{"id":22912,"date":"2022-07-14T06:55:32","date_gmt":"2022-07-14T06:55:32","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22912"},"modified":"2022-07-18T07:19:51","modified_gmt":"2022-07-18T07:19:51","slug":"seroxat","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/seroxat\/","title":{"rendered":"Seroxat &#8211; Paroxetine uses, dose and side effects"},"content":{"rendered":"\n<p>20 mg&nbsp;film-coated tablet<br>paroxetine&nbsp;(as hydrochloride hemihydrate)<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Seroxat is and what it is used for<\/h2>\n\n\n\n<p><strong>Seroxat is used to treat adults with depression and\/or<\/strong> anxiety.\u00a0The anxiety states that Seroxat is used for are: obsessive-compulsive disorder (repeated obsessive-compulsive disorder), panic disorder (attacks of panic disorder, including those that occur with\u00a0agoraphobia, ie fear of open spaces),\u00a0social phobia\u00a0(fear of or avoidance of social situations),\u00a0post-traumatic stress disorder.\u00a0stress syndrome\u00a0(anxiety after a traumatic experience) and generalized anxiety (general severe anxiety or worry).<\/p>\n\n\n\n<p>Seroxat belongs to a group of medicines called selective serotonin reuptake inhibitors (&nbsp;SSRIs&nbsp;).&nbsp;How Seroxat and other&nbsp;SSRIs&nbsp;work is not completely known but it could be because they raise the levels of&nbsp;serotonin&nbsp;in the brain.&nbsp;Proper treatment of your depression or anxiety is important to help you improve.<\/p>\n\n\n\n<p>The paroxetine contained\u00a0in Seroxat may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Seroxat<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Seroxat:<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td><strong>if you are taking medicines called\u00a0monoamine oxidase inhibitors<\/strong>\u00a0(\u00a0MAOIs, including moclobemide and methylthionine chloride (methylene blue)) or have taken them at any time during the last two weeks.\u00a0Your doctor will advise you on how to start taking Seroxat after you stop taking\u00a0MAOIs.<\/td><\/tr><tr><td>&#8211;<\/td><td><strong>if you are taking an antipsychotic medicine<\/strong>&nbsp;that contains either thioridazine or pimozide.<\/td><\/tr><tr><td>&#8211;<\/td><td><strong>if you are allergic<\/strong>&nbsp;to&nbsp;paroxetine&nbsp;or any of the other ingredients of this medicine (listed in section 6).<\/td><\/tr><tr><td><strong>If any of the above applies to you<\/strong>, tell your doctor before taking Seroxat.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor or pharmacist before using Seroxat<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Are you taking any other medicines (see&nbsp;<em>Other medicines and Seroxat<\/em>&nbsp;in this leaflet)?<\/td><\/tr><tr><td>&#8211;<\/td><td>Are you taking tamoxifen to treat breast cancer?&nbsp;Seroxat may reduce the effect of tamoxifen and your doctor may therefore recommend that you use other antidepressants.<\/td><\/tr><tr><td>&#8211;<\/td><td>Do you have kidney, liver, or heart problems?<\/td><\/tr><tr><td>&#8211;<\/td><td>Do you have&nbsp;epilepsy&nbsp;or have you ever had seizures or seizures?<\/td><\/tr><tr><td>&#8211;<\/td><td>Have you ever had manic episodes (overactive behavior or thoughts)?<\/td><\/tr><tr><td>&#8211;<\/td><td>Do you receive electroconvulsive therapy (ECT)?<\/td><\/tr><tr><td>&#8211;<\/td><td>Have you had a bleeding disorder or are taking any other medicines that may increase the risk of bleeding (blood thinners such as\u00a0warfarin, antipsychotics such as perfenazine or clozapine,\u00a0tricyclic antidepressants, painkillers and anti-inflammatory\u00a0drugs, so-called\u00a0NSAIDs\u00a0(non-steroidal anti-inflammatory drugs), such as\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a>,\u00a0ibuprofen, celecoxib, etodolac,\u00a0diclofenac, meloxicam)?<\/td><\/tr><tr><td>&#8211;<\/td><td>Do you have\u00a0diabetes?<\/td><\/tr><tr><td>&#8211;<\/td><td>Are you on a salt-reduced diet?<\/td><\/tr><tr><td>&#8211;<\/td><td>Do you have\u00a0glaucoma\u00a0(\u00a0glaucoma, increased pressure in the eye)?<\/td><\/tr><tr><td>&#8211;<\/td><td>Are you pregnant or planning to become pregnant (see\u00a0<em>Pregnancy, breast-feeding, and\u00a0fertility\u00a0<\/em>in this leaflet)?<\/td><\/tr><tr><td>&#8211;<\/td><td>Are you under 18 (see&nbsp;<em>Children and adolescents under 18<\/em>&nbsp;in this leaflet)?<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>If you answer YES to any of these questions and have not previously discussed this with your doctor, consult your doctor again and ask how to apply Seroxat.