{"id":23027,"date":"2022-07-19T06:48:34","date_gmt":"2022-07-19T06:48:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23027"},"modified":"2022-07-20T06:00:28","modified_gmt":"2022-07-20T06:00:28","slug":"sialanar","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sialanar\/","title":{"rendered":"Sialanar &#8211; Glycopyrronium uses, dose and side effects"},"content":{"rendered":"\n<p>320 micrograms\/ml\u00a0oral\u00a0solution<br>glycopyrronium<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Sialanar is and what it is used for<\/h2>\n\n\n\n<p>Sialanar contains the active substance glycopyrronium.<\/p>\n\n\n\n<p>Glycopyrronium belongs to a group of medicines called quaternary ammonium anticholinergics, which are substances that block or reduce the signal transmission between nerve cells.&nbsp;This reduced signal transmission can deactivate the cells that produce saliva.<\/p>\n\n\n\n<p>Sialanar is used to treat the overproduction of saliva in children and adolescents from 3 years of age.<\/p>\n\n\n\n<p>Drooling or overproduction of saliva is a common symptom of many diseases of the nerves and muscles.\u00a0It is mainly caused by impaired control of the muscles of the face.\u00a0Acute\u00a0increased drooling may be associated with\u00a0inflammation, dental infections, or\u00a0infection\u00a0in your mouth.<\/p>\n\n\n\n<p>Sialanar acts on the salivary glands to reduce saliva production.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Sialanar<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not give Sialanar about your child\/teenager<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>is allergic to glycopyrronium or any of the other ingredients of this medicine (listed in section 6)<\/li><li>is pregnant or breastfeeding<\/li><li>have\u00a0glaucoma\u00a0(increased pressure in the eye)<\/li><li>unable to empty the bladder (\u00a0urinary retention\u00a0)<\/li><li>have severe kidney disease have a narrowing of the stomach (pyloric stenosis) or the intestines that cause vomiting<\/li><li>have diarrhea (frequent, loose, and watery stools)<\/li><li>have\u00a0ulcerative colitis\u00a0(\u00a0inflammation\u00a0of the intestine)<\/li><li>has pain and swelling in the abdomen (paralytic\u00a0ileus\u00a0)<\/li><li>has\u00a0myasthenia gravis\u00a0(muscle weakness and fatigue)<\/li><li>take any of the following medicines (see section Other medicines and Sialanar): solid medicine (eg tablets or capsules) of potassium chloride to be swallowed, anticholinergic medicines. \u00a0\u00a0\u00a0<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor or pharmacist before giving Sialanar, if your child has:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart disease,\u00a0heart failure, irregular heartbeat, or high\u00a0blood pressure<\/li><li>digestive disorders (constipation;\u00a0chronic\u00a0heartburn and indigestion)<\/li><li>high body temperature (fever)<\/li><li>inability to sweat normally<\/li><li>kidney problems or difficulty urinating<\/li><li>the affected\u00a0blood-brain barrier\u00a0(the layer of cells that surround the brain)<\/li><\/ul>\n\n\n\n<p>If you are not sure if any of the above applies to your child, talk to a doctor or pharmacist before giving Sialanar.<\/p>\n\n\n\n<p>Discontinue treatment and consult a prescribing physician in the following cases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pneumonia<\/li><li>allergic reaction<\/li><li>difficult to empty the bladder (&nbsp;urinary retention&nbsp;)<\/li><li>behavioral changes<\/li><li>constipation<\/li><li>fever<\/li><\/ul>\n\n\n\n<p>Avoid&nbsp;exposing&nbsp;the child to heat or very high temperatures (hot weather, high room temperature).&nbsp;This is to avoid overheating and the risk of heat stroke.&nbsp;Talk to your child&#8217;s doctor in hot weather to see if&nbsp;dose&nbsp;one of Sialanar should be lowered.<\/p>\n\n\n\n<p>Reduced salivation can increase the risk of dental disease.&nbsp;The child&#8217;s teeth should therefore be brushed every day and the child should undergo regular dental check-ups.