{"id":22600,"date":"2022-07-04T07:44:52","date_gmt":"2022-07-04T07:44:52","guid":{"rendered":"https:\/\/zeepedia.com\/?p=22600"},"modified":"2022-07-04T11:50:48","modified_gmt":"2022-07-04T11:50:48","slug":"salazopyrin-en","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/salazopyrin-en\/","title":{"rendered":"Salazopyrin EN &#8211; Sulfasalazine uses, dose and side effects"},"content":{"rendered":"\n<p>500 mg\u00a0enteric tablet\u00a0is<br>sulfasalazine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Salazopyrin EN is and what it is used for<\/h2>\n\n\n\n<p>Salazopyrin EN has an\u00a0anti-inflammatory\u00a0and\u00a0antibacterial\u00a0effect and inhibits\u00a0inflammation, especially in the intestinal\u00a0mucosa.<\/p>\n\n\n\n<p>Salazopyrin EN is a gastric juice-resistant tablet specially designed for patients with active\u00a0rheumatoid arthritis\u00a0and patients experiencing gastrointestinal\u00a0side effects\u00a0from Salazopyrin tablets.<\/p>\n\n\n\n<p>Salazopyrin EN is used in the treatment of\u00a0rheumatoid arthritis\u00a0and inflammatory bowel diseases (\u00a0ulcerative colitis,\u00a0Crohn&#8217;s disease\u00a0).<\/p>\n\n\n\n<p>Salazopyrin EN is also used in the treatment of the skin disease\u00a0pyoderma gangrenous\u00a0, which is sometimes seen in patients with\u00a0ulcerative colitis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Salazopyrin EN<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Salazopyrin EN<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to sulfasalazine, its\u00a0metabolites, sulfa (\u00a0sulfonamides\u00a0) or\u00a0<a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a>\u00a0(included in some medicines for fever and pain), or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have\u00a0acute\u00a0intermittent\u00a0porphyria\u00a0(liver porphyria, increased presence of certain blood dyes caused by enzyme deficiency).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Salazopyrin EN<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you\u00a0have recurrent or\u00a0chronic\u00a0infection<\/li><li>if you have impaired kidney or liver function<\/li><li>if you have severe\u00a0allergies\u00a0or\u00a0asthma<\/li><li>if you have\u00a0glucose\u00a0-6-\u00a0phosphate\u00a0-dehydrogenase deficiency, you should inform your doctor before starting treatment.<\/li><li>if you are a man trying to have children because Salazopyrin EN may reduce sperm production (normalizes if medication is stopped)<\/li><li>if you are taking or have recently taken Salazopyrin EN or any other medicines that contain sulfasalazine, as they may affect your blood and urine test results.<\/li><\/ul>\n\n\n\n<p>Contact your doctor immediately if you develop a new&nbsp;infection&nbsp;during your treatment with Salazopyrin EN.&nbsp;Your doctor may stop treatment.<\/p>\n\n\n\n<p>Blood count, and renal and hepatic function should be checked before starting treatment and at the beginning of treatment.\u00a0Thereafter, the treating physician should be contacted for regular check-ups.<\/p>\n\n\n\n<p>Contact your doctor immediately if you get symptoms such as sore throat, fever, pallor, get a reddish or yellowish color in the skin.\u00a0This may indicate liver problems, as well as blood count changes and treatment, may need to be stopped.<\/p>\n\n\n\n<p>Skin reactions, which may be life-threatening (\u00a0Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis\u00a0), have been reported with sulfasalazine.\u00a0It can start as red-violet target-like or round spots with blistering in the middle, often symmetrically spread, on the torso.\u00a0Additional signs to be aware of are sores in the mouth, throat, nose, genitals, or eye inflammation (red and swollen eyes).\u00a0The skin reactions, which can be life-threatening, are often followed by\u00a0flu-like symptoms.\u00a0The rash can develop into blisters over large areas of skin detachment.\u00a0The risk of serious skin reactions is greatest during the first weeks of treatment.\u00a0If you suffer from\u00a0Stevens-Johnson\u00a0syndrome or\u00a0toxic epidermal necrolysisWhen you have used sulfasalazine contained in Salazopyrin EN, you must never use medicines containing sulfasalazine again.\u00a0If you get a rash or signs of these skin reactions, stop taking Salazopyrin EN immediately, and contact your doctor immediately and tell them that you are taking this medicine.<\/p>\n\n\n\n<p>Hypersensitivity reactions, which may be life-threatening (such as drug-induced skin rash (DRESS)), have been reported with the use of sulfasalazine.\u00a0Early signs of hypersensitivity may be rash, fever, or swollen\u00a0lymph nodes.\u00a0If you get symptoms of a\u00a0hypersensitivity reaction, contact your doctor immediately and tell them you are taking this medicine.<\/p>\n\n\n\n<p>During treatment with sulfasalazine, it is important to drink properly to prevent the formation of crystals in the urine and\u00a0kidney stones.