<\/strong><\/p>\n\n\n\n<p><strong>Children and adolescents under 18 years of age<\/strong><br><strong>Seroxat should not be used by children and adolescents under 18 years of age.\u00a0<\/strong>The risk of\u00a0side effects\u00a0such as suicide attempts, suicidal ideation, and hostility (mainly aggression, defiance, and anger) is greater in patients under 18 years of age using Seroxat.\u00a0If your doctor has prescribed Seroxat for you (or your child) and you want to discuss this, you should see your doctor again.\u00a0You should tell your doctor if you notice any of the above symptoms or if such symptoms worsen while you (or your child) are taking Seroxat.\u00a0The long-term effects on growth, maturity, and\u00a0cognitive\u00a0and behavioral development have not yet been established for children and adolescents under 18 years of age.<\/p>\n\n\n\n<p>In studies with Seroxat in patients under 18 years of age, common\u00a0side effects\u00a0that occurred in less than 1 in 10 children\/adolescents were the following: increased suicidal ideation and suicide attempts, self-harming behavior, hostile, aggressive, or unfriendly behavior, loss of appetite, tremors, abnormal sweating, hyperactivity (excess energy), agitation, emotional changes (including crying and mood swings) and unusual bruising or bleeding (eg nosebleeds).\u00a0The studies showed that the same symptoms also occurred in children and adolescents who received\u00a0a placebo\u00a0(an inactive substance) instead of Seroxat, but less often.<\/p>\n\n\n\n<p>Some patients in studies with people under 18 years of age experienced withdrawal symptoms when they stopped taking Seroxat.\u00a0These symptoms were mostly similar to those seen in adults after discontinuation of Seroxat (see section 3).\u00a0In addition, it was common (in less than 1 in 10) that patients under the age of 18 experienced abdominal pain, nervousness, and emotional changes (including crying, mood swings, attempted self-harm, thoughts of suicide, and suicide attempts).<\/p>\n\n\n\n<p><strong>If you start to feel worse and have thoughts of harming yourself<\/strong><\/p>\n\n\n\n<p>You who are depressed and\/or suffer from worry\/anxiety may sometimes have thoughts of harming yourself or committing suicide.\u00a0These symptoms may worsen when you start using antidepressants, as it takes time for this type of medicine to take effect, usually about 2 weeks, sometimes longer.<\/p>\n\n\n\n<p><strong>These thoughts may be common:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have previously had thoughts of harming yourself or committing suicide.<\/li><li>If you are younger than 25 years.&nbsp;Studies have shown that young adults (younger than 25 years) with mental illness who are treated with antidepressant drugs have an increased risk of suicidal thoughts and thoughts of harming themselves.<\/li><\/ul>\n\n\n\n<p><strong>Contact a doctor as soon as possible or go to the nearest hospital<\/strong>&nbsp;if you have thoughts of injuring yourself or committing suicide.<\/p>\n\n\n\n<p><strong>It can be helpful to tell a relative or close friend<\/strong>\u00a0that you are depressed and\/or suffering from anxiety.\u00a0Feel free to ask them to read this leaflet.\u00a0You can also ask them to tell you if they think you are feeling worse or if they think your behavior is changing.<\/p>\n\n\n\n<p><strong>Important\u00a0side effects\u00a0that have been seen with Seroxat<\/strong><br>Some patients who take Seroxat edevelopsomething called\u00a0akathisia, which means that they feel restless\u00a0and cannot sit or stand still.\u00a0Others may develop something called\u00a0serotonergic syndrome\u00a0or malignant neuroleptic syndrome.\u00a0This is meant some or all of the following symptoms: feeling very aroused or irritated, confusion, restlessness, feeling hot, sweating, shaking, chills, hallucinations (seeing or hearing strange things), muscle stiffness, sudden muscle twitching, or rapid heartbeat.\u00a0The severity can increase and lead to unconsciousness.\u00a0If you experience any of these symptoms, consult a doctor.\u00a0For more information on these or other\u00a0side effects\u00a0of Seroxat, see section 4.<\/p>\n\n\n\n<p>Drugs such as Seroxat (so-called&nbsp;SSRIs&nbsp;) can cause symptoms of sexual&nbsp;dysfunction&nbsp;(see section 4).&nbsp;In some cases, these symptoms have persisted after discontinuation of treatment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Seroxat<\/h2>\n\n\n\n<p>Some medicines may affect the way Seroxat works or increase the risk of\u00a0side effects.