<\/p>\n\n\n\n<p>Children with kidney problems may receive a lower\u00a0dose.<\/p>\n\n\n\n<p>Check the baby&#8217;s&nbsp;heart rate&nbsp;if it does not seem to be feeling well.&nbsp;Report a very slow or very fast heart rate to your doctor.<\/p>\n\n\n\n<p><strong>Long-term use<\/strong><\/p>\n\n\n\n<p>Efficacy and safety of long-term use of Sialanar have not been studied for use longer than 24 weeks.&nbsp;Continued use of Sialanar should be discussed with the child&#8217;s doctor every 3 months, to check that Sialanar is still right for the child.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children under 3 years<\/h2>\n\n\n\n<p>This medicine is a form of medicine that should be swallowed with a&nbsp;dose&nbsp;that should only be used in children and adolescents from 3 years of age.<\/p>\n\n\n\n<p>Sialanar is not recommended for children under 3 years of age.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Sialanar<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if your child is taking, has recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>If Sialanar is taken with the following medicines, it may affect the way Sialanar or the medicines listed work or it may increase the risk of side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Potassium chloride<\/strong>&nbsp;solid form of medicine (eg tablets or capsules) to be swallowed (see section \u201cDo not give Sialanar to your child or teenager\u201d)<\/li><li><strong>anticholinergic drugs<\/strong>&nbsp;(see section \u201cDo not give Sialanar to your child or teenager\u201d)<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>antispasmodics<\/strong>\u00a0used to treat nausea or vomiting e.g.\u00a0domperidone and metoclopramide<\/li><li><strong><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/topiramate-1a-pharma\/\">topiramate<\/a><\/strong>\u00a0used to treat\u00a0epilepsy<\/li><li><strong>antihistamines<\/strong>,\u00a0which are\u00a0used to treat certain\u00a0allergies<\/li><li>neuroleptics\/antipsychotics\u00a0(clozapine,\u00a0haloperidol, phenothiazines), used to treat certain mental illnesses<\/li><li>skeletal muscle relaxant\u00a0(botulinum toxin)<\/li><li>antidepressants\u00a0(\u00a0tricyclic antidepressants\u00a0)<\/li><li>opioids\u00a0are\u00a0used to treat severe pain<\/li><li>corticosteroids<strong>,<\/strong>\u00a0which are used to treat inflammatory diseases<\/li><\/ul>\n\n\n\n<p>Talk to your doctor or pharmacist for more information on medicines to avoid while taking Sialanar.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>This medicine is intended for use in children and adolescents.\u00a0Sialanar should not be given if the patient is pregnant (or may be pregnant), or breastfeeding (see section 2 \u201cDo not give Sialanar for the baby or teenager\u201d).\u00a0Discuss with your child&#8217;s doctor if there is a need for contraception.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Sialanar can affect vision and coordination skills.\u00a0This can affect the ability of skills such as driving, cycling, or using machines.\u00a0After receiving Sialanar, the patient should not drive, cycle or use machines until the effect on his vision and coordination has completely subsided.\u00a0If you have any further questions, ask your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sialanar contains sodium and benzoate (E211)<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per maximum\u00a0dose, ie it is essentially &#8216;sodium-free&#8217;.\u00a0This medicine contains 2.3 mg benzoate (E211) per ml. \u00a0<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Sialanar<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p><strong>Children and adolescents from 3 years to younger than 18 years:<\/strong><\/p>\n\n\n\n<p>Your doctor will decide on the right\u00a0dose\u00a0of Sialanar.\u00a0The first\u00a0dose\u00a0will be calculated based on the weight of the baby.\u00a0Dose increases are decided by the child&#8217;s doctor, using the table below as a guideline.