{"id":22748,"date":"2022-07-07T10:20:28","date_gmt":"2022-07-07T10:20:28","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22748"},"modified":"2022-07-09T11:30:10","modified_gmt":"2022-07-09T11:30:10","slug":"sedaconda","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sedaconda\/","title":{"rendered":"Sedaconda &#8211; Isoflurane uses, dose and side effects"},"content":{"rendered":"\n<p>100% V \/ V&nbsp;inhalation vapor&nbsp;, liquid<br>isoflurane<a><\/a><\/p>\n\n\n\n<p>Read all of this leaflet carefully befo<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Sedaconda is and what it is used for<\/h2>\n\n\n\n<p>Sedaconda contains an active substance called isoflurane and belongs to a group of medicines called&nbsp;anesthetics.&nbsp;It is used to provide&nbsp;sedation&nbsp;(a state of calm, drowsiness, or sleep) in adults who need a respirator (treatment with a special machine that helps patients breathe) during intensive care.<\/p>\n\n\n\n<p>Isoflurane contained in Sedaconda may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you get Sedaconda<\/h2>\n\n\n\n<p><strong>You will not receive Sedaconda<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to isoflurane or other halogenated anesthetics.<\/li><li>If you, or anyone in your family, have ever experienced a rapid rise in body temperature during&nbsp;sedation&nbsp;or anesthesia (a rare condition called&nbsp;malignant&nbsp;hyperthermia&nbsp;).&nbsp;See &#8220;Possible side effects&#8221;, for more information.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before receiving Sedaconda if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have ever had QT&nbsp;prolongation (change seen on an&nbsp;electrocardiogram&nbsp;(&nbsp;ECG&nbsp;) reading) or&nbsp;torsade de pointes&nbsp;(life-threatening irregular heartbeat).&nbsp;Isoflurane has in some cases been able to cause these.<\/li><li>you have a mitochondrial disease.&nbsp;Mitochondrial diseases are a group of rare genetic conditions that occur when mitochondria (small structures in the cells) do not produce enough energy for the body to function properly.<\/li><li>you have heart disease (eg coronary heart disease).<\/li><li>you have previously received an anesthetic to inhale, especially within the last three months.&nbsp;This can lead to an increased risk of liver damage.<\/li><li>you have an increased&nbsp;intracranial pressure&nbsp;(pressure around your brain) due to head injury, brain tumor, or other condition.&nbsp;Sedaconda can further increase the pressure inside your skull.<\/li><li>you have low&nbsp;blood pressure, low blood volume, or are weakened.&nbsp;You may need a lower&nbsp;dose&nbsp;of Sedaconda.<\/li><li>you have liver disease.<\/li><li>you have a condition that affects the nerves and muscles (a neuromuscular disease, such as Duchenne muscular dystrophy or&nbsp;myasthenia gravis&nbsp;).<\/li><li>you are taking medicines called muscle relaxants (see section \u201cOther medicines and Sedaconda\u201d).<\/li><\/ul>\n\n\n\n<p>Sedaconda can cause&nbsp;malignant&nbsp;hyperthermia, which is a rapid and marked increase in body temperature accompanied by muscle stiffness and other symptoms (see section 4).<\/p>\n\n\n\n<p>Sedaconda may in rare cases cause&nbsp;hyperkalemia&nbsp;(&nbsp;increased&nbsp;serum&nbsp;potassium&nbsp;) (see section 4).&nbsp;Patients with the neuromuscular disease appear to be most at risk.<\/p>\n\n\n\n<p>Sedaconda may cause breathing difficulties (&nbsp;respiratory depression&nbsp;) (see section 4).<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be given to children and adolescents under 18 years of age, as there is limited experience with this medicine in this age group.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Sedaconda<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>This is especially important if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some antidepressants, so-called non-selective&nbsp;monoamine oxidase&nbsp;(MAO) inhibitors, such as isocarboxazid, nialamide, phenelzine, etc. Your doctor will not give you Sedaconda for at least 15 days after taking an&nbsp;MAOI.<\/li><li>Drugs called beta-&nbsp;sympathomimetics&nbsp;(a broad group of drugs that affect the part of the nervous system that works automatically), e.g.