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Salazopyrin EN<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.\u00a0The treatment effect may be affected if Salazopyrin EN is taken at the same time as certain other medicines.\u00a0If you are taking any of the following medicines, a\u00a0dose\u00a0of Salazopyrin EN or the other medicine may need to be changed or other precautions may need to be taken.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Digoxin&nbsp;for heart disease<\/li><li>Folic acid&nbsp;for&nbsp;anemia<\/li><li>Rifampicin for&nbsp;tuberculosis<\/li><li>Mercaptopurine or azathioprine for&nbsp;leukopenia&nbsp;or transplantation and immunological diseases<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Salazopyrin EN with food, drink, and alcohol<\/h2>\n\n\n\n<p>The enteric tablets&nbsp;should be taken with a meal and distributed as evenly as possible during the day.&nbsp;The tablets are&nbsp;coated&nbsp;so that they do not dissolve until they reach the intestine.&nbsp;It is therefore important that they are swallowed whole so that the surface layer (coating) is not damaged.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Treatment with Salazopyrin EN may lead to <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triobe\/\">folic acid<\/a> deficiency.<\/p>\n\n\n\n<p>The concentration of the drug can be expected to be the same in the mother and the fetus and thus there is a risk of&nbsp;side effects&nbsp;in the fetus as well.&nbsp;However, animal studies do not indicate any risk of birth defects, but risks associated with use during pregnancy can not be completely ruled out.&nbsp;During pregnancy, Salazopyrin EN should be given only after special medical consideration.<\/p>\n\n\n\n<p>Sulfasalazine passes into breast milk in small amounts.\u00a0Bloody stools and diarrhea have been reported in infants where the breastfeeding woman has been treated with sulfasalazine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>No effects were observed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Salazopyrin EN contains propylene glycol<\/h2>\n\n\n\n<p>This medicine contains 5 mg of propylene glycol per tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Salazopyrin EN<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.&nbsp;Dose&nbsp;one is individually tailored for you.&nbsp;Carefully follow the&nbsp;dosage&nbsp;stated on the pharmacy label!<\/p>\n\n\n\n<p><em>In rheumatoid arthritis:<\/em><\/p>\n\n\n\n<p>The usual\u00a0dose, adults: 2 tablets twice daily.<\/p>\n\n\n\n<p><em>In&nbsp;inflammatory&nbsp;bowel disease:<\/em><\/p>\n\n\n\n<p>The usual\u00a0dose, adults: 2-4 tablets 2-4 times daily.<\/p>\n\n\n\n<p>The usual\u00a0dose, children:\u00a0dose\u00a0one depends on the weight of the child.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Salazopyrin EN than you should&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has inadvertently ingested the medicine, contact a doctor or hospital immediately for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Salazopyrin EN<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.\u00a0Medication should be continued for as long as your doctor prescribes, otherwise the disease may worsen and return.\u00a0As a rule, Salazopyrin EN should be taken for a long time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0In rare cases,\u00a0hypersensitivity reactions\u00a0may occur.<\/p>\n\n\n\n<p>During treatment with Salazopyrin EN, any&nbsp;side effects&nbsp;usually occur during the first 3 months of treatment.<\/p>\n\n\n\n<p>Common (affects more than 1 user in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;leukocyte&nbsp;count (&nbsp;white blood cells&nbsp;)<\/li><li>loss of appetite<\/li><li>headache, dizziness, taste changes<\/li><li>tinnitus<\/li><li>cough<\/li><li>nausea, abdominal pain, bloating, diarrhea, vomiting<\/li><li>hives<\/li><li>itching<\/li><li>purple discoloration of the skin<\/li><li>joint pain<\/li><li>protein&nbsp;in the urine<\/li><li>reduced sperm production (&nbsp;reversible&nbsp;)<\/li><li>fever<\/li><li>transient increase in liver enzymes<\/li><\/ul>\n\n\n\n<p>Uncommon (affects less than 1 user in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count&nbsp;(&nbsp;platelets&nbsp;)<\/li><li>swelling of the face<\/li><li>Depression,<\/li><li>breathing difficulties<\/li><li>hair loss<\/li><\/ul>\n\n\n\n<p>Rare (affects less than 1 user in 1,000):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nail changes, skin reactions that can be life-threatening (&nbsp;epidermal&nbsp;necrolysis&nbsp;and&nbsp;Stevens-Johnson syndrome&nbsp;)<\/li><li>jaundice<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pseudomembranous\u00a0colitis\u00a0(intestinal inflammation)<\/li><li>mononucleosis-like syndrome (false