\u00a0Dose increases will depend on both the effect of Sialanar and any\u00a0adverse reactions\u00a0experienced by the patient (therefore several dose levels are shown in the table below).\u00a0Section 4 covers possible\u00a0side effects\u00a0associated with the use of Sialanar.\u00a0These should be discussed with your child&#8217;s physician at all contact with a physician, including when discussing an increase and decrease in\u00a0dose, and at other times if you are concerned.<\/p>\n\n\n\n<p>The child should be monitored regularly (at least every 3 months) to check that Sialanar is still the correct treatment for the child.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><strong>Weight<\/strong><\/th><th scope=\"col\"><strong>Dose level 1<\/strong><\/th><th scope=\"col\"><strong>Dose level 2<\/strong><\/th><th scope=\"col\"><strong>Dose level 3<\/strong><\/th><th scope=\"col\"><strong>Dose level 4<\/strong><\/th><th scope=\"col\"><strong>Dose level 5<\/strong><\/th><\/tr><\/thead><tbody><tr><td><strong>kg<\/strong><\/td><td><strong>ml<\/strong><\/td><td><strong>ml<\/strong><\/td><td><strong>ml<\/strong><\/td><td><strong>ml<\/strong><\/td><td><strong>ml<\/strong><\/td><\/tr><tr><td>13-17<\/td><td>0.6<\/td><td>1.2<\/td><td>1.8<\/td><td>2.4<\/td><td>3.0<\/td><\/tr><tr><td>18-22<\/td><td>0.8<\/td><td>1.6<\/td><td>2.4<\/td><td>3.2<\/td><td>4.0<\/td><\/tr><tr><td>23-27<\/td><td>1.0<\/td><td>2.0<\/td><td>3.0<\/td><td>4.0<\/td><td>5.0<\/td><\/tr><tr><td>28-32<\/td><td>1.2<\/td><td>2.4<\/td><td>3.6<\/td><td>4.8<\/td><td>6.0<\/td><\/tr><tr><td>33-37<\/td><td>1.4<\/td><td>2.8<\/td><td>4.2<\/td><td>5.6<\/td><td>6.0<\/td><\/tr><tr><td>38-42<\/td><td>1.6<\/td><td>3.2<\/td><td>4.8<\/td><td>6.0<\/td><td>6.0<\/td><\/tr><tr><td>43-47<\/td><td>1.8<\/td><td>3.6<\/td><td>5.4<\/td><td>6.0<\/td><td>6.0<\/td><\/tr><tr><td>\u226548<\/td><td>2.0<\/td><td>4.0<\/td><td>6.0<\/td><td>6.0<\/td><td>6.0<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Give a\u00a0dose\u00a0that the doctor has prescribed to the child three times a day.\u00a0Dose\u00a0one should be given 1 hour before meals or 2 hours after meals.<\/strong><\/p>\n\n\n\n<p>One dose must be given at the same time each time about food intake.\u00a0Do not give the medicine with high-fat foods.<\/p>\n\n\n\n<p><strong>How to take the medicine<\/strong><\/p>\n\n\n\n<p>Sialanar should be taken by mouth.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p><strong>How to use the oral dosing syringe<\/strong><\/p>\n\n\n\n<p>Remove the child-resistant cap from the bottle.<\/p>\n\n\n\n<p>Insert the syringe adapter with the hole into the neck of the bottle (this may have already been done by the pharmacy staff).&nbsp;Insert the end of the syringe into the syringe adapter and check that it is secure.<\/p>\n\n\n\n<p>Hold the syringe in place and turn the bottle upside down.&nbsp;Carefully pull the plunger rod down to the correct level (see tables for correct&nbsp;dose&nbsp;).&nbsp;Make sure you have the right level.&nbsp;The maximum volume of the highest&nbsp;dose&nbsp;one is<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150306000014#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/2774628f-c9e2-4ff6-bcae-892c6d9e82fe\" alt=\"picture\" title=\"picture\"\/><\/a><\/figure>\n\n\n\n<p>6 ml<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150306000014#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/c903bd3e-3bc2-422c-8fa2-b49e9b4abfe5\" alt=\"picture\" title=\"picture\"\/><\/a><\/figure>\n\n\n\n<p>Turn the bottle upside down.<\/p>\n\n\n\n<p>Remove the syringe by holding the vial and gently twisting the oral syringe.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20150306000014#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/628e6c87-57af-481c-9545-1cb98f4419aa\" alt=\"picture\" title=\"picture\"\/><\/a><\/figure>\n\n\n\n<p>Place the syringe inside the baby&#8217;s mouth and push the plunger rod in slowly to gently release the medicine.