{"id":22658,"date":"2022-07-05T07:19:08","date_gmt":"2022-07-05T07:19:08","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22658"},"modified":"2022-07-05T10:39:42","modified_gmt":"2022-07-05T10:39:42","slug":"sandostatin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sandostatin\/","title":{"rendered":"Sandostatin &#8211; Octreotide uses, dose and side effects"},"content":{"rendered":"\n<p>50 micrograms \/ ml, 100 micrograms \/ ml and 500 micrograms \/ ml&nbsp;solution for injection \/ infusion<br>octreotide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Sandostatin is and what it is used for<\/h2>\n\n\n\n<p>Sandostatin is a\u00a0synthetic\u00a0version of somatostatin, a substance that occurs naturally in the body and which inhibits the effects of certain\u00a0hormones\u00a0such as.\u00a0growth hormone.\u00a0The advantages of Sandostatin compared to somatostatin are that it is stronger and that the effect lasts longer.<\/p>\n\n\n\n<p><strong>Sandostatin is used<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in\u00a0<strong>acromegaly<\/strong>, a condition in which the body produces too much\u00a0growth hormone.\u00a0Normally, growth hormone controls the\u00a0growth\u00a0of\u00a0tissues, organs, and bones.\u00a0Too much\u00a0growth hormone\u00a0causes the size of your bones and\u00a0tissues\u00a0to increase, especially in your hands and feet.\u00a0Sandostatin significantly reduces the symptoms of\u00a0acromegaly, which include headaches, excessive sweating, numbness in the hands and feet, fatigue, and joint pain.<\/li><li>to relieve symptoms associated with certain\u00a0tumors\u00a0in the gastrointestinal tract\u00a0(eg carcinoid\u00a0tumors,\u00a0VIP\u00a0tumors,\u00a0glucagon,\u00a0gastrinoma, insulinoma).\u00a0In these conditions, there is an overproduction of certain\u00a0hormones\u00a0and other similar substances in the stomach, intestines, or pancreas.\u00a0This overproduction upsets the natural hormone balance in the body and results in a variety of symptoms, such as\u00a0redness, diarrhea, low\u00a0blood pressure, rash, and weight loss.\u00a0Sandostatin treatment helps control these symptoms.<\/li><li>to prevent\u00a0complications after surgery on the pancreas.\u00a0Treatment with Sandostatin helps to reduce the risk of complications (eg accumulation in the abdomen and\u00a0inflammation\u00a0of the pancreas) after surgery.<\/li><li>to stop bleeding and protect against\u00a0re-bleeding from ruptured gastroesophageal varices\u00a0in patients with\u00a0cirrhosis\u00a0(\u00a0chronic\u00a0liver disease).\u00a0Sandostatin treatment helps control bleeding and reduces the need for\u00a0transfusions.<\/li><li>to treat pituitary tumors that produce too much thyroid-stimulating hormone\u00a0(\u00a0TSH\u00a0).\u00a0Too much thyroid-stimulating hormone\u00a0(\u00a0TSH\u00a0) leads to\u00a0hyperthyroidism. Sandostatin is used to treat people with pituitary tumors that produce too much thyroid-stimulating hormone\u00a0(\u00a0TSH\u00a0):<ul><li>when other types of treatments (\u00a0surgery\u00a0or radiation therapy) are not appropriate or have not worked.<\/li><li>after radiation treatment to cover the transition period until the radiation treatment becomes fully effective.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Octreotide contained in Sandostatin may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Sandostatin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Sandostatin:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to octreotide or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Sandostatin:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you know you have\u00a0gallstones\u00a0or have had it before or if you experience other complications such as fever, chills, abdominal pain, yellow skin, or yellow eyes, tell your doctor as long-term use of Sandostatin can lead to gallstone formation.\u00a0Your doctor may want to check your gallbladder at regular intervals.<\/li><li>if you have problems with your blood sugar levels, either they are too high (\u00a0diabetes\u00a0) or too low (hypoglycemia).