\u00a0Seroxat may also affect the way other medicines work.\u00a0Drugs affected are:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Medicines called\u00a0<strong>MAOIs<\/strong>, including moclobemide and methylthionine chloride (methylene blue) &#8211; see\u00a0<em>Do not use Seroxat<\/em>\u00a0in this leaflet.<\/td><\/tr><tr><td>&#8211;<\/td><td>Thioridazine or pimozide, which is\u00a0<strong>antipsychotic<\/strong>\u00a0&#8211; see\u00a0<em>Do not use Seroxat<\/em>\u00a0in this leaflet.<\/td><\/tr><tr><td>&#8211;<\/td><td>Acetylsalicylic acid,\u00a0ibuprofen,\u00a0or other so-called\u00a0NSAIDs\u00a0(non-steroidal anti-inflammatory drugs) such as celecoxib, etodolac,\u00a0diclofenac,\u00a0and meloxicam, are used for\u00a0pain and\u00a0inflammation.<\/td><\/tr><tr><td>&#8211;<\/td><td><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tramadol-retard-krka\/\">Tramadol<\/a>, buprenorphine, and pethidine are\u00a0<strong>painkillers<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Buprenorphine in combination with naloxone,\u00a0opioid dependence replacement therapy,<\/td><\/tr><tr><td>&#8211;<\/td><td>Drugs called triptans, such as sumatriptan, are used to&nbsp;<strong>treat migraines<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Other\u00a0<strong>antidepressant drugs<\/strong>\u00a0including other\u00a0SSRIs\u00a0and\u00a0tricyclic antidepressants\u00a0such as clomipramine, nortriptyline, and desipramine<\/td><\/tr><tr><td>&#8211;<\/td><td>A&nbsp;<strong>dietary supplement<\/strong>&nbsp;called tryptophan<\/td><\/tr><tr><td>&#8211;<\/td><td>Mivacurium and suxamethonium (used for anesthesia)<\/td><\/tr><tr><td>&#8211;<\/td><td>Drugs such as lithium,\u00a0risperidone, perfenazine, and clozapine (so-called antipsychotics), are used to treat certain\u00a0<strong>psychiatric illnesses<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>A combination of fosamprenavir and ritonavir used to&nbsp;<strong>treat&nbsp;<\/strong><strong>HIV&nbsp;infection<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>St. John&#8217;s wort, a natural remedy for\u00a0<strong>depression<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Fentanyl, used in\u00a0anesthesia\u00a0or the treatment of\u00a0<strong>chronic\u00a0pain<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Phenobarbital,\u00a0phenytoin, sodium valproate, or carbamazepine for the treatment of\u00a0<strong>seizures or\u00a0epilepsy<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Atomoxetine is a drug used to treat\u00a0<strong>ADHD\u00a0(Attention Deficit Hyperactivity Disorder)<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Procyclidine used to relieve tremors, especially in&nbsp;<strong>Parkinson&#8217;s disease<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Warfarin\u00a0or other\u00a0anticoagulants, ie\u00a0<strong>blood thinners<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Propafenone,\u00a0flecainide,\u00a0and medicines used to treat\u00a0<strong>irregular heartbeat<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Metoprolol, a\u00a0beta-blocker used to treat high\u00a0<strong>blood pressure\u00a0and heart problems<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Pravastatin is used to treat&nbsp;<strong>high&nbsp;cholesterol<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Rifampicin used to treat&nbsp;<strong>tuberculosis<\/strong><strong>&nbsp;and leprosy<\/strong><strong><\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Linezolid which is an&nbsp;<strong>antibiotic<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>Tamoxifen used to&nbsp;<strong>treat breast cancer<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>If you are taking or have recently taken any of the medicines listed above<\/strong>\u00a0and have not already discussed this with your doctor,\u00a0<strong>see your doctor again and ask for advice<\/strong>.\u00a0Your\u00a0dose\u00a0may need to be changed or you may need another medicine.<\/p>\n\n\n\n<p><br><strong>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines,<\/strong>\u00a0including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Seroxat with food, drink, and alcohol<\/h2>\n\n\n\n<p>Do not use alcohol while taking Seroxat.&nbsp;Alcohol can worsen your symptoms or side effects.&nbsp;Taking Seroxat in the morning with food may reduce the risk of nausea.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.\u00a0There are reports of an increased risk of malformations, especially heart malformations in children whose mothers took Seroxat during the first months of pregnancy.