glandular fever)<\/li><li>effects on the blood picture with, for example, severe\u00a0white blood cell deficiency\u00a0(\u00a0agranulocytosis\u00a0) and severe\u00a0anemia<\/li><li>hypersensitivity reaction,\u00a0angioedema\u00a0(swelling of the lips, eyelids, face, tongue, and throat), serum sickness (delayed\u00a0allergic reaction\u00a0)<\/li><li>deficiency of\u00a0folic acid<\/li><li>effects on the nervous system,\u00a0meningitis,\u00a0encephalopathy\u00a0(brain disease), altered olfactory sensations, myocarditis<\/li><li>pericarditis, decreased oxygenation of the blood leading to bluish discoloration of the skin, lips, and mucous membranes (cyanosis) and pallor<\/li><li>different types of lung diseases (such as fibrous alveolitis), pain in the mouth and throat<\/li><li>pancreatitis, worsening of\u00a0ulcerative colitis<\/li><li>hepatitis sometimes sudden onset, hepatic failure, narrowing of the bile ducts in the liver, and slower flow of bile in the gallbladder<\/li><li>drug-induced rash (DRESS see also Warnings and precautions), skin rash, reddening of the skin, severe skin inflammation with dandruff (exfoliative\u00a0dermatitis\u00a0), skin reactions to sun exposure<\/li><li>SLE\u00a0syndrome (autoimmune disease)<\/li><li>kidney effects, blood in the urine, crystals in the urine,\u00a0kidney stones<\/li><li>yellowing of skin and body fluids (eg sweat, saliva, urine, and tear fluid) and thus also yellowing of soft contact lenses<\/li><li>formation of\u00a0antibodies\u00a0directed against the body&#8217;s\u00a0tissues\u00a0(so-called autoantibodies)<\/li><\/ul>\n\n\n\n<p>If you get an\u00a0infection\u00a0with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/throat \/ mouth or urination problems, you should see a doctor as soon as possible so that a blood test can rule out a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0).\u00a0It is important that you then information about your medication.<\/p>\n\n\n\n<p>Stop taking Salazopyrin EN and contact a doctor immediately if you get any of the following symptoms (&nbsp;angioedema&nbsp;)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, tongue, or throat<\/li><li>difficulty swallowing<\/li><li>hives\u00a0and difficulty breathing<\/li><\/ul>\n\n\n\n<p>Skin reactions, which may be life-threatening (&nbsp;Stevens-Johnson syndrome&nbsp;and&nbsp;toxic epidermal necrolysis&nbsp;) have been reported (see section Warnings and precautions).<\/p>\n\n\n\n<p>If you get\u00a0any side effects, talk to your doctor or pharmacist.\u00a0This also applies to any\u00a0side effects\u00a0not mentioned in this information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Salazopyrin EN<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is sulfasalazine.&nbsp;One tablet contains 500 mg sulfasalazine.<\/li><li>The other ingredients are maize starch, magnesium stearate, povidone,&nbsp;colloidal&nbsp;silica, cellulose acetate phthalate, propylene glycol (E 1520) (see section 2 \u201cSalazopyrin EN contains propylene glycol\u201d), white beeswax, carnauba wax, glycerol monostearate, macrogol 20,000.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Jar with screw caps made of HD polyethylene and polypropylene, 100 pcs and 300 pcs.&nbsp;The lid has a notch so that, for example, a pencil can simplify opening.<\/p>\n\n\n\n<p>The tablet is yellow, arched, 10 \u00d7 18 mm with an engraved symbol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder<\/p>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Tel: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<\/p>\n\n\n\n<p>Manufacturer<\/p>\n\n\n\n<p>Recipharm Uppsala AB<\/p>\n\n\n\n<p>Bj\u00f6rkgatan 30<\/p>\n\n\n\n<p>751 82 Uppsala<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Salazopyrin EN has an anti-inflammatory and antibacterial effect and inhibits inflammation , especially in the intestinal mucosa .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18530],"tags":[23625,23628,23629,23620,23624,23623,23626,23621,23627,23622],"class_list":["post-22600","post","type-post","status-publish","format-standard","hentry","category-medicines","category-s","tag-salazopyrin-en","tag-salazopyrin-en-side-effects","tag-salazopyrin-en-tablet","tag-sulfasalazine","tag-sulfasalazine-side-effects","tag-sulfasalazine-tablet","tag-what-is-salazopyrin-en","tag-what-is-sulfasalazine","tag-what-salazopyrin-en-is-used-for","tag-what-sulfasalazine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=22600"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22600\/revisions"}],"predecessor-version":[{"id":22643,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/22600\/revisions\/22643"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=22600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=22600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=22600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}