{"id":22840,"date":"2022-07-13T07:17:10","date_gmt":"2022-07-13T07:17:10","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22840"},"modified":"2022-07-13T11:01:41","modified_gmt":"2022-07-13T11:01:41","slug":"sendolor-2","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sendolor-2\/","title":{"rendered":"Sendolor &#8211; Cyclophosphamide uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg&nbsp;coated tablet<br>cyclophosphamide<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Sendoxan is and what it is used for<\/h2>\n\n\n\n<p>Sendoxan is an anti-cancer agent that damages the genetic material in the cells in a way that inhibits cell division and kills the cells.&nbsp;Sendoxan also inhibits the immune system.<\/p>\n\n\n\n<p>Sendoxan is mainly used in various types of cancer and against certain so-called autoimmune diseases, such as long-term and severe&nbsp;rheumatoid arthritis&nbsp;(&nbsp;rheumatoid arthritis&nbsp;).<br><a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Sendoxan<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Sendoxan:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have ever had an\u00a0allergic reaction\u00a0to cyclophosphamide or any of the other ingredients of Sendoxan.\u00a0An\u00a0allergic reaction\u00a0may have symptoms such as difficulty breathing, wheezing, rash,\u00a0itching,\u00a0or swelling of the face and lips.<\/li><li>If your\u00a0bone marrow\u00a0is not working properly (especially if you have previously been treated with\u00a0chemotherapy\u00a0and\/or radiation therapy).\u00a0Your blood will be tested to check your bone marrow function.<\/li><li>if you have an ongoing\u00a0inflammation\u00a0of the bladder, which is manifested by pain when urinating (\u00a0cystitis\u00a0)<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have an ongoing\u00a0infection.<\/li><li>if you have difficulty urinating due to any urinary tract obstruction.<\/li><li>if you are breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Sendoxan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are receiving or have recently received radiation therapy or\u00a0chemotherapy.<\/li><li>if you have liver problems.<\/li><li>if you have kidney problems.\u00a0Your doctor will take blood samples to check how well your kidneys and liver are working.<\/li><li>if you have heart problems or have received radiation therapy to the heart area.<\/li><li>if you have generally poor health and are weak.<\/li><li>if you are older.<\/li><li>if you are planning to become pregnant (see section \u201cPregnancy, breast-feeding and\u00a0fertility\u00a0)<\/li><li>Sendoxan contains\u00a0lactose\u00a0.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/li><\/ul>\n\n\n\n<p>Sendoxan can in rare cases affect the white\u00a0blood cells\u00a0so that the defense against infection deteriorates.\u00a0If you get an\u00a0infection\u00a0with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/pharynx\/mouth or urination problems, you should see a doctor immediately so that a blood test can rule out a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0).\u00a0It is important that you then have information about your medication.<\/p>\n\n\n\n<p>Stop taking Sendoxan and contact your doctor as soon as possible if you experience unexplained muscle pain, muscle cramps, or muscle weakness.<\/p>\n\n\n\n<p><strong>Effects on the blood and immune system<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The blood cells are produced in the\u00a0bone marrow.\u00a0There are three types: red blood cells, which carry oxygen around the body, white blood cells that fight\u00a0infection,\u00a0and\u00a0platelets, which cause the blood to clot.<\/li><li>After taking Sendoxan, the number of all three types of blood cells will decrease.\u00a0This is an unavoidable side effect of Sendoxan.\u00a0The number of blood cells will reach its lowest level about 5 &#8211; 10 days after you start taking Sendoxan, and will remain low until a few days after the end of the treatment.\u00a0Most people achieve normal blood cell counts within 21-28 days.