{"id":22652,"date":"2022-07-05T07:11:52","date_gmt":"2022-07-05T07:11:52","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22652"},"modified":"2022-07-05T10:39:58","modified_gmt":"2022-07-05T10:39:58","slug":"sancuso","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/sancuso\/","title":{"rendered":"SANCUSO &#8211; Granisetron uses, dose and side effects"},"content":{"rendered":"\n<p>3.1 mg \/ 24 hours&nbsp;transdermal<br>patch granisetron<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What SANCUSO is and what it is used for<\/h2>\n\n\n\n<p>The active substance in SANCUSO is granisetron, which belongs to a group of medicines called antiemetics and anti-nausea drugs.<\/p>\n\n\n\n<p>SANCUSO is a\u00a0transdermal patch\u00a0used to prevent nausea and vomiting in adults who receive medicines used to treat cancer for three to five days.\u00a0The patch is used for people who have difficulty swallowing tablets (eg due to soreness, dryness, or\u00a0inflammation\u00a0of the mouth or throat).<\/p>\n\n\n\n<p>You need to talk to a doctor if you do not feel better or if you feel worse after the first day of\u00a0chemotherapy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using SANCUSO<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use SANCUSO<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to granisetron or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to any other anti-nausea medicine whose name ends in &#8220;section&#8221;, e.g.\u00a0ondansetron.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before using this treatment if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have been told that you have heart disease<\/li><li>if you have a stomach ache or your stomach is swollen<\/li><li>if you have kidney or liver problems.<\/li><\/ul>\n\n\n\n<p>The medicine may not have as good an effect and\/or may affect the skin if it is exposed to direct sunlight or light from sun lamps or tanning beds.\u00a0It is important to follow these instructions:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>while using the transdermal patch, protect it with clothing if you are out in the sun or near a sun lamp or solarium<\/li><li>the skin where the medicine has been applied should be covered for a further ten days after the transdermal patch has been removed to protect against direct sunlight.<\/li><\/ul>\n\n\n\n<p>It is unknown how activities such as swimming, strenuous exercise, sauna baths, or whirlpool baths can affect medicine.\u00a0Avoid these activities while using the transdermal patch.\u00a0You can continue to shower and wash as usual while using the transdermal patch.<\/p>\n\n\n\n<p>Heat, from e.g.&nbsp;hot water bottles or heating pads, should be avoided in the area where the transdermal patch is located.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be used by children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and SANCUSO<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you have recently taken, or might take any other medicines.\u00a0SANCUSO may affect the effectiveness of other medicines.\u00a0In addition, some other medicines may affect the effect of SANCUSO.\u00a0You should especially tell your doctor or nurse if you are taking the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>paracetamol\u00a0used for pain.<\/li><li>phenobarbital is used for\u00a0epilepsy.<\/li><li>ketoconazole\u00a0is used to treat fungal infections.<\/li><li>SSRIs\u00a0(selective serotonin reuptake inhibitors) are used to treat depression and\/or anxiety, including\u00a0fluoxetine,\u00a0paroxetine,\u00a0sertraline, fluvoxamine,\u00a0citalopram, and escitalopram.<\/li><li>SNRIs\u00a0(\u00a0serotonin\u00a0and norepinephrine reuptake inhibitors) are used to treat depression and\/or anxiety, including\u00a0venlafaxine, and duloxetine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not use this medicine if you are pregnant unless your doctor has explicitly recommended it.\u00a0If you are breastfeeding, stop breastfeeding while wearing the patch.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>SANCUSO has no or negligible effect on the ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use SANCUSO<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;If you are not sure, talk to your doctor or nurse.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is a\u00a0transdermal patch.\u00a0The drug in the transdermal patch gradually passes through the skin into the body and therefore the patch should be applied 1 to 2 days (24 to 48 hours) before starting cancer treatment.<\/p>\n\n\n\n<p>The drug is intended for use on the skin.\u00a0This medicine supplies the active substance slowly and steadily through the skin and into the bloodstream throughout the transdermal patch.<\/p>\n\n\n\n<p><strong>Things to remember when using the transdermal patch<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The transdermal patch must not be stored outside the sealed sachet.<\/li><li>The transdermal patch must not be cut into smaller pieces.<\/li><li>Use only one\u00a0transdermal patch\u00a0at a time.<\/li><li>When removing the transdermal patch, check your skin and tell your doctor if you notice any severe skin reaction (if your skin is very red, itchy, or if you have blisters).<\/li><li>The transdermal patch may be affected by direct sunlight or sunlight.