\u00a0In the general population, about 1 in 100 children is born with heart defects.\u00a0The risk is higher in children whose mothers have taken Seroxat, where the risk is 2 out of 100 children.\u00a0You and your doctor can decide together if you should switch to another treatment or if you should gradually reduce Seroxat while you are pregnant.\u00a0Depending on the circumstances, your doctor may decide that continued treatment with Seroxat is better for you.<\/p>\n\n\n\n<p><strong>Tell your midwife or doctor that you are using Seroxat.<\/strong><\/p>\n\n\n\n<p>Taking Seroxat at the end of your pregnancy may increase the risk of heavy&nbsp;vaginal&nbsp;bleeding shortly after delivery, especially if you have a history of bleeding disorders.&nbsp;Your doctor or midwife should be informed that you are taking Seroxat so that they can advise you on this.<\/p>\n\n\n\n<p>When drugs such as Seroxat are used during pregnancy, especially late in pregnancy, they may increase the risk of a serious condition called&nbsp;persistent&nbsp;pulmonary&nbsp;hypertension&nbsp;in the newborn (PPHN).&nbsp;In PPHN, the&nbsp;blood pressure&nbsp;in the blood vessels between the baby&#8217;s heart and lungs is too high.&nbsp;If you are taking Seroxat during the last 3 months of pregnancy, your newborn baby may also have other symptoms that usually start within the first 24 hours after birth and include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>difficulty breathing<\/li><li>bluish skin or that the child is too hot or cold<\/li><li>blue lips<\/li><li>vomiting or the child not eating properly<\/li><li>that the child is very tired, has difficulty sleeping, or cries persistently<\/li><li>tense or slack muscles<\/li><li>tremors, twitches, or cramps<\/li><li>excessive reflexes.<\/li><\/ul>\n\n\n\n<p>If your baby gets any of these symptoms after birth, or if you are worried about your baby&#8217;s health,&nbsp;<strong>contact your doctor or midwife for advice.<\/strong><\/p>\n\n\n\n<p><strong>Seroxat can be excreted in breast milk in very small amounts.\u00a0<\/strong>Consult your doctor before breastfeeding.\u00a0You and your doctor can decide together if you can breastfeed while taking Seroxat.<\/p>\n\n\n\n<p>In animal studies, it has been shown that\u00a0paroxetine\u00a0reduces the quality of semen.\u00a0In theory, this could affect\u00a0fertility, but no such reducing effect of\u00a0paroxetine\u00a0on\u00a0fertility\u00a0has yet been demonstrated in humans.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Possible\u00a0side effects\u00a0of Seroxat include dizziness, confusion, drowsiness, or blurred vision.\u00a0If you get these\u00a0side effects, do not drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Seroxat contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie it is essentially &#8216;sodium-free&#8217;.<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Seroxat<\/h2>\n\n\n\n<p><strong>Always use this medicine exactly as your doctor or pharmacist has told you.\u00a0<\/strong>Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Sometimes you may need to take more than one tablet or just half a tablet.&nbsp;This table shows you the number of tablets to take.<\/td><td><strong>Dose<\/strong><\/td><td><strong>The number of tablets to be taken<\/strong><\/td><\/tr><tr><td>10 mg<\/td><td>Half a tablet<\/td><\/tr><tr><td>20 mg<\/td><td>A pill<\/td><\/tr><tr><td>30 mg<\/td><td>One and a half tablets<\/td><\/tr><tr><td>40 mg<\/td><td>Two tablets<\/td><\/tr><tr><td>50 mg<\/td><td>Two and a half tablets<\/td><\/tr><tr><td>60 mg<\/td><td>Three tablets<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The normal\u00a0dosage\u00a0for different conditions is given in the table below.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td><strong>Starting dose<\/strong><\/td><td><strong>Recommended daily&nbsp;dose<\/strong><\/td><td><strong>Maximum daily&nbsp;dose<\/strong><\/td><\/tr><tr><td>Depression<\/td><td>20 mg<\/td><td>20 mg<\/td><td>50 mg<\/td><\/tr><tr><td>Obsessive-compulsive disorder<\/td><td>20 mg<\/td><td>40 mg<\/td><td>60 mg<\/td><\/tr><tr><td>Panic syndrome<\/td><td>10 mg<\/td><td>40 mg<\/td><td>60 mg<\/td><\/tr><tr><td>Social Phobia<\/td><td>20 mg<\/td><td>20 mg<\/td><td>50 mg<\/td><\/tr><tr><td>Posttraumatic stressyndrome<\/td><td>20 mg<\/td><td>20 mg<\/td><td>50 mg<\/td><\/tr><tr><td>Generalized anxiety disorder<\/td><td>20 mg<\/td><td>20 mg<\/td><td>50 mg<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Your doctor will advise you on which\u00a0dose\u00a0of Seroxat to start with.