\u00a0If you have received a lot of\u00a0chemotherapy\u00a0before, it may take longer to reach a normal level.<\/li><li>You will probably get an\u00a0infection\u00a0when the number of blood cells decreases.\u00a0Try to avoid close contact with people who cough, have a cold, or have other\u00a0infections.<\/li><li>Your doctor will check if the blood cell count is high enough before and during treatment with Sendoxan.<\/li><\/ul>\n\n\n\n<p><strong>Impact of the gums<\/strong><\/p>\n\n\n\n<p>Careful oral hygiene is important as sores and&nbsp;infections&nbsp;in your mouth can occur.&nbsp;Talk to your doctor about this if you are unsure.<\/p>\n\n\n\n<p><strong>Effects on the bladder<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sendoxan can damage the inner walls of the bladder and cause bleeding.\u00a0Your doctor knows that this may occur, and if necessary you will be given a medicine called Uromitexan (Mesna) which protects the bladder.<\/li><li>Uromitexane (Mesna) can be given as an\u00a0injection, mixed in the intravenous solution, or as tablets.<\/li><li>Most people who receive Sendoxan together with the mesna experience no problems with the bladder, but the doctor may want to test the urine for any blood content by using a urine stick or microscope.<\/li><li>Tell your doctor immediately if you notice blood in your urine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Sendoxan<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>When Sendoxan is used at the same time as other medicines, the effect may affect or be affected by the other medicines.&nbsp;This increases the risk of&nbsp;side effects&nbsp;and other unwanted effects.<\/p>\n\n\n\n<p>Examples of medicines that affect or are affected by Sendoxan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allopurinol, used against\u00a0gout, may aggravate the\u00a0side effects\u00a0of Sendoxan.<\/li><li>Suxamethone, a muscle relaxant used during surgeries, may have an enhanced effect.<\/li><li>Medicines used in connection with the treatment of cancer<\/li><li>Some medicines for\u00a0inflammation\u00a0and pain (indomethacin) increase the risk of slower excretion of water, which can lead to water accumulation in the body.<\/li><li>Certain medicines for\u00a0epilepsy\u00a0(phenobarbital,\u00a0phenytoin, carbamazepine)<\/li><li>Certain medicines for\u00a0stomach ulcers\u00a0(cimetidine)<\/li><li>Some medicines for high\u00a0blood pressure\u00a0(hydrochlorothiazide)<\/li><li>Some medicines for\u00a0infection\u00a0(such as\u00a0ciprofloxacin,\u00a0sulfonamides, clarithromycin, and telithromycin)<\/li><li>Some antifungal medicines (\u00a0fluconazole\u00a0, itraconazole,\u00a0ketoconazole\u00a0, posaconazole, voriconazole)<\/li><li>Some medicines for nausea (aprepitant)<\/li><li>Some drugs that inhibit the immune system (azathioprine, ciclosporin, natalizumab)<\/li><li>Rifampicin used for\u00a0tuberculosis<\/li><li>Busulfan given in bone marrow transplants<\/li><li>Bupropion used in smoking cessation may affect the effect of Sendoxan<\/li><li>Drugs that inhibit blood clotting, e.g.\u00a0warfarin\u00a0and prasugrel<\/li><li>Some\u00a0antibiotics\u00a0such as amphotericin B<\/li><li>Zidovudine, which is used to treat viral infections and a type of medicine called a\u00a0protease inhibitor<\/li><li>Tamoxifen, used in hormone therapy for breast cancer<\/li><li>Certain types of drugs for irregular heartbeat, such as\u00a0amiodarone<\/li><li>Some medicines for\u00a0heart failure\u00a0(\u00a0digoxin\u00a0)<\/li><li>Medicines for high\u00a0blood pressure\u00a0such as verapamil,\u00a0ACE inhibitors<\/li><li>Radiation therapy of the heart area<\/li><li>Medicines that belong to the group\u00a0of\u00a0corticosteroids<\/li><li>If you are going to be vaccinated, you must tell them that you are being treated with Sendoxan, as the effect of the vaccine can sometimes be impaired, and in some cases, the vaccination can cause an\u00a0infection.