&nbsp;isoprenaline,&nbsp;adrenaline,&nbsp;noradrenaline.&nbsp;If you take these medicines with Sedaconda, your heartbeat may become irregular.<\/li><li>Drugs called indirectly acting&nbsp;sympathomimetics&nbsp;such as amphetamines and their closely related drugs, psychostimulants, appetite suppressants,&nbsp;ephedrine,&nbsp;and closely related drugs.&nbsp;Taking these medicines with Sedaconda can lead to high&nbsp;blood pressure.<\/li><li>Beta-blockers&nbsp;(a group of medicines used to treat high&nbsp;blood pressure&nbsp;and certain heart diseases).&nbsp;Taking these medicines with Sedaconda can worsen so-called cardiac compensation reactions (reactions that help your body compensate for reduced blood and oxygen supply caused by&nbsp;heart failure&nbsp;).<\/li><li>Isoniazid&nbsp;(&nbsp;antibiotics&nbsp;for&nbsp;tuberculosis&nbsp;) may increase the risk of liver damage.<\/li><li>Calcium channel blockers (used to treat high&nbsp;blood pressure&nbsp;and certain heart diseases) such as amlodipine,&nbsp;diltiazem, nifedipine, and verapamil.<\/li><li>Opioids&nbsp;(eg morphine,&nbsp;fentanyl&nbsp;),&nbsp;benzodiazepines&nbsp;(eg midazolam,&nbsp;diazepam&nbsp;), and other sedatives can cause slow and ineffective breathing.<\/li><li>Muscle relaxants (eg suxamethonium, pancuronium, atracurium, vecuronium).&nbsp;Sedaconda may increase their effects.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n<p>Sedaconda can cause increased blood loss, such as if you are undergoing uterine surgery or giving birth.&nbsp;Your doctor will not give you this medicine unless the potential benefit outweighs the potential risks to you and your child.<\/p>\n\n\n\n<p>If you have been breastfeeding before receiving Sedaconda, you should stop breastfeeding until the medicine has disappeared from your body.&nbsp;Your doctor will tell you when it is safe for you to continue breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Sedaconda may impair your ability to drive and use machines for up to 6 days.&nbsp;Do not drive or use machines until your doctor tells you to.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Sedaconda<\/h2>\n\n\n\n<p>Sedaconda will only be given to you by qualified and experienced medical staff.&nbsp;Your doctor will determine the appropriate&nbsp;dose&nbsp;for you depending on your age, state of health, and sedation depth (sleepiness) that you need.<\/p>\n\n\n\n<p>Your doctor will give you the right starting dose to achieve the desired sedation depth by carefully following your reactions as well as vital signs (such as&nbsp;heart rate,&nbsp;blood pressure,&nbsp;respiration, etc.).<\/p>\n\n\n\n<p>Sedaconda is a liquid that is converted to steam (gas) using a carburetor.&nbsp;It is intended for&nbsp;inhalation, which means you will inhale it like a vapor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Sedaconda than you should<\/h2>\n\n\n\n<p>If you take too much Sedaconda and are deeply anesthetized, your&nbsp;blood pressure&nbsp;may drop (&nbsp;hypotension&nbsp;) and your breathing may become slow and ineffective.&nbsp;Your doctor will take steps to correct your&nbsp;blood pressure&nbsp;and breathing.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Adverse reactions&nbsp;that have been reported (occurring in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anaphylactic reaction&nbsp;(a severe, potentially life-threatening&nbsp;allergic reaction&nbsp;), other allergic reactions (manifested as red, itchy, windy, dry or cracked skin, rash, shortness of breath, wheezing, chest discomfort, swelling of the face),<\/li><li>elevated blood sugar or potassium levels,<\/li><li>mood swings,<\/li><li>impaired mental function and seizures, which is a medical condition in which the body muscles contract and quickly relax repeatedly, resulting in uncontrolled body movements,<\/li><li>irregular heartbeats, slow heartbeats, cardiac arrest (a condition in which the heart suddenly stops beating),&nbsp;QT&nbsp;prolongation (change seen on an&nbsp;electrocardiogram&nbsp;(&nbsp;ECG&nbsp;) reading), and&nbsp;torsade de pointes&nbsp;(life-threatening irregular heartbeats),<\/li><li>bronchospasm&nbsp;(contraction of the respiratory muscles leading to respiratory problems), shortness of breath, wheezing, slow shallow breathing,&nbsp;laryngospasm&nbsp;(contraction of the vocal cords which temporarily makes it difficult to speak or breathe),<\/li><li>intestinal blockage, vomiting, nausea,<\/li><li>liver cell death (liver necrosis) or damage, elevated levels of&nbsp;bilirubin (&nbsp;red blood cell&nbsp;breakdown product&nbsp;) in the blood,<\/li><li>blood test results show a change in renal function: elevated&nbsp;creatinine levels&nbsp;and decreased&nbsp;urea&nbsp;levels,<\/li><li>a rapid and marked increase in body temperature (&nbsp;malignant&nbsp;hyperthermia).