\u00a0Blood glucose control is mandatory when Sandostatin is used to treat bleeding gastroesophageal varices.<\/li><li>If you have had a B12 deficiency in the past, your doctor may want to check your B12 levels at regular intervals.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Octreotide can lower the heart rate and can\u00a0cause abnormal heart rhythms in very high\u00a0doses.\u00a0Your doctor may monitor your heart rate during treatment.<\/li><\/ul>\n\n\n\n<p><strong>Sampling and inspections<\/strong><\/p>\n\n\n\n<p>If you are being treated with Sandostatin for a long time, your doctor may want to check your thyroid function at regular intervals.<\/p>\n\n\n\n<p>Your doctor will check your liver function.<\/p>\n\n\n\n<p>Your doctor may want to check your pancreatic enzyme function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Experience with Sandostatin in children is limited<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Sandostatin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>You can usually continue to take other medicines while you are being treated with Sandostatin.\u00a0However, certain drugs such as cimetidine, ciclosporin, bromocriptine,\u00a0quinidine,\u00a0and terfenadine have been reported to be affected by Sandostatin.<\/p>\n\n\n\n<p>If you are being treated with medicine to control\u00a0your blood pressure\u00a0(such as a beta-blocker\u00a0or a calcium channel blocker) or medicine to regulate your fluid and electrolyte balance, your doctor may need to adjust your\u00a0dose.<\/p>\n\n\n\n<p>If you are diabetic, your doctor may need to adjust your insulin dose.<\/p>\n\n\n\n<p>If you are being treated with lutetium (\u00a0<sup>177<\/sup>\u00a0Lu) oxodotreotide, a radioactive medicine, your doctor may stop and\/or adjust your treatment with Sandostatin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Sandostatin should only be used during pregnancy if necessary.<\/p>\n\n\n\n<p>Female patients who may become pregnant should use a safe method of contraception during treatment.<\/p>\n\n\n\n<p>Do not breastfeed during treatment with Sandostatin.\u00a0It is not known if Sandostatin passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Sandostatin has no or negligible effects on the ability to drive and use machines.&nbsp;However, some of the&nbsp;side effects&nbsp;that you may get from Sandostatin treatment, such as headaches and fatigue, may impair your ability to drive and use machines safely.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Sandostatin contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0ampoule, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Sandostatin<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Depending on the condition being treated, Sandostatin is given as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>subcutaneous\u00a0(under the skin)\u00a0injection\u00a0or<\/li><li>intravenous\u00a0(in a vein)\u00a0infusion.<\/li><\/ul>\n\n\n\n<p>If you have&nbsp;liver cirrhosis&nbsp;(&nbsp;chronic&nbsp;liver disease), your doctor may need to adjust your maintenance dose.<\/p>\n\n\n\n<p>Your doctor or nurse will explain to you how to inject Sandostatin under the skin, but a vein&nbsp;infusion&nbsp;should always be performed by a healthcare professional.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Subcutaneous&nbsp;injection<\/strong><\/li><\/ul>\n\n\n\n<p>The upper arms, thighs, and abdomen are suitable areas for\u00a0subcutaneous\u00a0injection.<\/p>\n\n\n\n<p>Choose a new site for each&nbsp;subcutaneous&nbsp;injection&nbsp;so that you do not irritate a specific area.&nbsp;Patients who will inject themselves must receive careful instructions from a doctor or nurse.<\/p>\n\n\n\n<p>If you store the medicine in the refrigerator, it is recommended that you allow it to reach room temperature before using it.&nbsp;It reduces the risk of pain at the injection site.&nbsp;You can warm it in your hand but do not heat it.<\/p>\n\n\n\n<p>A few people experience pain at the site of the subcutaneous\u00a0injection.