<\/li><li>Medicines for mild depression also called\u00a0<em>hypericum<\/em>\u00a0such as St. John&#8217;s\u00a0wort<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Sendoxan with food, drink, and alcohol<\/h2>\n\n\n\n<p>The risk of nausea and vomiting increases with alcohol consumption.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>You should not get pregnant while taking cyclophosphamide.\u00a0This is because the fetus can be injured.\u00a0Tell your doctor if you are pregnant, suspect you may be pregnant, or are planning to have a baby.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Neither men nor women should try to have children within 6-12 months after finishing treatment.\u00a0Use an effective contraceptive.\u00a0Ask your doctor for advice.<\/li><li>Talk to your doctor about the possibility of freezing semen or eggs before starting treatment. Do not breastfeed during treatment with cyclophosphamide.\u00a0Ask your doctor for advice.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Certain\u00a0side effects\u00a0such as dizziness, blurred vision, and impaired vision can indirectly affect the ability to drive and use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Sendoxan<\/h2>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.<\/p>\n\n\n\n<p>Do not split or crush the tablet.<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;for adults is 1-2 (-4)&nbsp;<strong>&nbsp;<\/strong>tablets per day.<\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.&nbsp;Factors that determine the size of the dose are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>what disease you are being treated for<\/li><li>your height and weight<\/li><li>your general condition<\/li><li>if you are taking any other medicines for cancer or radiation therapySendoxan is usually given as a series of cures.&nbsp;After each treatment, a break is taken (a period without the addition of Sendoxan) before the next treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much Sendoxan&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine, always contact a doctor or hospital.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Sendoxan can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><em>Common (affects more than 1 user in 100):<\/em>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Impaired bone marrow function, can lead to a lack of\u00a0white blood cells\u00a0(susceptibility to infection),\u00a0platelets\u00a0(risk of bleeding), and\u00a0anemia<\/li><li>Inflammation\u00a0of the conjunctiva of the\u00a0eye<\/li><li>Nausea, vomiting, diarrhea, constipation, abdominal pain<\/li><li>Skin rash including\u00a0hives<\/li><li>Liver effects<\/li><li>Hair loss<\/li><li>Inflammation\u00a0of the bladder with blood in the urine<br>Rare (affects less than 1 user in 1,000):<\/li><li>Severe\u00a0hypersensitivity reaction\u00a0(anaphylactic\u00a0shock\u00a0)<\/li><li>Tumor disease\/cancer caused by the treatment<\/li><li>Reduced salinity in the blood<\/li><li>Fluid accumulation<\/li><li>Loss of appetite and weight loss<\/li><li>Dizziness<\/li><li>Dimsyn.<\/li><li>Heart effect.<\/li><li>Connective tissue changes in the lungs<\/li><li>Suva<\/li><li>Inflammation\u00a0and ulcers of the mucous membranes<\/li><li>Inflammation\u00a0of the pancreas<\/li><li>Bleeding and\u00a0inflammation\u00a0of the gastrointestinal tract<\/li><li>Skin and nail changes<\/li><li>Changes in kidney, ureter, and\u00a0bladder<\/li><li>Failure to menstruate,<\/li><li>Absence\/reduction of sperm in the semen<\/li><li>Headache<\/li><li>Fever<\/li><li>Local reactions at the injection site (swelling,\u00a0redness, sores)<br>Very rare (affects less than 1 user in 10,000):\u00a0<\/li><li>Severe\u00a0mucositis\u00a0&#8211; and skin inflammation with high fever (\u00a0Stevens-Johnson syndrome\u00a0) and severe skin reactions with skin detachment (\u00a0toxic epidermal necrolysis\u00a0).<br>Has been reported (occurs in an unknown number of users):<\/li><li>Pneumonia, blood poisoning<\/li><li>Rapid decay of tumor cells<\/li><li>Tumor\/cancer disease in offspring<\/li><li>Uncontrolled blood clotting (\u00a0DIC\u00a0)<\/li><li>Hemolytic uremic syndrome\u00a0(complex symptom picture with, among other things,\u00a0anemia, spotty bleeding in the skin, and sometimes\u00a0acute\u00a0kidney failure\u00a0.)