p><strong>Very common:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><\/ul>\n\n\n\n<p><strong>Usual:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Altered sleep habits, such as insomnia and drowsiness<\/li><li>Fatigue<\/li><li>Headache<\/li><li>Abnormal dreams<\/li><li>Constipation<\/li><li>Dizziness<\/li><li>Vomiting<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Strong need to behave unusually *<\/li><li>Heart failure\u00a0(heart problems that can cause shortness of breath and swollen ankles) *<\/li><li>Altered secretion of antidiuretic hormone *<\/li><li>Dyskinesia\u00a0(eg abnormal, involuntary movements of the arms and legs)<\/li><li>Hyperkinesia (increased movement and inability to stand still) *<\/li><li>Paranoia\u00a0(eg excessive concern for their health) *<\/li><li>Abnormal perception of reality *<\/li><li>Memory loss (\u00a0amnesia\u00a0) *<\/li><li>Hallucinations (abnormal vision, sound, or sensations)<\/li><li>Confusion<\/li><li>Excessive sleepiness during the day and suddenly falling asleep<\/li><li>Weight gain<\/li><li>Low\u00a0blood pressure\u00a0(\u00a0hypotension\u00a0)<\/li><li>Excess fluid, usually in the legs (peripheral\u00a0edema\u00a0)<\/li><li>Allergic reactions (eg skin rash,\u00a0itching\u00a0, hypersensitivity)<\/li><li>Fainting<\/li><li>Restlessness<\/li><li>Visual impairment<\/li><li>Weight loss including decreased appetite<\/li><li>Dyspnoea\u00a0(difficulty breathing)<\/li><li>Hiccup<\/li><li>Pneumonia\u00a0(\u00a0pneumonia\u00a0) *<\/li><li>Inability to resist the impulse, drive or desire to perform an act that may be harmful to yourself and others, which may include:<ul><li>Strong impulse to play excessively despite serious personal or family consequences *<\/li><li>Altered or increased sexual interest and behavior, of significant inconvenience to you or others, such as increased sexual drive *<\/li><li>Uncontrollable excessive buying behavior or wasting money *<\/li><li>Binge eating (eating large amounts of food for a short time) or compulsive eating (eating larger amounts of food than normal and more than is needed to satisfy hunger) *<\/li><\/ul><\/li><li>Mania (feeling upset, elated, or overexcited) *<\/li><li>Delirium\u00a0(decreased consciousness, confusion, loss of reality) *<\/li><\/ul>\n\n\n\n<p><strong>Has been reported:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>After discontinuation or reduction of treatment with SIFROL: depression,&nbsp;apathy&nbsp;, anxiety, fatigue, sweating or pain may occur (withdrawal syndrome after dopamine agonist treatment).<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor if you experience any of the above behaviors, and he will discuss how to manage or reduce the symptoms.<\/strong><\/p>\n\n\n\n<p>For&nbsp;side effects&nbsp;marked with *, an exact frequency estimate is not possible as these&nbsp;side effects&nbsp;have not been seen in&nbsp;clinical trials&nbsp;in 1395 patients treated with pramipexole.&nbsp;The frequency is probably not higher than &#8220;less common&#8221;.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store SIFROL<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is pramipexole.<\/p>\n\n\n\n<p>Each tablet contains 0.088 mg, 0.18 mg, 0.35 mg or 0.7 mg pramipexole as 0.125 mg, 0.25 mg, 0.5 mg and 1 mg pramipexole dihydrochloride monohydrate respectively.<\/p>\n\n\n\n<p>The other ingredients are mannitol, corn starch, anhydrous\u00a0colloidal\u00a0silica, povidone K 25, and magnesium stearate.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><strong>SIFROL 0.088 mg<\/strong>\u00a0tablets are white, round, flat, and not scored.<\/p>\n\n\n\n<p><strong>SIFROL 0.18 mg<\/strong>&nbsp;tablets and&nbsp;<strong>SIFROL 0.35 mg<\/strong>&nbsp;tablets are white, oval and flat.&nbsp;The tablets have a notch on both sides and can be divided into two equal parts.<\/p>\n\n\n\n<p><strong>SIFROL 0.7 mg<\/strong>&nbsp;tablets are white, round and flat.&nbsp;The tablets have a notch on both sides and can be divided into two equal parts.<\/p>\n\n\n\n<p>All tablets are marked with the Boehringer Ingelheim company symbol on one side and the codes P6, P7, P8, or P9 on the other side, which represent the tablet strengths 0.088 mg, 0.18 mg, 0.35 mg, and 0.7 mg respectively.<\/p>\n\n\n\n<p>All strengths of SIFROL are available in aluminum blister cards with 10 tablets in each card, in cartons containing 3 or 10 blister cards (30 or 100 tablets).