{"id":23024,"date":"2022-07-19T06:47:03","date_gmt":"2022-07-19T06:47:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=23024"},"modified":"2022-07-20T06:00:34","modified_gmt":"2022-07-20T06:00:34","slug":"shingrix","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/shingrix\/","title":{"rendered":"Shingrix &#8211; Herpes\u00a0zoster vaccine uses, dose and side effects"},"content":{"rendered":"\n<p>powder and\u00a0suspension\u00a0for\u00a0injection,\u00a0suspension<br>Herpes\u00a0zoster vaccine (\u00a0recombinant, adjuvant-containing)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Shingrix is \u200b\u200band what it is used for<\/h2>\n\n\n\n<p><strong>What Shingrix is \u200b\u200bused for<\/strong><\/p>\n\n\n\n<p>Shingrix is \u200b\u200ba vaccine that protects adults against\u00a0shingles\u00a0(\u00a0herpes\u00a0zoster) and nerve pain (postherpetic\u00a0neuralgia\u00a0), the long-term pain that follows\u00a0shingles.<\/p>\n\n\n\n<p>Shingrix is \u200b\u200bgiven to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>adults 50 years and older<\/li><li>adults 18 years and older with an increased risk of\u00a0shingles.<\/li><\/ul>\n\n\n\n<p>Shingrix can not be used to prevent chickenpox (varicella).<\/p>\n\n\n\n<p><strong>What&nbsp;shingles&nbsp;is<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Shingles\u00a0give a painful rash with blisters.\u00a0The blisters often sit on an area on one side of the body and can last for several weeks.<\/li><li>Shingles\u00a0are caused by the same\u00a0virus\u00a0that causes chickenpox.<\/li><li>After you have had chickenpox, the chickenpox virus stays in the body&#8217;s nerve cells.<\/li><li>Sometimes, after many years, the\u00a0virus\u00a0can cause\u00a0shingles\u00a0if the immune system (the body&#8217;s natural defense system) is weakened (due to age, illness, or drug treatment).<\/li><\/ul>\n\n\n\n<p><strong>Complications of&nbsp;shingles<\/strong><\/p>\n\n\n\n<p>Shingles&nbsp;can cause complications.<\/p>\n\n\n\n<p>The most common complications of&nbsp;shingles&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>long-term nerve pain &#8211; so-called nerve pain after\u00a0shingles\u00a0or postherpetic\u00a0neuralgia\u00a0(PHN).<\/li><li>When the blisters have healed, you can get severe pain in the healed area that can persist for months or even years.<\/li><\/ul>\n\n\n\n<p>Other complications of&nbsp;shingles&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>scars in places where blisters have been present.<\/li><li>skin infections, weakness, muscle paralysis, and hearing or vision loss &#8211; are less common.<\/li><\/ul>\n\n\n\n<p><strong>How Shingrix works<\/strong><\/p>\n\n\n\n<p>Shingrix reminds the body of the\u00a0virus\u00a0that causes\u00a0shingles.\u00a0This helps the immune system to be prepared to fight the\u00a0virus\u00a0and protect you from\u00a0shingles\u00a0and its complications.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you get Shingrix<\/h2>\n\n\n\n<p><strong>You should not receive Shingrix if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic (hypersensitive) to the active substance or any of the other ingredients of this vaccine (listed in section 6).\u00a0Signs of an\u00a0allergic reaction\u00a0may include itchy skin rash, shortness of breath, and swelling of the face or tongue.<\/li><\/ul>\n\n\n\n<p>You should not receive Shingrix if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Shingrix if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have a severe&nbsp;infection&nbsp;with fever.&nbsp;In these cases, the vaccination may need to be postponed until you have recovered.&nbsp;A minor&nbsp;infection&nbsp;such as a cold is probably not a problem, but talk to your doctor first.<\/li><li>you have a bleeding problem or a tendency to get bruises.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking Shingrix.<\/p>\n\n\n\n<p>Fainting may occur before or after a needle stick.\u00a0Therefore, tell your doctor or nurse if you faint in connection with a previous\u00a0injection.<\/p>\n\n\n\n<p>Shingrix can not be used as a treatment if you already have\u00a0shingles\u00a0or complications of\u00a0shingles.<\/p>\n\n\n\n<p>Like all vaccines, Shingrix may not provide complete protection to all vaccinated individuals.<\/p>\n\n\n\n<p>Talk to your doctor if you experience temporary\u00a0inflammation\u00a0of the nerves after vaccination with Shingrix, which causes pain, weakness, and paralysis (\u00a0Guillain-Barr\u00e9 syndrome,\u00a0GBS\u00a0).\u00a0A small increased risk of\u00a0GBS\u00a0(estimated to increase by 3 cases per million administered\u00a0doses\u00a0) has been reported in those 65 years of age and older after vaccination with Shingrix.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Shingrix<\/h2>\n\n\n\n<p>Tell your pharmacist or doctor if you have recently taken, or might take any other medicines, including medicines obtained without a prescription, or if you have recently been given any other vaccine.