&nbsp;This is a serious condition that will be treated immediately by your doctor.<\/li><li>chest discomfort, chills,<\/li><li>changes in blood test results: abnormal levels of certain liver enzymes, increased&nbsp;white blood cell count, increased fluoride levels, and decreased cholesterol levels,<\/li><li>abnormal electroencephalogram (&nbsp;EEG&nbsp;) results (a test that evaluates the electrical activity of the brain),<\/li><li>presence of myoglobin (a muscle protein) in the urine,&nbsp;and rhabdomyolysis&nbsp;(severe muscle damage).<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people) reported in a clinical study:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fast heartbeat<\/li><li>anxiety,&nbsp;delirium&nbsp;(sudden change in mental state, which can be confusion, anxiety, personality change, and difficulty understanding and remembering), during or after&nbsp;sedation<\/li><li>low&nbsp;blood pressure<\/li><li>increased levels of creatine phosphokinase (CK) (a muscle substance) in the blood<\/li><li>nausea, vomiting<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Sedaconda<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and bottle cap after \u201cEXP\u201d.<\/p>\n\n\n\n<p>The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Sedaconda&#8217;s shelf life after the&nbsp;Sedaconda refill adapter is attached is 14 days.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.&nbsp;Store the bottle in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Any unused product or waste material should be disposed of by local requirements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is isoflurane 100% V \/ V.&nbsp;There are no additional ingredients.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Sedaconda is an&nbsp;inhalation vapororor liquid&nbsp;It is a clear, colorless liquid available in 100 ml and 250 ml amber glass bottles.<\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p>6 x 100 ml<\/p>\n\n\n\n<p>6 x 250 ml<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<a><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Piramal Critical Care BV<\/p>\n\n\n\n<p>Rouboslaan 32 (ground floor)<\/p>\n\n\n\n<p>2252 TR, Advances<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p><strong>Sedaconda:<\/strong>&nbsp;Austria, Belgium, Croatia, Denmark, Finland, Germany, Ireland, Norway, the Netherlands, Poland, Portugal, Slovenia, Spain, and Sweden<\/p>\n\n\n\n<p><strong>Cedaconda:<\/strong>&nbsp;France<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sedaconda contains an active substance called isoflurane and belongs to a group of medicines called\u00a0anesthetics\u00a0.\u00a0It is used to provide\u00a0sedation\u00a0(a state of calm, drowsiness or sleep) in adults who need a respirator (treatment with a special machine that helps patients breathe) during intensive care.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[23829,23835,2498,23830,23831,23836,23837,12268,23832,12269],"class_list":["post-22748","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-isoflurane","tag-benefits-of-sedaconda","tag-isoflurane","tag-isoflurane-usage","tag-sedaconda","tag-sedaconda-dosage","tag-sedaconda-usage","tag-what-is-isoflurane","tag-what-is-sedaconda","tag-what-isoflurane-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22748","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22748"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22748\/revisions"}],"predecessor-version":[{"id":22837,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22748\/revisions\/22837"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}