\u00a0<\/strong>Most people start to feel better after a few weeks.\u00a0If you do not notice any improvement after this time, consult your doctor for advice.\u00a0Your doctor may decide to increase your\u00a0dose\u00a0gradually, by 10 mg at a time, up to the highest daily\u00a0dose.<\/p>\n\n\n\n<p><strong>Take Seroxat in the morning with food.<\/strong><br><strong>Swallow the tablets whole with a glass of water.&nbsp;Do not chew them.<\/strong><\/p>\n\n\n\n<p>Your doctor will discuss with you how long you need to continue taking Seroxat.&nbsp;It can be many months or even longer.<\/p>\n\n\n\n<p><strong>Elderly patients<\/strong><br>The maximum&nbsp;dose&nbsp;for patients over 65 years of age is 40 mg per day.<\/p>\n\n\n\n<p><strong>Patients with liver or kidney disease<\/strong><br>If you have liver problems or severe kidney disease, your doctor may decide that your&nbsp;dose&nbsp;of Seroxat should be lower than what is normally recommended.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Seroxat than you were told to<\/h2>\n\n\n\n<p><strong>Never take more Seroxat than your doctor advised.<\/strong><br>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.\u00a0Show the medicine package.<\/p>\n\n\n\n<p>A person who has overdosed on Seroxat may experience&nbsp;side effects&nbsp;listed in section 4.&nbsp;<em>Possible&nbsp;side effects&nbsp;or<\/em>&nbsp;the following symptoms: fever, uncontrollable muscle contraction.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Seroxat<\/h2>\n\n\n\n<p>Take Seroxat at the same time each day.<\/p>\n\n\n\n<p><strong>If you forget to take a\u00a0dose\u00a0and think about it before going to bed at night<\/strong>, take a\u00a0dose\u00a0immediately.\u00a0Continue as usual the next day.<\/p>\n\n\n\n<p><strong>If you forget to take a\u00a0dose\u00a0and only remember to do so overnight or the next day<\/strong>, do not take any extra\u00a0dose.\u00a0You may experience some withdrawal symptoms, but these should go away after you take your next\u00a0dose\u00a0at the usual time.<\/p>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<p><strong>If you do not feel any improvement<\/strong><br><strong>Seroxat will not relieve your symptoms immediately.&nbsp;<\/strong>All antidepressant drugs require time to work.&nbsp;Some patients improve after a couple of weeks while for others it may take longer.&nbsp;Some people who take antidepressants experience a worsening before they start to feel better.&nbsp;If you have not started to get better after a few weeks, contact your doctor for advice.&nbsp;Your doctor should suggest a return visit a few weeks after you start treatment.&nbsp;Tell your doctor if you do not notice any improvement.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Seroxat<\/h2>\n\n\n\n<p><strong>Do not stop taking Seroxat until your doctor tells you to.<\/strong><\/p>\n\n\n\n<p><strong>When stopping Seroxat,<\/strong>\u00a0your doctor will help you slowly reduce your\u00a0dose\u00a0over several weeks or months to reduce the risk of withdrawal symptoms.\u00a0One way to do this is to gradually reduce your\u00a0dose of\u00a0Seroxat by 10 mg per week.\u00a0Most people experience that the withdrawal symptoms are mild and disappear on their own within 2 weeks.\u00a0For some patients, the symptoms may be more severe or more prolonged.<\/p>\n\n\n\n<p><strong>If you experience withdrawal symptoms<\/strong>\u00a0when you stop your treatment, your doctor may recommend that you discontinue Seroxat more slowly.\u00a0Contact your doctor if you experience severe withdrawal symptoms.\u00a0Your doctor may ask you to start taking Seroxat again, then discontinue the medicine more slowly.<\/p>\n\n\n\n<p><strong>Even if you experience withdrawal symptoms, it will be possible for you to stop taking Seroxat.<\/strong><\/p>\n\n\n\n<p><strong><em>Withdrawal symptoms that may occur when treatment is stopped<\/em><\/strong><\/p>\n\n\n\n<p>According to studies, 3 out of 10 patients experience one or more withdrawal symptoms when stopping treatment with Seroxat.&nbsp;Some symptoms occur more often than others.<\/p>\n\n\n\n<p><strong>Common withdrawal symptoms<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 10 users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Dizziness (feeling of instability, balance difficulties)<\/td><\/tr><tr><td>&#8211;<\/td><td>Emotional disorders such as ant crawling, burning sensation and less common, feeling of electric shock even in the head, as well as buzzing, whistling, ringing, or other persistent sounds in the ears (\u00a0tinnitus\u00a0)<\/td><\/tr><tr><td>&#8211;<\/td><td>Sleep disorders (vivid dreams, nightmares, difficulty falling asleep)<\/td><\/tr><tr><td>&#8211;<\/td><td>Anxiety<\/td><\/tr><tr><td>&#8211;<\/td><td>Headache.