\u00a0While using the transdermal patch, you must have it covered, e.g.\u00a0under clothing, if there is a risk of exposure to sunlight or sun lamps.\u00a0Continue to keep the application site covered for another ten days after removing the transdermal patch.<\/li><li>Contact with water during a bath or shower does not change the effect of SANCUSO.\u00a0However, it may cause the transdermal patch to partially come off.\u00a0Avoid\u00a0exposing\u00a0the transdermal patch to water for a long time.<\/li><li>There is no information on the effect of other activities on the transdermal patch, e.g.\u00a0strenuous exercise or sauna bath, or whirlpool.\u00a0Therefore, you should avoid these activities while using the transdermal patch.<\/li><li>Heat (from eg hot water bottles or heating pads) should be avoided in the area where the transdermal patch is located.<\/li><\/ul>\n\n\n\n<p><strong>When to apply and remove the transdermal patch<\/strong><\/p>\n\n\n\n<p>Do not remove the transdermal patch from the sachet until you are ready to use it.\u00a0Apply a\u00a0transdermal patch\u00a0at least 1 day (24 hours) before you receive planned cancer treatment.\u00a0The transdermal patch can be applied up to 2 days (48 hours) before treatment.\u00a0Let the transdermal patch sit on at all times during the treatment.\u00a0The transdermal patch can last for up to seven days depending on how long the chemotherapy lasts.\u00a0Remove the transdermal patch at the earliest 1 day (24 hours) after the end of cancer treatment.<\/p>\n\n\n\n<p><strong>Where to apply the transdermal patch<\/strong><\/p>\n\n\n\n<p>Put the transdermal patch on a clean, dry and healthy area of \u200b\u200bskin on the outside of the upper arm.\u00a0If it is inappropriate to put the transdermal patch on your arms, your doctor may ask you to put it on your stomach.\u00a0The area you choose must not have oily skin or be freshly shaved.\u00a0There must also be no skin problems such as.\u00a0damage (scratches or abrasions) or irritation (\u00a0redness\u00a0or rash).\u00a0Do not apply SANCUSO to areas that have been treated with\u00a0creams, oils, lotions, powders, or other skin products that may prevent the transdermal patch from adhering well to the skin.<\/p>\n\n\n\n<p><strong>How to apply the transdermal patch<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Take a&nbsp;sachet&nbsp;out of the box and tear it up at the notch.&nbsp;Each&nbsp;sachet&nbsp;contains a&nbsp;transdermal patch&nbsp;that sits on a rigid plastic film.<\/li><li>Remove the transdermal patch from the sachet.<\/li><\/ol>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20101127000066#\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p>3. The sticky side of the transdermal patch is covered by a two-part, rigid plastic film.\u00a0Bend the transdermal patch in the middle and remove one-half of the rigid plastic film.\u00a0Be careful not to stick the transdermal patch together and avoid touching the sticky side of the transdermal patch.<br>4. Hold the remaining half of the rigid plastic film and place the transdermal patch on the skin on the outside of the upper arm.<br>5. Remove the remaining half of the rigid plastic film and press the entire transdermal patch firmly with your fingers and smooth it out.\u00a0Press firmly so that it is guaranteed to have good contact with the skin, especially around the edges.<br>6. Wash your hands after applying the transdermal patch.<br>7. Leave the transdermal patch on for the duration of your cancer treatment.<br>8. Do not reuse the transdermal patch after removing it.\u00a0See the instructions below on how to remove and dispose of the transdermal patch (see section 5).<\/p>\n\n\n\n<p><strong>After removing the transdermal patch<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>The transdermal patch used still contains some granisetron and should be discarded immediately as described in section 5.<\/li><li>After removing the transdermal patch, sticky material may remain on the skin.&nbsp;Wash the area gently with soap and water to remove it.&nbsp;Alcohol or other solvents such as nail polish remover can irritate the skin and should not be used.<\/li><li>Wash your hands.<\/li><li>You can see a slight&nbsp;redness&nbsp;on the skin when the transdermal patch has been removed.&nbsp;This&nbsp;redness&nbsp;should disappear over time.&nbsp;Talk to your doctor if it does not.<\/li><\/ol>\n\n\n\n<p><strong>If the transdermal patch comes off<\/strong><\/p>\n\n\n\n<p>If the transdermal patch starts to come off, you can apply the same&nbsp;transdermal patch&nbsp;to the same area of \u200b\u200bskin.&nbsp;If necessary, you can use surgical dressings or surgical tape to hold the transdermal patch in place.&nbsp;If you lose the transdermal patch or if it is damaged, contact your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more SANCUSO than you should&nbsp;<\/h2>\n\n\n\n<p>If you use more SANCUSO than you should, just remove the extra patch (s) and consult a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use SANCUSO<\/h2>\n\n\n\n<p>You must use the medicine according to your doctor&#8217;s instructions to prevent nausea or vomiting after the cancer treatment.\u00a0If you forget to put on the transdermal patch at the right time, put it on as soon as you remember, and tell your doctor as soon as possible before the cancer treatment.