{"id":23029,"date":"2022-07-19T06:50:17","date_gmt":"2022-07-19T06:50:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23029"},"modified":"2022-07-20T06:01:03","modified_gmt":"2022-07-20T06:01:03","slug":"sibnayal","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sibnayal\/","title":{"rendered":"Sibnayal &#8211; Potassium citrate and potassium bicarbonate uses, dose and side effects"},"content":{"rendered":"\n<p>8 mEq and 24 mEq&nbsp;depot granules potassium<br>citrate \/ potassium bicarbonate<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Sibnayal is and what it is used for<\/h2>\n\n\n\n<p>Sibnayal contains two active substances, potassium citrate and potassium bicarbonate (also called potassium bicarbonate).<\/p>\n\n\n\n<p>Sibnayal is an alkalizing drug (which makes the blood more alkaline) that is used to treat\u00a0acidity\u00a0(acidity) in the blood caused by a kidney disease called\u00a0renal\u00a0tubular\u00a0acidosis\u00a0(RTA).<\/p>\n\n\n\n<p>Sibnayal helps reduce the impact of data on your daily life.<\/p>\n\n\n\n<p>Sibnayal can be given to adults, adolescents, and children over 1 year of age.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Sibnayal<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Sibnayal<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to potassium citrate or potassium bicarbonate or any of the other ingredients of this medicine (listed in section 6),<\/li><li>if you have severe kidney disease or\u00a0kidney failure,<\/li><li>if you have high potassium levels in your blood (\u00a0hyperkalemia\u00a0)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Sibnayal<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a disease or are taking a medicine that can increase the level of potassium in your blood (see below &#8220;Other medicines and Sibnayal&#8221;),<\/li><li>if you often have gastrointestinal symptoms such as bloating, diarrhea, nausea, vomiting,<\/li><li>if you have chronic\u00a0kidney disease.<\/li><\/ul>\n\n\n\n<p>Sibnayal prolonged-release\u00a0granules\u00a0are designed to provide a slow\u00a0release\u00a0of the active substances after you have ingested\u00a0granules.\u00a0You may see remnants of\u00a0granules\u00a0in your stool.\u00a0This is normal and does not reduce the effect of the medicine.<\/p>\n\n\n\n<p>If you vomit within two hours of taking the medicine, take\u00a0another dose.<\/p>\n\n\n\n<p>You will need to see your doctor regularly.\u00a0From time to time, your doctor will need to take blood and urine samples or test your heart to adjust the\u00a0dose\u00a0of Sibnayal.\u00a0Your doctor will check your kidney function regularly if you are elderly and\/or if you have impaired kidney function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Do not give this medicine to children under 1 year of age as they may choke and suffocate.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Sibnayal<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines may affect the way Sibnayal works or make you more likely to get\u00a0side effects.\u00a0This includes the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs that increase the level of&nbsp;potassium&nbsp;in the blood such as<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>ACE inhibitors\u00a0(used to treat high\u00a0blood pressure, heart disease, and kidney disease in patients with type 1\u00a0diabetes\u00a0),<\/li><li>potassium-sparing\u00a0diuretics\u00a0(used to treat high\u00a0blood pressure, fluid retention in the\u00a0tissues\u00a0(\u00a0edema\u00a0), and heart disease),<\/li><li>potassium supplements (used to prevent or treat low levels of potassium in the blood), &#8211; cyclosporine (used to prevent or treat\u00a0transplant rejection\u00a0),<\/li><li>heparin sodium (used to prevent or delay blood clotting),<\/li><li>non-steroidal anti-inflammatory drugs (\u00a0NSAIDs\u00a0) (used to reduce fever, pain, and\u00a0inflammation\u00a0).<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs that can be affected by a change in the level of&nbsp;potassium&nbsp;in the blood such as<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>digitalis glycosides\u00a0(eg\u00a0digoxin, used to treat\u00a0heart failure\u00a0and certain heart rhythm disorders),<\/li><li>corticosteroids\u00a0(used to treat\u00a0inflammation\u00a0),<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>other drugs that can cause heart rhythm disorders such as<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>amiodarone&nbsp;and&nbsp;quinidine&nbsp;(used to control heart rhythm),<\/li><li>chlorpromazine (used to treat certain mental illnesses),<\/li><li>cisapride (used to treat heartburn),<\/li><li>sparfloxacin (used to treat certain bacterial infections).