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Uncommon withdrawal symptoms<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 100 users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Nausea<\/td><\/tr><tr><td>&#8211;<\/td><td>Sweating (including night sweats)<\/td><\/tr><tr><td>&#8211;<\/td><td>Restlessness or agitation<\/td><\/tr><tr><td>&#8211;<\/td><td>Tremor&nbsp;(shaking)<\/td><\/tr><tr><td>&#8211;<\/td><td>Confusion or disorientation<\/td><\/tr><tr><td>&#8211;<\/td><td>Diarrhea<\/td><\/tr><tr><td>&#8211;<\/td><td>Emotional instability or irritability<\/td><\/tr><tr><td>&#8211;<\/td><td>Visual disturbances<\/td><\/tr><tr><td>&#8211;<\/td><td>Fluttering and throbbing heartbeat (palpitations).<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>If you are concerned about withdrawal symptoms when stopping treatment with Seroxat, talk to your doctor.<\/strong><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Adverse reactions\u00a0occur more frequently during the first weeks of treatment with Seroxat.<\/p>\n\n\n\n<p><strong>If you get any of the following&nbsp;side effects&nbsp;during treatment, contact your doctor immediately or consult a hospital.<\/strong><\/p>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 100 users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td><strong>If you get unusual bruising or bleeding<\/strong>, bloody vomiting, or blood in the stool<strong>, contact a doctor or see a hospital immediately.<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td><strong>If you have difficulty urinating (throwing water), consult a doctor or see a hospital immediately.<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Rare&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 1,000 users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td><strong>If you have a seizure, consult a doctor or see a hospital immediately.<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td><strong>If you feel restless and have difficulty sitting or standing still<\/strong>, it may be something called\u00a0akathisia.\u00a0Increasing the Seroxat\u00a0dose\u00a0may worsen the symptoms.\u00a0<strong>Contact a doctor<\/strong>\u00a0if you experience these symptoms.<\/td><\/tr><tr><td>&#8211;<\/td><td><strong>If you feel tired, weak,<\/strong> or confused and have sore, stiff, or uncoordinated muscles, this may be due to too low a level of sodium in the blood.\u00a0<strong>Contact a doctor<\/strong>\u00a0if you get these symptoms.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Very rare&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 10,000 user<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td><strong>Allergic reaction<\/strong>, which may be severe, to Seroxat.\u00a0If you develop red and lumpy skin rash, swelling of eyelids, face, lips, mouth or tongue,\u00a0itching\u00a0or difficulty breathing (shortness of breath), or swallowing and feeling weak or dizzy resulting in fainting or unconsciousness,<strong>\u00a0consult a doctor or see a hospital. immediately.<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td><strong>If you have one or all of the following symptoms<\/strong>, it could be a so-called\u00a0serotonergic syndrome or malignant neuroleptic syndrome.\u00a0The symptoms consist of feeling very aroused or irritated, confusion, restlessness, feeling hot, sweating, shaking, shivering, hallucinations (hearing and seeing strange things), muscle stiffness, sudden muscle twitching, or palpitations.\u00a0The severity can increase and lead to unconsciousness.\u00a0<strong>Contact a doctor<\/strong>\u00a0if you experience this.<\/td><\/tr><tr><td>&#8211;<\/td><td><strong>Acute\u00a0glaucoma.<\/strong><\/td><\/tr><tr><td>&#8211;<\/td><td>If it suddenly hurts in your eyes and you get blurred vision,\u00a0<strong>consult a doctor<\/strong>.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Has been reported<\/strong><\/p>\n\n\n\n<p><strong>Occurs in an unknown number of users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Some people have had thoughts of harming themselves or taking their own lives while taking Seroxat or shortly after stopping treatment (see&nbsp;<em>If you start to feel worse and have thoughts of harming yourself<\/em>&nbsp;in section 2).<\/td><\/tr><tr><td>&#8211;<\/td><td>Some people have experienced aggression while taking Seroxat.