\u00a0This pain usually lasts only a short time.\u00a0If this happens to you, you can relieve the pain by gently rubbing the injection site for a few seconds after the\u00a0injection.<\/p>\n\n\n\n<p>Review the solution for particulate matter or discoloration before using a Sandostatin\u00a0ampoule.\u00a0Do not use it if you see anything unusual.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Sandostatin than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<p>The symptoms of overdose are: irregular heartbeat, low\u00a0blood pressure, cardiac arrest, decreased supply of oxygen to the brain, severe upper abdominal pain, yellowing of the skin and eyes, nausea, decreased appetite, diarrhea, weakness, fatigue, lack of energy, weight loss, swollen abdomen, discomfort, high levels of\u00a0lactic acid\u00a0in the blood and abnormal heart rhythm.<\/p>\n\n\n\n<p>If you think you have had an overdose and are experiencing such symptoms, talk to your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Sandostatin<\/h2>\n\n\n\n<p>Take a\u00a0dose\u00a0as soon as you remember, then continue as usual.\u00a0It does not harm if you miss a\u00a0dose, but you can temporarily get symptoms back before you return to the dosing schedule.<\/p>\n\n\n\n<p>Do not inject a double\u00a0dose\u00a0of Sandostatin to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Sandostatin<\/h2>\n\n\n\n<p>If you stop taking Sandostatin, your symptoms may return.&nbsp;Therefore, you should not stop treatment unless your doctor advises you to do so.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious.&nbsp;Talk to your doctor immediately if you get any of the following:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gallstones\u00a0lead to sudden back pain.<\/li><li>High blood sugar.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Underactive\u00a0thyroid gland\u00a0(\u00a0hypothyroidism\u00a0) which causes changes in heart rate, appetite, or weight;\u00a0fatigue, coldness, or swelling on the front of the throat.<\/li><li>Changes in thyroid function tests.<\/li><li>Inflammation\u00a0of the gallbladder (cholecystitis);\u00a0Symptoms may include pain in the upper right part of the abdomen, fever, nausea, yellowing of the skin, and eyes (jaundice).<\/li><li>Low blood sugar.<\/li><li>Impaired glucose tolerance.<\/li><li>Slow heartbeat.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Thirst, low urine production, dark urine, dry&nbsp;reddened&nbsp;skin.<\/li><li>Fast heartbeat.<\/li><\/ul>\n\n\n\n<p><strong>Other serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypersensitivity reaction\u00a0(allergic) including skin rash.<\/li><li>A type of\u00a0allergic reaction\u00a0(\u00a0anaphylaxis\u00a0) that can cause difficulty swallowing or breathing, swelling and tingling, and even drops in blood pressure that can lead to dizziness or unconsciousness.<\/li><li>Inflammation\u00a0of the pancreas (\u00a0pancreatitis\u00a0);\u00a0symptoms may include sudden pain in the upper abdomen, nausea, vomiting, and diarrhea.<\/li><li>Inflammation\u00a0of the liver (\u00a0hepatitis\u00a0);\u00a0Symptoms may include yellowing of the skin and eyes (jaundice), nausea, vomiting, loss of appetite, general malaise,\u00a0itching, and light-colored urine.<\/li><li>Irregular heartbeats.<\/li><li>Low\u00a0platelet count, may lead to an increased tendency for bleeding or bruising.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor immediately if you experience any of the&nbsp;side effects&nbsp;listed above.<\/p>\n\n\n\n<p><strong>Other side effects:<\/strong><\/p>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you notice any of the\u00a0side effects\u00a0below.\u00a0They are usually mild and tend to disappear during treatment.<\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea.<\/li><li>Stomach pain.<\/li><li>Nausea.<\/li><li>Constipation.<\/li><li>Gas formation.<\/li><li>Headache<\/li><li>Pain at the injection site.<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach upset after a meal (&nbsp;dyspepsia&nbsp;).<\/li><li>Vomiting.<\/li><li>Feeling full.<\/li><li>Fatty stools.