<\/p>\n\n\n\n<p>Shingrix can be given at the same time as other vaccines.&nbsp;Each vaccine is given at a new injection site.<\/p>\n\n\n\n<p>You will likely experience fever and\/or chills when a 23-valent pneumococcal polysaccharide vaccine is given at the same time as Shingrix.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this vaccine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>It is not known if Shingrix affects the ability to drive or use machines.&nbsp;However, do not drive or use machines if you feel sick.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Shingrix contains sodium and potassium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (39 mg)\u00a0potassium\u00a0per\u00a0dose, ie it is essentially &#8216;potassium-free&#8217;.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Shingrix is \u200b\u200bgiven<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Shingrix is \u200b\u200bgiven as an\u00a0injection\u00a0into a muscle (usually in the upper arm).<\/li><li>You will receive 2\u00a0injections, preferably at 2-month intervals.\u00a0If flexibility in the vaccination schedule is necessary, the second\u00a0dose\u00a0can be given between 2 and 6 months after the first\u00a0dose. Depending on your medical condition, your doctor may also recommend that you receive the second\u00a0injection\u00a01 month after the first\u00a0injection.<\/li><li>You will be informed when you will return for the second\u00a0dose\u00a0of Shingrix.<\/li><\/ul>\n\n\n\n<p>Remember to complete the vaccination series.&nbsp;This maximizes the protection that Shingrix provides.<\/p>\n\n\n\n<p>Shingrix can be given if you have previously been vaccinated with a live, attenuated&nbsp;herpes&nbsp;zoster vaccine.&nbsp;For more information, talk to your doctor.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this vaccine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects&nbsp;reported in&nbsp;clinical trials&nbsp;with Shingrix:<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 vaccine doses):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>gastrointestinal disorders (including nausea, vomiting, diarrhea, and\/or abdominal pain)<\/li><li>muscle aches<\/li><li>pain,\u00a0redness,\u00a0and swelling at the injection site<\/li><li>fatigue, chills, fever.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 vaccine doses):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>itching&nbsp;at the injection site<\/li><li>general malaise.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 vaccine doses):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swollen\u00a0glands\u00a0in the neck, armpits, or groin<\/li><li>joint pain.<\/li><\/ul>\n\n\n\n<p>Most of these\u00a0side effects\u00a0are mild to severe and not long-lasting.<\/p>\n\n\n\n<p>Adults aged 18\u201149 with a weakened immune system may experience more&nbsp;side effects&nbsp;than adults aged 50 or older with a weakened immune system.<\/p>\n\n\n\n<p>Adults aged 50\u201369 years may experience more&nbsp;side effects&nbsp;than adults aged 70 years or older.<\/p>\n\n\n\n<p>Side effects&nbsp;reported after Shingrix was introduced on the market:<\/p>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 vaccine doses):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions including skin rash,\u00a0urticaria,\u00a0and swelling of the face, tongue, or throat which may cause difficulty in swallowing or breathing (\u00a0angioedema\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Shingrix<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the label and carton.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2 \u00b0 C -8 \u00b0 C).<\/li><li>Do not freeze.<\/li><li>Store in the original package.&nbsp;Sensitive to light.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<p><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are: After\u00a0reconstitution, one\u00a0dose\u00a0(0.5 ml)\u00a0contains: Varicella zoster\u00a0&#8211;\u00a0virus\u00a01\u00a0glycoprotein\u00a0E\u00a0antigen\u00a02\u00a0\u00a0 50 micrograms<br>1\u00a0Varicella zoster\u00a0&#8211;\u00a0virus\u00a0=\u00a0VZV2\u00a0With AS01\u00a0B\u00a0&#8211;\u00a0adjuvant\u00a0containing: Quillaja Saponaria\u00a0Molina plant extract,\u00a0fraction\u00a021 (QS-21) 50 micrograms3-O-desacyl-4&#8242;-monophosphoryl lipid A (MPL) from\u00a0Salmonella\u00a0Minnesota\u00a0\u00a0 50 micrograms<br>Glycoprotein\u00a0E is a\u00a0protein\u00a0found in\u00a0the varicella-zoster\u00a0virus\u00a0(\u00a0the chickenpox virus).\u00a0This\u00a0protein\u00a0is not contagious.<br>Adjuvant\u00a0et (AS01\u00a0B\u00a0) is used to improve the body&#8217;s response to the vaccine.<\/li><li>Other ingredients are:<ul><li>Powder:\u00a0Sucrose, polysorbate 80 (E 433), sodium dihydrogen phosphate dihydrate (E 339), dipotassium phosphate (E 340).<\/li><li>Suspension:\u00a0Dioleoylphosphatidylcholine,\u00a0cholesterol\u00a0(E 322), sodium chloride, anhydrous disodium phosphate (E 339), potassium dihydrogen phosphate (E 340), and water for injections.