<\/td><\/tr><tr><td>&#8211;<\/td><td>Severe\u00a0vaginal\u00a0bleeding shortly after delivery (\u00a0postpartum hemorrhage), see\u00a0Pregnancy, breastfeeding,<em> and\u00a0fertility<\/em>\u00a0in section 2 for more information.<\/td><\/tr><tr><td><\/td><td><strong>If you experience these\u00a0side effects, consult your doctor.<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Other possible\u00a0side effects\u00a0are during the treatment<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>more than 1 in 10 user<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Nausea.&nbsp;Taking Seroxat with food in the morning reduces the risk of this.<\/td><\/tr><tr><td>&#8211;<\/td><td>Changes in sexual drive or function, such as missed orgasm, and in men,&nbsp;erectile dysfunction&nbsp;and ejaculation.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 10 users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Elevated blood cholesterol levels<\/td><\/tr><tr><td>&#8211;<\/td><td>Loss of appetite<\/td><\/tr><tr><td>&#8211;<\/td><td>Poor sleep (difficulty falling asleep) or drowsiness<\/td><\/tr><tr><td>&#8211;<\/td><td>Abnormal dreams (including nightmares)<\/td><\/tr><tr><td>&#8211;<\/td><td>Dizziness or tremors (&nbsp;tremor&nbsp;)<\/td><\/tr><tr><td>&#8211;<\/td><td>Headache<\/td><\/tr><tr><td>&#8211;<\/td><td>Concentration difficulties<\/td><\/tr><tr><td>&#8211;<\/td><td>Indignation<\/td><\/tr><tr><td>&#8211;<\/td><td>Unusual weakness<\/td><\/tr><tr><td>&#8211;<\/td><td>Dimsyn<\/td><\/tr><tr><td>&#8211;<\/td><td>Yawning,&nbsp;dry mouth<\/td><\/tr><tr><td>&#8211;<\/td><td>Diarrhea or constipation<\/td><\/tr><tr><td>&#8211;<\/td><td>Vomiting<\/td><\/tr><tr><td>&#8211;<\/td><td>Weight gain<\/td><\/tr><tr><td>&#8211;<\/td><td>Sweating.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 100 users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>A short-term increase in\u00a0blood pressure, or a short-term decrease that may make you feel dizzy or faint when you get up quickly<\/td><\/tr><tr><td>&#8211;<\/td><td>Faster&nbsp;heart rate&nbsp;than normal<\/td><\/tr><tr><td>&#8211;<\/td><td>Impairment of movement, stiffness, shaking, or abnormal movements of the mouth or tongue<\/td><\/tr><tr><td>&#8211;<\/td><td>Dilated&nbsp;pupil&nbsp;is<\/td><\/tr><tr><td>&#8211;<\/td><td>Rash<\/td><\/tr><tr><td>&#8211;<\/td><td>Itching<\/td><\/tr><tr><td>&#8211;<\/td><td>Confusion<\/td><\/tr><tr><td>&#8211;<\/td><td>Hallucinations (seeing and hearing strange things)<\/td><\/tr><tr><td>&#8211;<\/td><td>Inability to urinate (&nbsp;urinary retention&nbsp;) or uncontrollable, involuntary urination (urinary incontinence)<\/td><\/tr><tr><td>&#8211;<\/td><td>If you are a diabetic patient, you may experience a loss of control of your blood sugar levels while taking Seroxat.\u00a0Talk to your doctor about adjusting the\u00a0dose\u00a0of your\u00a0insulin\u00a0or diabetes medicine.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Rare&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 1,000 users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Abnormal production of breast milk in men and women<\/td><\/tr><tr><td>&#8211;<\/td><td>Slow&nbsp;pulse<\/td><\/tr><tr><td>&#8211;<\/td><td>Liver effects in the form of elevated liver function values \u200b\u200bin blood<\/td><\/tr><tr><td>&#8211;<\/td><td>Panic attacks<\/td><\/tr><tr><td>&#8211;<\/td><td>Overactive behavior or thoughts (mania)<\/td><\/tr><tr><td>&#8211;<\/td><td>The feeling of being outside your own body (depersonalization)<\/td><\/tr><tr><td>&#8211;<\/td><td>Anxiety<\/td><\/tr><tr><td>&#8211;<\/td><td>The uncontrollable need to move the legs (Restless Legs syndrome)<\/td><\/tr><tr><td>&#8211;<\/td><td>Pain in joints and muscles.<\/td><\/tr><tr><td>&#8211;<\/td><td>Increase of&nbsp;hormone&nbsp;and&nbsp;prolactin&nbsp;in the blood.<\/td><\/tr><tr><td>&#8211;<\/td><td>Menstrual disorders (including heavy or irregular menstrual bleeding, bleeding between periods, and absence or delayed menstruation).<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Very rare&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p>These can occur in\u00a0<strong>up to 1 in 10,000 users<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>Skin rashes that can cause blisters and look like small &#8220;targets&#8221; (a central dark spot surrounded by a paler area, with a dark ring around the edge) are called erythema multiforme<\/td><\/tr><tr><td>&#8211;<\/td><td>Extensive rash with blisters and flaky skin, especially around mouth, nose, eyes, and genitals (\u00a0Stevens-Johnson\u00a0syndrome)<\/td><\/tr><tr><td>&#8211;<\/td><td>Extensive skin rash with blisters and scales that occupy a large part of the body surface (&nbsp;toxic epidermal necrolysis&nbsp;)<\/td><\/tr><tr><td>&#8211;<\/td><td>Liver problems that cause the skin and whites of the eyes to turn yellow<\/td><\/tr><tr><td>&#8211;<\/td><td>Syndrome with insufficient production of\u00a0antidiuretic hormone\u00a0(SIADH), a condition that causes excess water and decreased\u00a0sodium\u00a0(salt) concentration in the body, this due to incorrect chemical signals.