<\/li><li>Loose stools.<\/li><li>Discolored stools.<\/li><li>Dizziness.<\/li><li>Loss of appetite.<\/li><li>Changes in liver function tests.<\/li><li>Hair loss.<\/li><li>Respiratory distress.<\/li><li>Faintness<\/li><\/ul>\n\n\n\n<p>If you get\u00a0any side effects, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p>A few people experience pain at the site of the subcutaneous\u00a0injection.\u00a0This pain usually lasts only a short time.\u00a0If this happens to you, you can relieve the pain by gently rubbing the injection site for a few seconds after the\u00a0injection.<\/p>\n\n\n\n<p>If you take Sandostatin as a\u00a0subcutaneous\u00a0injection, you can reduce the risk of\u00a0side effects\u00a0from the gastrointestinal tract if you avoid meals around the time of\u00a0injection.\u00a0It is therefore recommended that you inject Sandostatin between meals or at bedtime.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Sandostatin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>The ampoules&nbsp;can be stored at a maximum of 30 \u00b0 C for up to two weeks.<\/p>\n\n\n\n<p>The ampoules&nbsp;should be used immediately after opening.<\/p>\n\n\n\n<p>Diluted solutions should be used immediately after\u00a0reconstitution.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not use this medicine if you notice particles or discoloration.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is octreotide.Sandostatin 50 micrograms \/ ml: 1 ml solution contains 50 micrograms octreotide.Sandostatin 100 micrograms \/ ml: 1 ml solution contains 100 micrograms octreotide.Sandostatin 500 micrograms \/ ml: 1 ml solution contains 500 micrograms octreotide.<\/li><li>Other ingredients are: lactic acid, mannitol (E421), sodium bicarbonate, water for injections<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Stained&nbsp;glass ampoule&nbsp;with two color-coded rings containing clear, colorless solution<\/p>\n\n\n\n<p>Sandostatin 50 micrograms\/ml: one blue and one yellow<\/p>\n\n\n\n<p>Sandostatin 100 micrograms\/ml: one blue and one green<\/p>\n\n\n\n<p>Sandostatin 500 micrograms\/ml: one blue and one pink<\/p>\n\n\n\n<p>Packs of three, five, six, ten, twenty, and fifty\u00a0ampoules.<\/p>\n\n\n\n<p>Multipack of ten packs containing three&nbsp;ampoules&nbsp;each.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Sverige AB<\/p>\n\n\n\n<p>Box 1218<\/p>\n\n\n\n<p>SE-164 28 Kista<\/p>\n\n\n\n<p><strong>This medicinal product is authorized in the European Economic Area and the United Kingdom (Northern Ireland) under the names:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Bulgaria, Cyprus, Denmark, Estonia, Finland, United Kingdom (Northern Ireland), Greece, Iceland, Ireland, Croatia, Latvia, Lithuania, Malta, Norway, Poland, Romania, Slovakia, Slovenia, Spain, Sweden, Czech Republic, Germany, Hungary, Austria,<\/td><td>Sandostatin<\/td><\/tr><tr><td>Belgium, France, Luxembourg, the Netherlands<\/td><td>Sandostatin<\/td><\/tr><tr><td>Italy, Portugal<\/td><td>Sandostatin<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Sandostatin is a synthetic version of somatostatin, a substance that occurs naturally in the body and which inhibits the effects of certain hormones such as. growth hormone . The advantages of Sandostatin compared to somatostatin are that it is stronger and that the effect lasts longer.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[19615,23669,19611,19614,23665,23668,19612,23666,19613,23667],"class_list":["post-22658","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-octreotide","tag-benefits-of-sandostatin","tag-octreotide","tag-octreotide-side-effects","tag-sandostatin","tag-sandostatin-side-effects","tag-what-is-octreotide","tag-what-is-sandostatin","tag-what-octreotide-is-used-for","tag-what-sandostatin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22658"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22658\/revisions"}],"predecessor-version":[{"id":22689,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22658\/revisions\/22689"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}