<\/p>\n\n\n\n<p>After use, leave the syringe adapter in the neck of the bottle.&nbsp;Replace the closure.&nbsp;The syringe should be washed gently with warm water and allowed to dry after each use (ie three times a day).&nbsp;Do not use a dishwasher.<\/p>\n\n\n\n<p>If your child receives the medicine through a feeding tube, rinse the tube with 10 ml of water after giving the medicine.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have given too much Sialanar<\/h2>\n\n\n\n<p>It is important to ensure that the correct&nbsp;dose&nbsp;is given each time, to prevent the harmful effects of Sialanar due to dosing errors or overdose.<\/p>\n\n\n\n<p>Before giving Sialanar, make sure you have pulled it up to the correct level on the syringe.<\/p>\n\n\n\n<p>Contact a doctor immediately if the child is given too much Sialanar, even if the child seems to be feeling well.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to give Sialanar<\/h2>\n\n\n\n<p>Give the next\u00a0dose\u00a0when it&#8217;s time for it.\u00a0Do not give a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop giving your child Sialanar<\/h2>\n\n\n\n<p>Sialanar is not expected to cause any discomfort when treatment is stopped.\u00a0Your child&#8217;s doctor may decide to discontinue treatment with Sialanar if the\u00a0side effect\u00a0cannot be managed by lowering the\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If any of the following serious\u00a0side effects\u00a0occur, stop using the medicine and contact a doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>constipation (difficult to get the stool out) &#8211; very common<\/li><li>difficult to urinate (\u00a0urinary retention\u00a0) &#8211; very common<\/li><li>pneumonia\u00a0(severe\u00a0pneumonia\u00a0) &#8211; common<\/li><li>allergic reaction\u00a0(rash,\u00a0itching, red raised itchy rash (hives), difficulty breathing or swallowing, dizziness) &#8211; have been reported<\/li><\/ul>\n\n\n\n<p>The following\u00a0side effects\u00a0may be a sign of a severe\u00a0allergic reaction.\u00a0If they occur, stop taking Sialanar and contact a doctor or nearest emergency department immediately and take the medicine with you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the tongue, lips, face, or throat (possible signs of\u00a0angioedema\u00a0) &#8211; have been reported<\/li><\/ul>\n\n\n\n<p>Other side effects are:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dry mouth<\/li><li>difficult to get the stool out (constipation)<\/li><li>diarrhea<\/li><li>vomiting<\/li><li>flushing\u00a0(transient reddening of the skin)<\/li><li>nasal congestion<\/li><li>inability to empty the bladder (urinary retention)<\/li><li>decreased secretion production in the breast<\/li><li>irritability<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>upper respiratory tract infection (&nbsp;infection&nbsp;of the chest)<\/li><li>pneumonia&nbsp;(severe pneumonia)<\/li><li>urinary tract infection<\/li><li>drowsiness (sleepiness)<\/li><li>oro (&nbsp;agitation&nbsp;)<\/li><li>fever (&nbsp;pyrexia&nbsp;)<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>nosebleeds (&nbsp;epistaxis&nbsp;)<\/li><li>rash<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bad breath (halitosis)<\/li><li>fungal infection (cod) in the throat (candida infection in the esophagus)<\/li><li>abnormal contractions of the gastrointestinal tract when eating food (gastrointestinal motility disorders)<\/li><li>a disorder of the intestinal muscles and nerves that causes obstruction or blockage (pseudoobstruction)<\/li><li>dilation of the pupil of the eye (&nbsp;mydriasis&nbsp;)<\/li><li>involuntary eye movements (&nbsp;nystagmus&nbsp;)<\/li><li>headache<\/li><li>dehydration<\/li><li>thirsty in hot weather<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0that occur with anticholinergics but the whose frequency with glycopyrronium is not known<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction\u00a0(rash,\u00a0itching, red raised itchy rash (hives), difficulty breathing or