<\/p>\n\n\n\n<p><strong>If you stop using SANCUSO<\/strong><\/p>\n\n\n\n<p>You must use the medicine throughout your cancer treatment (up to seven days) to prevent nausea or vomiting after the cancer treatment.\u00a0Talk to your doctor if you want to remove the patch before the cancer treatment is over (up to seven days).<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you are receiving cancer treatment that may make you feel unwell or to a high degree, you may still feel unwell despite treatment with anti-nausea medicines, including this medicine.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if<\/strong>&nbsp;you get constipation or if your stomach hurts or swells.&nbsp;Constipation is a common&nbsp;side effect&nbsp;and occurs in less than 1 in 10 users.<\/p>\n\n\n\n<p><strong>Remove the transdermal patch and tell your doctor<\/strong>\u00a0if you notice any serious skin reaction (if your skin is very red, itchy, or if you have blisters).\u00a0Skin reactions at the application site, e.g.\u00a0irritation,\u00a0itching,\u00a0or\u00a0redness, are less common and occur in less than 1 in 100 users.<\/p>\n\n\n\n<p><strong>Other possible side effects:<\/strong><\/p>\n\n\n\n<p><em>Uncommon&nbsp;side effects&nbsp;are:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache and a feeling that it spins even when you stand still (\u00a0vertigo\u00a0)<\/li><li>decreased appetite and weight loss<\/li><li>herding (or\u00a0redness\u00a0)<\/li><li>nausea, nausea, and\u00a0dry mouth<\/li><li>joint pain<\/li><li>swelling due to water accumulating in the body (\u00a0edema\u00a0)<\/li><li>changes in liver function tests (if you are going to have blood tests, tell your doctor or nurse that you have received SANCUSO).<\/li><\/ul>\n\n\n\n<p><em>Rare&nbsp;side effects&nbsp;(may affect less than 1 in 1,000 people) are:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal muscle movements (eg tremors, muscle stiffness, and muscle cramps).<\/li><\/ul>\n\n\n\n<p><em>Side effects&nbsp;with no known frequency (can not be calculated from the available data):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic skin reactions.\u00a0These signs may be red, raised, or itchy bumps.<\/li><\/ul>\n\n\n\n<p><em>Other possible&nbsp;side effects&nbsp;are associated with granisetron drugs (no known frequency):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions including\u00a0urticaria\u00a0(itchy, red, raised skin rash) and\u00a0anaphylaxis\u00a0(a severe\u00a0allergic reaction\u00a0that may include sudden wheezing, difficulty breathing, swollen eyelids, swollen face, and swollen lips, rash, and\u00a0itching\u00a0)<\/li><li>difficult to sleep \/ disturbed sleep<\/li><li>excessive sleepiness<\/li><li>prolonged\u00a0ECT interval\u00a0in\u00a0ECG\u00a0(changes in heart rate recording (\u00a0ECG\u00a0) showing a heart rhythm disorder)<\/li><li>constipation<\/li><li>diarrhea<\/li><li>no energy \/ weakness \/ lost strength<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store SANCUSO<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and sachet after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Used&nbsp;transdermal patches&nbsp;still contain active ingredients that may be harmful to others.&nbsp;Fold the transdermal patch in the middle with the sticky side inwards and throw it away safely, out of the reach of children.&nbsp;Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is granisetron.&nbsp;Each 52 cm&nbsp;<sup>2&nbsp;<\/sup>transdermal patch&nbsp;contains 34.3 mg of granisetron which releases 3.1 mg of granisetron in one day.<\/li><li>Other ingredients are:<\/li><li>The adhesive of the transdermal patch: copolymer of acrylate and vinyl acetate<\/li><li>Backing: polyester<\/li><li>Rigid plastic film: siliconized polyester.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>SANCUSO is a thin, transparent, rectangular\u00a0transdermal patch\u00a0with rounded corners, attached to a rigid plastic film.\u00a0The transdermal patch is in a\u00a0sachet.\u00a0Each carton contains a\u00a0transdermal patch.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Kyowa Kirin Holdings BV<\/p>\n\n\n\n<p>Bloemlaan 2<\/p>\n\n\n\n<p>2132NP Hoofddorp<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Tel.&nbsp;+31 (0) 237200822<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br>Parboil Waltrop GmbH (a subsidiary of NextPharma)<br>I&#8217;m Wirrigen 25<br>45731 Waltrop<br>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in SANCUSO is granisetron, which belongs to a group of medicines called antiemetics and anti-nausea drugs.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[14060,23686,14056,14061,23682,23685,14058,14057,23683,23684],"class_list":["post-22652","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-benefits-of-granisetron","tag-benefits-of-sancuso","tag-granisetron","tag-granisetron-side-effects","tag-sancuso","tag-sancuso-side-effects","tag-what-granisetron-is-used-for","tag-what-is-granisetron","tag-what-is-sancuso","tag-what-sancuso-is-usedfor"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22652"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22652\/revisions"}],"predecessor-version":[{"id":22692,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22652\/revisions\/22692"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}