\u00a0Patients with SIADH may become seriously ill or may be completely asymptomatic.<\/td><\/tr><tr><td>&#8211;<\/td><td>Accumulation of fluid or water (which may cause swelling of the arms and legs)<\/td><\/tr><tr><td>&#8211;<\/td><td>Sensitivity to sunlight<\/td><\/tr><tr><td>&#8211;<\/td><td>Painful and persistent&nbsp;erection&nbsp;of the penis<\/td><\/tr><tr><td>&#8211;<\/td><td>Decreased number of&nbsp;platelets&nbsp;in the blood.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Has been reported<\/strong><\/p>\n\n\n\n<p><strong>Occurs in an unknown number of users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the colon (causing diarrhea)<\/li><li>Tooth grinding.<\/li><\/ul>\n\n\n\n<p>Some patients have experienced buzzing, whistling, ringing, or another persistent ringing in the ears (\u00a0tinnitus\u00a0) when using Seroxat.<\/p>\n\n\n\n<p>An increased risk of bone fractures has been seen in patients taking this type of drug.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Seroxat<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton or can and on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>If you use half tablets, be sure to store them safely in the package.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&#8211;<\/td><td>The active substance is&nbsp;paroxetine&nbsp;(20 mg), in the form of hydrochloride hemihydrate.<\/td><\/tr><tr><td>&#8211;<\/td><td>The other ingredients are<\/td><\/tr><tr><td>&nbsp;<\/td><td>\u03bf<\/td><td>in the tablet core: calcium hydrogen phosphate dihydrate (E341), magnesium stearate (E470b), and sodium starch glycolate (type A)<\/td><\/tr><tr><td>&nbsp;<\/td><td>\u03bf<\/td><td>in the film coating: hypromellose (E464), titanium dioxide (dye E171), macrogol 400, and polysorbate 80 (E433).<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><strong>Seroxat 20 mg film-coated tablet<\/strong>\u00a0is white, oval, and debossed with \u201c20\u201d on one side and a score line on the other side.\u00a0Seroxat 20 mg tablets are available in child-resistant pressure packs or 50 x 50, 1, 4, 10, 14, 20, 28, 30, 50, 56, 60, 98, 100, 250 or 500 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>GlaxoSmithKline AB, Box 516, 169 29 Solna<br>Tel .: 08-638 93 00<br>E-mail: info.produkt@gsk.com<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>GlaxoSmithKline Pharmaceuticals SA<\/p>\n\n\n\n<p>ul.&nbsp;Grunwaldzka 189<\/p>\n\n\n\n<p>60-322 Poznan<\/p>\n\n\n\n<p>Poland<\/p>\n\n\n\n<p><strong>This medicine is authorized in the European Economic Area<\/strong><\/p>\n\n\n\n<p><strong>and in the United Kingdom (Northern Ireland) under the names:<\/strong><\/p>\n\n\n\n<p><strong>20 mg film-coated tablet<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Austria, Belgium, Cyprus, Czech Republic, Denmark, Estonia, Finland, Germany, Greece, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Slovakia, Slovenia, Spain, Sweden, United Kingdom (Northern Ireland)<\/td><td>Seroxat<\/td><\/tr><tr><td>France<\/td><td>Deroxate<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>It may also be helpful for you to contact a self-help or patient organization support group to find out more about your illness.\u00a0Your doctor can give you the detailed information.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>20 mg\u00a0film-coated tablet<br \/>\nparoxetine\u00a0(as hydrochloride hemihydrate)<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[21040,21044,21043,23951,23955,23954,21041,21042,23953],"class_list":["post-22912","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-paroxetine","tag-paroxetine-side-effects","tag-paroxetine-tablet","tag-seroxat","tag-seroxat-side-effects","tag-seroxat-tablet","tag-what-is-paroxetine","tag-what-paroxetine-is-used-for","tag-what-seroxat-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22912"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22912\/revisions"}],"predecessor-version":[{"id":22954,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22912\/revisions\/22954"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}