swallowing, dizziness)<\/li><li>severe\u00a0allergic reaction\u00a0(\u00a0angioedema\u00a0);\u00a0Symptoms include swelling, mainly of the tongue, lips, face, or throat<\/li><li>restlessness;\u00a0overactivity;\u00a0shortened attention period;\u00a0frustration;\u00a0mood swings;\u00a0tantrums or explosive behavior;\u00a0excessive sensitivity;\u00a0severity or depression;\u00a0frequent crying attacks;\u00a0fear<\/li><li>insomnia (difficulty sleeping)<\/li><li>elevated pressure in the eye (which can cause\u00a0glaucoma\u00a0);\u00a0photophobia\u00a0(photosensitivity);\u00a0dry eyes<\/li><li>slow heart rate followed by fast heart rate, palpitations, and irregular heartbeat<\/li><li>inflammation\u00a0and swelling of the sinuses (\u00a0sinusitis\u00a0)<\/li><li>nausea<\/li><li>dry skin<\/li><li>impaired ability to sweat, which can cause fever and heat stroke<\/li><li>the sudden need to urinate<\/li><\/ul>\n\n\n\n<p>Side effects\u00a0can sometimes be difficult to recognize in patients with neurological problems who can not tell how they are feeling.<\/p>\n\n\n\n<p>Reduce\u00a0dose\u00a0one to the one you used before and consult a doctor if you think that a troublesome\u00a0side effect\u00a0occurs after you have increased a\u00a0dose.<\/p>\n\n\n\n<p>Tell your doctor if you notice any behavioral or other changes in your child.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Sialanar<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;This medicine must be used within 2 months of first opening the bottle.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Sialanar should not be used if the package has been opened or damaged.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is glycopyrronium.<\/p>\n\n\n\n<p>Each ml of solution contains 400 micrograms of glycopyrronium bromide equivalent to 320 micrograms of glycopyrronium.<\/p>\n\n\n\n<p>The other ingredients are sodium benzoate (E211) (see section 2 &#8220;Sialanar contains\u00a0sodium\u00a0and benzoate&#8221;), raspberry aroma (containing propylene glycol E1520), sucralose (E955), citric acid (E330), and purified water.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Sialanar\u00a0oral\u00a0solution is a clear, colorless liquid.\u00a0It is supplied in a 60 ml and 250 ml amber glass bottle in a cardboard box.\u00a0Each carton contains a bottle, an 8 ml\u00a0syringe\u00a0for\u00a0oral\u00a0use, and a syringe adapter.\u00a0Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Provence Pharma Ltd<\/p>\n\n\n\n<p>2 Dublin Landings<\/p>\n\n\n\n<p>North Wall Quay<\/p>\n\n\n\n<p>Dublin 1<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Center for Pharmaceutical Specialties (CSP),<\/p>\n\n\n\n<p>ZAC des Suzots,<\/p>\n\n\n\n<p>35 rue de la Chapelle,<\/p>\n\n\n\n<p>63450 Saint Amant Challenge,<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Unither Liquid Manufacturing,<\/p>\n\n\n\n<p>1-3 All\u00e9e de la Neste,<\/p>\n\n\n\n<p>ZI de Sigal,<\/p>\n\n\n\n<p>31770 Colomiers,<\/p>\n\n\n\n<p>France<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glycopyrronium belongs to a group of medicines called quaternary ammonium anticholinergics, which are substances that block or reduce the signal transmission between nerve cells.\u00a0This reduced signal transmission can deactivate the cells that produce saliva.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[14166,24043,8918,8921,24042,8920,8919,24040,24041],"class_list":["post-23027","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-glycopyrronium","tag-benefits-of-sialanar","tag-glycopyrronium","tag-glycopyrronium-side-effects","tag-sialanar-side-effects","tag-what-glycopyrronium-is-used-for","tag-what-is-glycopyrronium","tag-what-is-sialanar","tag-what-sialanar-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23027"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23027\/revisions"}],"predecessor-version":[{"id":23055,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23027\/revisions\/23055"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}