&nbsp;Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Boehringer Ingelheim International GmbH<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Boehringer Ingelheim France<\/p>\n\n\n\n<p>100-104 avenue de France<\/p>\n\n\n\n<p>75013 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>SCS Boehringer Ingelheim Comm.VTel: +32 2 773 33 11<\/td><td><strong>Lithuania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGLithuanian branchesTel: +370 5 2595942<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Boringer Inglehaim RIV Gemba and Co.&nbsp;KG- clone of BulgariaTel: +359 2 958 79 98<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>SCS Boehringer Ingelheim Comm.VTel: +32 2 773 33 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Boehringer Ingelheim spol.&nbsp;s roTel: +420 234 655 111<\/td><td><strong>Hungary<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGMagyarorsz\u00e1gi Fi\u00f3ktelepeTel: +36 1 299 89 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Boehringer Ingelheim Danmark A \/ STel: +45 39 15 88 88<\/td><td><strong>Malta<\/strong>Boehringer Ingelheim Ireland Ltd.Tel: +353 1 295 9620<\/td><\/tr><tr><td><strong>Germany<\/strong>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KGTel: +49 (0) 800 77 90 900<\/td><td><strong>The Netherlands<\/strong>Boehringer Ingelheim bvTel: +31 (0) 800 22 55889<\/td><\/tr><tr><td><strong>Eesti<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGEesti subsidiaryTel: +372 612 8000<\/td><td><strong>Norway<\/strong>Boehringer Ingelheim Norway KSTel: +47 66 76 13 00<\/td><\/tr><tr><td><strong>Elad<\/strong>Boehringer Ingelheim Ellas AET\u03b7\u03bb: +30 2 10 89 06 300<\/td><td><strong>Austria<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGTel: +43 1 80 105-7870<\/td><\/tr><tr><td><strong>Spain<\/strong>Boehringer Ingelheim Espa\u00f1a, SATel: +34 93 404 51 00<\/td><td><strong>Poland<\/strong>Boehringer Ingelheim Sp.zo.o.Tel: +48 22 699 0 699<\/td><\/tr><tr><td><strong>France<\/strong>Boehringer Ingelheim France SASTel: +33 3 26 50 45 33<\/td><td><strong>Portugal<\/strong>Boehringer IngelheimPortugal, Lda.Tel: +351 21 313 53 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Boehringer Ingelheim Zagreb dooTel: +385 1 2444 600<\/td><td><strong>Romania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGVienna &#8211; Sucursala BucharestTel: +40 21 302 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Boehringer Ingelheim Ireland Ltd.Tel: +353 1 295 9620<\/td><td><strong>Slovenia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGPodru\u017enica LjubljanaTel: +386 1 586 40 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGorganizing serviceTel: +421 2 5810 1211<\/td><\/tr><tr><td><strong>Italy<\/strong>Boehringer Ingelheim Italia SpATel: +39 02 5355 1<\/td><td><strong>Finland \/ Finland<\/strong>Boehringer Ingelheim Finland KyPuh \/ Tel: +358 10 3102 800<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Boehringer Ingelheim Ellas AET\u03b7\u03bb: +30 2 10 89 06 300<\/td><td><strong>Sweden<\/strong>Boehringer Ingelheim ABTel: +46 8 721 21 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGLatvian branchTel: +371 67 240 011<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Boehringer Ingelheim Ireland Ltd.Tel: +353 1 295 9620<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>SIFROL contains the active substance pramipexole and belongs to a group of medicines called dopamine agonists, which stimulate the dopamine receptors in the brain.\u00a0By stimulating dopamine receptors, nerve impulses are triggered in the brain that can help control the body&#8217;s movements.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[5888,5890,24022,24026,24025,5889,24023,20152,24024],"class_list":["post-23034","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-pramipexole","tag-pramipexole-side-effects","tag-sifrol","tag-sifrol-side-effects","tag-sifrol-tablet","tag-what-is-pramipexole","tag-what-is-sifrol","tag-what-pramipexole-is-used-for","tag-what-sifrol-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23034","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23034"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23034\/revisions"}],"predecessor-version":[{"id":23052,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23034\/revisions\/23052"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23034"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}