<\/li><\/ul>\n\n\n\n<p>Some medicines may be affected by elevated urinary&nbsp;pH&nbsp;in connection with treatment with Sibnayal such as<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>salicylates (used to treat pain and&nbsp;inflammation<\/li><li>acetylsalicylic acid-like drugs),<\/li><li>tetracyclines&nbsp;(used to treat certain bacterial infections),<\/li><li>barbiturates&nbsp;(sleeping pills).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Sibnayal with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not mix Sibnayal with hot food or hot drinks.&nbsp;Do not drink alcohol while taking Sibnayal.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Sibnayal is not expected to affect the ability to drive or use machines.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sibnayal contains potassium<\/h2>\n\n\n\n<p>Sibnayal 8 mEq contains 308 mg of&nbsp;potassium&nbsp;per&nbsp;sachet&nbsp;.&nbsp;This should be considered if you have impaired kidney function or if you have been prescribed a low-potassium diet.<\/p>\n\n\n\n<p>Sibnayal 24 mEq contains 924 mg of&nbsp;potassium&nbsp;per&nbsp;sachet&nbsp;.&nbsp;This should be considered if you have impaired kidney function or if you have been prescribed a low-potassium diet.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Sibnayal<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The amount of Sibnayal you should take depends on your age, weight, and condition.\u00a0Your doctor will tell you exactly what\u00a0dose\u00a0of Sibnayal to take.\u00a0This will always be one or more whole sachets.<\/p>\n\n\n\n<p>Your doctor may need to adjust the&nbsp;dose&nbsp;of Sibnayal.<\/p>\n\n\n\n<p>The use of this drug requires medical supervision.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>Dose&nbsp;one is adjusted by your doctor according to the level of bicarbonate in your blood.<\/p>\n\n\n\n<p><strong>How to use Sibnayal<\/strong><\/p>\n\n\n\n<p>Sibnayal is for&nbsp;oral&nbsp;use (should be swallowed).&nbsp;If you are not sure how to take Sibnayal, talk to a doctor or pharmacist.<\/p>\n\n\n\n<p>1. Hold the sachet vertically (upright) with your fingers over the dashed line.&nbsp;Shake it from side to side so that the contents move to the bottom of the sachet.&nbsp;<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191111000097#\" rel=\"noopener\"><\/a>2. Cut the sachet along the dotted line, using scissors if necessary.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191111000097#\" rel=\"noopener\"><\/a>3. Place all or part of the contents of the sachet directly in the mouth of the tongue.&nbsp;<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191111000097#\" rel=\"noopener\"><\/a>4. Swallow&nbsp;granules&nbsp;immediately with a large glass of water.&nbsp;Granules&nbsp;must not be chewed or crushed.&nbsp;<strong>Repeat steps 1 to 4<\/strong>&nbsp;as needed until you have taken the full&nbsp;dose&nbsp;one.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191111000097#\" rel=\"noopener\"><\/a><strong>For patients who cannot swallow&nbsp;granules<\/strong><\/p>\n\n\n\n<p>Mix Sibnayal with small amounts of soft and cold foods (eg fruit puree or yogurt) directly on the spoon.\u00a0You must swallow the soft food mixture immediately.\u00a0Do not save\u00a0the mixture\u00a0for later use.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191111000097#\" rel=\"noopener\"><\/a>2. Place the\u00a0mixture\u00a0directly in your mouth and swallow it without chewing.\u00a0Make sure that Sibnayal is not left in the mouth.\u00a0<strong>Repeat steps 1 and 2<\/strong>\u00a0as needed until the full\u00a0dose\u00a0is taken.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191111000097#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/293fd116-ea11-4b56-8e46-cf94e651b97b\" alt=\"Advice 6\" title=\"Advice 6\"\/><\/a><\/figure>\n\n\n\n<p>Do not\u00a0mix granules\u00a0with liquid before taking them.<\/p>\n\n\n\n<p><strong>When to take Sibnayal<\/strong><\/p>\n\n\n\n<p>Take Sibnayal in the morning and the evening, during a meal.\u00a0You must allow approximately 12 hours between each\u00a0dose\u00a0to cover the entire 24-hour period.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20191111000097#\" rel=\"noopener\"><\/a><strong>Dose adjustment<\/strong><\/p>\n\n\n\n<p>Dose increases and dose reductions should be done gradually and over a few weeks.\u00a0Your doctor will adjust the\u00a0dose\u00a0according to your condition.\u00a0The usual recommended\u00a0dose\u00a0is 4 to 6 whole sachets of 24 mEq per day.<\/p>\n\n\n\n<p>You should consult your doctor if you experience any&nbsp;side effects&nbsp;as he or she may need to adjust the dose of the medicine.