<\/li><li>Immunocompromised<\/li><li>Water poisoning (eg confusion, headache, dizziness)<\/li><li>Blood sugar changes<\/li><li>Confusion<\/li><li>Brain effects, seizures,\u00a0nerve effects (odor and taste changes)<\/li><li>Impaired vision, increased tear flow<\/li><li>Earrings, deafness<\/li><li>Cardiac arrhythmias<\/li><li>Heart failure<\/li><li>Myocardial infarction, angina (chest pain)<\/li><li>Blood clots in\u00a0vessels\u00a0and lungs<\/li><li>Blood pressure changes<\/li><li>Acute\u00a0Respiratory Syndrome (ARDS)<\/li><li>Lung impact e.g.\u00a0shortness of breath, cough, and lack of oxygen<\/li><li>Cramps in the trachea<\/li><li>Nasal congestion, sneezing<\/li><li>Inflammation\u00a0of the parotid gland<\/li><li>Stop in the bile ducts<\/li><li>Jaundice<\/li><li>Fluid in the abdomen<\/li><li>Muscle breakdown, muscle cramps<\/li><li>Increased sweating (\u00a0hyperhidrosis\u00a0)<\/li><li>Severe skin changes (\u00a0scleroderma\u00a0)<\/li><li>Muscle and joint pain<\/li><li>Renal impairment including\u00a0renal failure<\/li><li>Cystitis\u00a0, bladder contraction (contracture)<\/li><li>Large amounts of urine (\u00a0diabetes insipidus\u00a0)<\/li><li>Urinary tract bleeding including bleeding urinary tract infection\u00a0<\/li><li>Inability to have children (\u00a0infertility\u00a0)<\/li><li>Premature birth<\/li><li>Fetal death, malformations, or growth disorders in the fetus<\/li><li>Weakness, fatigue, the feeling of weakness<\/li><li>Flu-like illness, pain, chills<\/li><li>Changes in blood test results contact a doctor immediately if you see blood in the urine, get a sudden and unexplained fever, have unusual pain or swelling in the legs, hold in the chest and difficulty breathing or have a feeling of pain and heaviness in the chest.<\/li><\/ul>\n\n\n\n<p>Some&nbsp;side effects&nbsp;may occur after the end of treatment with Sendoxan.&nbsp;Therefore, also contact the hospital staff or your doctor if you suspect that you have experienced&nbsp;side effects&nbsp;after the end of treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Sendoxan<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<\/p>\n\n\n\n<p>Store below 25&nbsp;<sup>\u00b0<\/sup>&nbsp;C.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is cyclophosphamide monohydrate equivalent to cyclophosphamide 50 mg.<\/li><li>The other ingredients are sucrose, corn starch,\u00a0lactose monohydrate\u00a024.6 mg, talc, calcium hydrogen phosphate dihydrate, titanium dioxide (dye E 171),\u00a0calcium carbonate, and macrogol 35,000,\u00a0colloidal\u00a0silicon dioxide, magnesium stearate, gelatin, povidone,\u00a0polysorcolosol\u00a0% wax.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Printed packaging, 100 tablets<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Baxter Medical AB<\/p>\n\n\n\n<p>Box 63<\/p>\n\n\n\n<p>SE-16494 Kista<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Baxter Oncology GmbH<\/p>\n\n\n\n<p>Plant K\u00fcnsebeck<\/p>\n\n\n\n<p>Kantstrasse 2<\/p>\n\n\n\n<p>D-33790 Halle K\u00fcnsebeck<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sendoxan is an anti-cancer agent that damages the genetic material in the cells in a way that inhibits cell division and kills the cells.\u00a0Sendoxan also inhibits the immune system.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[23928,23932,23931,23933,23930,23929,23855,23856],"class_list":["post-22840","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-cyclophosphamide","tag-cyclophosphamide-side-effects","tag-cyclophosphamide-tablet","tag-sendolor-tablet","tag-what-cyclophosphamide-is-used-for","tag-what-is-cyclophosphamide","tag-what-is-sendolor","tag-what-sendolor-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22840"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22840\/revisions"}],"predecessor-version":[{"id":22884,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22840\/revisions\/22884"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}