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Powder and\u00a0suspension\u00a0for\u00a0injection,\u00a0suspension.<\/li><li>The powder is white.<\/li><li>Suspension\u00a0one is an opalescent, colorless to light brownish liquid.<\/li><\/ul>\n\n\n\n<p>A Shingrix package contains:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Powder (\u00a0antigen\u00a0) for 1\u00a0dose\u00a0in a\u00a0vial.<\/li><li>The suspension\u00a0(\u00a0adjuvant\u00a0) for 1\u00a0dose\u00a0in a\u00a0vial.<\/li><\/ul>\n\n\n\n<p>Shingrix is \u200b\u200bavailable in a pack size of 1\u00a0vial\u00a0of powder and 1\u00a0vial\u00a0of\u00a0suspension\u00a0or a pack size of 10 vials of powder and 10 vials of\u00a0suspension.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>GlaxoSmithKline Biologicals sa<\/p>\n\n\n\n<p>Rue de l&#8217;Institut 89<\/p>\n\n\n\n<p>B-1330 Rixensart<\/p>\n\n\n\n<p>Belgium<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>GlaxoSmithKline Pharmaceuticals sa \/ nvTel: + 32 10 85 52 00<\/td><td><strong>Lithuania<\/strong>GlaxoSmithKline Biologicals SATel: +370 80000334<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>GlaxoSmithKline Biologicals SATel.&nbsp;+ 359 80018205<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>GlaxoSmithKline Pharmaceuticals sa \/ nvTel: + 32 10 85 52 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline sroTel: + 420 2 22 00 11 11cz.info@gsk.com<\/td><td><strong>Hungary<\/strong>GlaxoSmithKline Biologicals SATel .: + 36 80088309<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A \/ STel: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>GlaxoSmithKline Biologicals SATel: + 356 80065004<\/td><\/tr><tr><td><strong>Germany<\/strong>GlaxoSmithKline GmbH &amp; Co.&nbsp;KGTel: + 49 (0) 89 360448701produkt.info@gsk.com<\/td><td><strong>The Netherlands<\/strong>GlaxoSmithKline BVTel: + 31 (0) 33 2081100<\/td><\/tr><tr><td><strong>Eesti<\/strong>GlaxoSmithKline Biologicals SATel: +372 8002640estonia@gsk.com<\/td><td><strong>Norway<\/strong>GlaxoSmithKline ASTel: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline A\u03bf\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03b7 AEBET\u03b7\u03bb: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>GlaxoSmithKline Pharma GmbHTel: + 43 (0) 1 97075 0at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>GlaxoSmithKline, SATel: + 34 900 202 700es-ci@gsk.com&nbsp;<\/td><td><strong>Poland<\/strong>GSK Services Sp.&nbsp;z ooTel .: + 48 (22) 576 9000<\/td><\/tr><tr><td><strong>France<\/strong>GlaxoSmithKline LaboratoryTel: + 33 (0) 1 39 17 84 44diam@gsk.com<\/td><td><strong>Portugal<\/strong>GlaxoSmithKline &#8211; Pharmaceutical Products, Lda.Tel: + 351 21 412 95 00FI.PT@gsk.com<\/td><\/tr><tr><td><strong>Croatia<\/strong>GlaxoSmithKline Biologicals SATel .: + 385 800787089<\/td><td><strong>Romania<\/strong>GlaxoSmithKline Biologicals SATel: +40 800672524<\/td><\/tr><tr><td><strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LtdTel: + 353 (0) 1 495 5000<\/td><td><strong>Slovenia<\/strong>GlaxoSmithKline Biologicals SATel: + 386 80688869<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>GlaxoSmithKline Biologicals SATel .: + 421 800500589<\/td><\/tr><tr><td><strong>Italy<\/strong>GlaxoSmithKline SpATel: + 39 (0) 45 7741 111<\/td><td><strong>Finland \/ Finland<\/strong>GlaxoSmithKline OyPuh \/ Tel: + 358 10 30 30 30<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>GlaxoSmithKline Biologicals SA:\u0397\u03bb: + 357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABTel: + 46 (0) 8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>GlaxoSmithKline Biologicals SATel: + 371 80205045<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>GlaxoSmithKline Biologicals SATel: +44 (0) 800 221 441customercontactuk@gsk.com<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shingrix is \u200b\u200ba vaccine that protects adults against\u00a0shingles\u00a0(\u00a0herpes\u00a0zoster) and nerve pain (postherpetic\u00a0neuralgia\u00a0), the long-term pain that follows\u00a0shingles\u00a0.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[24048,24053,24044,24047,24049,24052,24046,24045,24050,24051],"class_list":["post-23024","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-herpes-zoster-vaccine","tag-benefits-of-shingrix","tag-herpes-zoster-vaccine","tag-herpes-zoster-vaccine-side-effects","tag-shingrix","tag-shingrix-side-effects","tag-what-herpes-zoster-vaccine-is-used-for","tag-what-is-herpes-zoster-vaccine","tag-what-is-shingrix","tag-what-shingrix-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=23024"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23024\/revisions"}],"predecessor-version":[{"id":23056,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/23024\/revisions\/23056"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=23024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=23024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=23024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}