<\/p>\n\n\n\n<p><strong>Switching from another alkalizing drug<\/strong><\/p>\n\n\n\n<p>If you are switching from another alkalizing drug to Sibnayal, your doctor should closely monitor the change.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Sibnayal than you should&nbsp;<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist if you have taken too much Sibnayal.\u00a0You may feel nauseous, vomit, and have diarrhea.\u00a0If you have taken a large amount of Sibnayal, you may feel weak or have inexplicably stiff muscles, cramps (muscle contractions), abnormal stinging or burning sensation, crawling or numbness, and mental confusion, or abnormal heart rate.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Sibnayal<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.\u00a0Take a\u00a0dose\u00a0as soon as you remember it.\u00a0However, if your next\u00a0dose\u00a0is to be taken in less than six hours, skip the\u00a0dose\u00a0you forgot to take.\u00a0Do not take more than two\u00a0doses\u00a0per day.\u00a0Talk to your doctor if you forget to take one or\u00a0more\u00a0doses<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Sibnayal<\/h2>\n\n\n\n<p>This medicine is intended for long-term use.&nbsp;It will only work as long as you use it.&nbsp;You should not stop taking it unless your doctor tells you to, even if you feel better, as your illness may get worse.&nbsp;If you want to stop treatment, talk to your doctor first.&nbsp;If you have any further questions on the use of this product, ask your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Very common&nbsp;<\/strong>side effects&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<p>&#8211; abdominal pain (stomach pain)<\/p>\n\n\n\n<p><strong>Common&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<p>&#8211; upper abdominal pain (pain in the upper abdomen)<\/p>\n\n\n\n<p>&#8211; gastrointestinal pains and diseases (gastrointestinal pain and diseases),<\/p>\n\n\n\n<p>&#8211;&nbsp;dyspepsia&nbsp;(digestive problems),<\/p>\n\n\n\n<p>&#8211; vomiting,<\/p>\n\n\n\n<p>&#8211; diarrhea<\/p>\n\n\n\n<p>nausea at the start of treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Sibnayal<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after \u201cEXP\u201d or \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>After opening a&nbsp;sachet, discard&nbsp;all unused contents.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substances are potassium citrate and potassium bicarbonate (also called potassium bicarbonate).<\/p>\n\n\n\n<p>Each&nbsp;sachet&nbsp;of Sibnayal 8 mEq contains 282 mg of potassium citrate and 527 mg of potassium bicarbonate.<\/p>\n\n\n\n<p>Each&nbsp;sachet&nbsp;of Sibnayal 24 mEq contains 847 mg of potassium citrate and 1,582 mg of potassium bicarbonate.<\/p>\n\n\n\n<p>The other ingredients are hypromellose (E464), microcrystalline cellulose (E460 (i)), glycerol behenate, magnesium stearate (E470b),\u00a0colloidal\u00a0anhydrous silica, heavy magnesium oxide (E530), ethylcellulose (E462), chlorophyllin (E140 (ii)).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Sibnayal is a&nbsp;mixture&nbsp;of green and white&nbsp;depot granules&nbsp;that are delivered in sachets.&nbsp;The cartons contain 60 sachets.<\/p>\n\n\n\n<p>Sibnayal is available in multiple packs of 2, 3, 4, 5, and 6 cartons, each containing 60 sachets.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>ADVICE<\/p>\n\n\n\n<p>262 rue du Faubourg Saint Honor\u00e9<\/p>\n\n\n\n<p>75008 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>infomed@advicenne.com<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>ELAIAPHARM<\/p>\n\n\n\n<p>2881 route des Cr\u00eates<\/p>\n\n\n\n<p>ZI les Bouillides Sophia Antipolis<\/p>\n\n\n\n<p>06560 Valbonne<\/p>\n\n\n\n<p>France<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sibnayal contains two active substances, potassium citrate and potassium bicarbonate (also called potassium bicarbonate).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24038,15025,15028,24032,24035,24036,24033,24037,24034],"class_list":["post-23029","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-potassium-bicarbonate-side-effects","tag-potassium-citrate","tag-potassium-citrate-side-effects","tag-sibnayal","tag-sibnayal-side-effects","tag-what-is-potassium-bicarbonate","tag-what-is-sibnayal","tag-what-potassium-bicarbonate-is-used-for","tag-what-sibnayal-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23029"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23029\/revisions"}],"predecessor-version":[{"id":23060,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23029\/revisions\/23060"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}